Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6

Toxicology and Applied Pharmacology

Volumn 279, Issue 3, 2014, Pages 311-321

  Zhao, Haixia ^a   Zhang, Xinhua ^b   Chen, Xuewei ^a   Li, Ying ^a   Ke, Zunqiong ^a   Tang, Tian ^c   Chai, Hongyan ^d   Guo, Austin M ^a,e   Chen, Honglei ^a   Yang, Jing ^a  

^a WUHAN UNIVERSITY   (China)

^b HUBEI CANCER HOSPITAL   (China)

^c RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^d ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^e NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Colitis associated tumorigenesis; COX 2; IL 6; Inflammation; Isoliquiritigenin; Macrophage

Indexed keywords

ARGINASE 1; AZOXYMETHANE; CLODRONIC ACID; CYCLOOXYGENASE 2; DEXTRAN SULFATE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; ISOLIQUIRITIGENIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PROSTAGLANDIN E2; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; ZOLEDRONIC ACID;

ADD ON THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER INCIDENCE; CELL POLARITY; CHEMOPROPHYLAXIS; COLITIS ASSOCIATED TUMORIGENESIS; COLON CARCINOGENESIS; CONTROLLED STUDY; DEXTRAN SODIUM SULFATE-INDUCED COLITIS; DOWN REGULATION; GENE; GENE EXPRESSION; GLYCYRRHIZA; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; M2 MACROPHAGE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHARMACOLOGICAL BLOCKING; PLANT ROOT; POLARIZATION; PROTEIN EXPRESSION; REPEATED DRUG DOSE; TUMOR VOLUME;

COLITIS-ASSOCIATED TUMORIGENESIS; COX-2; IL-6; INFLAMMATION; ISOLIQUIRITIGENIN; MACROPHAGE;

ANIMALS; BLOTTING, WESTERN; CELL POLARITY; CELLS, CULTURED; CHALCONES; COLITIS; COLON; COLONIC NEOPLASMS; DINOPROSTONE; DOWN-REGULATION; ENZYME INHIBITORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCYRRHIZA; INTERLEUKIN-6; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; STAT3 TRANSCRIPTION FACTOR; TRANSFECTION;

EID: 84907176451     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.07.001     Document Type: Article

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