Licorice compounds glycyrrhizin and 18β-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes

Journal of Biological Chemistry

Volumn 280, Issue 11, 2005, Pages 10556-10563

  Gumpricht, Eric ^a   Dahl, Rolf ^a   Devereaux, Michael W ^a   Sokol, Ronald J ^a,b  

^a CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOLOGICAL MEMBRANES; CONCENTRATION (PROCESS); CYTOLOGY; HYDROPHOBICITY; OXIDATION; STRESSES; TOXICITY;

ANTIHEPATOTOXIC AGENTS; HYDROPHOBIC BILE ACIDS; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS;

CARBOXYLIC ACIDS;

BILE ACID; CASPASE 10; CASPASE 3; CYTOCHROME C; GLYCOCHENODEOXYCHOLIC ACID; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; ENZYME ACTIVATION; GLYCYRRHIZA; LIVER CELL; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BILE ACIDS AND SALTS; CASPASE 10; CASPASE 3; CASPASE 9; CASPASES; CELL NUCLEUS; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GLYCYRRHETINIC ACID; GLYCYRRHIZA; GLYCYRRHIZIC ACID; HEPATOCYTES; IMMUNOBLOTTING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; MALE; MAP KINASE KINASE 4; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOCHONDRIA, LIVER; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NECROSIS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TIME FACTORS;

GLYCYRRHIZA;

EID: 15444365508     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411673200     Document Type: Article

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