Licochalcone A inhibits the migration and invasion of human lung cancer cells via inactivation of the Akt signaling pathway with downregulation of MMP-1/-3 expression

Tumor Biology

Volumn 35, Issue 12, 2014, Pages 12139-12149

  Huang, Hung Che ^a   Tsai, Lo Lin ^b,c   Tsai, Jen Pi ^d   Hsieh, Shu Ching ^b   Yang, Shun Fa ^b   Hsueh, Jung Tsung ^b   Hsieh, Yi Hsien ^b  

^a CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

Author keywords

Invasion; LicA; Lung cancer cells; Migration; MMP 1; MMP 3; Sp1

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTINEOPLASTIC AGENT; COLLAGENASE 3; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; LICOCHALCONE A; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 17; PROTEIN C JUN; PROTEIN KINASE B; STROMELYSIN; STROMELYSIN 3; TRANSCRIPTION FACTOR SP1; CHALCONE DERIVATIVE;

A549 CELL LINE; ARTICLE; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; LUNG CANCER; LUNG CANCER CELL LINE; METASTASIS INHIBITION; METASTASIS POTENTIAL; MIGRATION INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR INVASION; CELL MOTION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL MOVEMENT; CHALCONES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 3; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR;

EID: 84925282687     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-2519-3     Document Type: Article

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