Novel plant-derived target drugs: A step forward from licorice?

Expert Opinion on Therapeutic Targets

Volumn 17, Issue 4, 2013, Pages 333-335

  Lorusso, Vito ^a   Marech, Ilaria ^b  

^a NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

Breast cancer; Chalcone; Isoliquritrigenin; MCF 7

Indexed keywords

ALPHA2 INTEGRIN; ARACHIDONATE 12 LIPOXYGENASE; AROMATASE; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; I KAPPA B; INDOMETACIN; INTERCELLULAR ADHESION MOLECULE 1; ISOLIQUIRITIGENIN; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; STRESS ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UROKINASE; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; BREAST CARCINOMA; CANCER CELL; CANCER INHIBITION; CELL ADHESION; CELL CYCLE ARREST; CELL FRACTIONATION; CELL INVASION; CELL MIGRATION; COLON CANCER; ENZYME ACTIVITY; ENZYME INHIBITION; GLYCYRRHIZA; HUMAN; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN SECRETION; REVIEW; SIGNAL TRANSDUCTION; SKIN PAPILLOMA; SKIN TUMOR;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CHALCONES; DRUG DISCOVERY; FEMALE; GLYCYRRHIZA; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASMS;

EID: 84875133881     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2013.773312     Document Type: Review

References (10)

1. Yamamoto S, Aizu E, Jiang H, et al. The potent anti-tumor promoting agent isoliquiritigenin. Carcinogenesis 1991;12(2):317-23
2. Kanazawa M, Satomi Y, Mizutani Y, et al. Isoliquiritigenin inhibits the growth of prostate cancer. Eur Urol 2003;43(5):580-6
3. Kwon GT, Cho HJ, Chung WY, et al. Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: Possible mediation by decreased JNK/AP-1 signaling. J Nutr Biochem 2009;20(9):663-76
4. Auyeung KK, Ko JK. Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell. Invest New Drugs 2010;28(1):1-13
5. Yadav VR, Prasad S, Sung B, Aggarwal BB. The role of chalcones in suppression of NF-kappaB-mediated inflammation and cancer. Int Immunopharmacol 2011;11(3):295-309
6. Chen X, Wu Y, Jiang Y, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl) 2012;90(11):1311-19
7. Maggiolini M, Statti G, Vivacqua A, et al. Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells. J Steroid Biochem Mol Biol 2002;82(4-5):315-22
8. Ye L, Gho WM, Chan FL, et al. Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overespressing aromatase. Int J Can 2009;124:1028-36
9. Lau GT, Ye L, Leung LK. The licorice flavonoid isoliquiritigenin suppresses phorbol ester-induced cyclooxygenase-2 expression in the non-tumorigenic MCF-10A breast cell line. Planta Med 2010;76(8):780-5
10. Wang KL, Hsia SM, Chan CJ, et al. Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells. Expert Opin Ther Targets 2013;17(4):337-49