Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion

Toxicology and Applied Pharmacology

Volumn 280, Issue 1, 2014, Pages 10-20

  Zheng, Hao ^a   Li, Ying ^a   Wang, Yuzhong ^b   Zhao, Haixia ^a   Zhang, Jing ^c   Chai, Hongyan ^d   Tang, Tian ^e   Yue, Jiang ^a   Guo, Austin M ^a,f   Yang, Jing ^a  

^a WUHAN UNIVERSITY   (China)

^b Wuhan University   (China)

^c WUHAN UNIVERSITY   (China)

^d ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^e RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^f NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Anoikis; Breast cancer; COX 2; CYP 4A; Isoliquiritigenin; Metastasis

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; CASPASE; CYCLOOXYGENASE 2; CYTOCHROME P450 4A; ISOLIQUIRITIGENIN; MESSENGER RNA; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; PROTEIN KINASE B; SERINE; THREONINE; TYROSINE; CASPASE 3; CASPASE 8; CASPASE 9; CYCLOOXYGENASE 1; CYTOCHROME P450; CYTOSOLIC PHOSPHOLIPASE A2; GELATINASE A; GELATINASE B; LEUKOTRIENE B4; SECRETORY PHOSPHOLIPASE A2; CHALCONE DERIVATIVE; ENZYME INHIBITOR; PLANT EXTRACT; PTGS2 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOIKIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER CELL LINE; BREAST METASTASIS; BT 549 CELL LINE; CANCER INHIBITION; CANCER RESISTANCE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; MDA MB 231 CELL LINE; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TUMOR INVASION; ANOIKIS RESISTANCE; APOPTOSIS; BREAST CANCER; CANCER CELL; CELL INVASION; CELL MIGRATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; PROSTAGLANDIN RELEASE; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BREAST NEOPLASMS; CELL MOTION; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; GLYCYRRHIZA; ISOLATION AND PURIFICATION; METABOLISM; NEOPLASM INVASIVENESS; NUDE MOUSE; PHYSIOLOGY; PROCEDURES; RANDOMIZATION; TUMOR CELL LINE;

ANIMALS; ANOIKIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CHALCONES; CYCLOOXYGENASE 2; CYTOCHROME P-450 CYP4A; DOWN-REGULATION; ENZYME INHIBITORS; FEMALE; GLYCYRRHIZA; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; PLANT EXTRACTS; RANDOM ALLOCATION; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84906491754     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.07.018     Document Type: Article

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