Selectivity of Action of Glycyrrhizin Derivatives on the Growth of MCF-7 and HEP-2 Cells

Anticancer Research

Volumn 23, Issue 5 A, 2003, Pages 3813-3818

  Rossi, Tiziana ^a   Castelli, Mario ^a   Zandomeneghi, Ginevra ^a   Ruberto, Antonio ^a   Benassi, Luisa ^a   Magnoni, Cristina ^a   Santachiara, Saverio ^b   Baggio, Giosué ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

18 glycyrrhetinic acid; Apoptosis; Glycyrrhizin; HEP 2 cells; MCF 7 cells

Indexed keywords

18ALPHA GLYCYRRHETINIC ACID; DAUNORUBICIN; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; GLYCYRRHIZIC ACID DERIVATIVE; MITOMYCIN C;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER GROWTH; CARCINOMA CELL; CELL PROLIFERATION; CERCOPITHECIDAE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SELECTIVITY; FEMALE; HUMAN; HUMAN CELL; KIDNEY CELL; LARYNX TUMOR; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; SPECIES COMPARISON;

ANIMALS; BREAST NEOPLASMS; CELL DIVISION; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; DRUG SCREENING ASSAYS, ANTITUMOR; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; HUMANS; IN SITU NICK-END LABELING; LARYNGEAL NEOPLASMS; VERO CELLS;

EID: 0344010967     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Abe N, Ebina T and Ishida N: Interferon induction by glycyrrhizin and glycyrrhetinic acid in mice. Microbiol Immunol 26: 535, 1982.
2. Wang Zhi Y, Agarwal R, Zhou ZC, Bickers DR and Mukhatar H: Inhibition of mutagenecity in Salmonella typhimurium and skin tumour initiating and tumour promoting activities in Senecar mice by glycyrrhetinic acid: comparison of 18alfa- and 18beta-stereoisomers. Carcinogenesis 12 (2): 187-192, 1991.
3. Rossi T, Galatulas I, Bossa R, Tampieri A, Tartoni P, Baggio G, Ruberto IA and Castelli M: Influence of Glycyrrhizin on the evolution and respiration of Ehrlich ascites tumour cells. In Vivo 9: 183-186, 1995.
4. Malagoli M, Castelli M, Baggio A, Cermelli C, Garuti L and Rossi T: Effect of Glycyrrhizin and its diastereoisomers on the growth of human tumour cells: preliminary findings. Phytotherapy Res 12: S95-S97, 1998.
5. Ishioka C, Kanamaru R, Sato T, Dei T, Konishi Y, Asamura M and Wakui A: Inhibitory effects of prostaglandin A2 on c-myc expression and cell cycle progression in human leukemia cell line HL-60. Cancer Res 48: 2813-2818, 1988.
6. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Meth 65: 55-63, 1983.
7. Gavrieli Y, Sherman Y and Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493-501, 1992.
8. Gorczyca W, Gong J and Darzinkiewicz Z: Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 53: 1945-1951, 1993.
9. Kao ST, Yeh CC, Hsieh CC, Yang MD, Lee MR, Liu HS and Lin JG: The Chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest. Life Sci 69: 1485-1496, 2001.
10. Yue TL, Wang C, Romanic AM, Kikly K, Keller P, De Wolf WE Jr, Hart TK, Thomas HC, Storer B, Gu JL, Wang X and Feuerstein GZ: Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3. J Mol Cell Cardiol 30: 495-507, 1998.
11. Liu W, Kato M, Akhanad AA, Hayakawa A, Takemura M, Yoshida S, Suzuki H and Nakashima I: The herbal medicine Sho-saiko-to inhibits the growth of malignant melanoma cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulation of cyclin dependent kinase. Int J Oncol 12: 1321-1326, 1998.
12. Ma J, Fu NY, Pang DB, Wu WY and Xu AL: Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells. Planta Med 67: 754-757, 2001.
13. Yano H, Mizoguchi A, Fukuda K, Haramaki M, Ogasawara S, Momosaki S and Kojiro M: The herbal medicine Sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase. Cancer Res 54: 448-454, 1994.
14. Rossi T, Fano RA, Castelli M, Malagoli M, Ruberto AI, Baggio G, Zennaro R, Migaldi M and Barbolini G: Correlation between high intake of glycyrrhizin and myolysis of the papillary muscles: an experimental in vivo study. Pharmacol Toxicol 85(5): 221-229, 1999.
15. Benassi L, Ottani D, Fantini F, Marconi A, Chiodino C, Giannetti A and Pincelli C: 1,25-dihydroxyvitamin D3, transforming growth factor beta 1, calcium, and ultraviolet B radiation induce apoptosis in cultured human keratinocytes. J Invest Dermatol 109(3): 276-282, 1997.
16. Maggiolini M, Statti G, Vivacqua A, Gabriele S, Rago V, Loizzo M, Manichini F and Amdo S: Estrogenic and anti-proliferative activities of isoliquiritigenin in MCF7 breast cancer cells. J Steroid Biochem Mol Biol 82(4-5): 315-322, 2002.