18β-glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancer

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Huang, Run Yue ^a   Chu, Yong Liang ^a   Huang, Qing Chun ^a   Chen, Xiu Min ^a   Jiang, Ze Bo ^a   Zhang, Xian ^a   Zeng, Xing ^a  

^a GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLYCYRRHETINIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL INTERFERING RNA; THROMBOXANE SYNTHASE; 18ALPHA-GLYCYRRHETINIC ACID; PRIMER DNA;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BRONCHUS MUCOSA; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM CELL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYME IMMUNOASSAY; ENZYMOLOGY; LUNG TUMOR; NUCLEOTIDE SEQUENCE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SMALL CELL LUNG CANCER; TUMOR CELL LINE;

BASE SEQUENCE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA PRIMERS; GLYCYRRHETINIC ACID; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SMALL CELL LUNG CARCINOMA; THROMBOXANE-A SYNTHASE;

EID: 84898827741     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093690     Document Type: Article

References (31)

1. Logashenko EB, Salomatina OV, Markov AV, Korchagina DV, Salakhutdinov NF, et al. (2011) Synthesis and pro-apoptotic activity of novel glycyrrhetinic acid derivatives. Chembiochem 12: 784-794.
2. Kalani K, Agarwal J, Alam S, Khan F, Pal A, et al. (2013) In Silico and In Vivo Anti-Malarial Studies of 18beta Glycyrrhetinic Acid from Glycyrrhiza glabra. PloS one 8: e74761.
3. Kuttan G, Pratheeshkumar P, Manu KA, Kuttan R (2011) Inhibition of tumor progression by naturally occurring terpenoids. Pharm Biol 49: 995-1007.
4. Ming LJ, Yin AC (2013) Therapeutic effects of glycyrrhizic acid. Nat Prod Commun 8: 415-418.
5. Lee CS, Yang JC, Kim YJ, Jang ER, Kim W, et al. (2010) 18beta-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines. Eur J Pharmacol 649: 354-361.
6. Lallemand B, Ouedraogo M, Wauthoz N, Lamkami T, Mathieu V, et al. (2013) Synthesis and plasma pharmacokinetics in CD-1 mice of a 18beta-glycyrrhetinic acid derivative displaying anti-cancer activity. J Pharm Pharmacol 65: 402-410.
7. Sharma G, Kar S, Palit S, Das PK (2012) 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. J Cell Physiol 227: 1923-1931.
8. Zarogoulidis K, Zarogoulidis P, Darwiche K, Boutsikou E, Machairiotis N, et al. (2013) Treatment of non-small cell lung cancer (NSCLC). J Thorac Dis 5: S389-S396.
9. Ermert L, Dierkes C, Ermert M (2003) Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. Clin Cancer Res 9: 1604-1610. (Pubitemid 36554582)
10. Cathcart MC, Gately K, Cummins R, Kay E, O'Byrne KJ, et al. (2011) Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer. Mol Cancer 10: 25.
11. Huang RY, Li MY, Hsin MK, Underwood MJ, Ma LT, et al. (2010) 4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor. Oncogene 30: 106-116.
12. Huang RY, Chen GG (2011) Cigarette smoking, cyclooxygenase-2 pathway and cancer. Biochim Biophys Acta 1815: 158-169.
13. Nakahata N (2008) Thromboxane A2: Physiology/pathophysiology, cellular signal transduction and pharmacology. Pharmacol Ther 118: 18-35.
14. Cathcart MC, Reynolds JV, O'Byrne KJ, Pidgeon GP (2010) The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer. Biochim Biophys Acta 1805: 153-166.
15. Ekambaram P, Lambiv W, Cazzolli R, Ashton AW, Honn KV (2011) The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis. Cancer Metastasis Rev 30: 397-408.
16. Huang RY, Li MY, Ng CS, Wan IY, Kong AW, et al. (2013) Thromboxane A2 receptor α promotes tumor growth through an autoregulatory feedback pathway. J Mol Cell Biol 5:380-390.
17. Ashton AW, Yokota R, John G, Zhao S, Suadicani SO, et al. (1999) Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2). J Biol Chem 274: 35562-35570. (Pubitemid 129512852)
18. Huang W, Huang J, Zhang D, Zhang R, Liao Z (2003) Study on anti-invasive effect and apoptosis induction of pentacyclic triterpenoid in human lung cancer cells. Zhongguo Fei Ai Za Zhi 6: 254-257. (Pubitemid 37039639)
19. Moussa O, Riker JM, Klein J, Fraig M, Halushka PV, et al. (2008) Inhibition of thromboxane synthase activity modulates bladder cancer cell responses to chemotherapeutic agents. Oncogene 27: 55-62.
20. Fujimori A, Tsutsumi M, Yamada H, Fukase M, Fujita T (1989) Arachidonic acid stimulates cell growth in an osteoblastic cell line, MC3T3-E1, by noneicosanoid mechanism. Calcif Tissue Int 44: 186-191. (Pubitemid 19076627)
21. Nie D, Che M, Zacharek A, Qiao Y, Li L, et al. (2004) Differential expression of thromboxane synthase in prostate carcinoma: role in tumor cell motility. Am J Pathol 164: 429-439. (Pubitemid 38364659)
22. Wei J, Yan W, Li X, Ding Y, Tai HH (2010) Thromboxane receptor alpha mediates tumor growth and angiogenesis via induction of vascular endothelial growth factor expression in human lung cancer cells. Lung cancer 69: 26-32.
23. Wei J, Yan W, Li X, Chang WC, Tai HH (2007) Activation of thromboxane receptor alpha induces expression of cyclooxygenase-2 through multiple signaling pathways in A549 human lung adenocarcinoma cells. Biochem Pharmacol 74: 787-800. (Pubitemid 47087763)
24. Satomi Y, Nishino H, Shibata S. (2005) Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2. Anticancer Res 25: 4043-4047. (Pubitemid 41665183)
25. Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, et al. (2009) Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res 15: 3423-3432.
26. Lim J, Lee SH, Cho S, Lee IS, Kang BY, et al. (2013) 4-methoxychalcone enhances cisplatin-induced oxidative stress and cytotoxicity by inhibiting the Nrf2/ARE-mediated defense mechanism in A549 lung cancer cells. Mol Cells 36: 340-346.
27. Moussa O, Ashton AW, Fraig M, Garrett-Mayer E, Ghoneim MA, et al. (2008) Novel role of thromboxane receptors b isoform in bladder cancer pathogenesis. Cancer Res 68: 4097-4104.
28. Chen GG, Lee TW, Yip JH, Xu H, Lee IK, et al. (2006) Increased thromboxane B(2) levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma. Cancer Lett 234: 193-198.
29. Ni YF, Kuai JK, Lu ZF, Yang GD, Fu HY, et al. (2011) Glycyrrhizin treatment is associated with attenuation of lipopolysaccharide-induced acute lung injury by inhibiting cyclooxygenase-2 and inducible nitric oxide synthase expression. J Surg Res 165: e29-e35.
30. Sakamoto KM, Frank DA (2009) CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy. Clin Cancer Res 15: 2583-2587.
31. Jariyawat S, Takeda M, Kobayashi M, Endou H (1997) Thromboxane A2 mediates cisplatin-induced apoptosis of renal tubule cells. Biochem Mol Biol Int 42: 113-121. (Pubitemid 28172115)