메뉴 건너뛰기




Volumn 8, Issue 2, 2013, Pages

Glycyrrhizic Acid Suppresses the Development of Precancerous Lesions via Regulating the Hyperproliferation, Inflammation, Angiogenesis and Apoptosis in the Colon of Wistar Rats

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIMETHYLHYDRAZINE; CASPASE 3; CASPASE 9; CONNEXIN 43; CYCLOOXYGENASE 2; GLYCYRRHIZIC ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; KI 67 ANTIGEN; PROTEIN P53; SIALOMUCIN; SULFOMUCIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

EID: 84874007222     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056020     Document Type: Article
Times cited : (111)

References (73)
  • 1
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien CA, Pollett A, Gallinger S, Dick JE, (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445: 106-110.
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 3
    • 0038543824 scopus 로고    scopus 로고
    • Chemoprevention of colorectal cancer
    • Janne PA, Mayer RJ, (2000) Chemoprevention of colorectal cancer. N Engl J Med 342(26): 1960-1968.
    • (2000) N Engl J Med , vol.342 , Issue.26 , pp. 1960-1968
    • Janne, P.A.1    Mayer, R.J.2
  • 4
    • 79957633659 scopus 로고    scopus 로고
    • Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats
    • Khan R, Sultana S, (2011) Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. Chem Biol Interact 192: 193-200.
    • (2011) Chem Biol Interact , vol.192 , pp. 193-200
    • Khan, R.1    Sultana, S.2
  • 5
    • 20644431770 scopus 로고    scopus 로고
    • Significance and role of early-lesions in experimental colorectal carcinogenesis
    • Mori H, Hata K, Yamada Y, Kuno T, Hara A, (2005) Significance and role of early-lesions in experimental colorectal carcinogenesis. Chem Biol Interact 155: 1-9.
    • (2005) Chem Biol Interact , vol.155 , pp. 1-9
    • Mori, H.1    Hata, K.2    Yamada, Y.3    Kuno, T.4    Hara, A.5
  • 6
    • 0023629080 scopus 로고
    • Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings
    • Bird RP, (1987) Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett 37: 147-151.
    • (1987) Cancer Lett , vol.37 , pp. 147-151
    • Bird, R.P.1
  • 8
    • 0026026294 scopus 로고
    • Identification and quantification of aberrant crypt foci and microadenomas in the human colon
    • Roncucci L, Stamp D, Medline A, Cullen JB, Bruce WR, (1991) Identification and quantification of aberrant crypt foci and microadenomas in the human colon. Hum Pathol 22: 287-294.
    • (1991) Hum Pathol , vol.22 , pp. 287-294
    • Roncucci, L.1    Stamp, D.2    Medline, A.3    Cullen, J.B.4    Bruce, W.R.5
  • 9
    • 0031468110 scopus 로고    scopus 로고
    • Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa
    • Nucci MR, Robinson CR, Longo P, Campbell P, Hamilton SR, (1997) Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa. Hum Pathol 28: 1396-1407.
    • (1997) Hum Pathol , vol.28 , pp. 1396-1407
    • Nucci, M.R.1    Robinson, C.R.2    Longo, P.3    Campbell, P.4    Hamilton, S.R.5
  • 10
    • 11344282310 scopus 로고    scopus 로고
    • Flat dysplastic aberrant crypt foci are related to tumorigenesis in the colon of azoxymethane-treated rat
    • Paulsen JE, Løberg EM, Olstørn HB, Knutsen H, Steffensen IL, et al. (2005) Flat dysplastic aberrant crypt foci are related to tumorigenesis in the colon of azoxymethane-treated rat. Cancer Res 65: 121-129.
    • (2005) Cancer Res , vol.65 , pp. 121-129
    • Paulsen, J.E.1    Løberg, E.M.2    Olstørn, H.B.3    Knutsen, H.4    Steffensen, I.L.5
  • 12
    • 0030982833 scopus 로고    scopus 로고
    • Identification of dysplasia in human colonic aberrant crypt foci
    • Siu IM, Pretlow TG, Amini SB, Pretlow TP, (1997) Identification of dysplasia in human colonic aberrant crypt foci. Am J Pathol 150: 1805-1813.
    • (1997) Am J Pathol , vol.150 , pp. 1805-1813
    • Siu, I.M.1    Pretlow, T.G.2    Amini, S.B.3    Pretlow, T.P.4
  • 13
    • 0028209258 scopus 로고
    • Aberrant crypt foci and colon tumors in F344 rats have similar increases in proliferative activity
    • Pretlow TP, Cheter C, O'Riordan MA, (1994) Aberrant crypt foci and colon tumors in F344 rats have similar increases in proliferative activity. Int J Cancer 56: 599-602.
    • (1994) Int J Cancer , vol.56 , pp. 599-602
    • Pretlow, T.P.1    Cheter, C.2    O'Riordan, M.A.3
  • 14
    • 0029003648 scopus 로고
    • Role of aberrant crypt foci in understanding the pathogenesis of colon cancer
    • Bird PR, (1995) Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 93: 55-71.
    • (1995) Cancer Lett , vol.93 , pp. 55-71
    • Bird, P.R.1
  • 15
    • 0026669295 scopus 로고
    • Expression of ras oncogene mRNA and protein in aberrant crypt foci
    • Stopera SA, Bird RP, (1992a) Expression of ras oncogene mRNA and protein in aberrant crypt foci. Carcinogenesis 13: 1863-1868.
    • (1992) Carcinogenesis , vol.13 , pp. 1863-1868
    • Stopera, S.A.1    Bird, R.P.2
  • 16
    • 0026480765 scopus 로고
    • Evidence for a ras gene mutation in azoxymethane-induced colonie aberrant crypts in Sprague-Dawley rats: earliest recognizable precursor lesions of experimental colon cancer
    • Stopera SA, Murphy LC, Bird RP, (1992b) Evidence for a ras gene mutation in azoxymethane-induced colonie aberrant crypts in Sprague-Dawley rats: earliest recognizable precursor lesions of experimental colon cancer. Carcinogenesis 13: 2081-2085.
    • (1992) Carcinogenesis , vol.13 , pp. 2081-2085
    • Stopera, S.A.1    Murphy, L.C.2    Bird, R.P.3
  • 17
    • 0027426123 scopus 로고
    • K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis
    • Vivona AA, Shpitz B, Medline A, Bruce WR, Hay K, et al. (1993) K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis. Carcinogenesis 14: 1777-1781.
    • (1993) Carcinogenesis , vol.14 , pp. 1777-1781
    • Vivona, A.A.1    Shpitz, B.2    Medline, A.3    Bruce, W.R.4    Hay, K.5
  • 19
    • 0026520750 scopus 로고
    • Colonie aberrant crypt foci are associated with increased expression of c-fos: the possible role of modified c-fos expression in preneoplastic lesions in colon cancer
    • Stopera SA, Davie JR, Bird RP, (1992c) Colonie aberrant crypt foci are associated with increased expression of c-fos: the possible role of modified c-fos expression in preneoplastic lesions in colon cancer. Carcinogenesis 13: 573-578.
    • (1992) Carcinogenesis , vol.13 , pp. 573-578
    • Stopera, S.A.1    Davie, J.R.2    Bird, R.P.3
  • 20
    • 0035392983 scopus 로고    scopus 로고
    • Qualitative and quantitative relationship between dysplastic aberrant crypt foci and tumorigenesis in the Min/+ mouse colon
    • Paulsen JE, Steffensen IL, Løberg EM, Husøy T, Namork E, et al. (2001) Qualitative and quantitative relationship between dysplastic aberrant crypt foci and tumorigenesis in the Min/+ mouse colon. Cancer Res 61: 5010-5015.
    • (2001) Cancer Res , vol.61 , pp. 5010-5015
    • Paulsen, J.E.1    Steffensen, I.L.2    Løberg, E.M.3    Husøy, T.4    Namork, E.5
  • 21
    • 0038181338 scopus 로고    scopus 로고
    • Identification of mucin-depleted foci in the unsectioned colon of azoxymethane-treated rats: correlation with carcinogenesis
    • Caderni G, Femia AP, Giannini A, Favuzza A, Luceri C, et al. (2003) Identification of mucin-depleted foci in the unsectioned colon of azoxymethane-treated rats: correlation with carcinogenesis. Cancer Res 63: 2388-2392.
    • (2003) Cancer Res , vol.63 , pp. 2388-2392
    • Caderni, G.1    Femia, A.P.2    Giannini, A.3    Favuzza, A.4    Luceri, C.5
  • 23
    • 84855485757 scopus 로고    scopus 로고
    • Identification of preneoplastic lesions as mucin-depleted foci in patients with sporadic colorectal cancer
    • Sakai E, Morioka T, Yamada E, Ohkubo H, Higurashi T, et al. (2011) Identification of preneoplastic lesions as mucin-depleted foci in patients with sporadic colorectal cancer. Cancer Sci 103: 144-149.
    • (2011) Cancer Sci , vol.103 , pp. 144-149
    • Sakai, E.1    Morioka, T.2    Yamada, E.3    Ohkubo, H.4    Higurashi, T.5
  • 24
    • 33846680079 scopus 로고    scopus 로고
    • Frequent mutation of Apc gene in rat colon tumorsand mucin-depleted foci, preneoplastic lesions in experimental colon carcinogenesis
    • Femia AP, Dolara P, Giannini A, Salvadori M, Biggeri A, et al. (2007) Frequent mutation of Apc gene in rat colon tumorsand mucin-depleted foci, preneoplastic lesions in experimental colon carcinogenesis. Cancer Res 67: 445-449.
    • (2007) Cancer Res , vol.67 , pp. 445-449
    • Femia, A.P.1    Dolara, P.2    Giannini, A.3    Salvadori, M.4    Biggeri, A.5
  • 25
    • 36749026194 scopus 로고    scopus 로고
    • K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine
    • Femia AP, Tarquini E, Salvadori M, Ferri S, Giannini A, et al. (2008b) K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine. Int J Cancer 122: 117-123.
    • (2008) Int J Cancer , vol.122 , pp. 117-123
    • Femia, A.P.1    Tarquini, E.2    Salvadori, M.3    Ferri, S.4    Giannini, A.5
  • 26
    • 20444447560 scopus 로고    scopus 로고
    • Mucin-depleted foci have beta-catenin gene mutations, altered expression of its protein, and are dose- and time-dependent in the colon of 1,2-dimethylhydrazinetreated rats
    • Femia AP, Bendinelli B, Giannini A, Salvadori M, Pinzani P, et al. (2005) Mucin-depleted foci have beta-catenin gene mutations, altered expression of its protein, and are dose- and time-dependent in the colon of 1,2-dimethylhydrazinetreated rats. Int J Cancer 116: 9-15.
    • (2005) Int J Cancer , vol.116 , pp. 9-15
    • Femia, A.P.1    Bendinelli, B.2    Giannini, A.3    Salvadori, M.4    Pinzani, P.5
  • 27
    • 84861561353 scopus 로고    scopus 로고
    • Sustained proliferation and resistance to apoptosis after a cytotoxic insult are early alterations in rat colon carcinogenesis
    • Femia AP, Salvianti F, Luceri C, Dolara P, Salvadori M, et al. (2012) Sustained proliferation and resistance to apoptosis after a cytotoxic insult are early alterations in rat colon carcinogenesis. Int J Cancer 131: 529-536.
    • (2012) Int J Cancer , vol.131 , pp. 529-536
    • Femia, A.P.1    Salvianti, F.2    Luceri, C.3    Dolara, P.4    Salvadori, M.5
  • 28
    • 67650097007 scopus 로고    scopus 로고
    • Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate
    • Femia AP, Dolara P, Luceri C, Salvadori M, Caderni G, (2009) Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate. Int J Cancer 125: 541-547.
    • (2009) Int J Cancer , vol.125 , pp. 541-547
    • Femia, A.P.1    Dolara, P.2    Luceri, C.3    Salvadori, M.4    Caderni, G.5
  • 29
    • 34247367946 scopus 로고    scopus 로고
    • Mucin-depleted foci are modulated by dietary treatments and show deregulation of proliferative activity in carcinogen-treated rodents
    • Femia AP, Caderni G, Bottini C, Salvadori M, Dolara P, et al. (2006) Mucin-depleted foci are modulated by dietary treatments and show deregulation of proliferative activity in carcinogen-treated rodents. Int J Cancer 120: 2301-2305.
    • (2006) Int J Cancer , vol.120 , pp. 2301-2305
    • Femia, A.P.1    Caderni, G.2    Bottini, C.3    Salvadori, M.4    Dolara, P.5
  • 31
    • 0036020941 scopus 로고    scopus 로고
    • NFkappaB as a therapeutic target in cancer
    • Orlowski RZ, Baldwin AS Jr, (2002) NFkappaB as a therapeutic target in cancer. Trends Mol Med 8: 385-389.
    • (2002) Trends Mol Med , vol.8 , pp. 385-389
    • Orlowski, R.Z.1    Baldwin Jr., A.S.2
  • 33
    • 33750711353 scopus 로고    scopus 로고
    • Immunohistochemical study of chymase-positive mast cells in inflammatory bowel disease
    • Andoh A, Deguchi Y, Inatomi O, Yagi Y, Bamba S, et al. (2006) Immunohistochemical study of chymase-positive mast cells in inflammatory bowel disease. Oncol Rep 16: 103-107.
    • (2006) Oncol Rep , vol.16 , pp. 103-107
    • Andoh, A.1    Deguchi, Y.2    Inatomi, O.3    Yagi, Y.4    Bamba, S.5
  • 34
    • 1142263309 scopus 로고    scopus 로고
    • Key role of mast cells and their major secretory products in inflammatory bowel disease
    • He SH, (2004) Key role of mast cells and their major secretory products in inflammatory bowel disease. World J Gastroenterol 10: 309-318.
    • (2004) World J Gastroenterol , vol.10 , pp. 309-318
    • He, S.H.1
  • 35
    • 14744294757 scopus 로고    scopus 로고
    • Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v) mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors
    • Wedemeyer J, Galli SJ, (2005) Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v) mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors. Lab Invest 85: 388-396.
    • (2005) Lab Invest , vol.85 , pp. 388-396
    • Wedemeyer, J.1    Galli, S.J.2
  • 36
    • 13944249962 scopus 로고    scopus 로고
    • Mast cells in the development of adaptive immune responses
    • Galli SJ, Nakae S, Tsai M, (2005) Mast cells in the development of adaptive immune responses. Nat Immunol 6: 135-142.
    • (2005) Nat Immunol , vol.6 , pp. 135-142
    • Galli, S.J.1    Nakae, S.2    Tsai, M.3
  • 37
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z, (2002) Inflammation and cancer. Nature 420: 860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 38
    • 0034131115 scopus 로고    scopus 로고
    • Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression
    • Wargovich MJ, Jimenez A, McKee K, Steele VE, Velasco M, et al. (2000) Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Carcinogenesis 21: 1149-1155.
    • (2000) Carcinogenesis , vol.21 , pp. 1149-1155
    • Wargovich, M.J.1    Jimenez, A.2    McKee, K.3    Steele, V.E.4    Velasco, M.5
  • 39
    • 65249119309 scopus 로고    scopus 로고
    • Inhibition of 11β-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans
    • Zhang MZ, Xu J, Yao B, Yin H, Cai Q, et al. (2009) Inhibition of 11β-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. J Clin Invest 119: 876-885.
    • (2009) J Clin Invest , vol.119 , pp. 876-885
    • Zhang, M.Z.1    Xu, J.2    Yao, B.3    Yin, H.4    Cai, Q.5
  • 40
    • 0018690103 scopus 로고
    • Glycyrrhizic acid inhibits virus growth and inactivates virus particles
    • Pompei R, Flore O, Marccialis MA, Pani A, Loddo B, (1979) Glycyrrhizic acid inhibits virus growth and inactivates virus particles. Nature 281: 689-690.
    • (1979) Nature , vol.281 , pp. 689-690
    • Pompei, R.1    Flore, O.2    Marccialis, M.A.3    Pani, A.4    Loddo, B.5
  • 41
    • 14644419026 scopus 로고    scopus 로고
    • Glycyrrhizic acid alters Kaposi sarcoma- associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes
    • Curreli F, Friedman-Kien AE, Flore O, (2005) Glycyrrhizic acid alters Kaposi sarcoma- associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes. J Clin Invest 115: 642-652.
    • (2005) J Clin Invest , vol.115 , pp. 642-652
    • Curreli, F.1    Friedman-Kien, A.E.2    Flore, O.3
  • 42
    • 0032897024 scopus 로고    scopus 로고
    • Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice
    • Shiota G, Harada K, Ishida M, Tomie Y, Okubo M, et al. (1999) Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice. Carcinogenesis 20: 59-63.
    • (1999) Carcinogenesis , vol.20 , pp. 59-63
    • Shiota, G.1    Harada, K.2    Ishida, M.3    Tomie, Y.4    Okubo, M.5
  • 43
    • 0025800623 scopus 로고
    • Inhibition of mouse skin tumor- initiating activity of DMBA by chronic oral feeding of glycyrrhizin in drinking water
    • Agarwal R, Wang ZY, Mukhtar H, (1991) Inhibition of mouse skin tumor- initiating activity of DMBA by chronic oral feeding of glycyrrhizin in drinking water. Nutr Cancer 15: 187-193.
    • (1991) Nutr Cancer , vol.15 , pp. 187-193
    • Agarwal, R.1    Wang, Z.Y.2    Mukhtar, H.3
  • 44
    • 0023749872 scopus 로고
    • Inhibitory effect of glycyrrhizin and caffeine on two-stage carcinogenesis in mice
    • Yasukawa K, Takido M, Takeuchi M, Nakagawa S, (1988) Inhibitory effect of glycyrrhizin and caffeine on two-stage carcinogenesis in mice. Yakugaku Zasshi 108: 794-796.
    • (1988) Yakugaku Zasshi , vol.108 , pp. 794-796
    • Yasukawa, K.1    Takido, M.2    Takeuchi, M.3    Nakagawa, S.4
  • 45
    • 0029856413 scopus 로고    scopus 로고
    • Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats; relevance to the intestinal bacterial hydrolysis
    • Takeda S, Ishthara K, Wakui Y, Amagaya S, Maruno M, et al. (1996) Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats; relevance to the intestinal bacterial hydrolysis. J Pharm Pharmacol 48(9): 902-905.
    • (1996) J Pharm Pharmacol , vol.48 , Issue.9 , pp. 902-905
    • Takeda, S.1    Ishthara, K.2    Wakui, Y.3    Amagaya, S.4    Maruno, M.5
  • 46
    • 1542754773 scopus 로고    scopus 로고
    • Simultaneous determination of glycyrrhizin metabolites formed by the incubation of glycyrrhizin with rat feces by semi-micro high-performance liquid chromatography
    • Okamura N, Miyauchi H, Choshi T, Ishizu T, Yagi A, (2003) Simultaneous determination of glycyrrhizin metabolites formed by the incubation of glycyrrhizin with rat feces by semi-micro high-performance liquid chromatography. Biol Pharm Bull 26(5): 658-661.
    • (2003) Biol Pharm Bull , vol.26 , Issue.5 , pp. 658-661
    • Okamura, N.1    Miyauchi, H.2    Choshi, T.3    Ishizu, T.4    Yagi, A.5
  • 47
    • 32944470031 scopus 로고    scopus 로고
    • Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells
    • Hibasami H, Iwase H, Yoshioka K, Takahashi H, (2005) Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells. Int J Mol Med 16: 233-236.
    • (2005) Int J Mol Med , vol.16 , pp. 233-236
    • Hibasami, H.1    Iwase, H.2    Yoshioka, K.3    Takahashi, H.4
  • 48
    • 33644866837 scopus 로고    scopus 로고
    • Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells
    • Hibasami H, Iwase H, Yoshioka K, Takahashi H, (2006) Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells. Int J Mol Med 17: 215-219.
    • (2006) Int J Mol Med , vol.17 , pp. 215-219
    • Hibasami, H.1    Iwase, H.2    Yoshioka, K.3    Takahashi, H.4
  • 49
    • 59249091038 scopus 로고    scopus 로고
    • Glycyrrhizin induces apoptosis in prostate cancer cell lines DU-145 and LNCaP
    • Thirugnanam S, Xu L, Ramaswamy K, Gnanasekar M, (2008) Glycyrrhizin induces apoptosis in prostate cancer cell lines DU-145 and LNCaP. Oncol Rep 20: 1387-1392.
    • (2008) Oncol Rep , vol.20 , pp. 1387-1392
    • Thirugnanam, S.1    Xu, L.2    Ramaswamy, K.3    Gnanasekar, M.4
  • 50
    • 0021070144 scopus 로고
    • Effects of glycyrrhizin on biochemical tests in patients with chronic hepatitis- double blind trail
    • Suzuki H, Ohta Y, Takino T, Fujisawa K, Hirayama C, (1983) Effects of glycyrrhizin on biochemical tests in patients with chronic hepatitis- double blind trail. Asian Med J 26: 423-438.
    • (1983) Asian Med J , vol.26 , pp. 423-438
    • Suzuki, H.1    Ohta, Y.2    Takino, T.3    Fujisawa, K.4    Hirayama, C.5
  • 51
    • 0031002861 scopus 로고    scopus 로고
    • The long term efficacy of glycyrrhizin in chronic hepatitis C patients
    • Arase Y, Ikeda K, Murashima N, Chayama K, Tsubota A, et al. (1997) The long term efficacy of glycyrrhizin in chronic hepatitis C patients. Cancer 79: 1494-1500.
    • (1997) Cancer , vol.79 , pp. 1494-1500
    • Arase, Y.1    Ikeda, K.2    Murashima, N.3    Chayama, K.4    Tsubota, A.5
  • 52
    • 0032753750 scopus 로고    scopus 로고
    • Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial
    • incorporate
    • van Rossum TG, Vulto AG, Hop WC, Brouwer JT, Niesters HG, et al. (1999) Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial. J Gastroenterol Hepatol 14: 1093-1099. incorporate.
    • (1999) J Gastroenterol Hepatol , vol.14 , pp. 1093-1099
    • van Rossum, T.G.1    Vulto, A.G.2    Hop, W.C.3    Brouwer, J.T.4    Niesters, H.G.5
  • 53
    • 84855948957 scopus 로고    scopus 로고
    • Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53
    • Khan R, Khan AQ, Qamar W, Lateef A, Tahir M, et al. (2012) Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. Toxicol Appl Pharmacol 258(3): 315-329.
    • (2012) Toxicol Appl Pharmacol , vol.258 , Issue.3 , pp. 315-329
    • Khan, R.1    Khan, A.Q.2    Qamar, W.3    Lateef, A.4    Tahir, M.5
  • 54
    • 79961051534 scopus 로고    scopus 로고
    • Molecular mechanisms underlying chemopreventive activities of glycyrrhizic acid against UVB-radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis
    • Cherng JM, Tsai KD, Yu YW, Lin JC, (2011) Molecular mechanisms underlying chemopreventive activities of glycyrrhizic acid against UVB-radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Radiat Res 176: 177-186.
    • (2011) Radiat Res , vol.176 , pp. 177-186
    • Cherng, J.M.1    Tsai, K.D.2    Yu, Y.W.3    Lin, J.C.4
  • 55
    • 10644254423 scopus 로고    scopus 로고
    • Structural diversity and specific distribution of O-glycans in normal human mucins along the intestinal tract
    • Robbe C, Capon C, Coddeville B, Michalski JC, (2004) Structural diversity and specific distribution of O-glycans in normal human mucins along the intestinal tract. Biochem J 384: 307-316.
    • (2004) Biochem J , vol.384 , pp. 307-316
    • Robbe, C.1    Capon, C.2    Coddeville, B.3    Michalski, J.C.4
  • 56
    • 0026081411 scopus 로고
    • Functional biology of intestinal goblet cells
    • Specian RD, Oliver MG, (1991) Functional biology of intestinal goblet cells. Am J Physiol 260: C183-C193.
    • (1991) Am J Physiol , vol.260
    • Specian, R.D.1    Oliver, M.G.2
  • 57
    • 0016200769 scopus 로고
    • Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma
    • Filipe MI, Branfoot AC, (1974) Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma. Cancer 34: 282-290.
    • (1974) Cancer , vol.34 , pp. 282-290
    • Filipe, M.I.1    Branfoot, A.C.2
  • 58
    • 0016696719 scopus 로고
    • Mucus secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine. A morphological and histochemical study
    • Filipe MI, (1975) Mucus secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine. A morphological and histochemical study. Br J Cancer 32: 60-77.
    • (1975) Br J Cancer , vol.32 , pp. 60-77
    • Filipe, M.I.1
  • 59
    • 0020566865 scopus 로고
    • Early histopathologic events to evolution of colon cancer in C57BL/6 and CFI mice treated with 1.2-dimethylhydrazine
    • Wargovich MJ, Medline A, Bruce WR, (1983) Early histopathologic events to evolution of colon cancer in C57BL/6 and CFI mice treated with 1.2-dimethylhydrazine. J Natl Cancer Inst 71: 125-131.
    • (1983) J Natl Cancer Inst , vol.71 , pp. 125-131
    • Wargovich, M.J.1    Medline, A.2    Bruce, W.R.3
  • 60
    • 0024271294 scopus 로고
    • Characterization of stereomicroscopically identified preneoplastic lesions during dimethylhydrazine-induced colonic carcinogenesis
    • Sandforth F, Heimpel S, Balzer T, Gutschmidt S, Riecken EO, (1988) Characterization of stereomicroscopically identified preneoplastic lesions during dimethylhydrazine-induced colonic carcinogenesis. Eur J Clin Invest 18: 655-662.
    • (1988) Eur J Clin Invest , vol.18 , pp. 655-662
    • Sandforth, F.1    Heimpel, S.2    Balzer, T.3    Gutschmidt, S.4    Riecken, E.O.5
  • 61
    • 0028096688 scopus 로고
    • Sialyl Lewis X mimics derived from a pharmacophore search are selectin inhibitors with anti-inflammatory activity
    • Rao BN, Anderson MB, Musser JH, Gilbert JH, Schaefer ME, et al. (1994) Sialyl Lewis X mimics derived from a pharmacophore search are selectin inhibitors with anti-inflammatory activity. J Biol Chem 269: 19663-19666.
    • (1994) J Biol Chem , vol.269 , pp. 19663-19666
    • Rao, B.N.1    Anderson, M.B.2    Musser, J.H.3    Gilbert, J.H.4    Schaefer, M.E.5
  • 62
    • 34247181253 scopus 로고    scopus 로고
    • Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities
    • Mollica L, De Marchis F, Spitaleri A, Dallacosta C, Pennacchini D, et al. (2007) Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities. Chem Biol 14: 431-441.
    • (2007) Chem Biol , vol.14 , pp. 431-441
    • Mollica, L.1    De Marchis, F.2    Spitaleri, A.3    Dallacosta, C.4    Pennacchini, D.5
  • 63
    • 0025881843 scopus 로고
    • Medicinal uses of licorice through the millennia: The good and plenty of it
    • Davis EA, Morris DJ, (1991) Medicinal uses of licorice through the millennia: The good and plenty of it. Mol Cell Endocrinol 78: 1-6.
    • (1991) Mol Cell Endocrinol , vol.78 , pp. 1-6
    • Davis, E.A.1    Morris, D.J.2
  • 64
    • 33847065970 scopus 로고    scopus 로고
    • The dietary charred meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine acts as both a tumor initiator and promoter in the rat ventral prostate
    • Nakai Y, Nelson WG, DeMarzo AM, (2007) The dietary charred meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine acts as both a tumor initiator and promoter in the rat ventral prostate. Cancer Res 67: 1378-1384.
    • (2007) Cancer Res , vol.67 , pp. 1378-1384
    • Nakai, Y.1    Nelson, W.G.2    DeMarzo, A.M.3
  • 65
    • 5644233966 scopus 로고    scopus 로고
    • Mast cells: the Jekyll and Hyde of tumor growth
    • Theoharides TC, Conti P, (2004) Mast cells: the Jekyll and Hyde of tumor growth. Trends Immunol 25: 235-241.
    • (2004) Trends Immunol , vol.25 , pp. 235-241
    • Theoharides, T.C.1    Conti, P.2
  • 66
    • 0030922493 scopus 로고    scopus 로고
    • Mast cell-tumor cell interactions: for or against tumour growth and metastasis?
    • Dimitriadou V, Koutsilieris M, (1997) Mast cell-tumor cell interactions: for or against tumour growth and metastasis? Anticancer Res 17: 1541-1549.
    • (1997) Anticancer Res , vol.17 , pp. 1541-1549
    • Dimitriadou, V.1    Koutsilieris, M.2
  • 67
    • 34948852371 scopus 로고    scopus 로고
    • Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
    • Soucek L, Lawlor ER, Soto D, Shchors K, Swigart LB, et al. (2007) Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nature Med 13: 1211-1218.
    • (2007) Nature Med , vol.13 , pp. 1211-1218
    • Soucek, L.1    Lawlor, E.R.2    Soto, D.3    Shchors, K.4    Swigart, L.B.5
  • 68
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: linking inflammation and immunity to cancer development and progression
    • Karin M, Greten FR, (2005) NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5: 749-759.
    • (2005) Nat Rev Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 69
    • 0033984235 scopus 로고    scopus 로고
    • The Ki-67 protein: from the known and the unknown
    • Scholzen T, Gerdes J, (2000) "The Ki-67 protein: from the known and the unknown". J Cell Physiol 182: 311-322.
    • (2000) J Cell Physiol , vol.182 , pp. 311-322
    • Scholzen, T.1    Gerdes, J.2
  • 70
    • 17344390158 scopus 로고    scopus 로고
    • Plasma membrane channels formed by connexins: their regulation and functions
    • Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC, (2003) Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev 83: 1359-1400.
    • (2003) Physiol Rev , vol.83 , pp. 1359-1400
    • Saez, J.C.1    Berthoud, V.M.2    Branes, M.C.3    Martinez, A.D.4    Beyer, E.C.5
  • 71
    • 84861576760 scopus 로고    scopus 로고
    • Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
    • Sirnes S, Bruun J, Kolberg M, Kjenseth A, Lind GE, et al. (2011) Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome. Int J Cancer 131: 570-581.
    • (2011) Int J Cancer , vol.131 , pp. 570-581
    • Sirnes, S.1    Bruun, J.2    Kolberg, M.3    Kjenseth, A.4    Lind, G.E.5
  • 72
  • 73
    • 0035211073 scopus 로고    scopus 로고
    • The p53 functional circuit
    • Jin S, Levine AJ, (2001) The p53 functional circuit. J Cell Sci 114: 4139-4140.
    • (2001) J Cell Sci , vol.114 , pp. 4139-4140
    • Jin, S.1    Levine, A.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.