Silica nanoparticles induce cardiotoxicity interfering with energetic status and Ca2+ handling in adult rat cardiomyocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 312, Issue 4, 2017, Pages H645-H661

  Guerrero Beltrán, Carlos Enrique ^a,b   Bernal Ramírez, Judith ^a   Lozano, Omar ^a,c   Oropeza Almazán, Yuriana ^a   Castillo, Elena Cristina ^a   Garza, Jesús Roberto ^a   García, Noemí ^a,b   Vela, Jorge ^a   García García, Alejandra ^e   Ortega, Eduardo ^d   Torre Amione, Guillermo ^a,b,f   Ornelas Soto, Nancy ^a   García Rivas, Gerardo ^a,b  

^a SCHOOL OF ENGINEERING AND SCIENCES   (Mexico)

^b HOSPITAL ZAMBRANO HELLION   (Mexico)

^c University of Namur   (Belgium)

^d UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^e CENTRO DE INVESTIGACIÓN EN MATERIALES AVANZADOS   (Mexico)

^f HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

Ca2+; Cardiomyocyte; Nanoparticle; Silicon dioxide; Toxicity

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; GLUTATHIONE; HYDROGEN PEROXIDE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SILICA NANOPARTICLE; CALCIUM; NANOPARTICLE; SILICON DIOXIDE;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CALCIUM CELL LEVEL; CARDIAC MUSCLE CELL; CARDIOTOXICITY; CELL CULTURE; CELL DEATH; CELL ISOLATION; CELL MEMBRANE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; ENZYME ACTIVITY; IC50; INTERNALIZATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PRIORITY JOURNAL; RAT; ANIMAL; DRUG EFFECTS; ENERGY METABOLISM; HEART MITOCHONDRION; METABOLISM;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CARDIOTOXICITY; CELL MEMBRANE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; GLUTATHIONE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; NANOPARTICLES; OXIDATIVE STRESS; RATS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SILICON DIOXIDE;

EID: 85016992552     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00564.2016     Document Type: Article

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