Antineoplastic copper coordinated complexes (Casiopeinas) uncouple oxidative phosphorylation and induce mitochondrial permeability transition in cardiac mitochondria and cardiomyocytes

Journal of Bioenergetics and Biomembranes

Volumn 48, Issue 1, 2016, Pages 43-54

  Silva Platas, Christian ^a   Guerrero Beltrán, Carlos Enrique ^a   Carrancá, Mariana ^a   Castillo, Elena Cristina ^a   Bernal Ramírez, Judith ^a   Oropeza Almazán, Yuriana ^a   González, Lorena N ^a   Rojo, Rocío ^a   Martínez, Luis Enrique ^a   Valiente Banuet, Juan ^b   Ruiz Azuara, Lena ^c   Bravo Gómez, María Elena ^c   García, Noemí ^a,d   Carvajal, Karla ^e   García Rivas, Gerardo ^a,d  

^a ESCUELA DE MEDICINA Y CIENCIAS DE LA SALUD   (Mexico)

^b SCHOOL OF ENGINEERING AND SCIENCES   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^d HOSPITAL ZAMBRANO HELLION   (Mexico)

^e INSTITUTO NACIONAL DE PEDIATRÍA   (Mexico)

Author keywords

Antineoplastic; Cardiomyocytes; Cardiotoxicity; Casiopeinas; Mitochondria; Permeability transition pore

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ANTINEOPLASTIC METAL COMPLEX; CASIOPEINAS; COPPER COMPLEX; CYCLOSPORIN A; CYTOCHROME C OXIDASE; DIGITONIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUCCINIC ACID; THIOL GROUP; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; COPPER;

ANIMAL EXPERIMENT; ARTICLE; BIOENERGY; CARDIOTOXICITY; CONFOCAL MICROSCOPY; ENZYME ACTIVITY; FLOW CYTOMETRY; HEART MITOCHONDRION; HEART MUSCLE CELL; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; ANIMAL; CARDIAC MUSCLE CELL; DRUG EFFECTS; METABOLISM; MITOCHONDRIAL MEMBRANE; PATHOLOGY; PERMEABILITY; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; COPPER; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANES; MYOCYTES, CARDIAC; OXIDATIVE PHOSPHORYLATION; PERMEABILITY; RATS;

EID: 84956700899     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-015-9640-x     Document Type: Article

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