Potential impact of quercetin and idebenone against immuno- inflammatory and oxidative renal damage induced in rats by titanium dioxide nanoparticles toxicity

Journal of Oleo Science

Volumn 62, Issue 11, 2013, Pages 961-971

  Al Rasheed, Nouf M ^a   Faddah, L M ^a   Mohamed, Azza M ^b,c   Abdel Baky, Nayira A ^a   Al Rasheed, Nawal M ^a   Mohammad, Raeesa A ^d  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^c NATIONAL RESEARCH CENTRE   (Egypt)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Idebenone; Pro inflammatory biomarkers; Quercetin; Renal; TiO2

Indexed keywords

HISTOLOGICAL EXAMINATION; IDEBENONE; QUERCETIN; RENAL; TIO; TITANIUM DIOXIDE NANOPARTICLES; TUMOR NECROSIS FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

ANTHROPOMETRY; BIOCHEMISTRY; BODY FLUIDS; ENDOTHELIAL CELLS; FLAVONOIDS; NANOPARTICLES; NITRIC OXIDE; PHENOLS; RATS; TOXICITY; UREA;

TITANIUM DIOXIDE;

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; AUTACOID; BIOLOGICAL MARKER; CREATININE; CYTOKINE; GLUCOSE BLOOD LEVEL; IDEBENONE; METAL NANOPARTICLE; QUERCETIN; TITANIUM; TITANIUM DIOXIDE; UBIQUINONE; UREA; DRUG DERIVATIVE;

ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMICALLY INDUCED; DOSE RESPONSE; GLUCOSE BLOOD LEVEL; KIDNEY DISEASES; MALE; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; RAT; TOXICITY; ARTICLE; CHEMICALLY INDUCED DISORDER; KIDNEY DISEASE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CREATININE; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; INFLAMMATION MEDIATORS; KIDNEY DISEASES; MALE; METAL NANOPARTICLES; PARTICLE SIZE; QUERCETIN; RATS; TITANIUM; UBIQUINONE; UREA;

EID: 84887292565     PISSN: 13458957     EISSN: 13473352     Source Type: Journal    
DOI: 10.5650/jos.62.961     Document Type: Article

References (53)

1. Oberdrster, G.; Oberdrster, E.; Oberdrster, J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113 (7), 823-839 (2005).
2. Wang, J. X.; Zhou, J. X.; Chen, C. Y.; Yu, H. W.; Wang, T. C.; Ma, Y. M.; Jia, G.; Gao, Y. X.; J. Sun, B. Li; Li, Y. F.; Jia, F.; Zhao, Y. L.; Chai, Z. F. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration, Toxicol. Lett. 168, 176-185 (2007).
3. 2 particles in mice. Biol Trace Elem Res. Summer. 129 (1-3), 170-80 (2009).
4. Gurr, J. R., Wang, A. S., Chen, C. H., Jan, K. Y. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicol. 213, 66-73 (2005).
5. Gui, S.; Zhang, Z.; Zheng, L.; Cui, Y.; Liu, X.; Li, N.; Sang, X.; Sun, Q.; Gao, G.; Cheng, Z.; Cheng, J.; Wang, L.; Tang, M.; Hong, F. Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles. J Hazard Mater. 195, 365-70 (2011).
6. Park, E. J.; Yi, J.; Chung, K. H.; Ryud, D. Y.; Choi, J.; Park, K. Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells. Toxicol. Lett. 180, 222-229 (2008).
7. Dias, A. S., Porawski, M., Alonso, M., Marron, N., Collado, P. S., Gallego, J. G. Quercetin Decreases Oxidative Stress, NF-κB Activation, and iNOS Overexpression in Liver of Streptozotocin-Induced Diabetic Rats. J. Nutr. 135, 2299-2304 (2005).
8. Liu, J., Li, X., Yue, Y., Li, J., He, T., He, Y. The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils. Cell. Mol. Immunol. 2, 455-60 (2005).
9. Bischoff, S. C. Quercetin: potentials in the prevention and therapy of disease. Curr. Opin. Clin. Nutr. Metab. Care. 11, 733-740 (2008).
10. Chana, S. T., Chuangb, C. H., Yehb, C. L., Liaoc, J. W., Liua, K. L., Tsenga, M. J., Yeha S.L., Quercetin supplementation suppresses the secretion of pro-inflammatory cytokines in the lungs of Mongolian gerbils and in A549 cells exposed to benzo[a] pyrene alone or in combination with β-carotene: in vivo and ex vivo studies J. Nutr. Biochem. 23 (2), 179-85 (2012).
11. Jung, W. J., Sung, M. K. Effects of major dietary antioxidant on inflammatory markers of RAW 264.7 macrophages. Biofactors. 21, 113-117 (2011).
12. Ciftci, O., Ozdemir, I.; Vardi, N.; Beytur, A.; Oguz, F. Ameliorating effects of quercetin and chrysin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced nephrotoxicity in rats. Toxicol Ind Health. 28 (10), 947-54 (2012).
13. Gillis, J. C.; Benefi, P.; McTavish, D. Idebenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in age-related cognitive disorders. Drugs Aging. 5, 133-52 (1994).
14. Suno, M.; Nagaoka, A. Inhibition of lipid peroxidation by a novel compound (CV-2619)in brain mitochondria and mode of action of the inhibition. Biochem. Biophys. Res. Commun. 125, 1046-1052 (1984).
15. Muscoli, C.; Fresta, M.; Cardile, V.; Palumbo, M.; Renis, M.; Puglisi, G.; Paolinod, D.; Nistico, S.; Rotiroti, D.; Mollace, V. Ethanol-induced injury in rat primary cortical astrocytes involves oxidative stress: effect of idebenone. Neurosci. Lett. 329, 21-24 (1994).
16. Nagai, Y.; Shibota, M.; Narumi, S.; Miyamoto, M.; Kakihana, M.; Nagaoka, A. Accelerating effect of idebenone (CV-2619)on cerebral glucose metabolism. Jpn. Pharmacol. Ther. 13, 13-20 (1985).
17. Nagaoka, A.; Suno, M.; Shibota, M.; Kakihana, M. Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia. Arch. Gerontol. Geriatr. 8, 193-202 (1989).
18. Sugiyama, Y.; Fujita, T. Stimulation of respiratory and phosphorylating activities in rat brain mitochondria by idebenone (CV-2619), a new agent improving cerebral metabolism. FEBS Lett. 184, 48-51 (1985).
19. OECD. OECD Guidelines for Testing of Chemicals. No 420: Acute Oral Toxicity-fixed Dose Method. Organisation for Economic Co-operation and Development, Paris (1992).
20. Kambe, D.; Kotani, M.; Yoshimoto, M.; Kaku, S.; Chaki, S.; Honda, K. Effects of Quercetin on the sleep-wake cycle in rats: involvement of gammaaminobutyric acid receptor type A in regulation of rapid eye movement sleep. Brain Res. 1330, 83-88 (2010).
21. Attia, H. A.; AL-Rasheed, N. M. I.; Faddah, L. M.; ALRasheed, N. M. I.; Ahmed, A. A. E. Ameliorating Effect of Idebenone And/or Melatonin Against Oxidative Stress and Energy Depletion in Brain of Hypoxic Rats. Res. J. Med. Med. Sci. 4 (2), 263-277 (2009).
22. Trinder, P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann. Clin. Biochem. 6, 24 (1962).
23. Hang, L.; Svanborg, C.; Andersson, G. Determination of Interleukin 6 in Human Urine and Epithelial Cell Supernatants. Int. Arch. Allergy Immunol. 105, 397-403 (1994).
24. Kim, N.; Kim, Y. J.; Cho, D. K. Gold nanoparticle-based signal augmentation of quartz crystal microbalance immunosensor measuring C-reactive protein. Curr. Appl. Phys. 10 (4), 1227-1230 (2010).
25. Yao, D. F.; Wu, X. H.; Zhu, Y.; Shi, G. S.; Dong, Z. Z.; Yao, D. B.; Wu, W.; Qiu, L. W., Meng, X. Y. Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma. Hepatobiliary Pancreat Dis. Int. 4 (2), 220-226 (2005).
26. Green, L.; Wagner, D.; Glogowski, J.; Skipper, P.; Wishnok, J. Tannenbaum, Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal. Biochem. 126, 131-138 (1982).
27. Bentler, E.; Duran, O.; Mikus K. B. Improved method for determination of blood glutathione. J. Lab. Clin. Med. 61, 882 (1963).
28. Semmler, M.; Seitz, J.; Erbe, F.; Mayer, P.; Heyder, J.; Oberdörster, G.; Kreyling, W. G. Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung, including transient translocation into secondary organs. Inhal Toxicol. 16, 453-459 (2004).
29. Chen, Z.; Meng, H.; Xing, G.; Chen, C.; Zhao, Y.; Jia, G.; Wang, T.; Yuan, H.; Ye, C.; Zhao, F.; Chai, Z.; Zhu, C.; Fang, X.; Ma, B.; Wan, L. Acute toxicological effects of copper of engineered nanomaterials. Nat. Nanotechnol. 2, 469-478 (2007).
30. 2. J. Exp. Nanosci. 5, 447-462 (2010).
31. Chen, H. W.; Su, S. F.; Chien, C. T.; Lin, W. H.; Yu, S. L.; Chou, C. C. et al., Titanium dioxide nanoparticles induce emphysema-like lung injury in mice, FASEB J. 20, 1732-1741 (2006).
32. 2 nanoparticles in the anatase and rutile crystal phases. Toxicol. Lett. 183, 72-80 (2008).
33. 2. Biol. Trace Elem. Res. 140, 186-197 (2011).
34. 2, Nanosacle Res. Lett. 4, 1275-2128 (2009).
35. Davis, G. S.; Pfeiffer, L. M.; Hemenway, D. R. Persistent overexpression of interleukin-1 beta and tumor necrosis factor-alpha in murine silicosis. J. Environ. Pathol. Toxicol. Oncol. 17, 99-114 (1998).
36. Hill, A. L.; Lowes, D. A.; Webster, N. R.; Sheth, C. C.; Gow, N. A.; Galley, H.F. Regulation of pentraxin-3 by antioxidants. Br J Anaesth. 103 (6), 833-9 (2009).
37. Xi, L.; Xiao, C.; Bandsma, R. H. J.; Naples, M.; Adeli, K.; Lewis, G. F. C-Reactive Protein Impairs Hepatic Insulin Sensitivity and Insulin Signaling in Rats: Role of Mitogen- Activated Protein Kinases. Hepatol. 53, 127-135 (2011).
38. Hattori, Y.; Matsumura, M.; Kasai, K. Vascular smooth muscle cell activation by C-reactive protein. Cardiovasc Res. 58, 186-195 (2003).
39. D'Alessandris, C.; Lauro, R.; Presta, I.; Sesti, G. C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport. Diabetologia. 50, 840-849 (2007).
40. Kim, J. H.; Kang, M. J.; Choi, H. N.; Jeong, S. M.; Lee, Y. M.; Kim, J. I. Quercetin attenuates fasting and postprandial hyperglycemia in animal models of diabetes mellitus. Nutr Res Pract. 5, 107-11 (2011).
41. Abdel Baky, N. A.; Zaidi, Z. F.; Fatania, A. J.; Sayed- Ahmed, M. M.; Yaqub, H. Nitric oxide pros and cons: The role of l-arginine, a nitric oxide precursor, and idebenone, a coenzyme-Q analogue in ameliorating cerebral hypoxia in rat. Brain Res Bulletin. 83, 49-56 (2010).
42. Choi, Y. J.; Chakraborty, S.; Nguyen, V.; Nguyen, C.; Kim, B. K.; Shim, S. I.; Suki, W. N.; Truong, L. D. Peritubular capillary loss is associated with chronic tubulointerstitial injury in human kidney: altered expression of vascular endothelial growth factor. Hum. Pathol. 31, 1491-7 (2000).
43. Frank, S.; Stallmeyer, B.; Kampfer, H.; Schaffner, C.; Pfeilschifter, J. Differential regulation of vascular endothelial growth factor and its receptor fms-like-tyrosine kinase is mediated by nitric oxide in rat renal mesangial cells. Biochem. J. 338, 367-374 (1999).
44. Markewitz, B. A.; Michael, J. R.; Kohan, D. E. Cytokine- induced expression of a nitric oxide synthase in rat renal tubule cells. J. Clin. Invest. 91 (5), 2138-2143 (1993).
45. Cook, H. T.; Ebrahim, H.; Jansen, A. S.; Foster, G. R.; Arginineen, P.; Cattell, V. Expression of the gene for inducible nitric oxide synthase in experimental glomerulonephritis in the rat. Clin. Exp. Immun. 97 (2), 315-320 (2008).
46. Tonnesen, M. G.; Feng, X.; Clark, R. A. Angiogenesis in wound healing. J. Invest. Dermatol. Symp. Proc. 5, 40-46 (2000).
47. Chade, A. R.; Kelsen, S. Renal microvascular disease determines the responses to revascularization in experimental renovascular disease. Circ. Cardiovasc. Interv. 3, 376-83 (2010).
48. Iliescu, R.; Fernandez, SR.; Kelsen, S.; Maric, C.; Chade, A. R. Role of renal microcirculation in experimental renovascular disease. Nephrol. Dial. Transplant. 25, 1079-87 (2010).
49. Clauss, M.; Grell, M.; Fangmann, C.; Fiers, W.; Scheurich, P.; Risau, W. Synergistic induction of endothelial tissue factor by tumor necrosis factor and vascular endothelial growth factor: functional analysis of the tumor necrosis factor receptors. FEBS Lett. 390, 334-338 (1996).
50. Mechtcheriakova, D.; Schabbauer G.; Lucerna, M.; Clauss, M.; De Martin, R.; Binder, B. R.; Hofer, E. Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor upregulation via EGR-1 in endothelial cells. FASEB J. 15, 230-242 (2001).
51. Gurkan, O. U.; O'Donnell, C.; Brower, R.; Ruckdeschel, E.; Becker, P. M. Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice. Am. J. Physiol. Lung. Cell. Mol. Physiol. 285, L710-L718 (2003).
52. Shukla, R. K.; Sharma, V.; Pandey, A. K.; Singh, S.; Sultana, S.; Dhawan, A. ROS mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells. Toxicol. In Vitro 25, 231-241 (2011).
53. Zs-Nagy, I. Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review. Arch Gerontol Geriatr. 11, 177-186 (1990