Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes

Circulation Research

Volumn 99, Issue 2, 2006, Pages 172-182

  Maack, Christoph ^a,b   Cortassa, Sonia ^a   Aon, Miguel A ^a   Ganesan, Anand N ^a   Liu, Ting ^a   O'Rourke, Brian ^a,c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b SAARLAND UNIVERSITY   (Germany)

^c Institute of Molecular Cardiobiology   (United States)

Author keywords

Calcium buffer; Calcium uniporter; Energy metabolism; Krebs cycle; Na+ Ca2+ exchange; Oxidative phosphorylation

Indexed keywords

7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; CALCIUM ION; ESTER DERIVATIVE; INDO 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SODIUM ION; CALCIUM; NICOTINAMIDE ADENINE DINUCLEOTIDE; SODIUM;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DEPOLARIZATION; ENERGY METABOLISM; ENERGY RESOURCE; EXCITATION CONTRACTION COUPLING; GUINEA PIG; HEART MUSCLE CELL; MITOCHONDRION; NONHUMAN; OXIDATION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; SODIUM CALCIUM EXCHANGE; VOLTAGE CLAMP; ANIMAL; CELL CULTURE; CYTOSOL; DRUG EFFECT; HEART CONTRACTION; HOMEOSTASIS; METABOLISM;

ANIMALS; CALCIUM; CELLS, CULTURED; CYTOSOL; ENERGY METABOLISM; GUINEA PIGS; HOMEOSTASIS; MITOCHONDRIA; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NAD; SODIUM;

EID: 33746824336     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000232546.92777.05     Document Type: Article

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