Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages

  Savi, Monia ^a,b   Rossi, Stefano ^a,b   Bocchi, Leonardo ^a   Gennaccaro, Laura ^a   Cacciani, Francesca ^a   Perotti, Alessio ^a   Amidani, Davide ^a   Alinovi, Rossella ^a,b   Goldoni, Matteo ^a,b   Aliatis, Irene ^a   Lottici, Pier Paolo ^a   Bersani, Danilo ^a   Campanini, Marco ^c   Pinelli, Silvana ^a,b   Petyx, Marta ^d   Frati, Caterina ^a   Gervasi, Andrea ^a   Urbanek, Konrad ^e   Quaini, Federico ^a   Buschini, Annamaria ^a   Stilli, Donatella ^a   Rivetti, Claudio ^a   Macchi, Emilio ^a,b   Mutti, Antonio ^a,b   Miragoli, Michele ^b,f   Zaniboni, Massimiliano ^a,b   more..

^a UNIVERSITY OF PARMA   (Italy)

^b Department of Clinical and Experimental Medicine   (Italy)

^c IMEM CNR   (Italy)

^d DEPARTMENT OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE   (Italy)

^e SECOND UNIVERSITY OF NAPLES   (Italy)

^f HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

Cardiac arrhythmia; Experimental model; Membrane leakage; Pollution; Supernormal conduction; Titanium dioxide nanoparticles

Indexed keywords

TITANIUM DIOXIDE NANOPARTICLE; AIR POLLUTANT; METAL NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; COMPUTER MODEL; CONTROLLED STUDY; DNA DAMAGE; EXPOSURE; HEART CONDUCTION; HEART MUSCLE CELL; HEART MUSCLE EXCITABILITY; HEART VENTRICLE CONTRACTION; IN VITRO STUDY; LIPID PEROXIDATION; MEMBRANE DAMAGE; MOLECULAR INTERACTION; MOUSE; NANOANALYSIS; NANOTOXICOLOGY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TISSUE INJURY; TOXICITY TESTING; TRANSMISSION ELECTRON MICROSCOPY; ACTION POTENTIAL; ADVERSE EFFECTS; AIR POLLUTANT; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CHEMICALLY INDUCED; COMPUTER SIMULATION; CYTOLOGY; DRUG EFFECTS; EXCITATION CONTRACTION COUPLING; HEART ARRHYTHMIA; HEART MUSCLE CONDUCTION SYSTEM; HEART VENTRICLE; MALE; PATHOPHYSIOLOGY; TOXICITY; ULTRASTRUCTURE; WISTAR RAT;

ACTION POTENTIALS; AIR POLLUTANTS; ANIMALS; ARRHYTHMIAS, CARDIAC; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; COMPUTER SIMULATION; DNA DAMAGE; EXCITATION CONTRACTION COUPLING; HEART CONDUCTION SYSTEM; HEART VENTRICLES; INHALATION EXPOSURE; LIPID PEROXIDATION; MALE; METAL NANOPARTICLES; MODELS, BIOLOGICAL; MYOCYTES, CARDIAC; RATS, WISTAR; TITANIUM; TOXICITY TESTS, ACUTE;

EID: 84928730216     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/s12989-014-0063-3     Document Type: Article

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