Mechanisms of toxicity induced by SiO2 nanoparticles of in vitro human alveolar barrier: Effects on cytokine production, oxidative stress induction, surfactant proteins A mRNA expression and nanoparticles uptake

Nanotoxicology

Volumn 7, Issue 6, 2012, Pages 1095-1110

  Farcal, Lucian Romeo ^a   Uboldi, Chiara ^a   Mehn, Dora ^a   Giudetti, Guido ^a   Nativo, Paola ^a   Ponti, Jessica ^a   Gilliland, Douglas ^a   Rossi, François ^a   Bal Price, Anna ^a  

^a JOINT RESEARCH CENTRE   (Italy)

Author keywords

Alveolar barrier; in vitro model; Inflammation; Silica nanoparticles; Toxicity mechanisms

Indexed keywords

INTERLEUKIN 8; NANOPARTICLE; SILICON DIOXIDE; SURFACTANT PROTEIN A; SURFACTANT PROTEIN A1; SURFACTANT PROTEIN A2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; CYTOKINE PRODUCTION; DOWN REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; MONOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SILICOSIS;

EID: 84881269479     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2012.710658     Document Type: Article

References (57)

1. Adili A, Crowe S, Beaux MF 2nd, Cantrell T, Shapiro PJ, McIlroy DN, et al. 2008. Differential cytotoxicity exhibited by silica nanowires and nanoparticles. Nanotoxicology 2:1-8
2. Akhtar MJ, Ahamed M, Kumar S, Siddiqui H, Patil G, Ashquin M, et al. 2010. Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells. Toxicology 276(2):95-102
3. Bartneck M, Keul HA, Singh S, Czaja K, Bornemann J, Bockstaller M, et al. 2010. Rapid uptake of gold nanorods by primary human blood phagocytes and immunomodulatory effects of surface chemistry. ACS Nano 4(6):3073-3086
4. Blumberg PM. 1980. In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: Part 1. Crit Rev Toxicol 8 (2):153-197
5. Borm PJ, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, et al. 2006. The potential risks of nanomaterials: A review carried out for ECETOC. Part Fibre Toxicol 3:11
6. Calzolai L, Gilliland D, Garcia CP, Rossi F. 2011. Separation and characterization of gold nanoparticle mixtures by flow-field-flow fractionation. J Chromatogr A 1218:4234-4239
7. Cho WS, Cho M, Jeong J, Choi M, Cho HY, Han BS, et al. 2009. Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles. Toxicol Appl Pharmacol 236(1):16-24
8. Choi EH, Ehrmantraut M, Foster CB, Moss J, Chanock SJ. 2006. Association of common haplotypes of surfactant protein A1 and A2 (SFTPA1 and SFTPA2) genes with severity of lung disease in cystic fibrosis. Pediatr Pulmonol 41(3):255-262
9. Eom JH, Choi J. 2009. Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B. Toxicol In Vitro 23:1326-1332
10. Esch RK, Han L, Foarde KK, Ensor DS. 2010. Endotoxin contamination of engineered nanomaterials. Nanotoxicology 4(1):73-83
11. Forti E, Bulgheroni A, Cetin Y, Hartung T, Jennings P, Pfaller W, et al. 2010. Characterisation of cadmium chloride induced molecular and functional alterations in airway epithelial cells. Cell Physiol Biochem 25(1):159-168
12. Geiser M, Casaulta M, Kupferschmid B, Schulz H, Semmler-Behnke M, Kreyling W. 2008. The role of macrophages in the clearance of inhaled ultrafine titanium dioxide particles. Am J Respir Cell Mol Biol 38(3):371-376
13. Geiser M. 2002. Morphological aspects of particle uptake by lung phagocytes. Microsc Res Tech 57(6):512-522
14. Gill S, Lobenberg R, Ku T, Azarmi S, Roa W, Prenner EJ. 2007. Nanoparticles: Characteristics, mechanisms of action, and toxicity in pulmonary drug delivery -A review. J Biomed Nanotechnol 3:107-119
15. Hawgood S, Clements JA. 1990. Pulmonary surfactant and its apoproteins. J Clin Invest 86(1):1-6
16. Hermanns MI, Kasper J, Dubruel P, Pohl C, Uboldi C, Vermeersch V, et al. 2010. An impaired alveolar-capillary barrier in vitro: Effect of proinflammatory cytokines and consequences on nanocarrier interaction. J R Soc Interface 7(Suppl 1):S41-S54
17. Hermanns MI, Unger RE, Kehe K, Peters K, Kirkpatrick CJ. 2004. Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: Development of an alveolo-capillary barrier in vitro. Lab Invest 84(6):736-752
18. Heyder J. 2004. Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery. Proc Am Thorac Soc 1(4):315-320
19. Free Radical Biology and Medicine >Kasper J, Hermanns MI, Bantz C, Maskos M, Stauber R, Pohl C, et al. 2011. Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: Comparison with conventional monocultures. Part Fibre Toxicol 8(1):6
20. Khubchandani KR, Snyder JM. 2001. Surfactant protein A (SP-A): The alveolus and beyond. FASEB J 15(1):59-69
21. Kishore U, Greenhough TJ, Waters P, Shrive AK, Ghai R, Kamran MF, et al. 2006. Surfactant proteins SP-A and SP-D: Structure, function and receptors. Mol Immunol 43(9):1293-1315
22. Kohro T, Tanaka T, Murakami T, Wada Y, Aburatani H, Hamakubo T, et al. 2004. A comparison of differences in the gene expression profiles of phorbol 12-myristate 13-Acetate differentiated THP-1 cells and human monocyte-derived macrophage. J Atheroscler Thromb 11(2):88-97
23. Kremlev SG, Phelps DS. 1994. Surfactant protein A stimulation of inflammatory cytokine and immunoglobulin production. Am J Physiol 267(6 Pt 1):L712-L719
24. Kremlev SG, Phelps DS. 1997. Effect of SP-A and surfactant lipids on expression of cell surface markers in the THP-1 monocytic cell line. Am J Physiol 272(6 Pt 1):L1070-L1077
25. Kremlev SG, Umstead TM, Phelps DS. 1997. Surfactant protein A regulates cytokine production in the monocytic cell line THP-1. Am J Physiol 272(5 Pt 1):L996-L1004
26. Lanone S, Rogerieux F, Geys J, Dupont A, Maillot-Marechal E, Boczkowski J, et al. 2009. Comparative toxicity of 24 manufactured nanoparticles in human alveolar epithelial and macrophage cell lines. Part Fibre Toxicol 6:14
27. Limbach LK, Li Y, Grass RN, Brunner TJ, Hintermann MA, Muller M, et al. 2005. Oxide nanoparticle uptake in human lung fibroblasts: Effects of particle size, agglomeration, and diffusion at low concentrations. Environ Sci Technol 39(23):9370-9376
28. Lin W, Huang YW, Zhou XD, Ma Y. 2006. In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol Appl Pharmacol 217(3):252-259
29. Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, et al. 2002. Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther 303 (3):1029-1037
30. Masuzawa M, Fujimura T, Hamada Y, Fujita Y, Hara H, Nishiyama S, et al. 1999. Establishment of a human hemangiosarcoma cell line (ISO-HAS). Int J Cancer 81(2):305-308
31. Miakotina OL, Snyder JM. 2002. TNF-Alpha inhibits SP-A gene expression in lung epithelial cells via p38 MAPK. Am J Physiol Lung Cell Mol Physiol 283(2):L418-L427
32. Muhlfeld C, Rothen-Rutishauser B, Blank F, Vanhecke D, Ochs M, Gehr P. 2008. Interactions of nanoparticles with pulmonary structures and cellular responses. Am J Physiol Lung Cell Mol Physiol 294(5):L817-L829
33. Müller L, Riediker M, Wick P, Mohr M, Gehr P, Rothen-Rutishauser B. 2010. Oxidative stress and inflammation response after nanoparticles exposure: Differences between human lung cell monocultures and an advanced three-dimensional model of the human epithelial airways. J R Soc Interface 7:27-40
34. Napierska D, Thomassen LC, Lison D, Martens JA, Hoet PH. 2010. The nanosilica hazard: Another variable entity. Part Fibre Toxicol 7(1):39
35. Oberdorster G, Ferin J, Lehnert BE. 1994. Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect 102(Suppl 5):173-179
36. Oberdorster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, et al. 2005. Principles for characterizing the potential human health effects from exposure to nanomaterials: Elements of a screening strategy. Part Fibre Toxicol 2:8
37. Ohmer-Schrock D, Schlatterer C, Plattner H, Schlepper-Schafer J. 1995. Lung surfactant protein A (SP-A) activates a phosphoinositide/ calcium signaling pathway in alveolar macrophages. J Cell Sci 108(Pt 12):3695-3702
38. Park EJ, Park K. 2009. Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol Lett 184:18-25
39. Pohl C, Hofmann H, Moisch M, Papritz M, Iris HM, Dei-Anang J, et al. 2010. Acute cytotoxicity and apoptotic effects after l-Pam exposure in different cocultures of the proximal and distal respiratory system. J Biotechnol 148(1):31-37
40. Pryhuber GS, O'Reilly MA, Clark JC, Hull WM, Fink I, Whitsett JA. 1990. Phorbol ester inhibits surfactant protein SP-A and SP-B expression. J Biol Chem 265(34):20822-20828
41. Rabolli V, Thomassen LC, Princen C, Napierska D, Gonzalez L, Kirsch-Volders M, et al. 2010. Influence of size, surface area and microporosity on the in vitro cytotoxic activity of amorphous silica nanoparticles in different cell types. Nanotoxicology 4(3): 307-318
42. Satsu H, Ishimoto Y, Nakano T, Mochizuki T, Iwanaga T, Shimizu M. 2006. Induction by activated macrophage-like THP-1 cells of apoptotic and necrotic cell death in intestinal epithelial Caco-2 monolayers via tumor necrosis factor-Alpha. Exp Cell Res 312(19): 3909-3919
43. Schleh C, Hohlfeld JM. 2009. Interaction of nanoparticles with the pulmonary surfactant system. Inhal Toxicol 21(Suppl 1):97-103
44. Schwarzer E, De Matteis F, Giribaldi G, Ulliers D, Valente E, Arese P. 1999. Hemozoin stability and dormant induction of heme oxygenase in hemozoin-fed human monocytes. Mol Biochem Parasitol 100(1):61-72
45. Schwende H, Fitzke E, Ambs P, Dieter P. 1996. Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1,25-dihydroxyvitamin D3. J Leukoc Biol 59(4):555-561
46. Shi Y, Yadav S, Wang F, Wang H. 2010. Endotoxin promotes adverse effects of amorphous silica nanoparticles on lung epithelial cells in vitro. J Toxicol Environ Health A 73(11):748-756
47. Song M, Phelps DS. 2000. Comparison of SP-A and LPS effects on the THP-1 monocytic cell line. Am J Physiol Lung Cell Mol Physiol 279(1):L110-L117
48. Striz I, Slavcev A, Kalanin J, Jaresova M, Rennard SI. 2001. Cell-cell contacts with epithelial cells modulate the phenotype of human macrophages. Inflammation 25(4):241-246
49. Tao F, Kobzik L. 2002. Lung macrophage-epithelial cell interactions amplify particle-mediated cytokine release. Am J Respir Cell Mol Biol 26(4):499-505
50. Traore K, TrushMA, GeorgeMJr, Spannhake EW, Anderson W, Asseffa A. 2005. Signal transduction of phorbol 12-myristate 13-Acetate (PMA)-induced growth inhibition of humanmonocytic leukemia THP-1 cells is reactive oxygen dependent. Leuk Res 29(8):863-879
51. Tsuchiya S, Kobayashi Y, Goto Y, Okumura H, Nakae S, Konno T, et al. 1982. Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Cancer Res 42(4):1530-1536
52. Uboldi C, Giudetti G, Broggi F, Gilliland D, Ponti J, Rossi F. 2012. Amorphous silica nanoparticles do not induce cytotoxicity, cell transformation or genotoxicity in Balb/3T3 mouse fibroblasts. Mutat Res 745(1-2):11-20
53. Wang G, Phelps DS, Umstead TM, Floros J. 2000. Human SP-A protein variants derived from one or both genes stimulate TNF-Alpha production in the THP-1 cell line. Am J Physiol Lung Cell Mol Physiol 278(5):L946-L954
54. Wang H, Joseph JA. 1999. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 27(5-6):612-616
55. Whitsett JA, Clark JC, Wispe JR, Pryhuber GS. 1992. Effects of TNF-Alpha and phorbol ester on human surfactant protein and MnSOD gene transcription in vitro. Am J Physiol 262(6 Pt 1): L688-L693
56. Wottrich R, Diabate S, Krug HF. 2004. Biological effects of ultrafine model particles in human macrophages and epithelial cells in mono-And co-culture. Int J Hyg Environ Health 207(4):353-361
57. Yang H, Liu C, Yang D, Zhang H, Zhuge X. 2008. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: The role of particle size, shape and composition. J Appl Toxicol 29:69-78