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Volumn 34, Issue 23, 2013, Pages 5853-5862

Cardiovascular toxicity evaluation of silica nanoparticles in endothelial cells and zebrafish model

Author keywords

Cardiovascular effects; Endothelium; Nanotoxicity; Silica nanoparticles; Zebrafish

Indexed keywords

CARDIOVASCULAR EFFECTS; ENDOTHELIUM; NANOTOXICITY; SILICA NANOPARTICLES; ZEBRAFISH;

EID: 84877803195     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.04.032     Document Type: Article
Times cited : (187)

References (62)
  • 1
    • 2942724312 scopus 로고    scopus 로고
    • Nanotoxicology. Nanotechnology grows up
    • Service R.F. Nanotoxicology. Nanotechnology grows up. Science 2004, 304:1732-1734.
    • (2004) Science , vol.304 , pp. 1732-1734
    • Service, R.F.1
  • 3
    • 78049454971 scopus 로고    scopus 로고
    • United States Government Accountability Office report on nanotechnology: nanomaterials are widely used in commerce, but EPA faces challenges in regulating risk
    • United States Government Accountability Office report on nanotechnology: nanomaterials are widely used in commerce, but EPA faces challenges in regulating risk. Int J Occup Environ Health 2010, 16:525-539.
    • (2010) Int J Occup Environ Health , vol.16 , pp. 525-539
  • 4
    • 84859881194 scopus 로고    scopus 로고
    • Photosensitizer encapsulated organically modified silica nanoparticles for direct two-photon photodynamic therapy and invivo functional imaging
    • Qian J., Wang D., Cai F., Zhan Q., Wang Y., He S. Photosensitizer encapsulated organically modified silica nanoparticles for direct two-photon photodynamic therapy and invivo functional imaging. Biomaterials 2012, 33:4851-4860.
    • (2012) Biomaterials , vol.33 , pp. 4851-4860
    • Qian, J.1    Wang, D.2    Cai, F.3    Zhan, Q.4    Wang, Y.5    He, S.6
  • 5
    • 84863337588 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles in biomedical applications
    • Li Z., Barnes J.C., Bosoy A., Stoddart J.F., Zink J.I. Mesoporous silica nanoparticles in biomedical applications. Chem Soc Rev 2012, 41:2590-2605.
    • (2012) Chem Soc Rev , vol.41 , pp. 2590-2605
    • Li, Z.1    Barnes, J.C.2    Bosoy, A.3    Stoddart, J.F.4    Zink, J.I.5
  • 6
    • 80054752813 scopus 로고    scopus 로고
    • Multifunctional mesoporous silica nanocomposite nanoparticles for theranostic applications
    • Lee J.E., Lee N., Kim T., Kim J., Hyeon T. Multifunctional mesoporous silica nanocomposite nanoparticles for theranostic applications. Acc Chem Res 2011, 44:893-902.
    • (2011) Acc Chem Res , vol.44 , pp. 893-902
    • Lee, J.E.1    Lee, N.2    Kim, T.3    Kim, J.4    Hyeon, T.5
  • 7
    • 79957873724 scopus 로고    scopus 로고
    • Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay
    • Park M.V., Verharen H.W., Zwart E., Hernandez L.G., van Benthem J., Elsaesser A., et al. Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay. Nanotoxicology 2011, 5:168-181.
    • (2011) Nanotoxicology , vol.5 , pp. 168-181
    • Park, M.V.1    Verharen, H.W.2    Zwart, E.3    Hernandez, L.G.4    van Benthem, J.5    Elsaesser, A.6
  • 9
    • 79955098280 scopus 로고    scopus 로고
    • Nanomaterials in the environment: from materials to high-throughput screening to organisms
    • Thomas C.R., George S., Horst A.M., Ji Z., Miller R.J., Peralta-Videa J.R., et al. Nanomaterials in the environment: from materials to high-throughput screening to organisms. ACS Nano 2011, 5:13-20.
    • (2011) ACS Nano , vol.5 , pp. 13-20
    • Thomas, C.R.1    George, S.2    Horst, A.M.3    Ji, Z.4    Miller, R.J.5    Peralta-Videa, J.R.6
  • 10
    • 77953229216 scopus 로고    scopus 로고
    • Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association
    • Brook R.D., Rajagopalan S., Pope C.A., Brook J.R., Bhatnagar A., Diez-Roux A.V., et al. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 2010, 121:2331-2378.
    • (2010) Circulation , vol.121 , pp. 2331-2378
    • Brook, R.D.1    Rajagopalan, S.2    Pope, C.A.3    Brook, J.R.4    Bhatnagar, A.5    Diez-Roux, A.V.6
  • 11
    • 0347086147 scopus 로고    scopus 로고
    • Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
    • Pope C.A., Burnett R.T., Thurston G.D., Thun M.J., Calle E.E., Krewski D., et al. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation 2004, 109:71-77.
    • (2004) Circulation , vol.109 , pp. 71-77
    • Pope, C.A.1    Burnett, R.T.2    Thurston, G.D.3    Thun, M.J.4    Calle, E.E.5    Krewski, D.6
  • 12
    • 77957330209 scopus 로고    scopus 로고
    • Changes in deceleration capacity of heart rate and heart rate variability induced by ambient air pollution in individuals with coronary artery disease
    • Schneider A., Hampel R., Ibald-Mulli A., Zareba W., Schmidt G., Schneider R., et al. Changes in deceleration capacity of heart rate and heart rate variability induced by ambient air pollution in individuals with coronary artery disease. Part Fibre Toxicol 2010, 7:29.
    • (2010) Part Fibre Toxicol , vol.7 , pp. 29
    • Schneider, A.1    Hampel, R.2    Ibald-Mulli, A.3    Zareba, W.4    Schmidt, G.5    Schneider, R.6
  • 13
    • 65449178474 scopus 로고    scopus 로고
    • Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells
    • Napierska D., Thomassen L.C., Rabolli V., Lison D., Gonzalez L., Kirsch-Volders M., et al. Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells. Small 2009, 5:846-853.
    • (2009) Small , vol.5 , pp. 846-853
    • Napierska, D.1    Thomassen, L.C.2    Rabolli, V.3    Lison, D.4    Gonzalez, L.5    Kirsch-Volders, M.6
  • 15
    • 69049089856 scopus 로고    scopus 로고
    • Simultaneous isolation of vascular endothelial cells and mesenchymal stem cells from the human umbilical cord
    • Kadam S.S., Tiwari S., Bhonde R.R. Simultaneous isolation of vascular endothelial cells and mesenchymal stem cells from the human umbilical cord. InVitro Cell Dev Biol Anim 2009, 45:23-27.
    • (2009) InVitro Cell Dev Biol Anim , vol.45 , pp. 23-27
    • Kadam, S.S.1    Tiwari, S.2    Bhonde, R.R.3
  • 17
    • 69249132449 scopus 로고    scopus 로고
    • Endothelial cell apoptosis is responsible for the formation of coronary thrombotic atherosclerotic plaques
    • Xu F., Sun Y., Chen Y., Li R., Liu C., Zhang C., et al. Endothelial cell apoptosis is responsible for the formation of coronary thrombotic atherosclerotic plaques. Tohoku J Exp Med 2009, 218:25-33.
    • (2009) Tohoku J Exp Med , vol.218 , pp. 25-33
    • Xu, F.1    Sun, Y.2    Chen, Y.3    Li, R.4    Liu, C.5    Zhang, C.6
  • 18
    • 65649104077 scopus 로고    scopus 로고
    • Zebrafish as a correlative and predictive model for assessing biomaterial nanotoxicity
    • Fako V.E., Furgeson D.Y. Zebrafish as a correlative and predictive model for assessing biomaterial nanotoxicity. Adv Drug Deliv Rev 2009, 61:478-486.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 478-486
    • Fako, V.E.1    Furgeson, D.Y.2
  • 19
    • 79959990108 scopus 로고    scopus 로고
    • Zebrafish as a model to study cardiac development and human cardiac disease
    • Bakkers J. Zebrafish as a model to study cardiac development and human cardiac disease. Cardiovasc Res 2011, 91:279-288.
    • (2011) Cardiovasc Res , vol.91 , pp. 279-288
    • Bakkers, J.1
  • 20
    • 82655181893 scopus 로고    scopus 로고
    • Cytotoxicity and mitochondrial damage caused by silica nanoparticles
    • Sun L., Li Y., Liu X., Jin M., Zhang L., Du Z., et al. Cytotoxicity and mitochondrial damage caused by silica nanoparticles. Toxicol InVitro 2011, 25:1619-1629.
    • (2011) Toxicol InVitro , vol.25 , pp. 1619-1629
    • Sun, L.1    Li, Y.2    Liu, X.3    Jin, M.4    Zhang, L.5    Du, Z.6
  • 21
    • 84857782902 scopus 로고    scopus 로고
    • Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model
    • Hu Y.L., Qi W., Han F., Shao J.Z., Gao J.Q. Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model. Int J Nanomedicine 2011, 6:3351-3359.
    • (2011) Int J Nanomedicine , vol.6 , pp. 3351-3359
    • Hu, Y.L.1    Qi, W.2    Han, F.3    Shao, J.Z.4    Gao, J.Q.5
  • 22
    • 82855170841 scopus 로고    scopus 로고
    • Expression pattern and functions of autophagy-related gene atg5 in zebrafish organogenesis
    • Hu Z., Zhang J., Zhang Q. Expression pattern and functions of autophagy-related gene atg5 in zebrafish organogenesis. Autophagy 2011, 7:1514-1527.
    • (2011) Autophagy , vol.7 , pp. 1514-1527
    • Hu, Z.1    Zhang, J.2    Zhang, Q.3
  • 23
    • 84876425519 scopus 로고    scopus 로고
    • Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2/M checkpoint
    • Duan J.C., Yu Y.B., Li Y., Yu Y., Li Y.B., Zhou X.Q., et al. Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2/M checkpoint. PLoS One 2013, 8:e62087.
    • (2013) PLoS One , vol.8
    • Duan, J.C.1    Yu, Y.B.2    Li, Y.3    Yu, Y.4    Li, Y.B.5    Zhou, X.Q.6
  • 24
    • 58149184031 scopus 로고    scopus 로고
    • Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies
    • Jiang J., Oberdörster G., Biswas P. Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies. JNanoparticle Res 2009, 11:77-89.
    • (2009) JNanoparticle Res , vol.11 , pp. 77-89
    • Jiang, J.1    Oberdörster, G.2    Biswas, P.3
  • 25
    • 46749091612 scopus 로고    scopus 로고
    • Bioconjugated quantum dots for invivo molecular and cellular imaging
    • Smith A.M., Duan H., Mohs A.M., Nie S. Bioconjugated quantum dots for invivo molecular and cellular imaging. Adv Drug Deliv Rev 2008, 60:1226-1240.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 1226-1240
    • Smith, A.M.1    Duan, H.2    Mohs, A.M.3    Nie, S.4
  • 26
    • 67650338048 scopus 로고    scopus 로고
    • Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles
    • Lu F., Wu S.H., Hung Y., Mou C.Y. Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles. Small 2009, 5:1408-1413.
    • (2009) Small , vol.5 , pp. 1408-1413
    • Lu, F.1    Wu, S.H.2    Hung, Y.3    Mou, C.Y.4
  • 27
    • 33646397592 scopus 로고    scopus 로고
    • Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
    • Chithrani B.D., Ghazani A.A., Chan W.C. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett 2006, 6:662-668.
    • (2006) Nano Lett , vol.6 , pp. 662-668
    • Chithrani, B.D.1    Ghazani, A.A.2    Chan, W.C.3
  • 28
    • 80052966765 scopus 로고    scopus 로고
    • Cytotoxicity of silica nanoparticles through exocytosis of von Willebrand factor and necrotic cell death in primary human endothelial cells
    • Bauer A.T., Strozyk E.A., Gorzelanny C., Westerhausen C., Desch A., Schneider M.F., et al. Cytotoxicity of silica nanoparticles through exocytosis of von Willebrand factor and necrotic cell death in primary human endothelial cells. Biomaterials 2011, 32:8385-8393.
    • (2011) Biomaterials , vol.32 , pp. 8385-8393
    • Bauer, A.T.1    Strozyk, E.A.2    Gorzelanny, C.3    Westerhausen, C.4    Desch, A.5    Schneider, M.F.6
  • 29
    • 77956161513 scopus 로고    scopus 로고
    • Endothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK/P53 and NF-kappaB pathways
    • Liu X., Sun J. Endothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK/P53 and NF-kappaB pathways. Biomaterials 2010, 31:8198-8209.
    • (2010) Biomaterials , vol.31 , pp. 8198-8209
    • Liu, X.1    Sun, J.2
  • 30
    • 0038141058 scopus 로고    scopus 로고
    • Apoptosis, a major determinant of atherothrombosis
    • Tedgui A., Mallat Z. Apoptosis, a major determinant of atherothrombosis. Arch Mal Coeur Vaiss 2003, 96:671-675.
    • (2003) Arch Mal Coeur Vaiss , vol.96 , pp. 671-675
    • Tedgui, A.1    Mallat, Z.2
  • 31
    • 84856478716 scopus 로고    scopus 로고
    • Endothelial dysfunction as a cellular mechanism for vascular failure
    • Hirase T., Node K. Endothelial dysfunction as a cellular mechanism for vascular failure. Am J Physiol Heart Circ Physiol 2012, 302:H499-H505.
    • (2012) Am J Physiol Heart Circ Physiol , vol.302
    • Hirase, T.1    Node, K.2
  • 32
    • 75949091374 scopus 로고    scopus 로고
    • Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells
    • Inayat-Hussain S.H., Chan K.M., Rajab N.F., Din L.B., Chow S.C., Kizilors A., et al. Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells. Toxicol Lett 2010, 193:108-114.
    • (2010) Toxicol Lett , vol.193 , pp. 108-114
    • Inayat-Hussain, S.H.1    Chan, K.M.2    Rajab, N.F.3    Din, L.B.4    Chow, S.C.5    Kizilors, A.6
  • 33
    • 77956181700 scopus 로고    scopus 로고
    • Influence of silica particle internalization on adhesion and migration of human dermal fibroblasts
    • Zhang Y., Hu L., Yu D., Gao C. Influence of silica particle internalization on adhesion and migration of human dermal fibroblasts. Biomaterials 2010, 31:8465-8474.
    • (2010) Biomaterials , vol.31 , pp. 8465-8474
    • Zhang, Y.1    Hu, L.2    Yu, D.3    Gao, C.4
  • 34
    • 59649103553 scopus 로고    scopus 로고
    • Toxicological effects of inorganic nanoparticles on human lung cancer A549 cells
    • Choi S.J., Oh J.M., Choy J.H. Toxicological effects of inorganic nanoparticles on human lung cancer A549 cells. JInorg Biochem 2009, 103:463-471.
    • (2009) JInorg Biochem , vol.103 , pp. 463-471
    • Choi, S.J.1    Oh, J.M.2    Choy, J.H.3
  • 35
    • 84860388978 scopus 로고    scopus 로고
    • Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma HepG2 cells
    • Li Y., Sun L., Jin M., Du Z., Liu X., Guo C., et al. Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma HepG2 cells. Toxicol InVitro 2011, 25:1343-1352.
    • (2011) Toxicol InVitro , vol.25 , pp. 1343-1352
    • Li, Y.1    Sun, L.2    Jin, M.3    Du, Z.4    Liu, X.5    Guo, C.6
  • 36
    • 0035960677 scopus 로고    scopus 로고
    • Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    • Heitzer T., Schlinzig T., Krohn K., Meinertz T., Munzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001, 104:2673-2678.
    • (2001) Circulation , vol.104 , pp. 2673-2678
    • Heitzer, T.1    Schlinzig, T.2    Krohn, K.3    Meinertz, T.4    Munzel, T.5
  • 37
    • 84861715726 scopus 로고    scopus 로고
    • Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects
    • Corbalan J.J., Medina C., Jacoby A., Malinski T., Radomski M.W. Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects. Int J Nanomedicine 2011, 6:2821-2835.
    • (2011) Int J Nanomedicine , vol.6 , pp. 2821-2835
    • Corbalan, J.J.1    Medina, C.2    Jacoby, A.3    Malinski, T.4    Radomski, M.W.5
  • 38
    • 4944250523 scopus 로고    scopus 로고
    • Prognostic value of systemic endothelial dysfunction in patients with acute coronary syndromes: further evidence for the existence of the "vulnerable" patient
    • Fichtlscherer S., Breuer S., Zeiher A.M. Prognostic value of systemic endothelial dysfunction in patients with acute coronary syndromes: further evidence for the existence of the "vulnerable" patient. Circulation 2004, 110:1926-1932.
    • (2004) Circulation , vol.110 , pp. 1926-1932
    • Fichtlscherer, S.1    Breuer, S.2    Zeiher, A.M.3
  • 39
    • 0342424181 scopus 로고    scopus 로고
    • Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
    • Schachinger V., Britten M.B., Zeiher A.M. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000, 101:1899-1906.
    • (2000) Circulation , vol.101 , pp. 1899-1906
    • Schachinger, V.1    Britten, M.B.2    Zeiher, A.M.3
  • 40
    • 84864875088 scopus 로고    scopus 로고
    • Functional mesoporous silica nanoparticles for photothermal-controlled drug delivery invivo
    • Yan H., Teh C., Sreejith S., Zhu L., Kwok A., Fang W., et al. Functional mesoporous silica nanoparticles for photothermal-controlled drug delivery invivo. Angew Chem Int Ed Engl 2012, 51:8373-8377.
    • (2012) Angew Chem Int Ed Engl , vol.51 , pp. 8373-8377
    • Yan, H.1    Teh, C.2    Sreejith, S.3    Zhu, L.4    Kwok, A.5    Fang, W.6
  • 42
    • 38349153561 scopus 로고    scopus 로고
    • Comparative toxicity of several metal oxide nanoparticle aqueous suspensions to Zebrafish (Danio rerio) early developmental stage
    • Zhu X., Zhu L., Duan Z., Qi R., Li Y., Lang Y. Comparative toxicity of several metal oxide nanoparticle aqueous suspensions to Zebrafish (Danio rerio) early developmental stage. JEnviron Sci Health Part A 2008, 43:278-284.
    • (2008) JEnviron Sci Health Part A , vol.43 , pp. 278-284
    • Zhu, X.1    Zhu, L.2    Duan, Z.3    Qi, R.4    Li, Y.5    Lang, Y.6
  • 43
    • 84862195139 scopus 로고    scopus 로고
    • Single nanoparticle spectroscopy for real-time invivo quantitative analysis of transport and toxicity of single nanoparticles in single embryos
    • Lee K.J., Nallathamby P.D., Browning L.M., Desai T., Cherukuri P.K., Xu X.H. Single nanoparticle spectroscopy for real-time invivo quantitative analysis of transport and toxicity of single nanoparticles in single embryos. Analyst 2012, 137:2973-2986.
    • (2012) Analyst , vol.137 , pp. 2973-2986
    • Lee, K.J.1    Nallathamby, P.D.2    Browning, L.M.3    Desai, T.4    Cherukuri, P.K.5    Xu, X.H.6
  • 44
    • 84859619182 scopus 로고    scopus 로고
    • Interactions of hydroxyapatite with proteins and its toxicological effect to zebrafish embryos development
    • Xu Z., Zhang Y.L., Song C., Wu L.L., Gao H.W. Interactions of hydroxyapatite with proteins and its toxicological effect to zebrafish embryos development. PLoS One 2012, 7:e32818.
    • (2012) PLoS One , vol.7
    • Xu, Z.1    Zhang, Y.L.2    Song, C.3    Wu, L.L.4    Gao, H.W.5
  • 45
    • 84861308958 scopus 로고    scopus 로고
    • Invivo quantitative study of sized-dependent transport and toxicity of single silver nanoparticles using zebrafish embryos
    • Lee K.J., Browning L.M., Nallathamby P.D., Desai T., Cherukuri P.K., Xu X.H. Invivo quantitative study of sized-dependent transport and toxicity of single silver nanoparticles using zebrafish embryos. Chem Res Toxicol 2012, 25:1029-1046.
    • (2012) Chem Res Toxicol , vol.25 , pp. 1029-1046
    • Lee, K.J.1    Browning, L.M.2    Nallathamby, P.D.3    Desai, T.4    Cherukuri, P.K.5    Xu, X.H.6
  • 46
    • 34447564864 scopus 로고    scopus 로고
    • Invivo evaluation of carbon fullerene toxicity using embryonic zebrafish
    • Usenko C.Y., Harper S.L., Tanguay R.L. Invivo evaluation of carbon fullerene toxicity using embryonic zebrafish. Carbon N Y 2007, 45:1891-1898.
    • (2007) Carbon N Y , vol.45 , pp. 1891-1898
    • Usenko, C.Y.1    Harper, S.L.2    Tanguay, R.L.3
  • 47
    • 84866464224 scopus 로고    scopus 로고
    • Zebrafish: a novel research tool for cardiac (patho)electrophysiology and ion channel disorders
    • Verkerk A.O., Remme C.A. Zebrafish: a novel research tool for cardiac (patho)electrophysiology and ion channel disorders. Front Physiol 2012, 3:255.
    • (2012) Front Physiol , vol.3 , pp. 255
    • Verkerk, A.O.1    Remme, C.A.2
  • 48
    • 58149389328 scopus 로고    scopus 로고
    • Functional evaluation of isolated zebrafish hearts
    • Hecker L., Khait L., Sessions S.K., Birla R.K. Functional evaluation of isolated zebrafish hearts. Zebrafish 2008, 5:319-322.
    • (2008) Zebrafish , vol.5 , pp. 319-322
    • Hecker, L.1    Khait, L.2    Sessions, S.K.3    Birla, R.K.4
  • 50
    • 84871729357 scopus 로고    scopus 로고
    • Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis
    • Pratheeshkumar P., Son Y.O., Budhraja A., Wang X., Ding S., Wang L., et al. Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. PLoS One 2012, 7:e52279.
    • (2012) PLoS One , vol.7
    • Pratheeshkumar, P.1    Son, Y.O.2    Budhraja, A.3    Wang, X.4    Ding, S.5    Wang, L.6
  • 51
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N., Gerber H.P., LeCouter J. The biology of VEGF and its receptors. Nat Med 2003, 9:669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 52
    • 1942469316 scopus 로고    scopus 로고
    • Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK
    • Cho C.H., Lee C.S., Chang M., Jang I.H., Kim S.J., Hwang I., et al. Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK. Am J Physiol Heart Circ Physiol 2004, 286:H1881-H1888.
    • (2004) Am J Physiol Heart Circ Physiol , vol.286
    • Cho, C.H.1    Lee, C.S.2    Chang, M.3    Jang, I.H.4    Kim, S.J.5    Hwang, I.6
  • 53
    • 84865161610 scopus 로고    scopus 로고
    • Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation
    • Hinits Y., Pan L., Walker C., Dowd J., Moens C.B., Hughes S.M. Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation. Dev Biol 2012, 369:199-210.
    • (2012) Dev Biol , vol.369 , pp. 199-210
    • Hinits, Y.1    Pan, L.2    Walker, C.3    Dowd, J.4    Moens, C.B.5    Hughes, S.M.6
  • 54
    • 64649085563 scopus 로고    scopus 로고
    • Physical interaction between TBX5 and MEF2C is required for early heart development
    • Ghosh T.K., Song F.F., Packham E.A., Buxton S., Robinson T.E., Ronksley J., et al. Physical interaction between TBX5 and MEF2C is required for early heart development. Mol Cell Biol 2009, 29:2205-2218.
    • (2009) Mol Cell Biol , vol.29 , pp. 2205-2218
    • Ghosh, T.K.1    Song, F.F.2    Packham, E.A.3    Buxton, S.4    Robinson, T.E.5    Ronksley, J.6
  • 55
    • 16244392084 scopus 로고    scopus 로고
    • Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress
    • Illi B., Scopece A., Nanni S., Farsetti A., Morgante L., Biglioli P., et al. Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. Circ Res 2005, 96:501-508.
    • (2005) Circ Res , vol.96 , pp. 501-508
    • Illi, B.1    Scopece, A.2    Nanni, S.3    Farsetti, A.4    Morgante, L.5    Biglioli, P.6
  • 56
    • 0030911475 scopus 로고    scopus 로고
    • Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C
    • Lin Q., Schwarz J., Bucana C., Olson E.N. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 1997, 276:1404-1407.
    • (1997) Science , vol.276 , pp. 1404-1407
    • Lin, Q.1    Schwarz, J.2    Bucana, C.3    Olson, E.N.4
  • 57
    • 53249113134 scopus 로고    scopus 로고
    • Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number
    • Targoff K.L., Schell T., Yelon D. Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number. Dev Biol 2008, 322:314-321.
    • (2008) Dev Biol , vol.322 , pp. 314-321
    • Targoff, K.L.1    Schell, T.2    Yelon, D.3
  • 58
    • 2142687110 scopus 로고    scopus 로고
    • Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans
    • Jay P.Y., Berul C.I., Tanaka M., Ishii M., Kurachi Y., Izumo S. Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans. Novartis Found Symp 2003, 250:227-238.
    • (2003) Novartis Found Symp , vol.250 , pp. 227-238
    • Jay, P.Y.1    Berul, C.I.2    Tanaka, M.3    Ishii, M.4    Kurachi, Y.5    Izumo, S.6
  • 59
    • 34247146253 scopus 로고    scopus 로고
    • Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development
    • Blaschke R.J., Hahurij N.D., Kuijper S., Just S., Wisse L.J., Deissler K., et al. Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development. Circulation 2007, 115:1830-1838.
    • (2007) Circulation , vol.115 , pp. 1830-1838
    • Blaschke, R.J.1    Hahurij, N.D.2    Kuijper, S.3    Just, S.4    Wisse, L.J.5    Deissler, K.6
  • 60
    • 0032479573 scopus 로고    scopus 로고
    • Congenital heart disease caused by mutations in the transcription factor NKX2-5
    • Schott J.J., Benson D.W., Basson C.T., Pease W., Silberbach G.M., Moak J.P., et al. Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science 1998, 281:108-111.
    • (1998) Science , vol.281 , pp. 108-111
    • Schott, J.J.1    Benson, D.W.2    Basson, C.T.3    Pease, W.4    Silberbach, G.M.5    Moak, J.P.6
  • 61
    • 80755142772 scopus 로고    scopus 로고
    • Reactive oxygen species driven angiogenesis by inorganic nanorods
    • Patra C.R., Kim J.H., Pramanik K., d'Uscio L.V., Patra S., Pal K., et al. Reactive oxygen species driven angiogenesis by inorganic nanorods. Nano Lett 2011, 11:4932-4938.
    • (2011) Nano Lett , vol.11 , pp. 4932-4938
    • Patra, C.R.1    Kim, J.H.2    Pramanik, K.3    d'Uscio, L.V.4    Patra, S.5    Pal, K.6
  • 62
    • 0035808005 scopus 로고    scopus 로고
    • Global burden of cardiovascular diseases
    • Yusuf S., Reddy S., Ôunpuu S., Anand S. Global burden of cardiovascular diseases. Circulation 2001, 104:2855-2864.
    • (2001) Circulation , vol.104 , pp. 2855-2864
    • Yusuf, S.1    Reddy, S.2    Ôunpuu, S.3    Anand, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.