메뉴 건너뛰기




Volumn 42, Issue 4, 2017, Pages

Neuroprotective strategies and the underlying molecular basis of cerebrovascular stroke

Author keywords

Cerebrovascular accident; Intracerebral hemorrhage; Intraparenchymal hemorrhage; Neuroprotection; Stroke

Indexed keywords

NEUROPROTECTIVE AGENT;

EID: 85016928437     PISSN: None     EISSN: 10920684     Source Type: Journal    
DOI: 10.3171/2017.1.FOCUS16522     Document Type: Article
Times cited : (61)

References (161)
  • 1
    • 0031941076 scopus 로고    scopus 로고
    • Hypervolemic hemodilution in acute ischemic stroke: the Multicenter Austrian Hemodilution Stroke Trial (MAHST)
    • Aichner FT, Fazekas F, Brainin M, Pölz W, Mamoli B, Zeiler K: Hypervolemic hemodilution in acute ischemic stroke: the Multicenter Austrian Hemodilution Stroke Trial (MAHST). Stroke 29:743-749, 1998
    • (1998) Stroke , vol.29 , pp. 743-749
    • Aichner, F.T.1    Fazekas, F.2    Brainin, M.3    Pölz, W.4    Mamoli, B.5    Zeiler, K.6
  • 2
    • 0028870990 scopus 로고
    • Safety, tolerability, and pharmacokinetics of the N-methyld-aspartate antagonist dextrorphan in patients with acute stroke
    • Albers GW, Atkinson RP, Kelley RE, Rosenbaum DM: Safety, tolerability, and pharmacokinetics of the N-methyld-aspartate antagonist dextrorphan in patients with acute stroke. Stroke 26:254-258, 1995
    • (1995) Stroke , vol.26 , pp. 254-258
    • Albers, G.W.1    Atkinson, R.P.2    Kelley, R.E.3    Rosenbaum, D.M.4
  • 3
    • 0035814418 scopus 로고    scopus 로고
    • Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial
    • Albers GW, Goldstein LB, Hall D, Lesko LM: Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial. JAMA 286:2673-2682, 2001
    • (2001) JAMA , vol.286 , pp. 2673-2682
    • Albers, G.W.1    Goldstein, L.B.2    Hall, D.3    Lesko, L.M.4
  • 4
    • 84991510934 scopus 로고    scopus 로고
    • Uric acid therapy prevents early ischemic stroke progression: a tertiary analysis of the URICO-ICTUS Trial (efficacy study of combined treatment with uric acid and r-tPA in acute ischemic stroke)
    • Amaro S, Laredo C, Renú A, Llull L, Rudilosso S, Obach V, et al: Uric acid therapy prevents early ischemic stroke progression: a tertiary analysis of the URICO-ICTUS Trial (efficacy study of combined treatment with uric acid and r-tPA in acute ischemic stroke). Stroke 47:2874-2876, 2016
    • (2016) Stroke , vol.47 , pp. 2874-2876
    • Amaro, S.1    Laredo, C.2    Renú, A.3    Llull, L.4    Rudilosso, S.5    Obach, V.6
  • 5
    • 84928204549 scopus 로고    scopus 로고
    • Uric acid improves glucose-driven oxidative stress in human ischemic stroke
    • Amaro S, Llull L, Renú A, Laredo C, Perez B, Vila E, et al: Uric acid improves glucose-driven oxidative stress in human ischemic stroke. Ann Neurol 77:775-783, 2015
    • (2015) Ann Neurol , vol.77 , pp. 775-783
    • Amaro, S.1    Llull, L.2    Renú, A.3    Laredo, C.4    Perez, B.5    Vila, E.6
  • 6
    • 20444417507 scopus 로고    scopus 로고
    • Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats
    • Amemiya S, Kamiya T, Nito C, Inaba T, Kato K, Ueda M, et al: Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. Eur J Pharmacol 516:125-130, 2005
    • (2005) Eur J Pharmacol , vol.516 , pp. 125-130
    • Amemiya, S.1    Kamiya, T.2    Nito, C.3    Inaba, T.4    Kato, K.5    Ueda, M.6
  • 7
    • 0026544260 scopus 로고
    • Clinical trial of nimodipine in acute ischemic stroke
    • American Nimodipine Study Group: Clinical trial of nimodipine in acute ischemic stroke. Stroke 23:3-8, 1992
    • (1992) Stroke , vol.23 , pp. 3-8
  • 8
    • 84919971321 scopus 로고    scopus 로고
    • An open-label evaluator-blinded clinical study of minocycline neuroprotection in ischemic stroke: genderdependent effect
    • Amiri-Nikpour MR, Nazarbaghi S, Hamdi-Holasou M, Rezaei Y: An open-label evaluator-blinded clinical study of minocycline neuroprotection in ischemic stroke: genderdependent effect. Acta Neurol Scand 131:45-50, 2015
    • (2015) Acta Neurol Scand , vol.131 , pp. 45-50
    • Amiri-Nikpour, M.R.1    Nazarbaghi, S.2    Hamdi-Holasou, M.3    Rezaei, Y.4
  • 9
    • 0024462207 scopus 로고
    • GM1 ganglioside therapy in acute ischemic stroke. Italian Acute Stroke Study-Hemodilution + Drug
    • Argentino C, Sacchetti ML, Toni D, Savoini G, D'Arcangelo E, Erminio F, et al: GM1 ganglioside therapy in acute ischemic stroke. Italian Acute Stroke Study-Hemodilution + Drug. Stroke 20:1143-1149, 1989
    • (1989) Stroke , vol.20 , pp. 1143-1149
    • Argentino, C.1    Sacchetti, M.L.2    Toni, D.3    Savoini, G.4    D'Arcangelo, E.5    Erminio, F.6
  • 10
    • 79958255054 scopus 로고    scopus 로고
    • Molecular pathophysiology of cerebral hemorrhage: secondary brain injury
    • Aronowski J, Zhao X: Molecular pathophysiology of cerebral hemorrhage: secondary brain injury. Stroke 42:1781-1786, 2011
    • (2011) Stroke , vol.42 , pp. 1781-1786
    • Aronowski, J.1    Zhao, X.2
  • 14
    • 84923035699 scopus 로고    scopus 로고
    • Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partialfactorial randomised controlled trial
    • Bath PM, Woodhouse L, Scutt P, Krishnan K, Wardlaw JM, Bereczki D, et al: Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partialfactorial randomised controlled trial. Lancet 385:617-628, 2015
    • (2015) Lancet , vol.385 , pp. 617-628
    • Bath, P.M.1    Woodhouse, L.2    Scutt, P.3    Krishnan, K.4    Wardlaw, J.M.5    Bereczki, D.6
  • 15
    • 0030739272 scopus 로고    scopus 로고
    • The glycine antagonist GV150526 protects somatosensory evoked potentials and reduces the infarct area in the MCAo model of focal ischemia in the rat
    • Bordi F, Pietra C, Ziviani L, Reggiani A: The glycine antagonist GV150526 protects somatosensory evoked potentials and reduces the infarct area in the MCAo model of focal ischemia in the rat. Exp Neurol 145:425-433, 1997
    • (1997) Exp Neurol , vol.145 , pp. 425-433
    • Bordi, F.1    Pietra, C.2    Ziviani, L.3    Reggiani, A.4
  • 16
    • 65549098614 scopus 로고    scopus 로고
    • Apoptotic mechanisms after cerebral ischemia
    • Broughton BR, Reutens DC, Sobey CG: Apoptotic mechanisms after cerebral ischemia. Stroke 40:e331-e339, 2009
    • (2009) Stroke , vol.40 , pp. e331-e339
    • Broughton, B.R.1    Reutens, D.C.2    Sobey, C.G.3
  • 17
    • 84898539374 scopus 로고    scopus 로고
    • Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial
    • Chamorro A, Amaro S, Castellanos M, Segura T, Arenillas J, Martí-Fábregas J, et al: Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial. Lancet Neurol 13:453-460, 2014
    • (2014) Lancet Neurol , vol.13 , pp. 453-460
    • Chamorro, A.1    Amaro, S.2    Castellanos, M.3    Segura, T.4    Arenillas, J.5    Martí-Fábregas, J.6
  • 18
    • 84995308974 scopus 로고    scopus 로고
    • The fate of medications evaluated for ischemic stroke pharmacotherapy over the period 1995-2015
    • Chen X, Wang K: The fate of medications evaluated for ischemic stroke pharmacotherapy over the period 1995-2015 Acta Pharm Sin B 6:522-530, 2016
    • (2016) Acta Pharm Sin , vol.B6 , pp. 522-530
    • Chen, X.1    Wang, K.2
  • 20
    • 0035856456 scopus 로고    scopus 로고
    • A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients
    • Clark WM, Wechsler LR, Sabounjian LA, Schwiderski UE: A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. Neurology 57:1595-1602, 2001
    • (2001) Neurology , vol.57 , pp. 1595-1602
    • Clark, W.M.1    Wechsler, L.R.2    Sabounjian, L.A.3    Schwiderski, U.E.4
  • 22
    • 84864277207 scopus 로고    scopus 로고
    • Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)
    • Dávalos A, Alvarez-Sabín J, Castillo J, Díez-Tejedor E, Ferro J, Martínez-Vila E, et al: Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). Lancet 380:349-357, 2012
    • (2012) Lancet , vol.380 , pp. 349-357
    • Dávalos, A.1    Alvarez-Sabín, J.2    Castillo, J.3    Díez-Tejedor, E.4    Ferro, J.5    Martínez-Vila, E.6
  • 23
    • 0036901469 scopus 로고    scopus 로고
    • Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials
    • Dávalos A, Castillo J, Alvarez-Sabín J, Secades JJ, Mercadal J, López S, et al: Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials. Stroke 33:2850-2857, 2002
    • (2002) Stroke , vol.33 , pp. 2850-2857
    • Dávalos, A.1    Castillo, J.2    Alvarez-Sabín, J.3    Secades, J.J.4    Mercadal, J.5    López, S.6
  • 24
  • 25
    • 0033951941 scopus 로고    scopus 로고
    • Selfotel in acute ischemic stroke: possible neurotoxic effects of an NMDA antagonist
    • Davis SM, Lees KR, Albers GW, Diener HC, Markabi S, Karlsson G, et al: Selfotel in acute ischemic stroke: possible neurotoxic effects of an NMDA antagonist. Stroke 31:347-354, 2000
    • (2000) Stroke , vol.31 , pp. 347-354
    • Davis, S.M.1    Lees, K.R.2    Albers, G.W.3    Diener, H.C.4    Markabi, S.5    Karlsson, G.6
  • 26
    • 0033975565 scopus 로고    scopus 로고
    • Diffusionweighted MRI of infarct growth in a rat photochemical stroke model: effect of lubeluzole
    • De Ryck M, Verhoye M, Van der Linden AM: Diffusionweighted MRI of infarct growth in a rat photochemical stroke model: effect of lubeluzole. Neuropharmacology 39:691-702, 2000
    • (2000) Neuropharmacology , vol.39 , pp. 691-702
    • De Ryck, M.1    Verhoye, M.2    Van der Linden, A.M.3
  • 28
    • 0034192486 scopus 로고    scopus 로고
    • Advances in the vascular pathophysiology of ischemic stroke
    • del Zoppo GJ, Hallenbeck JM: Advances in the vascular pathophysiology of ischemic stroke. Thromb Res 98:73-81, 2000
    • (2000) Thromb Res , vol.98 , pp. 73-81
    • del Zoppo, G.J.1    Hallenbeck, J.M.2
  • 29
    • 33846591479 scopus 로고    scopus 로고
    • Microglial activation and matrix protease generation during focal cerebral ischemia
    • del Zoppo GJ, Milner R, Mabuchi T, Hung S, Wang X, Berg GI, et al: Microglial activation and matrix protease generation during focal cerebral ischemia. Stroke 38 (2 Suppl):646-651, 2007
    • (2007) Stroke , vol.38 , Issue.2 , pp. 646-651
    • del Zoppo, G.J.1    Milner, R.2    Mabuchi, T.3    Hung, S.4    Wang, X.5    Berg, G.I.6
  • 30
    • 0031923952 scopus 로고    scopus 로고
    • Multinational randomised controlled trial of lubeluzole in acute ischaemic stroke
    • Diener HC: Multinational randomised controlled trial of lubeluzole in acute ischaemic stroke. Cerebrovasc Dis 8:172-181, 1998
    • (1998) Cerebrovasc Dis , vol.8 , pp. 172-181
    • Diener, H.C.1
  • 31
    • 0033766740 scopus 로고    scopus 로고
    • Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo
    • Diener HC, Cortens M, Ford G, Grotta J, Hacke W, Kaste M, et al: Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo. Stroke 31:2543-2551, 2000
    • (2000) Stroke , vol.31 , pp. 2543-2551
    • Diener, H.C.1    Cortens, M.2    Ford, G.3    Grotta, J.4    Hacke, W.5    Kaste, M.6
  • 32
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: an integrated view
    • Dirnagl U, Iadecola C, Moskowitz MA: Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22:391-397, 1999
    • (1999) Trends Neurosci , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 34
    • 84976870657 scopus 로고    scopus 로고
    • Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke
    • Dumitrascu OM, Lamb J, Lyden PD: Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke. J Cereb Blood Flow Metab 36:1157-1164, 2016
    • (2016) J Cereb Blood Flow Metab , vol.36 , pp. 1157-1164
    • Dumitrascu, O.M.1    Lamb, J.2    Lyden, P.D.3
  • 35
    • 0037229213 scopus 로고    scopus 로고
    • Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters
    • Edaravone Acute Infarction Study Group: Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 15:222-229, 2003
    • (2003) Cerebrovasc Dis , vol.15 , pp. 222-229
  • 37
    • 30944436640 scopus 로고    scopus 로고
    • Safety and therapeutical benefit of hemicraniectomy combined with mild hypothermia in comparison with hemicraniectomy alone in patients with malignant ischemic stroke
    • Els T, Oehm E, Voigt S, Klisch J, Hetzel A, Kassubek J: Safety and therapeutical benefit of hemicraniectomy combined with mild hypothermia in comparison with hemicraniectomy alone in patients with malignant ischemic stroke. Cerebrovasc Dis 21:79-85, 2006
    • (2006) Cerebrovasc Dis , vol.21 , pp. 79-85
    • Els, T.1    Oehm, E.2    Voigt, S.3    Klisch, J.4    Hetzel, A.5    Kassubek, J.6
  • 38
    • 0036904876 scopus 로고    scopus 로고
    • AMPA antagonist ZK200775 in patients with acute ischemic stroke: possible glial cell toxicity detected by monitoring of S-100B serum levels
    • Elting JW, Sulter GA, Kaste M, Lees KR, Diener HC, Hommel M, et al: AMPA antagonist ZK200775 in patients with acute ischemic stroke: possible glial cell toxicity detected by monitoring of S-100B serum levels. Stroke 33:2813-2818, 2002
    • (2002) Stroke , vol.33 , pp. 2813-2818
    • Elting, J.W.1    Sulter, G.A.2    Kaste, M.3    Lees, K.R.4    Diener, H.C.5    Hommel, M.6
  • 39
    • 0035940577 scopus 로고    scopus 로고
    • Use of anti-ICAM-1 therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial
    • Enlimomab Acute Stroke Trial Investigators: Use of anti-ICAM-1 therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial. Neurology 57:1428-1434, 2001
    • (2001) Neurology , vol.57 , pp. 1428-1434
  • 42
    • 84973333208 scopus 로고    scopus 로고
    • Standardisation of research strategies in acute ischaemic stroke
    • Fraser JF: Standardisation of research strategies in acute ischaemic stroke. Lancet Neurol 15:784-785, 2016
    • (2016) Lancet Neurol , vol.15 , pp. 784-785
    • Fraser, J.F.1
  • 43
    • 84919884557 scopus 로고    scopus 로고
    • Impact of an immune modulator fingolimod on acute ischemic stroke
    • Fu Y, Zhang N, Ren L, Yan Y, Sun N, Li YJ, et al: Impact of an immune modulator fingolimod on acute ischemic stroke. Proc Natl Acad Sci U S A 111:18315-18320, 2014
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 18315-18320
    • Fu, Y.1    Zhang, N.2    Ren, L.3    Yan, Y.4    Sun, N.5    Li, Y.J.6
  • 46
  • 48
    • 62949204563 scopus 로고    scopus 로고
    • Current status of neuroprotection for cerebral ischemia: synoptic overview
    • Ginsberg MD: Current status of neuroprotection for cerebral ischemia: synoptic overview. Stroke 40 (3 Suppl):S111-S114, 2009
    • (2009) Stroke , vol.40 , Issue.3 , pp. S111-S114
    • Ginsberg, M.D.1
  • 49
    • 84994017881 scopus 로고    scopus 로고
    • Expanding the concept of neuroprotection for acute ischemic stroke: the pivotal roles of reperfusion and the collateral circulation
    • Ginsberg MD: Expanding the concept of neuroprotection for acute ischemic stroke: the pivotal roles of reperfusion and the collateral circulation. Prog Neurobiol 145-146:46-77, 2016
    • (2016) Prog Neurobiol , vol.145-146 , pp. 46-77
    • Ginsberg, M.D.1
  • 50
    • 34249780840 scopus 로고    scopus 로고
    • Life after cerovive: a personal perspective on ischemic neuroprotection in the post-NXY-059 era
    • Ginsberg MD: Life after cerovive: a personal perspective on ischemic neuroprotection in the post-NXY-059 era. Stroke 38:1967-1972, 2007
    • (2007) Stroke , vol.38 , pp. 1967-1972
    • Ginsberg, M.D.1
  • 51
    • 48849089052 scopus 로고    scopus 로고
    • Neuroprotection for ischemic stroke: past, present and future
    • Ginsberg MD: Neuroprotection for ischemic stroke: past, present and future. Neuropharmacology 55:363-389, 2008
    • (2008) Neuropharmacology , vol.55 , pp. 363-389
    • Ginsberg, M.D.1
  • 52
    • 84929326673 scopus 로고    scopus 로고
    • Symptomatic intracranial hemorrhage in the ALIAS Multicenter Trial: relationship to endovascular thrombolytic therapy
    • Ginsberg MD, Hill MD: Symptomatic intracranial hemorrhage in the ALIAS Multicenter Trial: relationship to endovascular thrombolytic therapy. Int J Stroke 10:494-500, 2015
    • (2015) Int J Stroke , vol.10 , pp. 494-500
    • Ginsberg, M.D.1    Hill, M.D.2
  • 53
    • 33747195315 scopus 로고    scopus 로고
    • The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke-I: Physiological responses and safety results
    • Ginsberg MD, Hill MD, Palesch YY, Ryckborst KJ, Tamariz D: The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke-I: Physiological responses and safety results. Stroke 37:2100-2106, 2006
    • (2006) Stroke , vol.37 , pp. 2100-2106
    • Ginsberg, M.D.1    Hill, M.D.2    Palesch, Y.Y.3    Ryckborst, K.J.4    Tamariz, D.5
  • 54
    • 79451470799 scopus 로고    scopus 로고
    • The albumin in acute stroke (ALIAS) multicenter clinical trial: safety analysis of part 1 and rationale and design of part 2
    • Ginsberg MD, Palesch YY, Martin RH, Hill MD, Moy CS, Waldman BD, et al: The albumin in acute stroke (ALIAS) multicenter clinical trial: safety analysis of part 1 and rationale and design of part 2. Stroke 42:119-127, 2011
    • (2011) Stroke , vol.42 , pp. 119-127
    • Ginsberg, M.D.1    Palesch, Y.Y.2    Martin, R.H.3    Hill, M.D.4    Moy, C.S.5    Waldman, B.D.6
  • 56
    • 0031438509 scopus 로고    scopus 로고
    • Lubeluzole treatment of acute ischemic stroke
    • Grotta J: Lubeluzole treatment of acute ischemic stroke. Stroke 28:2338-2346, 1997
    • (1997) Stroke , vol.28 , pp. 2338-2346
    • Grotta, J.1
  • 57
    • 0028921447 scopus 로고
    • Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. Results of a phase IIa randomized trial
    • Grotta J, Clark W, Coull B, Pettigrew LC, Mackay B, Goldstein LB, et al: Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. Results of a phase IIa randomized trial. Stroke 26:602-605, 1995
    • (1995) Stroke , vol.26 , pp. 602-605
    • Grotta, J.1    Clark, W.2    Coull, B.3    Pettigrew, L.C.4    Mackay, B.5    Goldstein, L.B.6
  • 58
    • 20244368524 scopus 로고    scopus 로고
    • Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies
    • Haley EC Jr, Thompson JL, Levin B, Davis S, Lees KR, Pittman JG, et al: Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies. Stroke 36:1006-1010, 2005
    • (2005) Stroke , vol.36 , pp. 1006-1010
    • Haley, E.C.1    Thompson, J.L.2    Levin, B.3    Davis, S.4    Lees, K.R.5    Pittman, J.G.6
  • 59
    • 0029433307 scopus 로고
    • Inhibition of lipid peroxidation in central nervous system trauma and ischemia
    • Hall ED: Inhibition of lipid peroxidation in central nervous system trauma and ischemia. J Neurol Sci 134 Suppl:79-83, 1995
    • (1995) J Neurol Sci , vol.134 , pp. 79-83
    • Hall, E.D.1
  • 60
    • 80052690917 scopus 로고    scopus 로고
    • The ischemic penumbra: correlates in imaging and implications for treatment of ischemic stroke
    • Heiss WD: The ischemic penumbra: correlates in imaging and implications for treatment of ischemic stroke. Cerebrovasc Dis 32:307-320, 2011
    • (2011) Cerebrovasc Dis , vol.32 , pp. 307-320
    • Heiss, W.D.1
  • 61
    • 84867641191 scopus 로고    scopus 로고
    • Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial
    • Hill MD, Martin RH, Mikulis D, Wong JH, Silver FL, Terbrugge KG, et al: Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol 11:942-950, 2012
    • (2012) Lancet Neurol , vol.11 , pp. 942-950
    • Hill, M.D.1    Martin, R.H.2    Mikulis, D.3    Wong, J.H.4    Silver, F.L.5    Terbrugge, K.G.6
  • 62
    • 84893700213 scopus 로고    scopus 로고
    • Therapeutic hypothermia after recanalization in patients with acute ischemic stroke
    • (Erratum in Stroke 45:e12, 2014)
    • Hong JM, Lee JS, Song HJ, Jeong HS, Choi HA, Lee K: Therapeutic hypothermia after recanalization in patients with acute ischemic stroke. Stroke 45:134-140, 2014 (Erratum in Stroke 45:e12, 2014)
    • (2014) Stroke , vol.45 , pp. 134-140
    • Hong, J.M.1    Lee, J.S.2    Song, H.J.3    Jeong, H.S.4    Choi, H.A.5    Lee, K.6
  • 63
    • 0035134255 scopus 로고    scopus 로고
    • Very Early Nimodipine Use in Stroke (VENUS): a randomized, doubleblind, placebo-controlled trial
    • Horn J, de Haan RJ, Vermeulen M, Limburg M: Very Early Nimodipine Use in Stroke (VENUS): a randomized, doubleblind, placebo-controlled trial. Stroke 32:461-465, 2001
    • (2001) Stroke , vol.32 , pp. 461-465
    • Horn, J.1    de Haan, R.J.2    Vermeulen, M.3    Limburg, M.4
  • 64
    • 0034792905 scopus 로고    scopus 로고
    • Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review
    • Horn J, de Haan RJ, Vermeulen M, Luiten PG, Limburg M: Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review. Stroke 32:2433-2438, 2001
    • (2001) Stroke , vol.32 , pp. 2433-2438
    • Horn, J.1    de Haan, R.J.2    Vermeulen, M.3    Luiten, P.G.4    Limburg, M.5
  • 65
    • 84921431308 scopus 로고    scopus 로고
    • Calcium antagonists for acute ischemic stroke
    • Horn J, Limburg M: Calcium antagonists for acute ischemic stroke. Cochrane Database Syst Rev (2):CD001928, 2000
    • (2000) Cochrane Database Syst Rev , Issue.2
    • Horn, J.1    Limburg, M.2
  • 66
    • 0027982679 scopus 로고
    • Viability thresholds and the penumbra of focal ischemia
    • Hossmann KA: Viability thresholds and the penumbra of focal ischemia. Ann Neurol 36:557-565, 1994
    • (1994) Ann Neurol , vol.36 , pp. 557-565
    • Hossmann, K.A.1
  • 67
    • 0030979086 scopus 로고    scopus 로고
    • The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat
    • Hudome S, Palmer C, Roberts RL, Mauger D, Housman C, Towfighi J: The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat. Pediatr Res 41:607-616, 1997
    • (1997) Pediatr Res , vol.41 , pp. 607-616
    • Hudome, S.1    Palmer, C.2    Roberts, R.L.3    Mauger, D.4    Housman, C.5    Towfighi, J.6
  • 68
    • 33947234998 scopus 로고    scopus 로고
    • A chronic treatment with CDP-choline improves functional recovery and increases neuronal plasticity after experimental stroke
    • Hurtado O, Cárdenas A, Pradillo JM, Morales JR, Ortego F, Sobrino T, et al: A chronic treatment with CDP-choline improves functional recovery and increases neuronal plasticity after experimental stroke. Neurobiol Dis 26:105-111, 2007
    • (2007) Neurobiol Dis , vol.26 , pp. 105-111
    • Hurtado, O.1    Cárdenas, A.2    Pradillo, J.M.3    Morales, J.R.4    Ortego, F.5    Sobrino, T.6
  • 69
    • 0141676771 scopus 로고    scopus 로고
    • Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
    • Ikonomidou C, Turski L: Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol 1:383-386, 2002
    • (2002) Lancet Neurol , vol.1 , pp. 383-386
    • Ikonomidou, C.1    Turski, L.2
  • 70
    • 84925831343 scopus 로고    scopus 로고
    • Anesthetic neuroprotection: antecedents and an appraisal of preclinical and clinical data quality
    • Ishida K, Berger M, Nadler J, Warner DS: Anesthetic neuroprotection: antecedents and an appraisal of preclinical and clinical data quality. Curr Pharm Des 20:5751-5765, 2014
    • (2014) Curr Pharm Des , vol.20 , pp. 5751-5765
    • Ishida, K.1    Berger, M.2    Nadler, J.3    Warner, D.S.4
  • 71
    • 2442664421 scopus 로고    scopus 로고
    • Inflammatory responses to ischemia and reperfusion in the cerebral microcirculation
    • Ishikawa M, Zhang JH, Nanda A, Granger DN: Inflammatory responses to ischemia and reperfusion in the cerebral microcirculation. Front Biosci 9:1339-1347, 2004
    • (2004) Front Biosci , vol.9 , pp. 1339-1347
    • Ishikawa, M.1    Zhang, J.H.2    Nanda, A.3    Granger, D.N.4
  • 72
    • 84920218392 scopus 로고
    • Haemodilution in acute stroke: results of the Italian haemodilution trial
    • Italian Acute Stroke Study Group: Haemodilution in acute stroke: results of the Italian haemodilution trial. Lancet 1:318-321, 1988
    • (1988) Lancet , vol.1 , pp. 318-321
  • 73
    • 0028243698 scopus 로고
    • A randomized, double-blind, placebocontrolled trial of nimodipine in acute ischemic hemispheric stroke
    • Kaste M, Fogelholm R, Erilä T, Palomäki H, Murros K, Rissanen A, et al: A randomized, double-blind, placebocontrolled trial of nimodipine in acute ischemic hemispheric stroke. Stroke 25:1348-1353, 1994
    • (1994) Stroke , vol.25 , pp. 1348-1353
    • Kaste, M.1    Fogelholm, R.2    Erilä, T.3    Palomäki, H.4    Murros, K.5    Rissanen, A.6
  • 74
    • 84903782410 scopus 로고    scopus 로고
    • Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association
    • Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, et al: Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 45:2160-2236, 2014
    • (2014) Stroke , vol.45 , pp. 2160-2236
    • Kernan, W.N.1    Ovbiagele, B.2    Black, H.R.3    Bravata, D.M.4    Chimowitz, M.I.5    Ezekowitz, M.D.6
  • 75
    • 84891891614 scopus 로고    scopus 로고
    • Effect of glibenclamide on the prevention of secondary brain injury following ischemic stroke in humans
    • Khanna A, Walcott BP, Kahle KT, Simard JM: Effect of glibenclamide on the prevention of secondary brain injury following ischemic stroke in humans. Neurosurg Focus 36(1):E11, 2014
    • (2014) Neurosurg Focus , vol.36 , Issue.1 , pp. E11
    • Khanna, A.1    Walcott, B.P.2    Kahle, K.T.3    Simard, J.M.4
  • 76
    • 84884502741 scopus 로고    scopus 로고
    • Intravenous minocycline in acute stroke: a randomized, controlled pilot study and meta-analysis
    • Kohler E, Prentice DA, Bates TR, Hankey GJ, Claxton A, van Heerden J, et al: Intravenous minocycline in acute stroke: a randomized, controlled pilot study and meta-analysis. Stroke 44:2493-2499, 2013
    • (2013) Stroke , vol.44 , pp. 2493-2499
    • Kohler, E.1    Prentice, D.A.2    Bates, T.R.3    Hankey, G.J.4    Claxton, A.5    van Heerden, J.6
  • 77
    • 0242694372 scopus 로고    scopus 로고
    • Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279, 276 in acute ischemic stroke
    • Krams M, Lees KR, Hacke W, Grieve AP, Orgogozo JM, Ford GA: Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279, 276 in acute ischemic stroke. Stroke 34:2543-2548, 2003
    • (2003) Stroke , vol.34 , pp. 2543-2548
    • Krams, M.1    Lees, K.R.2    Hacke, W.3    Grieve, A.P.4    Orgogozo, J.M.5    Ford, G.A.6
  • 78
  • 79
    • 0033502692 scopus 로고    scopus 로고
    • Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat
    • Kuroda S, Tsuchidate R, Smith ML, Maples KR, Siesjö BK: Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 19:778-787, 1999
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 778-787
    • Kuroda, S.1    Tsuchidate, R.2    Smith, M.L.3    Maples, K.R.4    Siesjö, B.K.5
  • 80
    • 84867302438 scopus 로고    scopus 로고
    • A call for transparent reporting to optimize the predictive value of preclinical research
    • Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, et al: A call for transparent reporting to optimize the predictive value of preclinical research. Nature 490:187-191, 2012
    • (2012) Nature , vol.490 , pp. 187-191
    • Landis, S.C.1    Amara, S.G.2    Asadullah, K.3    Austin, C.P.4    Blumenstein, R.5    Bradley, E.W.6
  • 81
    • 0034600485 scopus 로고    scopus 로고
    • Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial
    • Lees KR, Asplund K, Carolei A, Davis SM, Diener HC, Kaste M, et al: Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial. Lancet 355:1949-1954, 2000
    • (2000) Lancet , vol.355 , pp. 1949-1954
    • Lees, K.R.1    Asplund, K.2    Carolei, A.3    Davis, S.M.4    Diener, H.C.5    Kaste, M.6
  • 83
    • 84908373385 scopus 로고    scopus 로고
    • Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?
    • Leng T, Shi Y, Xiong ZG, Sun D: Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke? Prog Neurobiol 115:189-209, 2014
    • (2014) Prog Neurobiol , vol.115 , pp. 189-209
    • Leng, T.1    Shi, Y.2    Xiong, Z.G.3    Sun, D.4
  • 85
    • 79952175153 scopus 로고    scopus 로고
    • Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke
    • Liesz A, Zhou W, Mracskó é, Karcher S, Bauer H, Schwarting S, et al: Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke. Brain 134:704-720, 2011
    • (2011) Brain , vol.134 , pp. 704-720
    • Liesz, A.1    Zhou, W.2    Mracskó, É.3    Karcher, S.4    Bauer, H.5    Schwarting, S.6
  • 86
    • 0032845121 scopus 로고    scopus 로고
    • Ischemic cell death in brain neurons
    • Lipton P: Ischemic cell death in brain neurons. Physiol Rev 79:1431-1568, 1999
    • (1999) Physiol Rev , vol.79 , pp. 1431-1568
    • Lipton, P.1
  • 87
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton SA, Rosenberg PA: Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330:613-622, 1994
    • (1994) N Engl J Med , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 88
    • 84863722988 scopus 로고    scopus 로고
    • Chronic protection against ischemia and reperfusioninduced endothelial dysfunction during therapy with different organic nitrates
    • Lisi M, Oelze M, Dragoni S, Liuni A, Steven S, Luca MC, et al: Chronic protection against ischemia and reperfusioninduced endothelial dysfunction during therapy with different organic nitrates. Clin Res Cardiol 101:453-459, 2012
    • (2012) Clin Res Cardiol , vol.101 , pp. 453-459
    • Lisi, M.1    Oelze, M.2    Dragoni, S.3    Liuni, A.4    Steven, S.5    Luca, M.C.6
  • 89
    • 84990029616 scopus 로고    scopus 로고
    • Gamma aminobutyric acid (GABA) receptor agonists for acute stroke
    • Liu J, Wang LN, Ma X, Ji X: Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. Cochrane Database Syst Rev 10:CD009622, 2016
    • (2016) Cochrane Database Syst Rev , vol.10
    • Liu, J.1    Wang, L.N.2    Ma, X.3    Ji, X.4
  • 90
    • 84862777945 scopus 로고    scopus 로고
    • Ginsenoside-Rd improves outcome of acute ischaemic stroke-a randomized, double-blind, placebo-controlled, multicenter trial
    • Liu X, Wang L, Wen A, Yang J, Yan Y, Song Y, et al: Ginsenoside-Rd improves outcome of acute ischaemic stroke-a randomized, double-blind, placebo-controlled, multicenter trial. Eur J Neurol 19:855-863, 2012
    • (2012) Eur J Neurol , vol.19 , pp. 855-863
    • Liu, X.1    Wang, L.2    Wen, A.3    Yang, J.4    Yan, Y.5    Song, Y.6
  • 91
    • 84938704875 scopus 로고    scopus 로고
    • Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia
    • Llovera G, Hofmann K, Roth S, Salas-Pérdomo A, Ferrer-Ferrer M, Perego C, et al: Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia. Sci Transl Med 7:299ra121, 2015
    • (2015) Sci Transl Med , vol.7
    • Llovera, G.1    Hofmann, K.2    Roth, S.3    Salas-Pérdomo, A.4    Ferrer-Ferrer, M.5    Perego, C.6
  • 92
    • 84944686283 scopus 로고    scopus 로고
    • Uric acid therapy improves clinical outcome in women with acute ischemic stroke
    • Llull L, Laredo C, Renú A, Pérez B, Vila E, Obach V, et al: Uric acid therapy improves clinical outcome in women with acute ischemic stroke. Stroke 46:2162-2167, 2015
    • (2015) Stroke , vol.46 , pp. 2162-2167
    • Llull, L.1    Laredo, C.2    Renú, A.3    Pérez, B.4    Vila, E.5    Obach, V.6
  • 93
    • 30944463969 scopus 로고    scopus 로고
    • Diazepam to improve acute stroke outcome: results of the early GABA-ergic activation study in stroke trial. A randomized double-blind placebo-controlled trial
    • Lodder J, van Raak L, Hilton A, Hardy E, Kessels A: Diazepam to improve acute stroke outcome: results of the early GABA-ergic activation study in stroke trial. A randomized double-blind placebo-controlled trial. Cerebrovasc Dis 21:120-127, 2006
    • (2006) Cerebrovasc Dis , vol.21 , pp. 120-127
    • Lodder, J.1    van Raak, L.2    Hilton, A.3    Hardy, E.4    Kessels, A.5
  • 94
    • 0032924640 scopus 로고    scopus 로고
    • Oxidative stress in brain ischemia
    • Love S: Oxidative stress in brain ischemia. Brain Pathol 9:119-131, 1999
    • (1999) Brain Pathol , vol.9 , pp. 119-131
    • Love, S.1
  • 95
    • 84912136772 scopus 로고    scopus 로고
    • High-dose erythropoietin for tissue protection
    • Lund A, Lundby C, Olsen NV: High-dose erythropoietin for tissue protection. Eur J Clin Invest 44:1230-1238, 2014
    • (2014) Eur J Clin Invest , vol.44 , pp. 1230-1238
    • Lund, A.1    Lundby, C.2    Olsen, N.V.3
  • 96
    • 84995489913 scopus 로고    scopus 로고
    • Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2)
    • Lyden P, Hemmen T, Grotta J, Rapp K, Ernstrom K, Rzesiewicz T, et al: Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2). Stroke 47:2888-2895, 2016
    • (2016) Stroke , vol.47 , pp. 2888-2895
    • Lyden, P.1    Hemmen, T.2    Grotta, J.3    Rapp, K.4    Ernstrom, K.5    Rzesiewicz, T.6
  • 98
    • 0032999917 scopus 로고    scopus 로고
    • Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species
    • Marshall JW, Cross AJ, Ridley RM: Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species. Exp Neurol 156:121-129, 1999
    • (1999) Exp Neurol , vol.156 , pp. 121-129
    • Marshall, J.W.1    Cross, A.J.2    Ridley, R.M.3
  • 99
    • 0035154631 scopus 로고    scopus 로고
    • NXY-059, a free radical-trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species
    • Marshall JW, Duffin KJ, Green AR, Ridley RM: NXY-059, a free radical-trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke 32:190-198, 2001
    • (2001) Stroke , vol.32 , pp. 190-198
    • Marshall, J.W.1    Duffin, K.J.2    Green, A.R.3    Ridley, R.M.4
  • 100
    • 0028365722 scopus 로고
    • Correlation between myeloperoxidasequantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion
    • Matsuo Y, Onodera H, Shiga Y, Nakamura M, Ninomiya M, Kihara T, et al: Correlation between myeloperoxidasequantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion. Stroke 25:1469-1475, 1994
    • (1994) Stroke , vol.25 , pp. 1469-1475
    • Matsuo, Y.1    Onodera, H.2    Shiga, Y.3    Nakamura, M.4    Ninomiya, M.5    Kihara, T.6
  • 101
    • 70349236876 scopus 로고    scopus 로고
    • Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders
    • Mattson MP: Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders. Exp Gerontol 44:625-633, 2009
    • (2009) Exp Gerontol , vol.44 , pp. 625-633
    • Mattson, M.P.1
  • 102
    • 0034065936 scopus 로고    scopus 로고
    • Glutamate as a neurotransmitter in the brain: review of physiology and pathology
    • Meldrum BS: Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 130 (4S Suppl):1007S-1015S, 2000
    • (2000) J Nutr , vol.130 , Issue.4 , pp. 1007S-1015S
    • Meldrum, B.S.1
  • 103
    • 33747190566 scopus 로고    scopus 로고
    • Is magnesium neuroprotective following global and focal cerebral ischaemia? A review of published studies
    • Meloni BP, Zhu H, Knuckey NW: Is magnesium neuroprotective following global and focal cerebral ischaemia? A review of published studies. Magnes Res 19:123-137, 2006
    • (2006) Magnes Res , vol.19 , pp. 123-137
    • Meloni, B.P.1    Zhu, H.2    Knuckey, N.W.3
  • 104
    • 5444233626 scopus 로고    scopus 로고
    • Pathophysiology of stroke: lessons from animal models
    • Mergenthaler P, Dirnagl U, Meisel A: Pathophysiology of stroke: lessons from animal models. Metab Brain Dis 19:151-167, 2004
    • (2004) Metab Brain Dis , vol.19 , pp. 151-167
    • Mergenthaler, P.1    Dirnagl, U.2    Meisel, A.3
  • 105
    • 0027522123 scopus 로고
    • Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-d-aspartate antagonist and reperfusion in experimental stroke in rats
    • Minematsu K, Fisher M, Li L, Sotak CH: Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-d-aspartate antagonist and reperfusion in experimental stroke in rats. Stroke 24:2074-2081, 1993
    • (1993) Stroke , vol.24 , pp. 2074-2081
    • Minematsu, K.1    Fisher, M.2    Li, L.3    Sotak, C.H.4
  • 106
    • 0030951354 scopus 로고    scopus 로고
    • Comparative analysis of brain protection by N-methyl-D-aspartate receptor antagonists after transient focal ischemia in cats
    • Miyabe M, Kirsch JR, Nishikawa T, Koehler RC, Traystman RJ: Comparative analysis of brain protection by N-methyl-D-aspartate receptor antagonists after transient focal ischemia in cats. Crit Care Med 25:1037-1043, 1997
    • (1997) Crit Care Med , vol.25 , pp. 1037-1043
    • Miyabe, M.1    Kirsch, J.R.2    Nishikawa, T.3    Koehler, R.C.4    Traystman, R.J.5
  • 108
    • 84991471840 scopus 로고    scopus 로고
    • Combination of thrombolysis and statins in acute stroke is safe: results of the STARS Randomized Trial (Stroke Treatment with Acute Reperfusion and Simvastatin)
    • Montaner J, Bustamante A, García-Matas S, Martínez-Zabaleta M, Jiménez C, de la Torre J, et al: Combination of thrombolysis and statins in acute stroke is safe: results of the STARS Randomized Trial (Stroke Treatment with Acute Reperfusion and Simvastatin). Stroke 47:2870-2873, 2016
    • (2016) Stroke , vol.47 , pp. 2870-2873
    • Montaner, J.1    Bustamante, A.2    García-Matas, S.3    Martínez-Zabaleta, M.4    Jiménez, C.5    de la Torre, J.6
  • 109
    • 84969376984 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2016 update: a report from the American Heart Association
    • Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al: Heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation 133:e38-e360, 2016
    • (2016) Circulation , vol.133 , pp. e38-e360
    • Mozaffarian, D.1    Benjamin, E.J.2    Go, A.S.3    Arnett, D.K.4    Blaha, M.J.5    Cushman, M.6
  • 110
    • 2942700683 scopus 로고    scopus 로고
    • Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial
    • Muir KW, Lees KR, Ford I, Davis S: Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Lancet 363:439-445, 2004
    • (2004) Lancet , vol.363 , pp. 439-445
    • Muir, K.W.1    Lees, K.R.2    Ford, I.3    Davis, S.4
  • 111
    • 0142153881 scopus 로고    scopus 로고
    • Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat
    • Mulcahy NJ, Ross J, Rothwell NJ, Loddick SA: Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat. Br J Pharmacol 140:471-476, 2003
    • (2003) Br J Pharmacol , vol.140 , pp. 471-476
    • Mulcahy, N.J.1    Ross, J.2    Rothwell, N.J.3    Loddick, S.A.4
  • 112
    • 58149357102 scopus 로고    scopus 로고
    • Extension of the thrombolytic time window with minocycline in experimental stroke
    • Murata Y, Rosell A, Scannevin RH, Rhodes KJ, Wang X, Lo EH: Extension of the thrombolytic time window with minocycline in experimental stroke. Stroke 39:3372-3377, 2008
    • (2008) Stroke , vol.39 , pp. 3372-3377
    • Murata, Y.1    Rosell, A.2    Scannevin, R.H.3    Rhodes, K.J.4    Wang, X.5    Lo, E.H.6
  • 113
    • 0034884323 scopus 로고    scopus 로고
    • Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
    • Namura S, Nagata I, Takami S, Masayasu H, Kikuchi H: Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke 32:1906-1911, 2001
    • (2001) Stroke , vol.32 , pp. 1906-1911
    • Namura, S.1    Nagata, I.2    Takami, S.3    Masayasu, H.4    Kikuchi, H.5
  • 114
    • 38149027855 scopus 로고    scopus 로고
    • Albumin therapy improves local vascular dynamics in a rat model of primary microvascular thrombosis: a two-photon laserscanning microscopy study
    • Nimmagadda A, Park HP, Prado R, Ginsberg MD: Albumin therapy improves local vascular dynamics in a rat model of primary microvascular thrombosis: a two-photon laserscanning microscopy study. Stroke 39:198-204, 2008
    • (2008) Stroke , vol.39 , pp. 198-204
    • Nimmagadda, A.1    Park, H.P.2    Prado, R.3    Ginsberg, M.D.4
  • 115
    • 84893784604 scopus 로고    scopus 로고
    • Translational strategies for neuroprotection in ischemic stroke-focusing on acidsensing ion channel 1a
    • O'Bryant Z, Vann KT, Xiong ZG: Translational strategies for neuroprotection in ischemic stroke-focusing on acidsensing ion channel 1a. Transl Stroke Res 5:59-68, 2014
    • (2014) Transl Stroke Res , vol.5 , pp. 59-68
    • O'Bryant, Z.1    Vann, K.T.2    Xiong, Z.G.3
  • 117
    • 0028636535 scopus 로고
    • Neurotoxicity of NMDA receptor antagonists: an overview
    • Olney JW: Neurotoxicity of NMDA receptor antagonists: an overview. Psychopharmacol Bull 30:533-540, 1994
    • (1994) Psychopharmacol Bull , vol.30 , pp. 533-540
    • Olney, J.W.1
  • 118
    • 84927944493 scopus 로고    scopus 로고
    • Middle cerebral artery remodeling following transient brain ischemia is linked to early postischemic hyperemia: a target of uric acid treatment
    • Onetti Y, Dantas AP, Pérez B, Cugota R, Chamorro A, Planas AM, et al: Middle cerebral artery remodeling following transient brain ischemia is linked to early postischemic hyperemia: a target of uric acid treatment. Am J Physiol Heart Circ Physiol 308:H862-H874, 2015
    • (2015) Am J Physiol Heart Circ Physiol , vol.308 , pp. H862-H874
    • Onetti, Y.1    Dantas, A.P.2    Pérez, B.3    Cugota, R.4    Chamorro, A.5    Planas, A.M.6
  • 119
    • 44449134787 scopus 로고    scopus 로고
    • Albumin therapy augments the effect of thrombolysis on local vascular dynamics in a rat model of arteriolar thrombosis: a two-photon laser-scanning microscopy study
    • Park HP, Nimmagadda A, DeFazio RA, Busto R, Prado R, Ginsberg MD: Albumin therapy augments the effect of thrombolysis on local vascular dynamics in a rat model of arteriolar thrombosis: a two-photon laser-scanning microscopy study. Stroke 39:1556-1562, 2008
    • (2008) Stroke , vol.39 , pp. 1556-1562
    • Park, H.P.1    Nimmagadda, A.2    DeFazio, R.A.3    Busto, R.4    Prado, R.5    Ginsberg, M.D.6
  • 120
    • 0043204506 scopus 로고    scopus 로고
    • A Randomized Trial of Tirilazad Mesylate in Patients with Acute Stroke (RANTTAS)
    • RANTTAS Investigators: A Randomized Trial of Tirilazad Mesylate in Patients with Acute Stroke (RANTTAS). Stroke 27:1453-1458, 1996
    • (1996) Stroke , vol.27 , pp. 1453-1458
  • 121
    • 26444518165 scopus 로고    scopus 로고
    • Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection
    • Rikitake Y, Kim HH, Huang Z, Seto M, Yano K, Asano T, et al: Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke 36:2251-2257, 2005
    • (2005) Stroke , vol.36 , pp. 2251-2257
    • Rikitake, Y.1    Kim, H.H.2    Huang, Z.3    Seto, M.4    Yano, K.5    Asano, T.6
  • 122
    • 84964705496 scopus 로고    scopus 로고
    • Endovascular treatment versus medical care alone for ischaemic stroke: systematic review and meta-analysis
    • Rodrigues FB, Neves JB, Caldeira D, Ferro JM, Ferreira JJ, Costa J: Endovascular treatment versus medical care alone for ischaemic stroke: systematic review and meta-analysis. BMJ 353:i1754, 2016
    • (2016) BMJ , vol.353 , pp. i1754
    • Rodrigues, F.B.1    Neves, J.B.2    Caldeira, D.3    Ferro, J.M.4    Ferreira, J.J.5    Costa, J.6
  • 123
    • 33845804424 scopus 로고    scopus 로고
    • Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke
    • Romanos E, Planas AM, Amaro S, Chamorro A: Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. J Cereb Blood Flow Metab 27:14-20, 2007
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 14-20
    • Romanos, E.1    Planas, A.M.2    Amaro, S.3    Chamorro, A.4
  • 124
    • 0035804844 scopus 로고    scopus 로고
    • Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial
    • Sacco RL, DeRosa JT, Haley EC Jr, Levin B, Ordronneau P, Phillips SJ, et al: Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial. JAMA 285:1719-1728, 2001
    • (2001) JAMA , vol.285 , pp. 1719-1728
    • Sacco, R.L.1    DeRosa, J.T.2    Haley, E.C.3    Levin, B.4    Ordronneau, P.5    Phillips, S.J.6
  • 126
    • 0023919998 scopus 로고
    • Multicenter trial of hemodilution in acute ischemic stroke. Results of subgroup analyses
    • Scandinavian Stroke Study Group: Multicenter trial of hemodilution in acute ischemic stroke. Results of subgroup analyses. Stroke 19:464-471, 1988
    • (1988) Stroke , vol.19 , pp. 464-471
  • 127
    • 0342757797 scopus 로고    scopus 로고
    • The N-methyl-d-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats
    • Schäbitz WR, Li F, Fisher M: The N-methyl-d-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 31:1709-1714, 2000
    • (2000) Stroke , vol.31 , pp. 1709-1714
    • Schäbitz, W.R.1    Li, F.2    Fisher, M.3
  • 128
    • 84973652548 scopus 로고    scopus 로고
    • Citicoline for Acute Ischemic Stroke: a systematic review and formal meta-analysis of randomized, double-blind, and placebo-controlled trials
    • Secades JJ, Alvarez-Sabín J, Castillo J, Díez-Tejedor E, Martínez-Vila E, Ríos J, et al: Citicoline for Acute Ischemic Stroke: a systematic review and formal meta-analysis of randomized, double-blind, and placebo-controlled trials. J Stroke Cerebrovasc Dis 25:1984-1996, 2016
    • (2016) J Stroke Cerebrovasc Dis , vol.25 , pp. 1984-1996
    • Secades, J.J.1    Alvarez-Sabín, J.2    Castillo, J.3    Díez-Tejedor, E.4    Martínez-Vila, E.5    Ríos, J.6
  • 129
    • 33846625176 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke
    • Sena E, Wheble P, Sandercock P, Macleod M: Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke. Stroke 38:388-394, 2007
    • (2007) Stroke , vol.38 , pp. 388-394
    • Sena, E.1    Wheble, P.2    Sandercock, P.3    Macleod, M.4
  • 130
    • 84990898443 scopus 로고    scopus 로고
    • Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial
    • Sheth KN, Elm JJ, Molyneaux BJ, Hinson H, Beslow LA, Sze GK, et al: Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol 15:1160-1169, 2016
    • (2016) Lancet Neurol , vol.15 , pp. 1160-1169
    • Sheth, K.N.1    Elm, J.J.2    Molyneaux, B.J.3    Hinson, H.4    Beslow, L.A.5    Sze, G.K.6
  • 131
    • 84893689596 scopus 로고    scopus 로고
    • Pilot study of intravenous glyburide in patients with a large ischemic stroke
    • Sheth KN, Kimberly WT, Elm JJ, Kent TA, Mandava P, Yoo AJ, et al: Pilot study of intravenous glyburide in patients with a large ischemic stroke. Stroke 45:281-283, 2014
    • (2014) Stroke , vol.45 , pp. 281-283
    • Sheth, K.N.1    Kimberly, W.T.2    Elm, J.J.3    Kent, T.A.4    Mandava, P.5    Yoo, A.J.6
  • 132
    • 27644505297 scopus 로고    scopus 로고
    • Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial
    • Shibuya M, Hirai S, Seto M, Satoh S, Ohtomo E: Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial. J Neurol Sci 238:31-39, 2005
    • (2005) J Neurol Sci , vol.238 , pp. 31-39
    • Shibuya, M.1    Hirai, S.2    Seto, M.3    Satoh, S.4    Ohtomo, E.5
  • 133
    • 62849084592 scopus 로고    scopus 로고
    • Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial)
    • Shinohara Y, Saito I, Kobayashi S, Uchiyama S: Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial). Cerebrovasc Dis 27:485-492, 2009
    • (2009) Cerebrovasc Dis , vol.27 , pp. 485-492
    • Shinohara, Y.1    Saito, I.2    Kobayashi, S.3    Uchiyama, S.4
  • 135
    • 84945209058 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors to improve outcome in acute ischemic stroke: possible mechanisms and clinical evidence
    • Siepmann T, Penzlin AI, Kepplinger J, Illigens BM, Weidner K, Reichmann H, et al: Selective serotonin reuptake inhibitors to improve outcome in acute ischemic stroke: possible mechanisms and clinical evidence. Brain Behav 5:e00373, 2015
    • (2015) Brain Behav , vol.5
    • Siepmann, T.1    Penzlin, A.I.2    Kepplinger, J.3    Illigens, B.M.4    Weidner, K.5    Reichmann, H.6
  • 138
    • 0031718663 scopus 로고    scopus 로고
    • Inflammation and glial responses in ischemic brain lesions
    • Stoll G, Jander S, Schroeter M: Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56:149-171, 1998
    • (1998) Prog Neurobiol , vol.56 , pp. 149-171
    • Stoll, G.1    Jander, S.2    Schroeter, M.3
  • 139
    • 0344065373 scopus 로고    scopus 로고
    • Recommendations for standards regarding preclinical neuroprotective and restorative drug development
    • Stroke Therapy Academic Industry Roundtable (STAIR): Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 30:2752-2758, 1999
    • (1999) Stroke , vol.30 , pp. 2752-2758
  • 140
    • 0028871455 scopus 로고
    • The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat
    • Sydserff SG, Cross AJ, Green AR: The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat. Neurodegeneration 4:323-328, 1995
    • (1995) Neurodegeneration , vol.4 , pp. 323-328
    • Sydserff, S.G.1    Cross, A.J.2    Green, A.R.3
  • 141
    • 84986270347 scopus 로고    scopus 로고
    • Therapeutic hypothermia and ischemic stroke: a literature review
    • Tahir RA, Pabaney AH: Therapeutic hypothermia and ischemic stroke: a literature review. Surg Neurol Int 7 (Suppl 14):S381-S386, 2016
    • (2016) Surg Neurol Int , vol.7 , pp. S381-S386
    • Tahir, R.A.1    Pabaney, A.H.2
  • 142
    • 0036963806 scopus 로고    scopus 로고
    • YM872: a selective, potent and highly water-soluble a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist
    • Takahashi M, Kohara A, Shishikura J, Kawasaki-Yatsugi S, Ni JW, Yatsugi S, et al: YM872: a selective, potent and highly water-soluble a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist. CNS Drug Rev 8:337-352, 2002
    • (2002) CNS Drug Rev , vol.8 , pp. 337-352
    • Takahashi, M.1    Kohara, A.2    Shishikura, J.3    Kawasaki-Yatsugi, S.4    Ni, J.W.5    Yatsugi, S.6
  • 143
    • 70350534678 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, tolerability, and pharmacokinetic/ pharmacodynamic effects of a targeted exposure of intravenous repinotan in patients with acute ischemic stroke: modified Randomized Exposure Controlled Trial (mRECT)
    • Teal P, Davis S, Hacke W, Kaste M, Lyden PD, Fierus M: A randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, tolerability, and pharmacokinetic/ pharmacodynamic effects of a targeted exposure of intravenous repinotan in patients with acute ischemic stroke: modified Randomized Exposure Controlled Trial (mRECT). Stroke 40:3518-3525, 2009
    • (2009) Stroke , vol.40 , pp. 3518-3525
    • Teal, P.1    Davis, S.2    Hacke, W.3    Kaste, M.4    Lyden, P.D.5    Fierus, M.6
  • 144
    • 0033816426 scopus 로고    scopus 로고
    • Tirilazad mesylate in acute ischemic stroke: a systematic review
    • Tirilazad International Steering Committee: Tirilazad mesylate in acute ischemic stroke: a systematic review. Stroke 31:2257-2265, 2000
    • (2000) Stroke , vol.31 , pp. 2257-2265
  • 145
    • 84889248163 scopus 로고    scopus 로고
    • Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage
    • Tosun C, Kurland DB, Mehta R, Castellani RJ, deJong JL, Kwon MS, et al: Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage. Stroke 44:3522-3528, 2013
    • (2013) Stroke , vol.44 , pp. 3522-3528
    • Tosun, C.1    Kurland, D.B.2    Mehta, R.3    Castellani, R.J.4    deJong, J.L.5    Kwon, M.S.6
  • 146
    • 0025114628 scopus 로고
    • Randomised, double-blind, placebocontrolled trial of nimodipine in acute stroke
    • Trust Study Group: Randomised, double-blind, placebocontrolled trial of nimodipine in acute stroke. Lancet 336:1205-1209, 1990
    • (1990) Lancet , vol.336 , pp. 1205-1209
  • 147
  • 148
    • 84902119838 scopus 로고    scopus 로고
    • EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke
    • van der Worp HB, Macleod MR, Bath PM, Demotes J, Durand-Zaleski I, Gebhardt B, et al: EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke. Int J Stroke 9:642-645, 2014
    • (2014) Int J Stroke , vol.9 , pp. 642-645
    • van der Worp, H.B.1    Macleod, M.R.2    Bath, P.M.3    Demotes, J.4    Durand-Zaleski, I.5    Gebhardt, B.6
  • 149
    • 0001694755 scopus 로고
    • Intravenous Nimodipine West European Stroke Trial (INWEST) of nimodipine in the treatment of acute ischaemic stroke
    • Wahlgren NG, MacMahon DG, DeKeyser J, Indredavik B, Ryman T: Intravenous Nimodipine West European Stroke Trial (INWEST) of nimodipine in the treatment of acute ischaemic stroke. Cerebrovasc Dis 4:204-210, 1994
    • (1994) Cerebrovasc Dis , vol.4 , pp. 204-210
    • Wahlgren, N.G.1    MacMahon, D.G.2    DeKeyser, J.3    Indredavik, B.4    Ryman, T.5
  • 150
    • 0032953495 scopus 로고    scopus 로고
    • Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients
    • Wahlgren NG, Ranasinha KW, Rosolacci T, Franke CL, van Erven PM, Ashwood T, et al: Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients. Stroke 30:21-28, 1999
    • (1999) Stroke , vol.30 , pp. 21-28
    • Wahlgren, N.G.1    Ranasinha, K.W.2    Rosolacci, T.3    Franke, C.L.4    van Erven, P.M.5    Ashwood, T.6
  • 151
    • 27644527749 scopus 로고    scopus 로고
    • The AMPA antagonist ZK 200775 in patients with acute ischaemic stroke: a double-blind, multicentre, placebo-controlled safety and tolerability study
    • Walters MR, Kaste M, Lees KR, Diener HC, Hommel M, De Keyser J, et al: The AMPA antagonist ZK 200775 in patients with acute ischaemic stroke: a double-blind, multicentre, placebo-controlled safety and tolerability study. Cerebrovasc Dis 20:304-309, 2005
    • (2005) Cerebrovasc Dis , vol.20 , pp. 304-309
    • Walters, M.R.1    Kaste, M.2    Lees, K.R.3    Diener, H.C.4    Hommel, M.5    De Keyser, J.6
  • 152
  • 153
    • 0033757829 scopus 로고    scopus 로고
    • Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging
    • Warach S, Pettigrew LC, Dashe JF, Pullicino P, Lefkowitz DM, Sabounjian L, et al: Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 48:713-722, 2000
    • (2000) Ann Neurol , vol.48 , pp. 713-722
    • Warach, S.1    Pettigrew, L.C.2    Dashe, J.F.3    Pullicino, P.4    Lefkowitz, D.M.5    Sabounjian, L.6
  • 154
    • 79551495392 scopus 로고    scopus 로고
    • Fingolimod provides long-term protection in rodent models of cerebral ischemia
    • Wei Y, Yemisci M, Kim HH, Yung LM, Shin HK, Hwang SK, et al: Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol 69:119-129, 2011
    • (2011) Ann Neurol , vol.69 , pp. 119-129
    • Wei, Y.1    Yemisci, M.2    Kim, H.H.3    Yung, L.M.4    Shin, H.K.5    Hwang, S.K.6
  • 155
    • 18044395508 scopus 로고    scopus 로고
    • Dose finding study of intravenous magnesium sulphate in transient focal cerebral ischemia in rats
    • Westermaier T, Zausinger S, Baethmann A, Schmid-Elsaesser R: Dose finding study of intravenous magnesium sulphate in transient focal cerebral ischemia in rats. Acta Neurochir (Wien) 147:525-532, 2005
    • (2005) Acta Neurochir (Wien) , vol.147 , pp. 525-532
    • Westermaier, T.1    Zausinger, S.2    Baethmann, A.3    Schmid-Elsaesser, R.4
  • 156
    • 15944376243 scopus 로고    scopus 로고
    • A systematic review of nitric oxide donors and l-arginine in experimental stroke; effects on infarct size and cerebral blood flow
    • Willmot M, Gray L, Gibson C, Murphy S, Bath PM: A systematic review of nitric oxide donors and l-arginine in experimental stroke; effects on infarct size and cerebral blood flow. Nitric Oxide 12:141-149, 2005
    • (2005) Nitric Oxide , vol.12 , pp. 141-149
    • Willmot, M.1    Gray, L.2    Gibson, C.3    Murphy, S.4    Bath, P.M.5
  • 157
    • 0031963836 scopus 로고    scopus 로고
    • Ebselen in acute ischemic stroke: a placebocontrolled, double-blind clinical trial
    • Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, et al: Ebselen in acute ischemic stroke: a placebocontrolled, double-blind clinical trial. Stroke 29:12-17, 1998
    • (1998) Stroke , vol.29 , pp. 12-17
    • Yamaguchi, T.1    Sano, K.2    Takakura, K.3    Saito, I.4    Shinohara, Y.5    Asano, T.6
  • 158
    • 0034640147 scopus 로고    scopus 로고
    • Survival and histological evaluation of therapeutic window of post-ischemia treatment with magnesium sulfate in embolic stroke model of rat
    • Yang Y, Li Q, Ahmad F, Shuaib A: Survival and histological evaluation of therapeutic window of post-ischemia treatment with magnesium sulfate in embolic stroke model of rat. Neurosci Lett 285:119-122, 2000
    • (2000) Neurosci Lett , vol.285 , pp. 119-122
    • Yang, Y.1    Li, Q.2    Ahmad, F.3    Shuaib, A.4
  • 159
    • 84931570036 scopus 로고    scopus 로고
    • Brain transient receptor potential channels and stroke
    • Zhang E, Liao P: Brain transient receptor potential channels and stroke. J Neurosci Res 93:1165-1183, 2015
    • (2015) J Neurosci Res , vol.93 , pp. 1165-1183
    • Zhang, E.1    Liao, P.2
  • 161
    • 0029096735 scopus 로고
    • Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat
    • Zhang RL, Chopp M, Jiang N, Tang WX, Prostak J, Manning AM, et al: Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat. Stroke 26:1438-1443, 1995
    • (1995) Stroke , vol.26 , pp. 1438-1443
    • Zhang, R.L.1    Chopp, M.2    Jiang, N.3    Tang, W.X.4    Prostak, J.5    Manning, A.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.