-
1
-
-
84898539374
-
Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): A randomized, double-blind phase 2b/3 trial
-
for the URICO-ICTUS Investigators.
-
Chamorro A, Amaro S, Castellanos M, et al for the URICO-ICTUS Investigators. Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomized, double-blind phase 2b/3 trial. Lancet Neurol 2014; 13: 453-460.
-
(2014)
Lancet Neurol
, vol.13
, pp. 453-460
-
-
Chamorro, A.1
Amaro, S.2
Castellanos, M.3
-
3
-
-
0027958061
-
Hyperglycemia in the acute phase of stroke and stress response
-
Tracey F, Stout RW,. Hyperglycemia in the acute phase of stroke and stress response. Stroke 1994; 25: 524-525.
-
(1994)
Stroke
, vol.25
, pp. 524-525
-
-
Tracey, F.1
Stout, R.W.2
-
4
-
-
34250846386
-
Moderate hyperglycemia is associated with favorable outcome in acute lacunar stroke
-
Uyttenboogaart M, Koch MW, Stewart RE, et al. Moderate hyperglycemia is associated with favorable outcome in acute lacunar stroke. Brain 2007; 130: 1626-1630.
-
(2007)
Brain
, vol.130
, pp. 1626-1630
-
-
Uyttenboogaart, M.1
Koch, M.W.2
Stewart, R.E.3
-
5
-
-
0035881349
-
Transient hyperglycemia in ischemic stroke patients
-
Szczudlik A, Slowik A, Turaj W, et al. Transient hyperglycemia in ischemic stroke patients. J Neurol Sci 2001; 189: 105-111.
-
(2001)
J Neurol Sci
, vol.189
, pp. 105-111
-
-
Szczudlik, A.1
Slowik, A.2
Turaj, W.3
-
6
-
-
28144442255
-
Admission hyperglycemia and other risk factors as predictors of hospital mortality in a medical ICU population
-
Freire AX, Bridges L, Umpierrez GE, et al. Admission hyperglycemia and other risk factors as predictors of hospital mortality in a medical ICU population. Chest 2005; 128: 3109-3116.
-
(2005)
Chest
, vol.128
, pp. 3109-3116
-
-
Freire, A.X.1
Bridges, L.2
Umpierrez, G.E.3
-
8
-
-
0034800666
-
Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: A systematic overview
-
Capes SE, Hunt D, Malmberg K, et al. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 2001; 32: 2426-2432.
-
(2001)
Stroke
, vol.32
, pp. 2426-2432
-
-
Capes, S.E.1
Hunt, D.2
Malmberg, K.3
-
9
-
-
47649085123
-
Management of hyperglycemia in acute stroke: How, when, and for whom?
-
McCormick MT, Muir KW, Gray CS, Walters MR,. Management of hyperglycemia in acute stroke: how, when, and for whom? Stroke 2008; 39: 2177-2185.
-
(2008)
Stroke
, vol.39
, pp. 2177-2185
-
-
McCormick, M.T.1
Muir, K.W.2
Gray, C.S.3
Walters, M.R.4
-
10
-
-
0037056360
-
Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial
-
NINDS rt-PA Stroke Study Group.
-
Bruno A, Levine SR, Frankel MR, et al, NINDS rt-PA Stroke Study Group. Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial. Neurology 2002; 59: 669-674.
-
(2002)
Neurology
, vol.59
, pp. 669-674
-
-
Bruno, A.1
Levine, S.R.2
Frankel, M.R.3
-
11
-
-
54949153147
-
A risk score to predict intracranial hemorrhage after recombinant tissue plasminogen activator for acute ischemic stroke
-
Cucchiara B, Tanne D, Levine SR, et al. A risk score to predict intracranial hemorrhage after recombinant tissue plasminogen activator for acute ischemic stroke. J Stroke Cerebrovasc Dis 2008; 17: 331-333.
-
(2008)
J Stroke Cerebrovasc Dis
, vol.17
, pp. 331-333
-
-
Cucchiara, B.1
Tanne, D.2
Levine, S.R.3
-
12
-
-
0035859850
-
Predictors of good outcome after intravenous tPA for acute ischemic stroke
-
Multicentre tPA Stroke Survey Group.
-
Demchuk AM, Tanne D, Hill MD, et al, Multicentre tPA Stroke Survey Group. Predictors of good outcome after intravenous tPA for acute ischemic stroke. Neurology 2001; 57: 474-480.
-
(2001)
Neurology
, vol.57
, pp. 474-480
-
-
Demchuk, A.M.1
Tanne, D.2
Hill, M.D.3
-
13
-
-
49849087927
-
Older age does not increase risk of hemorrhagic complications after intravenous and/or intra-arterial thrombolysis for acute stroke
-
Pundik S, McWilliams-Dunnigan L, Blackham KL, et al. Older age does not increase risk of hemorrhagic complications after intravenous and/or intra-arterial thrombolysis for acute stroke. J Stroke Cerebrovasc Dis 2008; 17: 266-272.
-
(2008)
J Stroke Cerebrovasc Dis
, vol.17
, pp. 266-272
-
-
Pundik, S.1
McWilliams-Dunnigan, L.2
Blackham, K.L.3
-
14
-
-
0041917474
-
Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome
-
Baird TA, Parsons MW, Phanh T, et al. Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome. Stroke 2003; 34: 2208-2214.
-
(2003)
Stroke
, vol.34
, pp. 2208-2214
-
-
Baird, T.A.1
Parsons, M.W.2
Phanh, T.3
-
15
-
-
0036187573
-
Hyperglycemia in patients with focal cerebral ischemia after intravenous thrombolysis: Influence on clinical outcome and infarct size
-
Els T, Klisch J, Orszagh M, et al. Hyperglycemia in patients with focal cerebral ischemia after intravenous thrombolysis: influence on clinical outcome and infarct size. Cerebrovasc Dis 2002; 13: 89-94.
-
(2002)
Cerebrovasc Dis
, vol.13
, pp. 89-94
-
-
Els, T.1
Klisch, J.2
Orszagh, M.3
-
16
-
-
0036288571
-
Acute hyperglycemia adversely affects stroke outcome: A magnetic resonance imaging and spectroscopy study
-
Parsons MW, Barber PA, Desmond PM, et al. Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study. Ann Neurol 2002; 52: 20-28.
-
(2002)
Ann Neurol
, vol.52
, pp. 20-28
-
-
Parsons, M.W.1
Barber, P.A.2
Desmond, P.M.3
-
17
-
-
34447626017
-
Hyperglycemia during ischemia rapidly accelerates brain damage in stroke patients treated with tPA
-
Ribo M, Molina CA, Delgado P, et al. Hyperglycemia during ischemia rapidly accelerates brain damage in stroke patients treated with tPA. J Cereb Blood Flow Metab 2007; 27: 1616-1622.
-
(2007)
J Cereb Blood Flow Metab
, vol.27
, pp. 1616-1622
-
-
Ribo, M.1
Molina, C.A.2
Delgado, P.3
-
18
-
-
79956105568
-
Hyperglycemia and the fate of apparent diffusion coefficient-defined ischemic penumbra
-
Rosso C, Attal Y, Deltour S, et al. Hyperglycemia and the fate of apparent diffusion coefficient-defined ischemic penumbra. AJNR Am J Neuroradiol 2011; 32: 852-856.
-
(2011)
AJNR Am J Neuroradiol
, vol.32
, pp. 852-856
-
-
Rosso, C.1
Attal, Y.2
Deltour, S.3
-
19
-
-
39349094881
-
Treatment of hyperglycemia in ischemic stroke (THIS): A randomized pilot trial
-
Bruno A, Kent TA, Coull BM, et al. Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial. Stroke 2008; 39: 384-389.
-
(2008)
Stroke
, vol.39
, pp. 384-389
-
-
Bruno, A.1
Kent, T.A.2
Coull, B.M.3
-
20
-
-
79960528754
-
The Glucose Regulation in Acute Stroke Patients (GRASP) trial outcome results
-
for the GRASP Investigators February 18, San Diego, CA
-
Johnston KC, Hall CE, Kissela BM, for the GRASP Investigators. The Glucose Regulation in Acute Stroke Patients (GRASP) trial outcome results. Presented at: International Stroke Conference; February 18, 2009; San Diego, CA.
-
(2009)
International Stroke Conference
-
-
Johnston, K.C.1
Hall, C.E.2
Kissela, B.M.3
-
21
-
-
57649135334
-
Pragmatic management of hyperglycemia in acute ischemic stroke: Safety and feasibility of intensive intravenous insulin treatment
-
Kreisel SH, Berschin UM, Hammes HP, et al. Pragmatic management of hyperglycemia in acute ischemic stroke: safety and feasibility of intensive intravenous insulin treatment. Cerebrovasc Dis 2009; 27: 167-175.
-
(2009)
Cerebrovasc Dis
, vol.27
, pp. 167-175
-
-
Kreisel, S.H.1
Berschin, U.M.2
Hammes, H.P.3
-
22
-
-
33746326439
-
A randomized, controlled pilot study to investigate the potential benefit of intervention with insulin in hyperglycemic acute ischemic stroke patients
-
Walters MR, Weir CJ, Lees KR,. A randomized, controlled pilot study to investigate the potential benefit of intervention with insulin in hyperglycemic acute ischemic stroke patients. Cerebrovasc Dis 2006; 22: 116-122.
-
(2006)
Cerebrovasc Dis
, vol.22
, pp. 116-122
-
-
Walters, M.R.1
Weir, C.J.2
Lees, K.R.3
-
23
-
-
34047255739
-
Glucose-potassium-insulin infusions in the management of post-stroke hyperglycemia: The UK Glucose Insulin in Stroke Trial (GIST-UK)
-
GIST Trialists Collaboration.
-
Gray CS, Hildreth AJ, Sandercock PA, et al, GIST Trialists Collaboration. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycemia: the UK Glucose Insulin in Stroke Trial (GIST-UK). Lancet Neurol 2007; 6: 397-406.
-
(2007)
Lancet Neurol
, vol.6
, pp. 397-406
-
-
Gray, C.S.1
Hildreth, A.J.2
Sandercock, P.A.3
-
24
-
-
0142139346
-
Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia
-
Sugawara T, Chan PH,. Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid Redox Signal 2003; 5: 597-607.
-
(2003)
Antioxid Redox Signal
, vol.5
, pp. 597-607
-
-
Sugawara, T.1
Chan, P.H.2
-
25
-
-
0025817655
-
Effect of plasma glucose on infarct size in focal cerebral ischemia-reperfusion
-
Yip PK, He YY, Hsu CY, et al. Effect of plasma glucose on infarct size in focal cerebral ischemia-reperfusion. Neurology 1991; 41: 899-905.
-
(1991)
Neurology
, vol.41
, pp. 899-905
-
-
Yip, P.K.1
He, Y.Y.2
Hsu, C.Y.3
-
26
-
-
0020211722
-
Moderate hyperglycemia augments ischemic brain damage: A neuropathologic study in the rat
-
Pulsinelli WA, Waldman S, Rawlinson D, Plum F,. Moderate hyperglycemia augments ischemic brain damage: a neuropathologic study in the rat. Neurology 1982; 32: 1239-1246.
-
(1982)
Neurology
, vol.32
, pp. 1239-1246
-
-
Pulsinelli, W.A.1
Waldman, S.2
Rawlinson, D.3
Plum, F.4
-
27
-
-
84901913666
-
Opposing effects of glucose on stroke and reperfusion injury: Acidosis, oxidative stress, and energy metabolism
-
Robbins NM, Swanson RA,. Opposing effects of glucose on stroke and reperfusion injury: acidosis, oxidative stress, and energy metabolism. Stroke 2014; 45: 1881-1886.
-
(2014)
Stroke
, vol.45
, pp. 1881-1886
-
-
Robbins, N.M.1
Swanson, R.A.2
-
28
-
-
33847215407
-
Hyperglycemia in acute ischemic stroke: A vascular perspective
-
Martini SR, Kent TA,. Hyperglycemia in acute ischemic stroke: a vascular perspective. J Cereb Blood Flow Metab 2007; 27: 435-451.
-
(2007)
J Cereb Blood Flow Metab
, vol.27
, pp. 435-451
-
-
Martini, S.R.1
Kent, T.A.2
-
29
-
-
0035906544
-
Effects of hyperglycemia or hypoglycemia on brain cell membrane function and energy metabolism during the immediate reoxygenation-reperfusion period after acute transient global hypoxia-ischemia in the newborn piglet
-
Park WS, Chang YS, Lee M,. Effects of hyperglycemia or hypoglycemia on brain cell membrane function and energy metabolism during the immediate reoxygenation-reperfusion period after acute transient global hypoxia-ischemia in the newborn piglet. Brain Res 2001; 901: 102-108.
-
(2001)
Brain Res
, vol.901
, pp. 102-108
-
-
Park, W.S.1
Chang, Y.S.2
Lee, M.3
-
30
-
-
58149268010
-
Glucose and NADPH oxidase drive neuronal superoxide formation in stroke
-
Suh SW, Shin BS, Ma H, et al. Glucose and NADPH oxidase drive neuronal superoxide formation in stroke. Ann Neurol 2008; 64: 654-663.
-
(2008)
Ann Neurol
, vol.64
, pp. 654-663
-
-
Suh, S.W.1
Shin, B.S.2
Ma, H.3
-
31
-
-
34547673497
-
Peroxynitrite: Biochemistry, pathophysiology and development of therapeutics
-
Szabõ C, Ischiropoulos H, Radi R,. Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov 2007; 6: 662-680.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 662-680
-
-
Szabõ, C.1
Ischiropoulos, H.2
Radi, R.3
-
32
-
-
0034655982
-
Reaction of uric acid with peroxynitrite and implications for the mechanism of neuroprotection by uric acid
-
Squadrito GL, Cueto R, Splenser AE, et al. Reaction of uric acid with peroxynitrite and implications for the mechanism of neuroprotection by uric acid. Arch Biochem Biophys 2000; 376: 333-337.
-
(2000)
Arch Biochem Biophys
, vol.376
, pp. 333-337
-
-
Squadrito, G.L.1
Cueto, R.2
Splenser, A.E.3
-
33
-
-
77955154086
-
The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms
-
Amaro S, Cánovas D, Castellanos M, et al. The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms. Int J Stroke 2010; 5: 325-328.
-
(2010)
Int J Stroke
, vol.5
, pp. 325-328
-
-
Amaro, S.1
Cánovas, D.2
Castellanos, M.3
-
34
-
-
39549086157
-
Uric acid administration in patients with acute stroke: A novel approach to neuroprotection
-
Amaro S, Planas AM, Chamorro A,. Uric acid administration in patients with acute stroke: a novel approach to neuroprotection. Expert Rev Neurother 2008; 8: 259-270.
-
(2008)
Expert Rev Neurother
, vol.8
, pp. 259-270
-
-
Amaro, S.1
Planas, A.M.2
Chamorro, A.3
-
35
-
-
79955482316
-
Translational stroke research of the combination of thrombolysis and antioxidant therapy
-
Amaro S, Chamorro Á,. Translational stroke research of the combination of thrombolysis and antioxidant therapy. Stroke 2011; 42: 1495-1499.
-
(2011)
Stroke
, vol.42
, pp. 1495-1499
-
-
Amaro, S.1
Chamorro Á.2
-
36
-
-
33646359238
-
Reactive oxygen species: Influence on cerebral vascular tone
-
Faraci FM,. Reactive oxygen species: influence on cerebral vascular tone. J Appl Physiol 2006; 100: 739-743.
-
(2006)
J Appl Physiol
, vol.100
, pp. 739-743
-
-
Faraci, F.M.1
-
37
-
-
77955487488
-
The science of stroke: Mechanisms in search of treatments
-
Moskowitz MA, Lo EH, Iadecola C,. The science of stroke: mechanisms in search of treatments. Neuron 2010; 67: 181-198.
-
(2010)
Neuron
, vol.67
, pp. 181-198
-
-
Moskowitz, M.A.1
Lo, E.H.2
Iadecola, C.3
-
38
-
-
0028936118
-
Local cerebral glucose utilization and cytoskeletal proteolysis as indices of evolving focal ischemic injury in core and penumbra
-
Yao H, Ginsberg MD, Eveleth DD, et al. Local cerebral glucose utilization and cytoskeletal proteolysis as indices of evolving focal ischemic injury in core and penumbra. J Cereb Blood Flow Metab 1995; 15: 398-408.
-
(1995)
J Cereb Blood Flow Metab
, vol.15
, pp. 398-408
-
-
Yao, H.1
Ginsberg, M.D.2
Eveleth, D.D.3
-
39
-
-
18344391962
-
Hyperglycemia enhances the cytokine production and oxidative responses to a low but not high dose of endotoxin in rats
-
Ling P, Smith R, Bistrian B,. Hyperglycemia enhances the cytokine production and oxidative responses to a low but not high dose of endotoxin in rats. Crit Care Med 2005; 33: 1084-1089.
-
(2005)
Crit Care Med
, vol.33
, pp. 1084-1089
-
-
Ling, P.1
Smith, R.2
Bistrian, B.3
-
40
-
-
0031441165
-
Differential hydroxylation of salicylate in core and penumbra regions during focal reversible cerebral ischemia
-
Solenski NJ, Kwan AL, Yanamoto H, et al. Differential hydroxylation of salicylate in core and penumbra regions during focal reversible cerebral ischemia. Stroke 1997; 28: 2545-2552.
-
(1997)
Stroke
, vol.28
, pp. 2545-2552
-
-
Solenski, N.J.1
Kwan, A.L.2
Yanamoto, H.3
-
41
-
-
3242797399
-
Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises
-
Stentz FB, Umpierrez GE, Cuervo R, Kitabchi AE,. Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises. Diabetes 2004; 53: 2079-2086.
-
(2004)
Diabetes
, vol.53
, pp. 2079-2086
-
-
Stentz, F.B.1
Umpierrez, G.E.2
Cuervo, R.3
Kitabchi, A.E.4
-
42
-
-
84869797378
-
Hyperglycemia accentuates persistent "functional uncoupling" of cerebral microvascular nitric oxide and superoxide following focal ischemia/reperfusion in rats
-
Fabian RH, Kent TA,. Hyperglycemia accentuates persistent "functional uncoupling" of cerebral microvascular nitric oxide and superoxide following focal ischemia/reperfusion in rats. Transl Stroke Res 2012; 3: 482-490.
-
(2012)
Transl Stroke Res
, vol.3
, pp. 482-490
-
-
Fabian, R.H.1
Kent, T.A.2
-
43
-
-
7944227011
-
Optimal blood glucose levels while using insulin to minimize the size of infarction in focal cerebral ischemia
-
Zhu CZ, Auer RN,. Optimal blood glucose levels while using insulin to minimize the size of infarction in focal cerebral ischemia. J Neurosurg 2004; 101: 664-668.
-
(2004)
J Neurosurg
, vol.101
, pp. 664-668
-
-
Zhu, C.Z.1
Auer, R.N.2
-
44
-
-
77957997618
-
J-shaped association between serum glucose and functional outcome in acute ischemic stroke
-
Ntaios G, Egli M, Faouzi M, Michel P,. J-shaped association between serum glucose and functional outcome in acute ischemic stroke. Stroke 2010; 41: 2366-2370.
-
(2010)
Stroke
, vol.41
, pp. 2366-2370
-
-
Ntaios, G.1
Egli, M.2
Faouzi, M.3
Michel, P.4
-
45
-
-
0023840629
-
Hyperglycemia increases infarct size in collaterally perfused but not end-arterial vascular territories
-
Prado R, Ginsberg MD, Dietrich WD, et al. Hyperglycemia increases infarct size in collaterally perfused but not end-arterial vascular territories. J Cereb Blood Flow Metab 1988; 8: 186-192.
-
(1988)
J Cereb Blood Flow Metab
, vol.8
, pp. 186-192
-
-
Prado, R.1
Ginsberg, M.D.2
Dietrich, W.D.3
|