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Volumn 111, Issue 51, 2014, Pages 18315-18320

Impact of an immune modulator fingolimod on acute ischemic stroke

Author keywords

Acute ischemic stroke; Fingolimod; Immune modulation

Indexed keywords

CD19 ANTIGEN; CD56 ANTIGEN; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; PROPANEDIOL DERIVATIVE; SPHINGOSINE;

EID: 84919884557     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1416166111     Document Type: Article
Times cited : (230)

References (39)
  • 1
    • 52649165720 scopus 로고    scopus 로고
    • Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    • Hacke W, et al.; ECASS Investigators (2008) Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359(13):1317-1329.
    • (2008) N Engl J Med , vol.359 , Issue.13 , pp. 1317-1329
    • Hacke, W.1
  • 2
    • 77952112006 scopus 로고    scopus 로고
    • Time to treatment with intravenous alteplase and outcome in stroke: An updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials
    • Lees KR, et al.; ECASS, ATLANTIS, NINDS and EPITHET rt-PA Study Group (2010) Time to treatment with intravenous alteplase and outcome in stroke: An updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 375(9727):1695-1703.
    • (2010) Lancet , vol.375 , Issue.9727 , pp. 1695-1703
    • Lees, K.R.1    ECASS2    ATLANTIS3    NINDS4
  • 3
    • 79960101157 scopus 로고    scopus 로고
    • How to make better use of thrombolytic therapy in acute ischemic stroke
    • Donnan GA, et al. (2011) How to make better use of thrombolytic therapy in acute ischemic stroke. Nat Rev Neurol 7(7):400-409.
    • (2011) Nat Rev Neurol , vol.7 , Issue.7 , pp. 400-409
    • Donnan, G.A.1
  • 4
    • 84891546178 scopus 로고    scopus 로고
    • Advances and challenges in treatment and prevention of ischemic stroke
    • Grossman AW, Broderick JP (2013) Advances and challenges in treatment and prevention of ischemic stroke. Ann Neurol 74(3):363-372.
    • (2013) Ann Neurol , vol.74 , Issue.3 , pp. 363-372
    • Grossman, A.W.1    Broderick, J.P.2
  • 5
    • 84863726869 scopus 로고    scopus 로고
    • The immunology of acute stroke
    • Chamorro Á, et al. (2012) The immunology of acute stroke. Nat Rev Neurol 8(7):401-410.
    • (2012) Nat Rev Neurol , vol.8 , Issue.7 , pp. 401-410
    • Chamorro, Á.1
  • 6
    • 77955850207 scopus 로고    scopus 로고
    • Inflammation after stroke: Mechanisms and therapeutic approaches
    • Ahmad M, Graham SH (2010) Inflammation after stroke: Mechanisms and therapeutic approaches. Transl Stroke Res 1(2):74-84.
    • (2010) Transl Stroke Res , vol.1 , Issue.2 , pp. 74-84
    • Ahmad, M.1    Graham, S.H.2
  • 7
    • 79951829343 scopus 로고    scopus 로고
    • Hypoxia and inflammation
    • Eltzschig HK, Carmeliet P (2011) Hypoxia and inflammation. N Engl J Med 364(7):656-665.
    • (2011) N Engl J Med , vol.364 , Issue.7 , pp. 656-665
    • Eltzschig, H.K.1    Carmeliet, P.2
  • 8
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: From mechanisms to translation
    • Iadecola C, Anrather J (2011) The immunology of stroke: From mechanisms to translation. Nat Med 17(7):796-808.
    • (2011) Nat Med , vol.17 , Issue.7 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 9
    • 8844270954 scopus 로고    scopus 로고
    • Human cerebral infarct: A proposed histopathologic classification based on 137 cases
    • Mena H, Cadavid D, Rushing EJ (2004) Human cerebral infarct: A proposed histopathologic classification based on 137 cases. Acta Neuropathol 108(6):524-530.
    • (2004) Acta Neuropathol , vol.108 , Issue.6 , pp. 524-530
    • Mena, H.1    Cadavid, D.2    Rushing, E.J.3
  • 10
    • 84894340282 scopus 로고    scopus 로고
    • Ischemic neurons recruit natural killer cells that accelerate brain infarction
    • Gan Y, et al. (2014) Ischemic neurons recruit natural killer cells that accelerate brain infarction. Proc Natl Acad Sci USA 111(7):2704-2709.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.7 , pp. 2704-2709
    • Gan, Y.1
  • 11
    • 77952557777 scopus 로고    scopus 로고
    • Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation
    • Kleinschnitz C, et al. (2010) Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation. Blood 115(18):3835-3842.
    • (2010) Blood , vol.115 , Issue.18 , pp. 3835-3842
    • Kleinschnitz, C.1
  • 12
    • 68349160698 scopus 로고    scopus 로고
    • Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury
    • Shichita T, et al. (2009) Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nat Med 15(8):946-950.
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 946-950
    • Shichita, T.1
  • 13
    • 77449106966 scopus 로고    scopus 로고
    • Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats
    • Hasegawa Y, Suzuki H, Sozen T, Rolland W, Zhang JH (2010) Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke 41(2):368-374.
    • (2010) Stroke , vol.41 , Issue.2 , pp. 368-374
    • Hasegawa, Y.1    Suzuki, H.2    Sozen, T.3    Rolland, W.4    Zhang, J.H.5
  • 14
    • 79551495392 scopus 로고    scopus 로고
    • Fingolimod provides long-term protection in rodent models of cerebral ischemia
    • Wei Y, et al. (2011) Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol 69(1):119-129.
    • (2011) Ann Neurol , vol.69 , Issue.1 , pp. 119-129
    • Wei, Y.1
  • 15
    • 33748695513 scopus 로고    scopus 로고
    • Fingolimod and sphingosine-1-phosphate - Modifiers of lymphocyte migration
    • Massberg S, von Andrian UH (2006) Fingolimod and sphingosine-1-phosphate - Modifiers of lymphocyte migration. N Engl J Med 355(11):1088-1091.
    • (2006) N Engl J Med , vol.355 , Issue.11 , pp. 1088-1091
    • Massberg, S.1    Von Andrian, U.H.2
  • 16
    • 24644469502 scopus 로고    scopus 로고
    • Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    • Schwab SR, et al. (2005) Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309(5741):1735-1739.
    • (2005) Science , vol.309 , Issue.5741 , pp. 1735-1739
    • Schwab, S.R.1
  • 17
    • 79955455801 scopus 로고    scopus 로고
    • Mechanisms of fingolimod' s efficacy and adverse effects in multiple sclerosis
    • Cohen JA, Chun J (2011) Mechanisms of fingolimod' s efficacy and adverse effects in multiple sclerosis. Ann Neurol 69(5):759-777.
    • (2011) Ann Neurol , vol.69 , Issue.5 , pp. 759-777
    • Cohen, J.A.1    Chun, J.2
  • 18
    • 76149093586 scopus 로고    scopus 로고
    • A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
    • Kappos L, et al.; FREEDOMS Study Group (2010) A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 362(5):387-401.
    • (2010) N Engl J Med , vol.362 , Issue.5 , pp. 387-401
    • Kappos, L.1
  • 19
    • 84866844026 scopus 로고    scopus 로고
    • Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain
    • Cannon RE, Peart JC, Hawkins BT, Campos CR, Miller DS (2012) Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. Proc Natl Acad Sci USA 109(39):15930-15935.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.39 , pp. 15930-15935
    • Cannon, R.E.1    Peart, J.C.2    Hawkins, B.T.3    Campos, C.R.4    Miller, D.S.5
  • 20
    • 84881130975 scopus 로고    scopus 로고
    • FTY720 treatment in the convalescence period improves functional recovery and reduces reactive astrogliosis in photothrombotic stroke
    • Brunkhorst R, et al. (2013) FTY720 treatment in the convalescence period improves functional recovery and reduces reactive astrogliosis in photothrombotic stroke. PLoS ONE 8(7):e70124.
    • (2013) PLoS ONE , vol.8 , Issue.7 , pp. e70124
    • Brunkhorst, R.1
  • 21
    • 70349682405 scopus 로고    scopus 로고
    • Hypoxic preconditioning-induced cerebral ischemic tolerance: Role of microvascular sphingosine kinase 2
    • Wacker BK, Park TS, Gidday JM (2009) Hypoxic preconditioning-induced cerebral ischemic tolerance: Role of microvascular sphingosine kinase 2. Stroke 40(10):3342-3348.
    • (2009) Stroke , vol.40 , Issue.10 , pp. 3342-3348
    • Wacker, B.K.1    Park, T.S.2    Gidday, J.M.3
  • 22
    • 70349327371 scopus 로고    scopus 로고
    • The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia
    • Czech B, et al. (2009) The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochem Biophys Res Commun 389(2):251-256.
    • (2009) Biochem Biophys Res Commun , vol.389 , Issue.2 , pp. 251-256
    • Czech, B.1
  • 23
    • 79953139969 scopus 로고    scopus 로고
    • Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice
    • Pfeilschifter W, et al. (2011) Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice. Exp Transl Stroke Med 9(3):2-7.
    • (2011) Exp Transl Stroke Med , vol.9 , Issue.3 , pp. 2-7
    • Pfeilschifter, W.1
  • 24
    • 80053112315 scopus 로고    scopus 로고
    • Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia
    • Pfeilschifter W, et al. (2011) Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. Biochem Biophys Res Commun 413(2):212-217.
    • (2011) Biochem Biophys Res Commun , vol.413 , Issue.2 , pp. 212-217
    • Pfeilschifter, W.1
  • 25
    • 84888304640 scopus 로고    scopus 로고
    • FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection
    • Kraft P, et al. (2013) FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection. Stroke 44(11):3202-3210.
    • (2013) Stroke , vol.44 , Issue.11 , pp. 3202-3210
    • Kraft, P.1
  • 26
    • 84872981973 scopus 로고    scopus 로고
    • Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model
    • Campos F, et al. (2013) Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model. Stroke 44(2):505-511.
    • (2013) Stroke , vol.44 , Issue.2 , pp. 505-511
    • Campos, F.1
  • 27
    • 54049107725 scopus 로고    scopus 로고
    • Establishing final infarct volume: Stroke lesion evolution past 30 days is insignificant
    • Gaudinski MR, et al. (2008) Establishing final infarct volume: Stroke lesion evolution past 30 days is insignificant. Stroke 39(10):2765-2768.
    • (2008) Stroke , vol.39 , Issue.10 , pp. 2765-2768
    • Gaudinski, M.R.1
  • 28
    • 84879937393 scopus 로고    scopus 로고
    • Effects of microvascular permeability changes on contrastenhanced T1 and pharmacokinetic MR imagings after ischemia
    • Liu HS, et al. (2013) Effects of microvascular permeability changes on contrastenhanced T1 and pharmacokinetic MR imagings after ischemia. Stroke 44(7):1872-1877.
    • (2013) Stroke , vol.44 , Issue.7 , pp. 1872-1877
    • Liu, H.S.1
  • 29
    • 0036205659 scopus 로고    scopus 로고
    • First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients
    • Budde K, et al. (2002) First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients. J Am Soc Nephrol 13(4):1073-1083.
    • (2002) J Am Soc Nephrol , vol.13 , Issue.4 , pp. 1073-1083
    • Budde, K.1
  • 30
    • 79959300120 scopus 로고    scopus 로고
    • FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia
    • Liesz A, et al. (2011) FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia. PLoS ONE 6(6):e21312.
    • (2011) PLoS ONE , vol.6 , Issue.6 , pp. e21312
    • Liesz, A.1
  • 31
    • 0029914446 scopus 로고    scopus 로고
    • 'Malignant' middle cerebral artery territory infarction: Clinical course and prognostic signs
    • Hacke W, et al. (1996) 'Malignant' middle cerebral artery territory infarction: Clinical course and prognostic signs. Arch Neurol 53(4):309-315.
    • (1996) Arch Neurol , vol.53 , Issue.4 , pp. 309-315
    • Hacke, W.1
  • 32
    • 80055019036 scopus 로고    scopus 로고
    • Blood-brain barrier breakdown in acute and chronic cerebrovascular disease
    • Yang Y, Rosenberg GA (2011) Blood-brain barrier breakdown in acute and chronic cerebrovascular disease. Stroke 42(11):3323-3328.
    • (2011) Stroke , vol.42 , Issue.11 , pp. 3323-3328
    • Yang, Y.1    Rosenberg, G.A.2
  • 33
    • 0031729295 scopus 로고    scopus 로고
    • Time course of lesion development in patients with acute stroke: Serial diffusion- and hemodynamic-weighted magnetic resonance imaging
    • Schwamm LH, et al. (1998) Time course of lesion development in patients with acute stroke: Serial diffusion- and hemodynamic-weighted magnetic resonance imaging. Stroke 29(11):2268-2276.
    • (1998) Stroke , vol.29 , Issue.11 , pp. 2268-2276
    • Schwamm, L.H.1
  • 34
    • 0030958501 scopus 로고    scopus 로고
    • Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging
    • Baird AE, et al. (1997) Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 41(5):581-589.
    • (1997) Ann Neurol , vol.41 , Issue.5 , pp. 581-589
    • Baird, A.E.1
  • 35
    • 79952175153 scopus 로고    scopus 로고
    • Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke
    • Liesz A, et al. (2011) Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke. Brain 134(Pt 3):704-720.
    • (2011) Brain , vol.134 , pp. 704-720
    • Liesz, A.1
  • 36
    • 0033049143 scopus 로고    scopus 로고
    • Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
    • Moalem G, et al. (1999) Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 5(1):49-55.
    • (1999) Nat Med , vol.5 , Issue.1 , pp. 49-55
    • Moalem, G.1
  • 37
    • 84884502741 scopus 로고    scopus 로고
    • Intravenous minocycline in acute stroke: A randomized, controlled pilot study and meta-analysis
    • Kohler E, et al. (2013) Intravenous minocycline in acute stroke: A randomized, controlled pilot study and meta-analysis. Stroke 44(9):2493-2499.
    • (2013) Stroke , vol.44 , Issue.9 , pp. 2493-2499
    • Kohler, E.1
  • 38
    • 24944503596 scopus 로고    scopus 로고
    • Statins and stroke
    • Endres M (2005) Statins and stroke. J Cereb Blood Flow Metab 25(9):1093-1110.
    • (2005) J Cereb Blood Flow Metab , vol.25 , Issue.9 , pp. 1093-1110
    • Endres, M.1
  • 39
    • 84907216848 scopus 로고    scopus 로고
    • Fingolimod for the treatment of intracerebral hemorrhage: A 2-arm proof-of-concept study
    • Fu Y, et al. (2014) Fingolimod for the treatment of intracerebral hemorrhage: A 2-arm proof-of-concept study. JAMA Neurol 71(9):1092-1101.
    • (2014) JAMA Neurol , vol.71 , Issue.9 , pp. 1092-1101
    • Fu, Y.1


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