메뉴 건너뛰기




Volumn 1, Issue , 2016, Pages 37-45

The complex role of NRF2 in cancer: A genomic view

Author keywords

Cancer; CUL3; KEAP1; NRF2; Somatic mutations

Indexed keywords

FUMARYLACETOACETASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLYCOGEN SYNTHASE KINASE 3BETA; KELCH LIKE ECH ASSOCIATED PROTEIN 1; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; NOTCH RECEPTOR; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UBIQUITIN PROTEIN LIGASE E3;

EID: 85016782538     PISSN: None     EISSN: 24682020     Source Type: Journal    
DOI: 10.1016/j.cotox.2016.09.003     Document Type: Review
Times cited : (9)

References (65)
  • 2
    • 77958125017 scopus 로고    scopus 로고
    • Discovery of the negative regulator of Nrf2, Keap1: a historical overview
    • 2 Itoh, K., Mimura, J., Yamamoto, M., Discovery of the negative regulator of Nrf2, Keap1: a historical overview. Antioxid Redox Signal 13:11 (2010), 1665–1678.
    • (2010) Antioxid Redox Signal , vol.13 , Issue.11 , pp. 1665-1678
    • Itoh, K.1    Mimura, J.2    Yamamoto, M.3
  • 3
    • 0033523113 scopus 로고    scopus 로고
    • Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast
    • 3 Lee, J., Godon, C., Lagniel, G., Spector, D., Garin, J., Labarre, J., et al. Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast. J Biol Chem 274:23 (1999), 16040–16046.
    • (1999) J Biol Chem , vol.274 , Issue.23 , pp. 16040-16046
    • Lee, J.1    Godon, C.2    Lagniel, G.3    Spector, D.4    Garin, J.5    Labarre, J.6
  • 4
    • 28044446334 scopus 로고    scopus 로고
    • Regulation of the caenorhabditis elegans oxidative stress defense protein Skn-1 by glycogen synthase kinase-3
    • 4 An, J.H., Vranas, K., Lucke, M., Inoue, H., Hisamoto, N., Matsumoto, K., et al. Regulation of the caenorhabditis elegans oxidative stress defense protein Skn-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A 102:45 (2005), 16275–16280.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.45 , pp. 16275-16280
    • An, J.H.1    Vranas, K.2    Lucke, M.3    Inoue, H.4    Hisamoto, N.5    Matsumoto, K.6
  • 5
    • 48249134039 scopus 로고    scopus 로고
    • Mechanisms of cell cycle control revealed by a systematic and quantitative overexpression screen in S. cerevisiae
    • 5 Niu, W., Li, Z., Zhan, W., Iyer, V.R., Marcotte, E.M., Mechanisms of cell cycle control revealed by a systematic and quantitative overexpression screen in S. cerevisiae. PLoS Genet, 4(7), 2008, e1000120.
    • (2008) PLoS Genet , vol.4 , Issue.7 , pp. e1000120
    • Niu, W.1    Li, Z.2    Zhan, W.3    Iyer, V.R.4    Marcotte, E.M.5
  • 6
    • 0026529831 scopus 로고
    • Skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo
    • 6 Bowerman, B., Eaton, B.A., Priess, J.R., Skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo. Cell 68:6 (1992), 1061–1075.
    • (1992) Cell , vol.68 , Issue.6 , pp. 1061-1075
    • Bowerman, B.1    Eaton, B.A.2    Priess, J.R.3
  • 7
    • 84970951874 scopus 로고    scopus 로고
    • Roles of Nrf2 in cell proliferation and differentiation
    • 7 Murakami, S., Motohashi, H., Roles of Nrf2 in cell proliferation and differentiation. Free Radic Biol Med 88:Pt B (2015), 168–178.
    • (2015) Free Radic Biol Med , vol.88 , pp. 168-178
    • Murakami, S.1    Motohashi, H.2
  • 8
    • 84913606109 scopus 로고    scopus 로고
    • Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity
    • 8 Skoko, J.J., Wakabayashi, N., Noda, K., Kimura, S., Tobita, K., Shigemura, N., et al. Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity. Toxicol Sci Off J Soc Toxicol 141:1 (2014), 112–119.
    • (2014) Toxicol Sci Off J Soc Toxicol , vol.141 , Issue.1 , pp. 112-119
    • Skoko, J.J.1    Wakabayashi, N.2    Noda, K.3    Kimura, S.4    Tobita, K.5    Shigemura, N.6
  • 9
    • 84892833777 scopus 로고    scopus 로고
    • Discovery and saturation analysis of cancer genes across 21 tumour types
    • 9 Lawrence, M.S., Stojanov, P., Mermel, C.H., Robinson, J.T., Garraway, L.A., Golub, T.R., et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505:7484 (2014), 495–501.
    • (2014) Nature , vol.505 , Issue.7484 , pp. 495-501
    • Lawrence, M.S.1    Stojanov, P.2    Mermel, C.H.3    Robinson, J.T.4    Garraway, L.A.5    Golub, T.R.6
  • 10
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • 10 Kobayashi, A., Kang, M.I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24:16 (2004), 7130–7139.
    • (2004) Mol Cell Biol , vol.24 , Issue.16 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.I.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5    Chiba, T.6
  • 11
    • 10044228504 scopus 로고    scopus 로고
    • Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
    • 11 Zhang, D.D., Lo, S.C., Cross, J.V., Templeton, D.J., Hannink, M., Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 24:24 (2004), 10941–10953.
    • (2004) Mol Cell Biol , vol.24 , Issue.24 , pp. 10941-10953
    • Zhang, D.D.1    Lo, S.C.2    Cross, J.V.3    Templeton, D.J.4    Hannink, M.5
  • 12
    • 0242580049 scopus 로고    scopus 로고
    • Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    • 12 Zhang, D.D., Hannink, M., Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 23:22 (2003), 8137–8151.
    • (2003) Mol Cell Biol , vol.23 , Issue.22 , pp. 8137-8151
    • Zhang, D.D.1    Hannink, M.2
  • 13
    • 0037015035 scopus 로고    scopus 로고
    • Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    • 13 Dinkova-Kostova, A.T., Holtzclaw, W.D., Cole, R.N., Itoh, K., Wakabayashi, N., Katoh, Y., et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A 99:18 (2002), 11908–11913.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.18 , pp. 11908-11913
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Cole, R.N.3    Itoh, K.4    Wakabayashi, N.5    Katoh, Y.6
  • 14
    • 77957237159 scopus 로고    scopus 로고
    • Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through chip-seq profiling and network analysis
    • 14 Malhotra, D., Portales-Casamar, E., Singh, A., Srivastava, S., Arenillas, D., Happel, C., et al. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through chip-seq profiling and network analysis. Nucleic Acids Res 38:17 (2010), 5718–5734.
    • (2010) Nucleic Acids Res , vol.38 , Issue.17 , pp. 5718-5734
    • Malhotra, D.1    Portales-Casamar, E.2    Singh, A.3    Srivastava, S.4    Arenillas, D.5    Happel, C.6
  • 15
    • 84867317004 scopus 로고    scopus 로고
    • Identification of novel NRF2-regulated genes by ChiP-Seq: influence on retinoid X receptor alpha
    • 15 Chorley, B.N., Campbell, M.R., Wang, X., Karaca, M., Sambandan, D., Bangura, F., et al. Identification of novel NRF2-regulated genes by ChiP-Seq: influence on retinoid X receptor alpha. Nucleic Acids Res 40:15 (2012), 7416–7429.
    • (2012) Nucleic Acids Res , vol.40 , Issue.15 , pp. 7416-7429
    • Chorley, B.N.1    Campbell, M.R.2    Wang, X.3    Karaca, M.4    Sambandan, D.5    Bangura, F.6
  • 16
    • 78650509515 scopus 로고    scopus 로고
    • Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
    • 16 McMahon, M., Lamont, D.J., Beattie, K.A., Hayes, J.D., Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals. Proc Natl Acad Sci U S A 107:44 (2010), 18838–18843.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.44 , pp. 18838-18843
    • McMahon, M.1    Lamont, D.J.2    Beattie, K.A.3    Hayes, J.D.4
  • 18
    • 84876011848 scopus 로고    scopus 로고
    • Proteomic analysis of ubiquitin ligase Keap1 reveals associated proteins that inhibit Nrf2 ubiquitination
    • 18 Hast, B.E., Goldfarb, D., Mulvaney, K.M., Hast, M.A., Siesser, P.F., Yan, F., et al. Proteomic analysis of ubiquitin ligase Keap1 reveals associated proteins that inhibit Nrf2 ubiquitination. Cancer Res 73:7 (2013), 2199–2210.
    • (2013) Cancer Res , vol.73 , Issue.7 , pp. 2199-2210
    • Hast, B.E.1    Goldfarb, D.2    Mulvaney, K.M.3    Hast, M.A.4    Siesser, P.F.5    Yan, F.6
  • 19
    • 67449128222 scopus 로고    scopus 로고
    • Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
    • 19 Chen, W., Sun, Z., Wang, X.J., Jiang, T., Huang, Z., Fang, D., et al. Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell 34:6 (2009), 663–673.
    • (2009) Mol Cell , vol.34 , Issue.6 , pp. 663-673
    • Chen, W.1    Sun, Z.2    Wang, X.J.3    Jiang, T.4    Huang, Z.5    Fang, D.6
  • 20
    • 77953366801 scopus 로고    scopus 로고
    • A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62
    • 20 Lau, A., Wang, X.J., Zhao, F., Villeneuve, N.F., Wu, T., Jiang, T., et al. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol 30:13 (2010), 3275–3285.
    • (2010) Mol Cell Biol , vol.30 , Issue.13 , pp. 3275-3285
    • Lau, A.1    Wang, X.J.2    Zhao, F.3    Villeneuve, N.F.4    Wu, T.5    Jiang, T.6
  • 21
    • 79952256187 scopus 로고    scopus 로고
    • Scf/{beta}-Trcp promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
    • 21 Rada, P., Rojo, A.I., Chowdhry, S., McMahon, M., Hayes, J.D., Cuadrado, A., Scf/{beta}-Trcp promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol Cell Biol 31:6 (2011), 1121–1133.
    • (2011) Mol Cell Biol , vol.31 , Issue.6 , pp. 1121-1133
    • Rada, P.1    Rojo, A.I.2    Chowdhry, S.3    McMahon, M.4    Hayes, J.D.5    Cuadrado, A.6
  • 22
    • 84898874270 scopus 로고    scopus 로고
    • Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis
    • 22 Wu, T., Zhao, F., Gao, B., Tan, C., Yagishita, N., Nakajima, T., et al. Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. Genes Dev 28:7 (2014), 708–722.
    • (2014) Genes Dev , vol.28 , Issue.7 , pp. 708-722
    • Wu, T.1    Zhao, F.2    Gao, B.3    Tan, C.4    Yagishita, N.5    Nakajima, T.6
  • 23
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • 23 DeNicola, G.M., Karreth, F.A., Humpton, T.J., Gopinathan, A., Wei, C., Frese, K., et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475:7354 (2011), 106–109.
    • (2011) Nature , vol.475 , Issue.7354 , pp. 106-109
    • DeNicola, G.M.1    Karreth, F.A.2    Humpton, T.J.3    Gopinathan, A.4    Wei, C.5    Frese, K.6
  • 24
    • 84918576027 scopus 로고    scopus 로고
    • Oncogenic KRAS confers chemoresistance by upregulating Nrf2
    • 24 Tao, S., Wang, S., Moghaddam, S.J., Ooi, A., Chapman, E., Wong, P.K., et al. Oncogenic KRAS confers chemoresistance by upregulating Nrf2. Cancer Res 74:24 (2014), 7430–7441.
    • (2014) Cancer Res , vol.74 , Issue.24 , pp. 7430-7441
    • Tao, S.1    Wang, S.2    Moghaddam, S.J.3    Ooi, A.4    Chapman, E.5    Wong, P.K.6
  • 25
    • 0035853157 scopus 로고    scopus 로고
    • Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in Nrf2 transcription factor-deficient mice
    • 25 Ramos-Gomez, M., Kwak, M.K., Dolan, P.M., Itoh, K., Yamamoto, M., Talalay, P., et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in Nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A 98:6 (2001), 3410–3415.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.6 , pp. 3410-3415
    • Ramos-Gomez, M.1    Kwak, M.K.2    Dolan, P.M.3    Itoh, K.4    Yamamoto, M.5    Talalay, P.6
  • 26
    • 40649108843 scopus 로고    scopus 로고
    • Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
    • 26 Pearson, K.J., Lewis, K.N., Price, N.L., Chang, J.W., Perez, E., Cascajo, M.V., et al. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A 105:7 (2008), 2325–2330.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.7 , pp. 2325-2330
    • Pearson, K.J.1    Lewis, K.N.2    Price, N.L.3    Chang, J.W.4    Perez, E.5    Cascajo, M.V.6
  • 27
    • 33344456501 scopus 로고    scopus 로고
    • Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
    • 27 Padmanabhan, B., Tong, K.I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., et al. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell 21:5 (2006), 689–700.
    • (2006) Mol Cell , vol.21 , Issue.5 , pp. 689-700
    • Padmanabhan, B.1    Tong, K.I.2    Ohta, T.3    Nakamura, Y.4    Scharlock, M.5    Ohtsuji, M.6
  • 28
    • 33750885385 scopus 로고    scopus 로고
    • Dysfunctional Keap1-Nrf2 interaction in non-small-cell lung cancer
    • 28 Singh, A., Misra, V., Thimmulappa, R.K., Lee, H., Ames, S., Hoque, M.O., et al. Dysfunctional Keap1-Nrf2 interaction in non-small-cell lung cancer. PLoS Med, 3(10), 2006, e420.
    • (2006) PLoS Med , vol.3 , Issue.10 , pp. e420
    • Singh, A.1    Misra, V.2    Thimmulappa, R.K.3    Lee, H.4    Ames, S.5    Hoque, M.O.6
  • 29
    • 84885944468 scopus 로고    scopus 로고
    • The emerging role of the Nrf2-Keap1 signaling pathway in cancer
    • 29 Jaramillo, M.C., Zhang, D.D., The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev 27:20 (2013), 2179–2191.
    • (2013) Genes Dev , vol.27 , Issue.20 , pp. 2179-2191
    • Jaramillo, M.C.1    Zhang, D.D.2
  • 30
    • 84938788904 scopus 로고    scopus 로고
    • Sustained NRF2 activation in hereditary leiomyomatosis and renal cell cancer (HLRCC) and in hereditary tyrosinemia type 1 (HT1)
    • 30 Sandhu, I.S., Maksim, N.J., Amouzougan, E.A., Gallion, B.W., Raviele, A.L., Ooi, A., Sustained NRF2 activation in hereditary leiomyomatosis and renal cell cancer (HLRCC) and in hereditary tyrosinemia type 1 (HT1). Biochem Soc Trans 43:4 (2015), 650–656.
    • (2015) Biochem Soc Trans , vol.43 , Issue.4 , pp. 650-656
    • Sandhu, I.S.1    Maksim, N.J.2    Amouzougan, E.A.3    Gallion, B.W.4    Raviele, A.L.5    Ooi, A.6
  • 31
    • 80054772589 scopus 로고    scopus 로고
    • An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma
    • 31 Ooi, A., Wong, J.C., Petillo, D., Roossien, D., Perrier-Trudova, V., Whitten, D., et al. An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. Cancer Cell 20:4 (2011), 511–523.
    • (2011) Cancer Cell , vol.20 , Issue.4 , pp. 511-523
    • Ooi, A.1    Wong, J.C.2    Petillo, D.3    Roossien, D.4    Perrier-Trudova, V.5    Whitten, D.6
  • 32
    • 49649101835 scopus 로고    scopus 로고
    • Activation of nuclear factor E2-related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development
    • 32 Marhenke, S., Lamle, J., Buitrago-Molina, L.E., Canon, J.M., Geffers, R., Finegold, M., et al. Activation of nuclear factor E2-related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development. Hepatology 48:2 (2008), 487–496.
    • (2008) Hepatology , vol.48 , Issue.2 , pp. 487-496
    • Marhenke, S.1    Lamle, J.2    Buitrago-Molina, L.E.3    Canon, J.M.4    Geffers, R.5    Finegold, M.6
  • 33
    • 84876005313 scopus 로고    scopus 로고
    • CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma
    • 33 Ooi, A., Dykema, K., Ansari, A., Petillo, D., Snider, J., Kahnoski, R., et al. CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma. Cancer Res 73:7 (2013), 2044–2051.
    • (2013) Cancer Res , vol.73 , Issue.7 , pp. 2044-2051
    • Ooi, A.1    Dykema, K.2    Ansari, A.3    Petillo, D.4    Snider, J.5    Kahnoski, R.6
  • 35
    • 84979895385 scopus 로고    scopus 로고
    • Insights into the genetic basis of the renal cell carcinomas from the cancer genome atlas
    • 35 Haake, S.M., Weyandt, J.D., Rathmell, W.K., Insights into the genetic basis of the renal cell carcinomas from the cancer genome atlas. Mol Cancer Res, 2016.
    • (2016) Mol Cancer Res
    • Haake, S.M.1    Weyandt, J.D.2    Rathmell, W.K.3
  • 36
    • 84905029258 scopus 로고    scopus 로고
    • Comprehensive molecular profiling of lung adenocarcinoma
    • 36 Cancer Genome Atlas Research N, Comprehensive molecular profiling of lung adenocarcinoma. Nature 511:7511 (2014), 543–550.
    • (2014) Nature , vol.511 , Issue.7511 , pp. 543-550
    • Cancer Genome Atlas Research N1
  • 37
    • 84897022815 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of urothelial bladder carcinoma
    • 37 Cancer Genome Atlas Research N, Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 507:7492 (2014), 315–322.
    • (2014) Nature , vol.507 , Issue.7492 , pp. 315-322
    • Cancer Genome Atlas Research N1
  • 38
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • 38 Cancer Genome Atlas Research N, Comprehensive genomic characterization of squamous cell lung cancers. Nature 489:7417 (2012), 519–525.
    • (2012) Nature , vol.489 , Issue.7417 , pp. 519-525
    • Cancer Genome Atlas Research N1
  • 39
    • 84929129284 scopus 로고    scopus 로고
    • Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
    • 39 Schulze, K., Imbeaud, S., Letouze, E., Alexandrov, L.B., Calderaro, J., Rebouissou, S., et al. Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat Genet 47:5 (2015), 505–511.
    • (2015) Nat Genet , vol.47 , Issue.5 , pp. 505-511
    • Schulze, K.1    Imbeaud, S.2    Letouze, E.3    Alexandrov, L.B.4    Calderaro, J.5    Rebouissou, S.6
  • 40
    • 84861625981 scopus 로고    scopus 로고
    • Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
    • 40 Guichard, C., Amaddeo, G., Imbeaud, S., Ladeiro, Y., Pelletier, L., Maad, I.B., et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet 44:6 (2012), 694–698.
    • (2012) Nat Genet , vol.44 , Issue.6 , pp. 694-698
    • Guichard, C.1    Amaddeo, G.2    Imbeaud, S.3    Ladeiro, Y.4    Pelletier, L.5    Maad, I.B.6
  • 41
    • 45849133744 scopus 로고    scopus 로고
    • Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
    • 41 Wang, R., An, J., Ji, F., Jiao, H., Sun, H., Zhou, D., Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues. Biochem Biophys Res Commun 373:1 (2008), 151–154.
    • (2008) Biochem Biophys Res Commun , vol.373 , Issue.1 , pp. 151-154
    • Wang, R.1    An, J.2    Ji, F.3    Jiao, H.4    Sun, H.5    Zhou, D.6
  • 42
    • 84857997256 scopus 로고    scopus 로고
    • Methylation of the Keap1 gene promoter region in human colorectal cancer
    • 42 Hanada, N., Takahata, T., Zhou, Q., Ye, X., Sun, R., Itoh, J., et al. Methylation of the Keap1 gene promoter region in human colorectal cancer. BMC Cancer, 12, 2012, 66.
    • (2012) BMC Cancer , vol.12 , pp. 66
    • Hanada, N.1    Takahata, T.2    Zhou, Q.3    Ye, X.4    Sun, R.5    Itoh, J.6
  • 43
    • 84872038941 scopus 로고    scopus 로고
    • Aberrant Keap1 methylation in breast cancer and association with clinicopathological features
    • 43 Barbano, R., Muscarella, L.A., Pasculli, B., Valori, V.M., Fontana, A., Coco, M., et al. Aberrant Keap1 methylation in breast cancer and association with clinicopathological features. Epigenetics 8:1 (2013), 105–112.
    • (2013) Epigenetics , vol.8 , Issue.1 , pp. 105-112
    • Barbano, R.1    Muscarella, L.A.2    Pasculli, B.3    Valori, V.M.4    Fontana, A.5    Coco, M.6
  • 44
    • 79952377052 scopus 로고    scopus 로고
    • Regulation of Keap1 expression by promoter methylation in malignant gliomas and association with patient's outcome
    • 44 Muscarella, L.A., Barbano, R., D'Angelo, V., Copetti, M., Coco, M., Balsamo, T., et al. Regulation of Keap1 expression by promoter methylation in malignant gliomas and association with patient's outcome. Epigenetics 6:3 (2011), 317–325.
    • (2011) Epigenetics , vol.6 , Issue.3 , pp. 317-325
    • Muscarella, L.A.1    Barbano, R.2    D'Angelo, V.3    Copetti, M.4    Coco, M.5    Balsamo, T.6
  • 45
    • 84925267081 scopus 로고    scopus 로고
    • Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution
    • 45 Kovac, M., Navas, C., Horswell, S., Salm, M., Bardella, C., Rowan, A., et al. Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution. Nat Commun, 6, 2015, 6336.
    • (2015) Nat Commun , vol.6 , pp. 6336
    • Kovac, M.1    Navas, C.2    Horswell, S.3    Salm, M.4    Bardella, C.5    Rowan, A.6
  • 46
    • 84975468197 scopus 로고    scopus 로고
    • P62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells
    • 46 Umemura, A., He, F., Taniguchi, K., Nakagawa, H., Yamachika, S., et al. P62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells. Cancer Cell 29:6 (2016), 935–948.
    • (2016) Cancer Cell , vol.29 , Issue.6 , pp. 935-948
    • Umemura, A.1    He, F.2    Taniguchi, K.3    Nakagawa, H.4    Yamachika, S.5
  • 47
    • 77954695549 scopus 로고    scopus 로고
    • Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
    • 47 Solis, L.M., Behrens, C., Dong, W., Suraokar, M., Ozburn, N.C., Moran, C.A., et al. Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features. Clin Cancer Res 16:14 (2010), 3743–3753.
    • (2010) Clin Cancer Res , vol.16 , Issue.14 , pp. 3743-3753
    • Solis, L.M.1    Behrens, C.2    Dong, W.3    Suraokar, M.4    Ozburn, N.C.5    Moran, C.A.6
  • 48
    • 84880048347 scopus 로고    scopus 로고
    • Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis
    • 48 Satoh, H., Moriguchi, T., Takai, J., Ebina, M., Yamamoto, M., Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis. Cancer Res 73:13 (2013), 4158–4168.
    • (2013) Cancer Res , vol.73 , Issue.13 , pp. 4158-4168
    • Satoh, H.1    Moriguchi, T.2    Takai, J.3    Ebina, M.4    Yamamoto, M.5
  • 49
    • 66149168685 scopus 로고    scopus 로고
    • Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer
    • 49 Homma, S., Ishii, Y., Morishima, Y., Yamadori, T., Matsuno, Y., Haraguchi, N., et al. Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res 15:10 (2009), 3423–3432.
    • (2009) Clin Cancer Res , vol.15 , Issue.10 , pp. 3423-3432
    • Homma, S.1    Ishii, Y.2    Morishima, Y.3    Yamadori, T.4    Matsuno, Y.5    Haraguchi, N.6
  • 50
    • 20144387888 scopus 로고    scopus 로고
    • Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers’ non-small cell lung carcinomas
    • 50 Fukumoto, S., Yamauchi, N., Moriguchi, H., Hippo, Y., Watanabe, A., Shibahara, J., et al. Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers’ non-small cell lung carcinomas. Clin Cancer Res 11:5 (2005), 1776–1785.
    • (2005) Clin Cancer Res , vol.11 , Issue.5 , pp. 1776-1785
    • Fukumoto, S.1    Yamauchi, N.2    Moriguchi, H.3    Hippo, Y.4    Watanabe, A.5    Shibahara, J.6
  • 51
    • 0031577292 scopus 로고    scopus 로고
    • An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
    • 51 Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236:2 (1997), 313–322.
    • (1997) Biochem Biophys Res Commun , vol.236 , Issue.2 , pp. 313-322
    • Itoh, K.1    Chiba, T.2    Takahashi, S.3    Ishii, T.4    Igarashi, K.5    Katoh, Y.6
  • 52
    • 4844225631 scopus 로고    scopus 로고
    • Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice
    • 52 Li, J., Stein, T.D., Johnson, J.A., Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice. Physiol Genomics 18:3 (2004), 261–272.
    • (2004) Physiol Genomics , vol.18 , Issue.3 , pp. 261-272
    • Li, J.1    Stein, T.D.2    Johnson, J.A.3
  • 53
    • 11444261268 scopus 로고    scopus 로고
    • Gene expression profiling of Nrf2-mediated protection against oxidative injury
    • 53 Cho, H.Y., Reddy, S.P., Debiase, A., Yamamoto, M., Kleeberger, S.R., Gene expression profiling of Nrf2-mediated protection against oxidative injury. Free Radic Biol Med 38:3 (2005), 325–343.
    • (2005) Free Radic Biol Med , vol.38 , Issue.3 , pp. 325-343
    • Cho, H.Y.1    Reddy, S.P.2    Debiase, A.3    Yamamoto, M.4    Kleeberger, S.R.5
  • 54
    • 84857918033 scopus 로고    scopus 로고
    • Transcriptomic and proteomic profiling of Keap1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles
    • 54 Agyeman, A.S., Chaerkady, R., Shaw, P.G., Davidson, N.E., Visvanathan, K., Pandey, A., et al. Transcriptomic and proteomic profiling of Keap1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles. Breast Cancer Res Treat 132:1 (2012), 175–187.
    • (2012) Breast Cancer Res Treat , vol.132 , Issue.1 , pp. 175-187
    • Agyeman, A.S.1    Chaerkady, R.2    Shaw, P.G.3    Davidson, N.E.4    Visvanathan, K.5    Pandey, A.6
  • 55
    • 79953788716 scopus 로고    scopus 로고
    • The transcriptome of Nrf2−/− mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes
    • 55 Gebel, S., Diehl, S., Pype, J., Friedrichs, B., Weiler, H., Schuller, J., et al. The transcriptome of Nrf2−/− mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes. Toxicol Sci Off J Soc Toxicol 115:1 (2010), 238–252.
    • (2010) Toxicol Sci Off J Soc Toxicol , vol.115 , Issue.1 , pp. 238-252
    • Gebel, S.1    Diehl, S.2    Pype, J.3    Friedrichs, B.4    Weiler, H.5    Schuller, J.6
  • 56
    • 84878681301 scopus 로고    scopus 로고
    • The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism
    • 56 Mitsuishi, Y., Motohashi, H., Yamamoto, M., The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism. Front Oncol, 2, 2012.
    • (2012) Front Oncol , vol.2
    • Mitsuishi, Y.1    Motohashi, H.2    Yamamoto, M.3
  • 57
    • 77956640097 scopus 로고    scopus 로고
    • Regulation of Notch1 signaling by Nrf2: implications for tissue regeneration
    • 57 Wakabayashi, N., Shin, S., Slocum, S.L., Agoston, E.S., Wakabayashi, J., Kwak, M.K., et al. Regulation of Notch1 signaling by Nrf2: implications for tissue regeneration. Sci Signal, 3(130), 2010, ra52.
    • (2010) Sci Signal , vol.3 , Issue.130 , pp. ra52
    • Wakabayashi, N.1    Shin, S.2    Slocum, S.L.3    Agoston, E.S.4    Wakabayashi, J.5    Kwak, M.K.6
  • 58
    • 84893836947 scopus 로고    scopus 로고
    • Nrf2-mediated notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation
    • 58 Kim, J.H., Thimmulappa, R.K., Kumar, V., Cui, W., Kumar, S., Kombairaju, P., et al. Nrf2-mediated notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation. J Clin Invest 124:2 (2014), 730–741.
    • (2014) J Clin Invest , vol.124 , Issue.2 , pp. 730-741
    • Kim, J.H.1    Thimmulappa, R.K.2    Kumar, V.3    Cui, W.4    Kumar, S.5    Kombairaju, P.6
  • 59
    • 84905905334 scopus 로고    scopus 로고
    • Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent notch signaling
    • 59 Paul, M.K., Bisht, B., Darmawan, D.O., Chiou, R., Ha, V.L., Wallace, W.D., et al. Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent notch signaling. Cell Stem Cell 15:2 (2014), 199–214.
    • (2014) Cell Stem Cell , vol.15 , Issue.2 , pp. 199-214
    • Paul, M.K.1    Bisht, B.2    Darmawan, D.O.3    Chiou, R.4    Ha, V.L.5    Wallace, W.D.6
  • 60
    • 77950553993 scopus 로고    scopus 로고
    • Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity
    • 60 Pi, J., Leung, L., Xue, P., Wang, W., Hou, Y., Liu, D., et al. Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J Biol Chem 285:12 (2010), 9292–9300.
    • (2010) J Biol Chem , vol.285 , Issue.12 , pp. 9292-9300
    • Pi, J.1    Leung, L.2    Xue, P.3    Wang, W.4    Hou, Y.5    Liu, D.6
  • 61
    • 84863764614 scopus 로고    scopus 로고
    • Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
    • 61 Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., et al. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell 22:1 (2012), 66–79.
    • (2012) Cancer Cell , vol.22 , Issue.1 , pp. 66-79
    • Mitsuishi, Y.1    Taguchi, K.2    Kawatani, Y.3    Shibata, T.4    Nukiwa, T.5    Aburatani, H.6
  • 62
    • 84990222841 scopus 로고    scopus 로고
    • Mapping protein-DNA interactions using chip-exo and illumina-based sequencing
    • 62 Barfeld, S.J., Mills, I.G., Mapping protein-DNA interactions using chip-exo and illumina-based sequencing. Methods Mol Biol 1443 (2016), 119–137.
    • (2016) Methods Mol Biol , vol.1443 , pp. 119-137
    • Barfeld, S.J.1    Mills, I.G.2
  • 63
    • 84873020117 scopus 로고    scopus 로고
    • Chip-exo method for identifying genomic location of DNA-binding proteins with near-single-nucleotide accuracy
    • [Edited by Frederick M Ausubel [et al]] Chapter 21(Unit 21.24)
    • 63 Rhee, H.S., Pugh, B.F., Chip-exo method for identifying genomic location of DNA-binding proteins with near-single-nucleotide accuracy. [Edited by Frederick M Ausubel [et al]] Curr Protoc Mol Biol, 2012 Chapter 21(Unit 21.24).
    • (2012) Curr Protoc Mol Biol
    • Rhee, H.S.1    Pugh, B.F.2
  • 64
    • 84926619310 scopus 로고    scopus 로고
    • Chip-nexus enables improved detection of in vivo transcription factor binding footprints
    • 64 He, Q., Johnston, J., Zeitlinger, J., Chip-nexus enables improved detection of in vivo transcription factor binding footprints. Nat Biotechnol 33:4 (2015), 395–401.
    • (2015) Nat Biotechnol , vol.33 , Issue.4 , pp. 395-401
    • He, Q.1    Johnston, J.2    Zeitlinger, J.3
  • 65
    • 84955111268 scopus 로고    scopus 로고
    • Cy-preds: an algorithm and a web service for the analysis and prediction of cysteine reactivity
    • 65 Soylu, I., Marino, S.M., Cy-preds: an algorithm and a web service for the analysis and prediction of cysteine reactivity. Proteins 84:2 (2016), 278–291.
    • (2016) Proteins , vol.84 , Issue.2 , pp. 278-291
    • Soylu, I.1    Marino, S.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.