-
1
-
-
77952263737
-
The genetic basis of kidney cancer: A metabolic disease
-
Linehan WM, Srinivasan R, Schmidt LS. The genetic basis of kidney cancer: a metabolic disease. Nat Rev Urol 2010; 7: 277-85.
-
(2010)
Nat Rev Urol
, vol.7
, pp. 277-285
-
-
Linehan, W.M.1
Srinivasan, R.2
Schmidt, L.S.3
-
2
-
-
84868309625
-
Genetic basis of kidney cancer: Role of genomics for the development of disease-based therapeutics
-
Linehan WM. Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics. Genome Res 2012; 22: 2089-100.
-
(2012)
Genome Res
, vol.22
, pp. 2089-2100
-
-
Linehan, W.M.1
-
3
-
-
0030788677
-
Papillary renal cell carcinoma: A clinicopathologic and immunohistochemical study of 105 tumors
-
Delahunt B, Eble JN. Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. Mod Pathol 1997; 10: 537-44.
-
(1997)
Mod Pathol
, vol.10
, pp. 537-544
-
-
Delahunt, B.1
Eble, J.N.2
-
4
-
-
0028157342
-
Hereditary papillary renal cell carcinoma
-
Zbar B, Tory K, Merino MJ, et al. Hereditary papillary renal cell carcinoma. J Urol 1994; 151: 561-6.
-
(1994)
J Urol
, vol.151
, pp. 561-566
-
-
Zbar, B.1
Tory, K.2
Merino, M.J.3
-
5
-
-
17344381429
-
Germline and somatic mutations in the tyrosine kinase domain of the met protooncogene in papillary renal carcinomas
-
Schmidt LS, Duh FM, Chen F, et al. Germline and somatic mutations in the tyrosine kinase domain of the MET protooncogene in papillary renal carcinomas. Nat Genet 1997; 16: 68-73.
-
(1997)
Nat Genet
, vol.16
, pp. 68-73
-
-
Schmidt, L.S.1
Duh, F.M.2
Chen, F.3
-
6
-
-
0033535530
-
Novel mutations of the met protooncogene in papillary renal carcinomas
-
Schmidt LS, Junker K, Nakaigawa N, et al. Novel mutations of the MET protooncogene in papillary renal carcinomas. Oncogene 1999; 18: 2343-50.
-
(1999)
Oncogene
, vol.18
, pp. 2343-2350
-
-
Schmidt, L.S.1
Junker, K.2
Nakaigawa, N.3
-
7
-
-
85028129789
-
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes
-
Durinck S, Stawiski EW, Pavía-Jiménez A, et al. Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes. Nat Genet 2015; 47: 13-21.
-
(2015)
Nat Genet
, vol.47
, pp. 13-21
-
-
Durinck, S.1
Stawiski, E.W.2
Pavía-Jiménez, A.3
-
8
-
-
0035853166
-
Inherited susceptibility to uterine leiomyomas and renal cell cancer
-
Launonen V, Vierimaa O, Kiuru M, et al. Inherited susceptibility to uterine leiomyomas and renal cell cancer. Proc Natl Acad Sci U S A 2001; 98: 3387-92.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 3387-3392
-
-
Launonen, V.1
Vierimaa, O.2
Kiuru, M.3
-
9
-
-
34248336258
-
Hereditary leiomyomatosis and renal cell cancer: A syndrome associated with an aggressive form of inherited renal cancer
-
Grubb RL III, Franks ME, Toro J, et al. Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancer. J Urol 2007; 177: 2074-9.
-
(2007)
J Urol
, vol.177
, pp. 2074-2079
-
-
Grubb, R.L.1
Franks, M.E.2
Toro, J.3
-
10
-
-
18544365990
-
Germline mutations in fh predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
-
Tomlinson IP, Alam NA, Rowan AJ, et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 2002; 30: 406-10.
-
(2002)
Nat Genet
, vol.30
, pp. 406-410
-
-
Tomlinson, I.P.1
Alam, N.A.2
Rowan, A.J.3
-
11
-
-
67651204610
-
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hif-1 alpha stabilization by glucose-dependent generation of reactive oxygen species
-
Sudarshan S, Sourbier C, Kong HS, et al. Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and HIF-1 alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol 2009; 15: 4080-90.
-
(2009)
Mol Cell Biol
, vol.15
, pp. 4080-4090
-
-
Sudarshan, S.1
Sourbier, C.2
Kong, H.S.3
-
12
-
-
80054772589
-
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma
-
Ooi A, Wong JC, Petillo D, et al. An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. Cancer Cell 2011; 20: 511-23.
-
(2011)
Cancer Cell
, vol.20
, pp. 511-523
-
-
Ooi, A.1
Wong, J.C.2
Petillo, D.3
-
13
-
-
84876005313
-
Cul3 and nrf2 mutations confer an nrf2 activation phenotype in a sporadic form of papillary renal cell carcinoma
-
Ooi A, Dykema K, Ansari A, et al. CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma. Cancer Res 2013; 73: 2044-51.
-
(2013)
Cancer Res
, vol.73
, pp. 2044-2051
-
-
Ooi, A.1
Dykema, K.2
Ansari, A.3
-
14
-
-
0031794033
-
Chromosomal imbalances in papillary renal cell carcinoma: Genetic differences between histological subtypes
-
Jiang F, Richter J, Schraml P, et al. Chromosomal imbalances in papillary renal cell carcinoma: genetic differences between histological subtypes. Am J Pathol 1998; 153: 1467-73.
-
(1998)
Am J Pathol
, vol.153
, pp. 1467-1473
-
-
Jiang, F.1
Richter, J.2
Schraml, P.3
-
15
-
-
84892833777
-
Discovery and saturation analysis of cancer genes across 21 tumour types
-
Lawrence MS, Stojanov P, Mermel CH, et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 2014; 505: 495-501.
-
(2014)
Nature
, vol.505
, pp. 495-501
-
-
Lawrence, M.S.1
Stojanov, P.2
Mermel, C.H.3
-
16
-
-
84905983018
-
Molecular genetics and cellular features of tfe3 and tfeb fusion kidney cancers
-
Kauffman EC, Ricketts CJ, Rais-Bahrami S, et al. Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers. Nat Rev Urol 2014; 11: 465-75.
-
(2014)
Nat Rev Urol
, vol.11
, pp. 465-475
-
-
Kauffman, E.C.1
Ricketts, C.J.2
Rais-Bahrami, S.3
-
17
-
-
0032522486
-
Two north American families with hereditary papillary renal carcinoma and identical novel mutations in the met protooncogene
-
Schmidt LS, Junker K, Weirich G, et al. Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET protooncogene. Cancer Res 1998; 58: 1719-22.
-
(1998)
Cancer Res
, vol.58
, pp. 1719-1722
-
-
Schmidt, L.S.1
Junker, K.2
Weirich, G.3
-
18
-
-
71049184440
-
Discovery and optimization of potent and selective triazolopyridazine series of c-met inhibitors
-
Boezio AA, Berry L, Albrecht BK, et al. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg Med Chem Lett 2009; 19: 6307-12.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 6307-6312
-
-
Boezio, A.A.1
Berry, L.2
Albrecht, B.K.3
-
19
-
-
84904310622
-
Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-Associated cryptic promoters and somatically acquired regulatory elements
-
Muratani M, Deng N, Ooi WF, et al. Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-Associated cryptic promoters and somatically acquired regulatory elements. Nat Commun 2014; 5: 4361.
-
(2014)
Nat Commun
, vol.5
, pp. 4361
-
-
Muratani, M.1
Deng, N.2
Ooi, W.F.3
-
20
-
-
84886089551
-
The epidermal growth factor receptor variant III (egfrvIII): Where wild things are altered
-
Gan HK, Cvrljevic AN, Johns TG. The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered. FEBS J 2013; 280: 5350-70.
-
(2013)
FEBS J
, vol.280
, pp. 5350-5370
-
-
Gan, H.K.1
Cvrljevic, A.N.2
Johns, T.G.3
-
21
-
-
84879890360
-
Comprehensive molecular characterization of clear cell renal cell carcinoma
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 2013; 499: 43-9.
-
(2013)
Nature
, vol.499
, pp. 43-49
-
-
-
22
-
-
84875745673
-
Interplay between the cancer genome and epigenome
-
Shen H, Laird PW. Interplay between the cancer genome and epigenome. Cell 2013; 153: 38-55.
-
(2013)
Cell
, vol.153
, pp. 38-55
-
-
Shen, H.1
Laird, P.W.2
-
23
-
-
0035985177
-
Identification of genes periodically expressed in the human cell cycle and their expression in tumors
-
Whitfield ML, Sherlock G, Saldanha AJ, et al. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell 2002; 13: 1977-2000.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 1977-2000
-
-
Whitfield, M.L.1
Sherlock, G.2
Saldanha, A.J.3
-
24
-
-
0036359548
-
Hypoxia-A key regulatory factor in tumour growth
-
Harris AL. Hypoxia-A key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2: 38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
25
-
-
80052572942
-
The glycolytic shift in fumaratehydratase-deficient kidney cancer lowers ampk levels, increases anabolic propensities and lowers cellular iron levels
-
Tong WH, Sourbier C, Kovtunovych G, et al. The glycolytic shift in fumaratehydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels. Cancer Cell 2011; 20: 315-27.
-
(2011)
Cancer Cell
, vol.20
, pp. 315-327
-
-
Tong, W.H.1
Sourbier, C.2
Kovtunovych, G.3
-
26
-
-
84881574290
-
Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma
-
Yang Y, Lane AN, Ricketts CJ, et al. Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma. PLoS One 2013; 8(8): e72179.
-
(2013)
PLoS One
, vol.8
, Issue.8
, pp. e72179
-
-
Yang, Y.1
Lane, A.N.2
Ricketts, C.J.3
-
27
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Cancer Genome Atlas Network
-
Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 2012; 490: 61-70.
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
-
28
-
-
84908460595
-
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
-
Hoadley KA, Yau C, Wolf DM, et al. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell 2014; 158: 929-44.
-
(2014)
Cell
, vol.158
, pp. 929-944
-
-
Hoadley, K.A.1
Yau, C.2
Wolf, D.M.3
-
29
-
-
0029906134
-
Nrf1 and nrf2 positively and c-fos and fra1 negatively regulate the human antioxidant response element-mediated expression of nad(p)h:quinone oxidoreductase1 gene
-
Venugopal R, Jaiswal AK. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. Proc Natl Acad Sci U S A 1996; 93: 14960-5.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 14960-14965
-
-
Venugopal, R.1
Jaiswal, A.K.2
-
30
-
-
84925267081
-
Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution
-
Kovac M, Navas C, Horswell S, et al. Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution. Nat Commun 2015; 6: 6336.
-
(2015)
Nat Commun
, vol.6
, pp. 6336
-
-
Kovac, M.1
Navas, C.2
Horswell, S.3
-
31
-
-
77952108366
-
Identification of a cpg island methylator phenotype that defines a distinct subgroup of glioma
-
Noushmehr H, Weisenberger DJ, Diefes K, et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 2010; 17: 510-22.
-
(2010)
Cancer Cell
, vol.17
, pp. 510-522
-
-
Noushmehr, H.1
Weisenberger, D.J.2
Diefes, K.3
-
32
-
-
84905029258
-
Comprehensive molecular profiling of lung adenocarcinoma
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature 2014; 511: 543-50.
-
(2014)
Nature
, vol.511
, pp. 543-550
-
-
-
33
-
-
84907270779
-
Comprehensive molecular characterization of gastric adenocarcinoma
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 2014; 513: 202-9.
-
(2014)
Nature
, vol.513
, pp. 202-209
-
-
-
34
-
-
84879875481
-
Molecular pathways: Fumarate hydratase-deficient kidney cancer-targeting the warburg effect in cancer
-
Linehan WM, Rouault TA. Molecular pathways: fumarate hydratase-deficient kidney cancer-targeting the Warburg effect in cancer. Clin Cancer Res 2013; 19: 3345-52.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3345-3352
-
-
Linehan, W.M.1
Rouault, T.A.2
-
35
-
-
84862632865
-
Inhibition of ?-kg-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of fh and sdh tumor suppressors
-
Xiao M, Yang H, Xu W, et al. Inhibition of ?-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev 2012; 26: 1326-38.
-
(2012)
Genes Dev
, vol.26
, pp. 1326-1338
-
-
Xiao, M.1
Yang, H.2
Xu, W.3
-
36
-
-
84872548337
-
Phase II and biomarker study of the dual met/vegfr2 inhibitor foretinib in patients with papillary renal cell carcinoma
-
Choueiri TK, Vaishampayan U, Rosenberg JE, et al. Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma. J Clin Oncol 2013; 31: 181-6.
-
(2013)
J Clin Oncol
, vol.31
, pp. 181-186
-
-
Choueiri, T.K.1
Vaishampayan, U.2
Rosenberg, J.E.3
-
37
-
-
84891748709
-
The two faces of hippo: Targeting the hippo pathway for regenerative medicine and cancer treatment
-
Johnson R, Halder G. The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov 2014; 13: 63-79.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 63-79
-
-
Johnson, R.1
Halder, G.2
-
38
-
-
84864348569
-
Nrf2 and cancer: The good, the bad and the importance of context
-
Sporn MB, Liby KT. NRF2 and cancer: the good, the bad and the importance of context. Nat Rev Cancer 2012; 12: 564-71.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 564-571
-
-
Sporn, M.B.1
Liby, K.T.2
-
39
-
-
84919489602
-
Targeting abl1-mediated oxidative stress adaptation in fumarate hydratasedeficient cancer
-
Sourbier C, Ricketts CJ, Matsumoto S, et al. Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratasedeficient cancer. Cancer Cell 2014; 26: 840-50.
-
(2014)
Cancer Cell
, vol.26
, pp. 840-850
-
-
Sourbier, C.1
Ricketts, C.J.2
Matsumoto, S.3
|