Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity

Toxicological Sciences

Volumn 141, Issue 1, 2014, Pages 112-119

  Skoko, John J ^a,b   Wakabayashi, Nobunao ^a   Noda, Kentaro ^c   Kimura, Shoko ^a   Tobita, Kimimasa ^a   Shigemura, Norihisa ^c   Tsujita, Tadayuki ^d   Yamamoto, Masayuki ^d   Kensler, Thomas W ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^d TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Acetaminophen toxicity; Intrahepatic shunt; Liver zonation; Nrf2; Portacaval shunt

Indexed keywords

CYTOCHROME P450 2E1; LIVER PROTEIN; OXYGEN; PARACETAMOL; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); TRANSCRIPTION FACTOR NRF2; NFE2L2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; CONGENITAL INTRAHEPATIC SHUNT; CONTROLLED STUDY; DUCTUS VENOSUS; IMMUNOHISTOCHEMISTRY; INFERIOR CAVA VEIN; LIVER DISEASE; LIVER TOXICITY; MOUSE; NONHUMAN; OXYGENATION; PATHOPHYSIOLOGY; PORTAL VEIN; PROTEIN DEPLETION; PROTEIN EXPRESSION; TRANSACTIVATION; ANIMAL; ARTERIOVENOUS MALFORMATION; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; DRUG-INDUCED LIVER INJURY; ENZYMOLOGY; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; KNOCKOUT MOUSE; LIVER; LIVER CIRCULATION; METABOLISM; PATHOLOGY; VASCULARIZATION;

MUS;

ACETAMINOPHEN; ANIMALS; ARTERIOVENOUS MALFORMATIONS; CYTOCHROME P-450 CYP2E1; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; LIVER; LIVER CIRCULATION; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; OXYGEN;

EID: 84913606109     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu109     Document Type: Article

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