-
1
-
-
0034614637
-
The hallmarks of cancer
-
COI: 1:CAS:528:DC%2BD3cXks1CktA%3D%3D, PID: 10647931
-
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1):57–70
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
COI: 1:CAS:528:DC%2BC3MXjsFeqtrk%3D, PID: 21376230
-
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674. doi:10.1016/j.cell.2011.02.013
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
39849102836
-
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
-
COI: 1:CAS:528:DC%2BD1cXjsVKgs74%3D, PID: 18328425
-
Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegue E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G (2008) HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13(3):206–220. doi:10.1016/j.ccr.2008.01.034
-
(2008)
Cancer Cell
, vol.13
, Issue.3
, pp. 206-220
-
-
Du, R.1
Lu, K.V.2
Petritsch, C.3
Liu, P.4
Ganss, R.5
Passegue, E.6
Song, H.7
Vandenberg, S.8
Johnson, R.S.9
Werb, Z.10
Bergers, G.11
-
4
-
-
84925937153
-
Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome
-
COI: 1:CAS:528:DC%2BC2MXksF2htbY%3D, PID: 25774835
-
Dulloo I, Phang BH, Othman R, Tan SY, Vijayaraghavan A, Goh LK, Martin-Lopez M, Marques MM, Li CW, de Wang Y, Marin MC, Xian W, McKeon F, Sabapathy K (2015) Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome. Nat Cell Biol 17(4):511–523. doi:10.1038/ncb3130
-
(2015)
Nat Cell Biol
, vol.17
, Issue.4
, pp. 511-523
-
-
Dulloo, I.1
Phang, B.H.2
Othman, R.3
Tan, S.Y.4
Vijayaraghavan, A.5
Goh, L.K.6
Martin-Lopez, M.7
Marques, M.M.8
Li, C.W.9
de Wang, Y.10
Marin, M.C.11
Xian, W.12
McKeon, F.13
Sabapathy, K.14
-
5
-
-
84975478448
-
Role of stromal cell-derived factor 1alpha pathway in bone metastatic prostate cancer
-
PID: 27533927
-
Gupta N, Duda DG (2016) Role of stromal cell-derived factor 1alpha pathway in bone metastatic prostate cancer. J Biomed Res 30(3):181–185. doi:10.7555/JBR.30.20150114
-
(2016)
J Biomed Res
, vol.30
, Issue.3
, pp. 181-185
-
-
Gupta, N.1
Duda, D.G.2
-
6
-
-
34250724520
-
The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis
-
COI: 1:CAS:528:DC%2BD2sXmvV2gtb0%3D, PID: 17560169
-
Petit I, Jin D, Rafii S (2007) The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. Trends Immunol 28(7):299–307. doi:10.1016/j.it.2007.05.007
-
(2007)
Trends Immunol
, vol.28
, Issue.7
, pp. 299-307
-
-
Petit, I.1
Jin, D.2
Rafii, S.3
-
7
-
-
0030961006
-
Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
COI: 1:CAS:528:DyaK2sXlvFGitLk%3D, PID: 9278421
-
Salceda S, Caro J (1997) Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272(36):22642–22647
-
(1997)
J Biol Chem
, vol.272
, Issue.36
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
8
-
-
34547820876
-
Tumor refractoriness to anti-VEGF treatment is mediated by CD11b + Gr1 + myeloid cells
-
COI: 1:CAS:528:DC%2BD2sXos12ntLk%3D, PID: 17664940
-
Shojaei F, Wu X, Malik AK, Zhong C, Baldwin ME, Schanz S, Fuh G, Gerber HP, Ferrara N (2007) Tumor refractoriness to anti-VEGF treatment is mediated by CD11b + Gr1 + myeloid cells. Nat Biotechnol 25(8):911–920. doi:10.1038/nbt1323
-
(2007)
Nat Biotechnol
, vol.25
, Issue.8
, pp. 911-920
-
-
Shojaei, F.1
Wu, X.2
Malik, A.K.3
Zhong, C.4
Baldwin, M.E.5
Schanz, S.6
Fuh, G.7
Gerber, H.P.8
Ferrara, N.9
-
9
-
-
0015008620
-
Isolation of a tumor factor responsible for angiogenesis
-
COI: 1:STN:280:DyaE38%2Fot1SgsA%3D%3D, PID: 4332371
-
Folkman J, Merler E, Abernathy C, Williams G (1971) Isolation of a tumor factor responsible for angiogenesis. J Exp Med 133(2):275–288
-
(1971)
J Exp Med
, vol.133
, Issue.2
, pp. 275-288
-
-
Folkman, J.1
Merler, E.2
Abernathy, C.3
Williams, G.4
-
10
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
COI: 1:CAS:528:DC%2BD2MXhtlSksrnI, PID: 16355214
-
Ferrara N, Kerbel RS (2005) Angiogenesis as a therapeutic target. Nature 438(7070):967–974. doi:10.1038/nature04483
-
(2005)
Nature
, vol.438
, Issue.7070
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
11
-
-
0028929803
-
Angiogenesis in cancer, vascular, rheumatoid and other disease
-
COI: 1:CAS:528:DyaK2MXjs1KnsLk%3D, PID: 7584949
-
Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1(1):27–31
-
(1995)
Nat Med
, vol.1
, Issue.1
, pp. 27-31
-
-
Folkman, J.1
-
12
-
-
33947732977
-
Angiogenesis: an organizing principle for drug discovery?
-
COI: 1:CAS:528:DC%2BD2sXjs1SisL4%3D, PID: 17396134
-
Folkman J (2007) Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6(4):273–286. doi:10.1038/nrd2115
-
(2007)
Nat Rev Drug Discov
, vol.6
, Issue.4
, pp. 273-286
-
-
Folkman, J.1
-
13
-
-
43249095919
-
Tumor angiogenesis
-
COI: 1:CAS:528:DC%2BD1cXlsFyrtro%3D, PID: 18463380
-
Kerbel RS (2008) Tumor angiogenesis. N Engl J Med 358(19):2039–2049. doi:10.1056/NEJMra0706596
-
(2008)
N Engl J Med
, vol.358
, Issue.19
, pp. 2039-2049
-
-
Kerbel, R.S.1
-
14
-
-
0034000453
-
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
-
COI: 1:CAS:528:DC%2BD3cXhtl2qsLo%3D, PID: 10699287
-
Maeda H, Wu J, Sawa T, Matsumura Y, Hori K (2000) Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 65(1–2):271–284
-
(2000)
J Control Release
, vol.65
, Issue.1-2
, pp. 271-284
-
-
Maeda, H.1
Wu, J.2
Sawa, T.3
Matsumura, Y.4
Hori, K.5
-
15
-
-
84877870613
-
Vascular normalization as an emerging strategy to enhance cancer immunotherapy
-
COI: 1:CAS:528:DC%2BC3sXnsFejs7s%3D, PID: 23440426
-
Huang Y, Goel S, Duda DG, Fukumura D, Jain RK (2013) Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Res 73(10):2943–2948. doi:10.1158/0008-5472.CAN-12-4354
-
(2013)
Cancer Res
, vol.73
, Issue.10
, pp. 2943-2948
-
-
Huang, Y.1
Goel, S.2
Duda, D.G.3
Fukumura, D.4
Jain, R.K.5
-
16
-
-
0036842215
-
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
-
COI: 1:CAS:528:DC%2BD38Xpt1CjtL0%3D, PID: 12409337
-
Dvorak HF (2002) Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 20(21):4368–4380. doi:10.1200/JCO.2002.10.088
-
(2002)
J Clin Oncol
, vol.20
, Issue.21
, pp. 4368-4380
-
-
Dvorak, H.F.1
-
17
-
-
84887425841
-
Hypoxia and inflammation are two sides of the same coin
-
COI: 1:CAS:528:DC%2BC3sXhvVygsLvN, PID: 24187149
-
Bartels K, Grenz A, Eltzschig HK (2013) Hypoxia and inflammation are two sides of the same coin. Proc Natl Acad Sci USA 110(46):18351–18352. doi:10.1073/pnas.1318345110
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.46
, pp. 18351-18352
-
-
Bartels, K.1
Grenz, A.2
Eltzschig, H.K.3
-
18
-
-
84868612850
-
Hypoxia-induced angiogenesis: good and evil
-
PID: 22866203
-
Krock BL, Skuli N, Simon MC (2011) Hypoxia-induced angiogenesis: good and evil. Genes Cancer 2(12):1117–1133. doi:10.1177/1947601911423654
-
(2011)
Genes Cancer
, vol.2
, Issue.12
, pp. 1117-1133
-
-
Krock, B.L.1
Skuli, N.2
Simon, M.C.3
-
19
-
-
0038376002
-
Molecular regulation of vessel maturation
-
COI: 1:CAS:528:DC%2BD3sXktFOnurw%3D, PID: 12778167
-
Jain RK (2003) Molecular regulation of vessel maturation. Nat Med 9(6):685–693. doi:10.1038/nm0603-685
-
(2003)
Nat Med
, vol.9
, Issue.6
, pp. 685-693
-
-
Jain, R.K.1
-
20
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
COI: 1:CAS:528:DyaK28XltVSks7s%3D, PID: 8756718
-
Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86(3):353–364
-
(1996)
Cell
, vol.86
, Issue.3
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
21
-
-
84855912001
-
Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway
-
COI: 1:CAS:528:DC%2BC38Xht1Skurs%3D, PID: 22264789
-
Cooke VG, LeBleu VS, Keskin D, Khan Z, O’Connell JT, Teng Y, Duncan MB, Xie L, Maeda G, Vong S, Sugimoto H, Rocha RM, Damascena A, Brentani RR, Kalluri R (2012) Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway. Cancer Cell 21(1):66–81. doi:10.1016/j.ccr.2011.11.024
-
(2012)
Cancer Cell
, vol.21
, Issue.1
, pp. 66-81
-
-
Cooke, V.G.1
LeBleu, V.S.2
Keskin, D.3
Khan, Z.4
O’Connell, J.T.5
Teng, Y.6
Duncan, M.B.7
Xie, L.8
Maeda, G.9
Vong, S.10
Sugimoto, H.11
Rocha, R.M.12
Damascena, A.13
Brentani, R.R.14
Kalluri, R.15
-
22
-
-
84862907457
-
VEGF-induced vascular permeability is mediated by FAK
-
COI: 1:CAS:528:DC%2BC38XhtFChsLg%3D, PID: 22264731
-
Chen XL, Nam JO, Jean C, Lawson C, Walsh CT, Goka E, Lim ST, Tomar A, Tancioni I, Uryu S, Guan JL, Acevedo LM, Weis SM, Cheresh DA, Schlaepfer DD (2012) VEGF-induced vascular permeability is mediated by FAK. Dev Cell 22(1):146–157. doi:10.1016/j.devcel.2011.11.002
-
(2012)
Dev Cell
, vol.22
, Issue.1
, pp. 146-157
-
-
Chen, X.L.1
Nam, J.O.2
Jean, C.3
Lawson, C.4
Walsh, C.T.5
Goka, E.6
Lim, S.T.7
Tomar, A.8
Tancioni, I.9
Uryu, S.10
Guan, J.L.11
Acevedo, L.M.12
Weis, S.M.13
Cheresh, D.A.14
Schlaepfer, D.D.15
-
23
-
-
0346727319
-
What brings pericytes to tumor vessels?
-
COI: 1:CAS:528:DC%2BD3sXotlWisrc%3D, PID: 14561696
-
Jain RK, Booth MF (2003) What brings pericytes to tumor vessels? J Clin Invest 112(8):1134–1136. doi:10.1172/JCI20087
-
(2003)
J Clin Invest
, vol.112
, Issue.8
, pp. 1134-1136
-
-
Jain, R.K.1
Booth, M.F.2
-
24
-
-
79955580873
-
HCC and angiogenesis: possible targets and future directions
-
COI: 1:CAS:528:DC%2BC3MXltl2qsLk%3D, PID: 21386818
-
Zhu AX, Duda DG, Sahani DV, Jain RK (2011) HCC and angiogenesis: possible targets and future directions. Nat Rev Clin Oncol 8(5):292–301. doi:10.1038/nrclinonc.2011.30
-
(2011)
Nat Rev Clin Oncol
, vol.8
, Issue.5
, pp. 292-301
-
-
Zhu, A.X.1
Duda, D.G.2
Sahani, D.V.3
Jain, R.K.4
-
25
-
-
11844254414
-
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
-
COI: 1:CAS:528:DC%2BD2MXnvFar, PID: 15637262
-
Jain RK (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307(5706):58–62. doi:10.1126/science.1104819
-
(2005)
Science
, vol.307
, Issue.5706
, pp. 58-62
-
-
Jain, R.K.1
-
26
-
-
0034796595
-
Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
-
COI: 1:CAS:528:DC%2BD3MXmvFOmsrc%3D, PID: 11533692
-
Jain RK (2001) Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 7(9):987–989. doi:10.1038/nm0901-987
-
(2001)
Nat Med
, vol.7
, Issue.9
, pp. 987-989
-
-
Jain, R.K.1
-
27
-
-
67650380136
-
Biomarkers of response and resistance to antiangiogenic therapy
-
COI: 1:CAS:528:DC%2BD1MXms12gtb4%3D, PID: 19483739
-
Jain RK, Duda DG, Willett CG, Sahani DV, Zhu AX, Loeffler JS, Batchelor TT, Sorensen AG (2009) Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol 6(6):327–338. doi:10.1038/nrclinonc.2009.63
-
(2009)
Nat Rev Clin Oncol
, vol.6
, Issue.6
, pp. 327-338
-
-
Jain, R.K.1
Duda, D.G.2
Willett, C.G.3
Sahani, D.V.4
Zhu, A.X.5
Loeffler, J.S.6
Batchelor, T.T.7
Sorensen, A.G.8
-
28
-
-
79957534572
-
Targeting hypoxia in cancer therapy
-
COI: 1:CAS:528:DC%2BC3MXmsVGmtbk%3D, PID: 21606941
-
Wilson WR, Hay MP (2011) Targeting hypoxia in cancer therapy. Nat Rev Cancer 11(6):393–410. doi:10.1038/nrc3064
-
(2011)
Nat Rev Cancer
, vol.11
, Issue.6
, pp. 393-410
-
-
Wilson, W.R.1
Hay, M.P.2
-
29
-
-
84876993950
-
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers
-
COI: 1:CAS:528:DC%2BC3sXhtVSntbvK, PID: 23669226
-
Jain RK (2013) Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J Clin Oncol 31(17):2205–2218. doi:10.1200/JCO.2012.46.3653
-
(2013)
J Clin Oncol
, vol.31
, Issue.17
, pp. 2205-2218
-
-
Jain, R.K.1
-
30
-
-
0037208589
-
Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
-
COI: 1:CAS:528:DC%2BD2cXpsVWru7Y%3D, PID: 12506171
-
Kabbinavar F, Hurwitz HI, Fehrenbacher L, Meropol NJ, Novotny WF, Lieberman G, Griffing S, Bergsland E (2003) Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 21(1):60–65. doi:10.1200/JCO.2003.10.066
-
(2003)
J Clin Oncol
, vol.21
, Issue.1
, pp. 60-65
-
-
Kabbinavar, F.1
Hurwitz, H.I.2
Fehrenbacher, L.3
Meropol, N.J.4
Novotny, W.F.5
Lieberman, G.6
Griffing, S.7
Bergsland, E.8
-
31
-
-
84922569615
-
Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer
-
COI: 1:CAS:528:DC%2BC2MXhtFKhsbc%3D, PID: 25605928
-
Heist RS, Duda DG, Sahani DV, Ancukiewicz M, Fidias P, Sequist LV, Temel JS, Shaw AT, Pennell NA, Neal JW, Gandhi L, Lynch TJ, Engelman JA, Jain RK (2015) Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer. Proc Natl Acad Sci USA 112(5):1547–1552. doi:10.1073/pnas.1424024112
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, Issue.5
, pp. 1547-1552
-
-
Heist, R.S.1
Duda, D.G.2
Sahani, D.V.3
Ancukiewicz, M.4
Fidias, P.5
Sequist, L.V.6
Temel, J.S.7
Shaw, A.T.8
Pennell, N.A.9
Neal, J.W.10
Gandhi, L.11
Lynch, T.J.12
Engelman, J.A.13
Jain, R.K.14
-
32
-
-
33846149645
-
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
-
COI: 1:CAS:528:DC%2BD2sXhtFClsLc%3D, PID: 17222792
-
Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK (2007) AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11(1):83–95. doi:10.1016/j.ccr.2006.11.021
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 83-95
-
-
Batchelor, T.T.1
Sorensen, A.G.2
di Tomaso, E.3
Zhang, W.T.4
Duda, D.G.5
Cohen, K.S.6
Kozak, K.R.7
Cahill, D.P.8
Chen, P.J.9
Zhu, M.10
Ancukiewicz, M.11
Mrugala, M.M.12
Plotkin, S.13
Drappatz, J.14
Louis, D.N.15
Ivy, P.16
Scadden, D.T.17
Benner, T.18
Loeffler, J.S.19
Wen, P.Y.20
Jain, R.K.21
more..
-
33
-
-
84947609778
-
Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients
-
COI: 1:CAS:528:DC%2BC2MXhslKlurrP, PID: 26578779
-
Tolaney SM, Boucher Y, Duda DG, Martin JD, Seano G, Ancukiewicz M, Barry WT, Goel S, Lahdenrata J, Isakoff SJ, Yeh ED, Jain SR, Golshan M, Brock J, Snuderl M, Winer EP, Krop IE, Jain RK (2015) Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients. Proc Natl Acad Sci USA 112(46):14325–14330. doi:10.1073/pnas.1518808112
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, Issue.46
, pp. 14325-14330
-
-
Tolaney, S.M.1
Boucher, Y.2
Duda, D.G.3
Martin, J.D.4
Seano, G.5
Ancukiewicz, M.6
Barry, W.T.7
Goel, S.8
Lahdenrata, J.9
Isakoff, S.J.10
Yeh, E.D.11
Jain, S.R.12
Golshan, M.13
Brock, J.14
Snuderl, M.15
Winer, E.P.16
Krop, I.E.17
Jain, R.K.18
-
34
-
-
84883050174
-
Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): primary results of a randomised, phase 3 trial
-
COI: 1:CAS:528:DC%2BC3sXht1GmtLzO, PID: 23932548
-
Cameron D, Brown J, Dent R, Jackisch C, Mackey J, Pivot X, Steger GG, Suter TM, Toi M, Parmar M, Laeufle R, Im YH, Romieu G, Harvey V, Lipatov O, Pienkowski T, Cottu P, Chan A, Im SA, Hall PS, Bubuteishvili-Pacaud L, Henschel V, Deurloo RJ, Pallaud C, Bell R (2013) Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): primary results of a randomised, phase 3 trial. Lancet Oncol 14(10):933–942. doi:10.1016/S1470-2045(13)70335-8
-
(2013)
Lancet Oncol
, vol.14
, Issue.10
, pp. 933-942
-
-
Cameron, D.1
Brown, J.2
Dent, R.3
Jackisch, C.4
Mackey, J.5
Pivot, X.6
Steger, G.G.7
Suter, T.M.8
Toi, M.9
Parmar, M.10
Laeufle, R.11
Im, Y.H.12
Romieu, G.13
Harvey, V.14
Lipatov, O.15
Pienkowski, T.16
Cottu, P.17
Chan, A.18
Im, S.A.19
Hall, P.S.20
Bubuteishvili-Pacaud, L.21
Henschel, V.22
Deurloo, R.J.23
Pallaud, C.24
Bell, R.25
more..
-
35
-
-
0036782278
-
VEGF and the quest for tumour angiogenesis factors
-
COI: 1:CAS:528:DC%2BD38XnsVGrtbk%3D, PID: 12360282
-
Ferrara N (2002) VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2(10):795–803. doi:10.1038/nrc909
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.10
, pp. 795-803
-
-
Ferrara, N.1
-
36
-
-
0037699954
-
The biology of VEGF and its receptors
-
COI: 1:CAS:528:DC%2BD3sXktFOnur4%3D, PID: 12778165
-
Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9(6):669–676. doi:10.1038/nm0603-669
-
(2003)
Nat Med
, vol.9
, Issue.6
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
LeCouter, J.3
-
37
-
-
34347332447
-
Neuropilins in physiological and pathological angiogenesis
-
COI: 1:CAS:528:DC%2BD2sXosVymsrc%3D, PID: 17503412
-
Staton CA, Kumar I, Reed MW, Brown NJ (2007) Neuropilins in physiological and pathological angiogenesis. J Pathol 212(3):237–248. doi:10.1002/path.2182
-
(2007)
J Pathol
, vol.212
, Issue.3
, pp. 237-248
-
-
Staton, C.A.1
Kumar, I.2
Reed, M.W.3
Brown, N.J.4
-
38
-
-
0036344496
-
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
-
COI: 1:CAS:528:DC%2BD38Xls12mtrg%3D, PID: 12091880
-
Hattori K, Heissig B, Wu Y, Dias S, Tejada R, Ferris B, Hicklin DJ, Zhu Z, Bohlen P, Witte L, Hendrikx J, Hackett NR, Crystal RG, Moore MA, Werb Z, Lyden D, Rafii S (2002) Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med 8(8):841–849. doi:10.1038/nm740
-
(2002)
Nat Med
, vol.8
, Issue.8
, pp. 841-849
-
-
Hattori, K.1
Heissig, B.2
Wu, Y.3
Dias, S.4
Tejada, R.5
Ferris, B.6
Hicklin, D.J.7
Zhu, Z.8
Bohlen, P.9
Witte, L.10
Hendrikx, J.11
Hackett, N.R.12
Crystal, R.G.13
Moore, M.A.14
Werb, Z.15
Lyden, D.16
Rafii, S.17
-
39
-
-
84874760414
-
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma
-
COI: 1:CAS:528:DC%2BC3sXjsFeqsr0%3D, PID: 23452854
-
Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK (2013) Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell 152(5):1065–1076. doi:10.1016/j.cell.2013.01.036
-
(2013)
Cell
, vol.152
, Issue.5
, pp. 1065-1076
-
-
Snuderl, M.1
Batista, A.2
Kirkpatrick, N.D.3
Ruiz de Almodovar, C.4
Riedemann, L.5
Walsh, E.C.6
Anolik, R.7
Huang, Y.8
Martin, J.D.9
Kamoun, W.10
Knevels, E.11
Schmidt, T.12
Farrar, C.T.13
Vakoc, B.J.14
Mohan, N.15
Chung, E.16
Roberge, S.17
Peterson, T.18
Bais, C.19
Zhelyazkova, B.H.20
Yip, S.21
Hasselblatt, M.22
Rossig, C.23
Niemeyer, E.24
Ferrara, N.25
Klagsbrun, M.26
Duda, D.G.27
Fukumura, D.28
Xu, L.29
Carmeliet, P.30
Jain, R.K.31
more..
-
40
-
-
35548934659
-
alphaPlGF: a new kid on the antiangiogenesis block
-
COI: 1:CAS:528:DC%2BD2sXhtlWitr%2FN, PID: 17981110
-
Jain RK, Xu L (2007) alphaPlGF: a new kid on the antiangiogenesis block. Cell 131(3):443–445. doi:10.1016/j.cell.2007.10.023
-
(2007)
Cell
, vol.131
, Issue.3
, pp. 443-445
-
-
Jain, R.K.1
Xu, L.2
-
41
-
-
84911896669
-
Neuropilin regulation of angiogenesis
-
COI: 1:CAS:528:DC%2BC2cXhvFalsb7N, PID: 25399580
-
Lampropoulou A, Ruhrberg C (2014) Neuropilin regulation of angiogenesis. Biochem Soc Trans 42(6):1623–1628. doi:10.1042/BST20140244
-
(2014)
Biochem Soc Trans
, vol.42
, Issue.6
, pp. 1623-1628
-
-
Lampropoulou, A.1
Ruhrberg, C.2
-
42
-
-
77952593669
-
A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use
-
COI: 1:CAS:528:DC%2BC3cXns1yktr4%3D, PID: 19840194
-
Wu FT, Stefanini MO, Mac Gabhann F, Kontos CD, Annex BH, Popel AS (2010) A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use. J Cell Mol Med 14(3):528–552. doi:10.1111/j.1582-4934.2009.00941.x
-
(2010)
J Cell Mol Med
, vol.14
, Issue.3
, pp. 528-552
-
-
Wu, F.T.1
Stefanini, M.O.2
Mac Gabhann, F.3
Kontos, C.D.4
Annex, B.H.5
Popel, A.S.6
-
44
-
-
15144358851
-
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
-
COI: 1:CAS:528:DyaK2sXksVyhu78%3D, PID: 9204896
-
Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (1997) Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277(5322):55–60
-
(1997)
Science
, vol.277
, Issue.5322
, pp. 55-60
-
-
Maisonpierre, P.C.1
Suri, C.2
Jones, P.F.3
Bartunkova, S.4
Wiegand, S.J.5
Radziejewski, C.6
Compton, D.7
McClain, J.8
Aldrich, T.H.9
Papadopoulos, N.10
Daly, T.J.11
Davis, S.12
Sato, T.N.13
Yancopoulos, G.D.14
-
45
-
-
0030480322
-
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
-
COI: 1:CAS:528:DyaK2sXit1GhtQ%3D%3D, PID: 8980224
-
Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN, Yancopoulos GD (1996) Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87(7):1171–1180
-
(1996)
Cell
, vol.87
, Issue.7
, pp. 1171-1180
-
-
Suri, C.1
Jones, P.F.2
Patan, S.3
Bartunkova, S.4
Maisonpierre, P.C.5
Davis, S.6
Sato, T.N.7
Yancopoulos, G.D.8
-
46
-
-
29044432545
-
Differential expression of angiopoietin-1 and angiopoietin-2 may enhance recruitment of bone-marrow-derived endothelial precursor cells into brain tumors
-
COI: 1:CAS:528:DC%2BD28Xks1WltA%3D%3D, PID: 16354539
-
Udani V, Santarelli J, Yung Y, Cheshier S, Andrews A, Kasad Z, Tse V (2005) Differential expression of angiopoietin-1 and angiopoietin-2 may enhance recruitment of bone-marrow-derived endothelial precursor cells into brain tumors. Neurol Res 27(8):801–806. doi:10.1179/016164105X49319
-
(2005)
Neurol Res
, vol.27
, Issue.8
, pp. 801-806
-
-
Udani, V.1
Santarelli, J.2
Yung, Y.3
Cheshier, S.4
Andrews, A.5
Kasad, Z.6
Tse, V.7
-
47
-
-
84883174690
-
Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression
-
COI: 1:CAS:528:DC%2BC3sXhtlGmtbfI, PID: 23899555
-
Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK (2013) Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. J Natl Cancer Inst 105(16):1188–1201. doi:10.1093/jnci/djt164
-
(2013)
J Natl Cancer Inst
, vol.105
, Issue.16
, pp. 1188-1201
-
-
Goel, S.1
Gupta, N.2
Walcott, B.P.3
Snuderl, M.4
Kesler, C.T.5
Kirkpatrick, N.D.6
Heishi, T.7
Huang, Y.8
Martin, J.D.9
Ager, E.10
Samuel, R.11
Wang, S.12
Yazbek, J.13
Vakoc, B.J.14
Peterson, R.T.15
Padera, T.P.16
Duda, D.G.17
Fukumura, D.18
Jain, R.K.19
-
48
-
-
33746467198
-
Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer
-
COI: 1:CAS:528:DC%2BD28Xjs1KisLw%3D, PID: 16525658
-
Gu J, Yamamoto H, Ogawa M, Ngan CY, Danno K, Hemmi H, Kyo N, Takemasa I, Ikeda M, Sekimoto M, Monden M (2006) Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer. Oncol Rep 15(4):779–783
-
(2006)
Oncol Rep
, vol.15
, Issue.4
, pp. 779-783
-
-
Gu, J.1
Yamamoto, H.2
Ogawa, M.3
Ngan, C.Y.4
Danno, K.5
Hemmi, H.6
Kyo, N.7
Takemasa, I.8
Ikeda, M.9
Sekimoto, M.10
Monden, M.11
-
49
-
-
84883269689
-
A role for angiopoietin-2 in organ-specific metastasis
-
COI: 1:CAS:528:DC%2BC3sXhtlKqs73I, PID: 23993444
-
Rigamonti N, De Palma M (2013) A role for angiopoietin-2 in organ-specific metastasis. Cell Rep 4(4):621–623. doi:10.1016/j.celrep.2013.07.034
-
(2013)
Cell Rep
, vol.4
, Issue.4
, pp. 621-623
-
-
Rigamonti, N.1
De Palma, M.2
-
50
-
-
84964402874
-
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
-
COI: 1:CAS:528:DC%2BC28Xltlarur0%3D, PID: 27044098
-
Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, Jung K, Snuderl M, Muzikansky A, Stubenrauch KG, Krieter O, Wakimoto H, Xu L, Munn LL, Duda DG, Fukumura D, Batchelor TT, Jain RK (2016) Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proc Natl Acad Sci USA 113(16):4476–4481. doi:10.1073/pnas.1525360113
-
(2016)
Proc Natl Acad Sci USA
, vol.113
, Issue.16
, pp. 4476-4481
-
-
Kloepper, J.1
Riedemann, L.2
Amoozgar, Z.3
Seano, G.4
Susek, K.5
Yu, V.6
Dalvie, N.7
Amelung, R.L.8
Datta, M.9
Song, J.W.10
Askoxylakis, V.11
Taylor, J.W.12
Lu-Emerson, C.13
Batista, A.14
Kirkpatrick, N.D.15
Jung, K.16
Snuderl, M.17
Muzikansky, A.18
Stubenrauch, K.G.19
Krieter, O.20
Wakimoto, H.21
Xu, L.22
Munn, L.L.23
Duda, D.G.24
Fukumura, D.25
Batchelor, T.T.26
Jain, R.K.27
more..
-
51
-
-
79960096827
-
Normalization of the vasculature for treatment of cancer and other diseases
-
COI: 1:CAS:528:DC%2BC3MXhtFyjurzO, PID: 21742796
-
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK (2011) Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 91(3):1071–1121. doi:10.1152/physrev.00038.2010
-
(2011)
Physiol Rev
, vol.91
, Issue.3
, pp. 1071-1121
-
-
Goel, S.1
Duda, D.G.2
Xu, L.3
Munn, L.L.4
Boucher, Y.5
Fukumura, D.6
Jain, R.K.7
-
52
-
-
64149106522
-
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
-
COI: 1:CAS:528:DC%2BD1MXjsVCqtb4%3D, PID: 19305413
-
Reynolds AR, Hart IR, Watson AR, Welti JC, Silva RG, Robinson SD, Da Violante G, Gourlaouen M, Salih M, Jones MC, Jones DT, Saunders G, Kostourou V, Perron-Sierra F, Norman JC, Tucker GC, Hodivala-Dilke KM (2009) Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med 15(4):392–400. doi:10.1038/nm.1941
-
(2009)
Nat Med
, vol.15
, Issue.4
, pp. 392-400
-
-
Reynolds, A.R.1
Hart, I.R.2
Watson, A.R.3
Welti, J.C.4
Silva, R.G.5
Robinson, S.D.6
Da Violante, G.7
Gourlaouen, M.8
Salih, M.9
Jones, M.C.10
Jones, D.T.11
Saunders, G.12
Kostourou, V.13
Perron-Sierra, F.14
Norman, J.C.15
Tucker, G.C.16
Hodivala-Dilke, K.M.17
-
53
-
-
79956328903
-
Molecular mechanisms and clinical applications of angiogenesis
-
COI: 1:CAS:528:DC%2BC3MXmtlemurg%3D, PID: 21593862
-
Carmeliet P, Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473(7347):298–307. doi:10.1038/nature10144
-
(2011)
Nature
, vol.473
, Issue.7347
, pp. 298-307
-
-
Carmeliet, P.1
Jain, R.K.2
-
54
-
-
33847635620
-
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting
-
COI: 1:CAS:528:DC%2BD2sXjtVCntr8%3D, PID: 17296940
-
Lobov IB, Renard RA, Papadopoulos N, Gale NW, Thurston G, Yancopoulos GD, Wiegand SJ (2007) Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci USA 104(9):3219–3224. doi:10.1073/pnas.0611206104
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.9
, pp. 3219-3224
-
-
Lobov, I.B.1
Renard, R.A.2
Papadopoulos, N.3
Gale, N.W.4
Thurston, G.5
Yancopoulos, G.D.6
Wiegand, S.J.7
-
55
-
-
33847046849
-
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
-
PID: 17259973
-
Hellstrom M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, Alva J, Nilsson AK, Karlsson L, Gaiano N, Yoon K, Rossant J, Iruela-Arispe ML, Kalen M, Gerhardt H, Betsholtz C (2007) Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445(7129):776–780. doi:10.1038/nature05571
-
(2007)
Nature
, vol.445
, Issue.7129
, pp. 776-780
-
-
Hellstrom, M.1
Phng, L.K.2
Hofmann, J.J.3
Wallgard, E.4
Coultas, L.5
Lindblom, P.6
Alva, J.7
Nilsson, A.K.8
Karlsson, L.9
Gaiano, N.10
Yoon, K.11
Rossant, J.12
Iruela-Arispe, M.L.13
Kalen, M.14
Gerhardt, H.15
Betsholtz, C.16
-
56
-
-
79952756887
-
Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation
-
COI: 1:CAS:528:DC%2BC3MXivFOns7k%3D, PID: 21321210
-
Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK (2011) Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation. Proc Natl Acad Sci USA 108(9):3725–3730. doi:10.1073/pnas.1100446108
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.9
, pp. 3725-3730
-
-
Hiratsuka, S.1
Goel, S.2
Kamoun, W.S.3
Maru, Y.4
Fukumura, D.5
Duda, D.G.6
Jain, R.K.7
-
57
-
-
0036544562
-
Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling
-
COI: 1:CAS:528:DC%2BD38Xis1Knsbw%3D, PID: 11927607
-
Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA (2002) Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol 157(1):149–160. doi:10.1083/jcb.200109079
-
(2002)
J Cell Biol
, vol.157
, Issue.1
, pp. 149-160
-
-
Eliceiri, B.P.1
Puente, X.S.2
Hood, J.D.3
Stupack, D.G.4
Schlaepfer, D.D.5
Huang, X.Z.6
Sheppard, D.7
Cheresh, D.A.8
-
58
-
-
34250026140
-
Structural basis for the autoinhibition of focal adhesion kinase
-
COI: 1:CAS:528:DC%2BD2sXntVOnt7g%3D, PID: 17574028
-
Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ (2007) Structural basis for the autoinhibition of focal adhesion kinase. Cell 129(6):1177–1187. doi:10.1016/j.cell.2007.05.041
-
(2007)
Cell
, vol.129
, Issue.6
, pp. 1177-1187
-
-
Lietha, D.1
Cai, X.2
Ceccarelli, D.F.3
Li, Y.4
Schaller, M.D.5
Eck, M.J.6
-
59
-
-
78549246804
-
Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics
-
COI: 1:CAS:528:DC%2BC3cXhsVWmsLnI, PID: 21045155
-
Canel M, Serrels A, Miller D, Timpson P, Serrels B, Frame MC, Brunton VG (2010) Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res 70(22):9413–9422. doi:10.1158/0008-5472.CAN-10-1454
-
(2010)
Cancer Res
, vol.70
, Issue.22
, pp. 9413-9422
-
-
Canel, M.1
Serrels, A.2
Miller, D.3
Timpson, P.4
Serrels, B.5
Frame, M.C.6
Brunton, V.G.7
-
60
-
-
0030004485
-
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
-
COI: 1:CAS:528:DyaK28XitVKqtLk%3D, PID: 8602242
-
Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O’Shea KS, Powell-Braxton L, Hillan KJ, Moore MW (1996) Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380(6573):439–442. doi:10.1038/380439a0
-
(1996)
Nature
, vol.380
, Issue.6573
, pp. 439-442
-
-
Ferrara, N.1
Carver-Moore, K.2
Chen, H.3
Dowd, M.4
Lu, L.5
O’Shea, K.S.6
Powell-Braxton, L.7
Hillan, K.J.8
Moore, M.W.9
-
61
-
-
84885458908
-
The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer
-
COI: 1:CAS:528:DC%2BC3sXhs1Kiu7%2FM, PID: 24143206
-
Lieu CH, Tran H, Jiang ZQ, Mao M, Overman MJ, Lin E, Eng C, Morris J, Ellis L, Heymach JV, Kopetz S (2013) The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer. PLoS ONE 8(10):e77117. doi:10.1371/journal.pone.0077117
-
(2013)
PLoS ONE
, vol.8
, Issue.10
-
-
Lieu, C.H.1
Tran, H.2
Jiang, Z.Q.3
Mao, M.4
Overman, M.J.5
Lin, E.6
Eng, C.7
Morris, J.8
Ellis, L.9
Heymach, J.V.10
Kopetz, S.11
-
62
-
-
20544455330
-
Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy
-
COI: 1:CAS:528:DC%2BD2MXlsVChtLs%3D, PID: 15961063
-
Ferrara N, Hillan KJ, Novotny W (2005) Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem Biophys Res Commun 333(2):328–335. doi:10.1016/j.bbrc.2005.05.132
-
(2005)
Biochem Biophys Res Commun
, vol.333
, Issue.2
, pp. 328-335
-
-
Ferrara, N.1
Hillan, K.J.2
Novotny, W.3
-
63
-
-
67649921334
-
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study
-
COI: 1:CAS:528:DC%2BD1MXoslyisLY%3D, PID: 19470921
-
Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, Lahdenranta J, Chung DC, Fischman AJ, Lauwers GY, Shellito P, Czito BG, Wong TZ, Paulson E, Poleski M, Vujaskovic Z, Bentley R, Chen HX, Clark JW, Jain RK (2009) Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol 27(18):3020–3026. doi:10.1200/JCO.2008.21.1771
-
(2009)
J Clin Oncol
, vol.27
, Issue.18
, pp. 3020-3026
-
-
Willett, C.G.1
Duda, D.G.2
di Tomaso, E.3
Boucher, Y.4
Ancukiewicz, M.5
Sahani, D.V.6
Lahdenranta, J.7
Chung, D.C.8
Fischman, A.J.9
Lauwers, G.Y.10
Shellito, P.11
Czito, B.G.12
Wong, T.Z.13
Paulson, E.14
Poleski, M.15
Vujaskovic, Z.16
Bentley, R.17
Chen, H.X.18
Clark, J.W.19
Jain, R.K.20
more..
-
64
-
-
20044364346
-
Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
-
COI: 1:CAS:528:DC%2BD2MXitVKitrk%3D, PID: 15681523
-
Miller KD, Chap LI, Holmes FA, Cobleigh MA, Marcom PK, Fehrenbacher L, Dickler M, Overmoyer BA, Reimann JD, Sing AP, Langmuir V, Rugo HS (2005) Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 23(4):792–799. doi:10.1200/JCO.2005.05.098
-
(2005)
J Clin Oncol
, vol.23
, Issue.4
, pp. 792-799
-
-
Miller, K.D.1
Chap, L.I.2
Holmes, F.A.3
Cobleigh, M.A.4
Marcom, P.K.5
Fehrenbacher, L.6
Dickler, M.7
Overmoyer, B.A.8
Reimann, J.D.9
Sing, A.P.10
Langmuir, V.11
Rugo, H.S.12
-
65
-
-
84870244259
-
Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial
-
PID: 23168362
-
de Gramont A, Van Cutsem E, Schmoll HJ, Tabernero J, Clarke S, Moore MJ, Cunningham D, Cartwright TH, Hecht JR, Rivera F, Im SA, Bodoky G, Salazar R, Maindrault-Goebel F, Shacham-Shmueli E, Bajetta E, Makrutzki M, Shang A, Andre T, Hoff PM (2012) Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial. Lancet Oncol 13(12):1225–1233. doi:10.1016/S1470-2045(12)70509-0
-
(2012)
Lancet Oncol
, vol.13
, Issue.12
, pp. 1225-1233
-
-
de Gramont, A.1
Van Cutsem, E.2
Schmoll, H.J.3
Tabernero, J.4
Clarke, S.5
Moore, M.J.6
Cunningham, D.7
Cartwright, T.H.8
Hecht, J.R.9
Rivera, F.10
Im, S.A.11
Bodoky, G.12
Salazar, R.13
Maindrault-Goebel, F.14
Shacham-Shmueli, E.15
Bajetta, E.16
Makrutzki, M.17
Shang, A.18
Andre, T.19
Hoff, P.M.20
more..
-
66
-
-
84861736119
-
OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer
-
COI: 1:CAS:528:DC%2BC38XhtVynsbvO, PID: 22529265
-
Aghajanian C, Blank SV, Goff BA, Judson PL, Teneriello MG, Husain A, Sovak MA, Yi J, Nycum LR (2012) OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol 30(17):2039–2045. doi:10.1200/JCO.2012.42.0505
-
(2012)
J Clin Oncol
, vol.30
, Issue.17
, pp. 2039-2045
-
-
Aghajanian, C.1
Blank, S.V.2
Goff, B.A.3
Judson, P.L.4
Teneriello, M.G.5
Husain, A.6
Sovak, M.A.7
Yi, J.8
Nycum, L.R.9
-
67
-
-
84855425106
-
Incorporation of bevacizumab in the primary treatment of ovarian cancer
-
COI: 1:CAS:528:DC%2BC38XktVWhsg%3D%3D, PID: 22204724
-
Burger RA, Brady MF, Bookman MA, Fleming GF, Monk BJ, Huang H, Mannel RS, Homesley HD, Fowler J, Greer BE, Boente M, Birrer MJ, Liang SX, Gynecologic Oncology G (2011) Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med 365(26):2473–2483. doi:10.1056/NEJMoa1104390
-
(2011)
N Engl J Med
, vol.365
, Issue.26
, pp. 2473-2483
-
-
Burger, R.A.1
Brady, M.F.2
Bookman, M.A.3
Fleming, G.F.4
Monk, B.J.5
Huang, H.6
Mannel, R.S.7
Homesley, H.D.8
Fowler, J.9
Greer, B.E.10
Boente, M.11
Birrer, M.J.12
Liang, S.X.13
Gynecologic Oncology, G.14
-
68
-
-
34248173883
-
Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200
-
COI: 1:CAS:528:DC%2BD2sXlsVyntbc%3D, PID: 17442997
-
Giantonio BJ, Catalano PJ, Meropol NJ, O’Dwyer PJ, Mitchell EP, Alberts SR, Schwartz MA, Benson AB, 3rd, Eastern Cooperative Oncology Group Study E (2007) Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 25(12):1539–1544. doi:10.1200/JCO.2006.09.6305
-
(2007)
J Clin Oncol
, vol.25
, Issue.12
, pp. 1539-1544
-
-
Giantonio, B.J.1
Catalano, P.J.2
Meropol, N.J.3
O’Dwyer, P.J.4
Mitchell, E.P.5
Alberts, S.R.6
Schwartz, M.A.7
Benson, A.B.8
-
69
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
COI: 1:CAS:528:DC%2BD2cXks1Gjt74%3D, PID: 15175435
-
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, Ferrara N, Fyfe G, Rogers B, Ross R, Kabbinavar F (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350(23):2335–2342. doi:10.1056/NEJMoa032691
-
(2004)
N Engl J Med
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
Berlin, J.7
Baron, A.8
Griffing, S.9
Holmgren, E.10
Ferrara, N.11
Fyfe, G.12
Rogers, B.13
Ross, R.14
Kabbinavar, F.15
-
70
-
-
84855466019
-
A phase 3 trial of bevacizumab in ovarian cancer
-
COI: 1:CAS:528:DC%2BC38XktVWltA%3D%3D, PID: 22204725
-
Perren TJ, Swart AM, Pfisterer J, Ledermann JA, Pujade-Lauraine E, Kristensen G, Carey MS, Beale P, Cervantes A, Kurzeder C, du Bois A, Sehouli J, Kimmig R, Stahle A, Collinson F, Essapen S, Gourley C, Lortholary A, Selle F, Mirza MR, Leminen A, Plante M, Stark D, Qian W, Parmar MK, Oza AM, Investigators I (2011) A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med 365(26):2484–2496. doi:10.1056/NEJMoa1103799
-
(2011)
N Engl J Med
, vol.365
, Issue.26
, pp. 2484-2496
-
-
Perren, T.J.1
Swart, A.M.2
Pfisterer, J.3
Ledermann, J.A.4
Pujade-Lauraine, E.5
Kristensen, G.6
Carey, M.S.7
Beale, P.8
Cervantes, A.9
Kurzeder, C.10
du Bois, A.11
Sehouli, J.12
Kimmig, R.13
Stahle, A.14
Collinson, F.15
Essapen, S.16
Gourley, C.17
Lortholary, A.18
Selle, F.19
Mirza, M.R.20
Leminen, A.21
Plante, M.22
Stark, D.23
Qian, W.24
Parmar, M.K.25
Oza, A.M.26
Investigators, I.27
more..
-
71
-
-
84899837376
-
Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: the AURELIA open-label randomized phase III trial
-
COI: 1:CAS:528:DC%2BC2cXhtVCqsbjE, PID: 24637997
-
Pujade-Lauraine E, Hilpert F, Weber B, Reuss A, Poveda A, Kristensen G, Sorio R, Vergote I, Witteveen P, Bamias A, Pereira D, Wimberger P, Oaknin A, Mirza MR, Follana P, Bollag D, Ray-Coquard I (2014) Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: the AURELIA open-label randomized phase III trial. J Clin Oncol 32(13):1302–1308. doi:10.1200/JCO.2013.51.4489
-
(2014)
J Clin Oncol
, vol.32
, Issue.13
, pp. 1302-1308
-
-
Pujade-Lauraine, E.1
Hilpert, F.2
Weber, B.3
Reuss, A.4
Poveda, A.5
Kristensen, G.6
Sorio, R.7
Vergote, I.8
Witteveen, P.9
Bamias, A.10
Pereira, D.11
Wimberger, P.12
Oaknin, A.13
Mirza, M.R.14
Follana, P.15
Bollag, D.16
Ray-Coquard, I.17
-
72
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study
-
COI: 1:CAS:528:DC%2BD1cXlvFaqs7g%3D, PID: 18421054
-
Saltz LB, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R, Koski S, Lichinitser M, Yang TS, Rivera F, Couture F, Sirzen F, Cassidy J (2008) Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 26(12):2013–2019. doi:10.1200/JCO.2007.14.9930
-
(2008)
J Clin Oncol
, vol.26
, Issue.12
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
Scheithauer, W.4
Figer, A.5
Wong, R.6
Koski, S.7
Lichinitser, M.8
Yang, T.S.9
Rivera, F.10
Couture, F.11
Sirzen, F.12
Cassidy, J.13
-
73
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BD28XhtlWqsbzI, PID: 17167137
-
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R, Johnson DH (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355(24):2542–2550. doi:10.1056/NEJMoa061884
-
(2006)
N Engl J Med
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
74
-
-
84894207820
-
Improved survival with bevacizumab in advanced cervical cancer
-
COI: 1:CAS:528:DC%2BC2cXjt1alu7k%3D, PID: 24552320
-
Tewari KS, Sill MW, Long HJ 3rd, Penson RT, Huang H, Ramondetta LM, Landrum LM, Oaknin A, Reid TJ, Leitao MM, Michael HE, Monk BJ (2014) Improved survival with bevacizumab in advanced cervical cancer. N Engl J Med 370(8):734–743. doi:10.1056/NEJMoa1309748
-
(2014)
N Engl J Med
, vol.370
, Issue.8
, pp. 734-743
-
-
Tewari, K.S.1
Sill, M.W.2
Long, H.J.3
Penson, R.T.4
Huang, H.5
Ramondetta, L.M.6
Landrum, L.M.7
Oaknin, A.8
Reid, T.J.9
Leitao, M.M.10
Michael, H.E.11
Monk, B.J.12
-
75
-
-
84951085442
-
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial
-
COI: 1:CAS:528:DC%2BC2MXitVyqsLzM, PID: 26719230
-
Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Riviere F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A, French Cooperative Thoracic I (2016) Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial. Lancet 387(10026):1405–1414. doi:10.1016/S0140-6736(15)01238-6
-
(2016)
Lancet
, vol.387
, Issue.10026
, pp. 1405-1414
-
-
Zalcman, G.1
Mazieres, J.2
Margery, J.3
Greillier, L.4
Audigier-Valette, C.5
Moro-Sibilot, D.6
Molinier, O.7
Corre, R.8
Monnet, I.9
Gounant, V.10
Riviere, F.11
Janicot, H.12
Gervais, R.13
Locher, C.14
Milleron, B.15
Tran, Q.16
Lebitasy, M.P.17
Morin, F.18
Creveuil, C.19
Parienti, J.J.20
Scherpereel, A.21
more..
-
76
-
-
84899630091
-
Randomized phase III trial of temsirolimus and bevacizumab versus interferon alfa and bevacizumab in metastatic renal cell carcinoma: INTORACT trial
-
COI: 1:CAS:528:DC%2BC2cXnsl2iur4%3D, PID: 24297945
-
Rini BI, Bellmunt J, Clancy J, Wang K, Niethammer AG, Hariharan S, Escudier B (2014) Randomized phase III trial of temsirolimus and bevacizumab versus interferon alfa and bevacizumab in metastatic renal cell carcinoma: INTORACT trial. J Clin Oncol 32(8):752–759. doi:10.1200/JCO.2013.50.5305
-
(2014)
J Clin Oncol
, vol.32
, Issue.8
, pp. 752-759
-
-
Rini, B.I.1
Bellmunt, J.2
Clancy, J.3
Wang, K.4
Niethammer, A.G.5
Hariharan, S.6
Escudier, B.7
-
77
-
-
84899976063
-
Adjuvant bevacizumab in patients with melanoma at high risk of recurrence (AVAST-M): preplanned interim results from a multicentre, open-label, randomised controlled phase 3 study
-
COI: 1:CAS:528:DC%2BC2cXmtlCqsrY%3D, PID: 24745696
-
Corrie PG, Marshall A, Dunn JA, Middleton MR, Nathan PD, Gore M, Davidson N, Nicholson S, Kelly CG, Marples M, Danson SJ, Marshall E, Houston SJ, Board RE, Waterston AM, Nobes JP, Harries M, Kumar S, Young G, Lorigan P (2014) Adjuvant bevacizumab in patients with melanoma at high risk of recurrence (AVAST-M): preplanned interim results from a multicentre, open-label, randomised controlled phase 3 study. Lancet Oncol 15(6):620–630. doi:10.1016/S1470-2045(14)70110-X
-
(2014)
Lancet Oncol
, vol.15
, Issue.6
, pp. 620-630
-
-
Corrie, P.G.1
Marshall, A.2
Dunn, J.A.3
Middleton, M.R.4
Nathan, P.D.5
Gore, M.6
Davidson, N.7
Nicholson, S.8
Kelly, C.G.9
Marples, M.10
Danson, S.J.11
Marshall, E.12
Houston, S.J.13
Board, R.E.14
Waterston, A.M.15
Nobes, J.P.16
Harries, M.17
Kumar, S.18
Young, G.19
Lorigan, P.20
more..
-
78
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
COI: 1:CAS:528:DC%2BD2MXhtFOrtLrF, PID: 16226705
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D (2005) Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8(4):299–309. doi:10.1016/j.ccr.2005.09.005
-
(2005)
Cancer Cell
, vol.8
, Issue.4
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
79
-
-
84989159343
-
Antiangiogenic therapy in oncology: current status and future directions
-
COI: 1:CAS:528:DC%2BC28Xit12rur0%3D, PID: 26853587
-
Jayson GC, Kerbel R, Ellis LM, Harris AL (2016) Antiangiogenic therapy in oncology: current status and future directions. Lancet 388(10043):518–529. doi:10.1016/S0140-6736(15)01088-0
-
(2016)
Lancet
, vol.388
, Issue.10043
, pp. 518-529
-
-
Jayson, G.C.1
Kerbel, R.2
Ellis, L.M.3
Harris, A.L.4
-
80
-
-
84867047384
-
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
-
PID: 22949147
-
Van Cutsem E, Tabernero J, Lakomy R, Prenen H, Prausova J, Macarulla T, Ruff P, van Hazel GA, Moiseyenko V, Ferry D, McKendrick J, Polikoff J, Tellier A, Castan R, Allegra C (2012) Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 30(28):3499–3506. doi:10.1200/JCO.2012.42.8201
-
(2012)
J Clin Oncol
, vol.30
, Issue.28
, pp. 3499-3506
-
-
Van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
Prenen, H.4
Prausova, J.5
Macarulla, T.6
Ruff, P.7
van Hazel, G.A.8
Moiseyenko, V.9
Ferry, D.10
McKendrick, J.11
Polikoff, J.12
Tellier, A.13
Castan, R.14
Allegra, C.15
-
81
-
-
82755183572
-
Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial
-
COI: 1:CAS:528:DC%2BC3MXhsFGqsL%2FP, PID: 22056247
-
Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, Michaelson MD, Gorbunova VA, Gore ME, Rusakov IG, Negrier S, Ou YC, Castellano D, Lim HY, Uemura H, Tarazi J, Cella D, Chen C, Rosbrook B, Kim S, Motzer RJ (2011) Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 378(9807):1931–1939. doi:10.1016/S0140-6736(11)61613-9
-
(2011)
Lancet
, vol.378
, Issue.9807
, pp. 1931-1939
-
-
Rini, B.I.1
Escudier, B.2
Tomczak, P.3
Kaprin, A.4
Szczylik, C.5
Hutson, T.E.6
Michaelson, M.D.7
Gorbunova, V.A.8
Gore, M.E.9
Rusakov, I.G.10
Negrier, S.11
Ou, Y.C.12
Castellano, D.13
Lim, H.Y.14
Uemura, H.15
Tarazi, J.16
Cella, D.17
Chen, C.18
Rosbrook, B.19
Kim, S.20
Motzer, R.J.21
more..
-
82
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
-
COI: 1:CAS:528:DC%2BD1cXhsFChtbnM, PID: 19095497
-
Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, Xu J, Sun Y, Liang H, Liu J, Wang J, Tak WY, Pan H, Burock K, Zou J, Voliotis D, Guan Z (2009) Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 10(1):25–34. doi:10.1016/S1470-2045(08)70285-7
-
(2009)
Lancet Oncol
, vol.10
, Issue.1
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
Tsao, C.J.4
Qin, S.5
Kim, J.S.6
Luo, R.7
Feng, J.8
Ye, S.9
Yang, T.S.10
Xu, J.11
Sun, Y.12
Liang, H.13
Liu, J.14
Wang, J.15
Tak, W.Y.16
Pan, H.17
Burock, K.18
Zou, J.19
Voliotis, D.20
Guan, Z.21
more..
-
83
-
-
84904855170
-
Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial
-
COI: 1:CAS:528:DC%2BC2cXnt1ehtrk%3D, PID: 24768112
-
Brose MS, Nutting CM, Jarzab B, Elisei R, Siena S, Bastholt L, de la Fouchardiere C, Pacini F, Paschke R, Shong YK, Sherman SI, Smit JW, Chung J, Kappeler C, Pena C, Molnar I, Schlumberger MJ, investigators D (2014) Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial. Lancet 384(9940):319–328. doi:10.1016/S0140-6736(14)60421-9
-
(2014)
Lancet
, vol.384
, Issue.9940
, pp. 319-328
-
-
Brose, M.S.1
Nutting, C.M.2
Jarzab, B.3
Elisei, R.4
Siena, S.5
Bastholt, L.6
de la Fouchardiere, C.7
Pacini, F.8
Paschke, R.9
Shong, Y.K.10
Sherman, S.I.11
Smit, J.W.12
Chung, J.13
Kappeler, C.14
Pena, C.15
Molnar, I.16
Schlumberger, M.J.17
investigators, D.18
-
84
-
-
84872892692
-
Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial
-
COI: 1:CAS:528:DC%2BC38XhslarsLvL, PID: 23177515
-
Demetri GD, Reichardt P, Kang YK, Blay JY, Rutkowski P, Gelderblom H, Hohenberger P, Leahy M, von Mehren M, Joensuu H, Badalamenti G, Blackstein M, Le Cesne A, Schoffski P, Maki RG, Bauer S, Nguyen BB, Xu J, Nishida T, Chung J, Kappeler C, Kuss I, Laurent D, Casali PG, investigators Gs (2013) Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 381(9863):295–302. doi:10.1016/S0140-6736(12)61857-1
-
(2013)
Lancet
, vol.381
, Issue.9863
, pp. 295-302
-
-
Demetri, G.D.1
Reichardt, P.2
Kang, Y.K.3
Blay, J.Y.4
Rutkowski, P.5
Gelderblom, H.6
Hohenberger, P.7
Leahy, M.8
von Mehren, M.9
Joensuu, H.10
Badalamenti, G.11
Blackstein, M.12
Le Cesne, A.13
Schoffski, P.14
Maki, R.G.15
Bauer, S.16
Nguyen, B.B.17
Xu, J.18
Nishida, T.19
Chung, J.20
Kappeler, C.21
Kuss, I.22
Laurent, D.23
Casali, P.G.24
more..
-
85
-
-
84863698793
-
Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial
-
COI: 1:CAS:528:DC%2BC38Xht1aisbbM, PID: 22614970
-
George S, Wang Q, Heinrich MC, Corless CL, Zhu M, Butrynski JE, Morgan JA, Wagner AJ, Choy E, Tap WD, Yap JT, Van den Abbeele AD, Manola JB, Solomon SM, Fletcher JA, von Mehren M, Demetri GD (2012) Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial. J Clin Oncol 30(19):2401–2407. doi:10.1200/JCO.2011.39.9394
-
(2012)
J Clin Oncol
, vol.30
, Issue.19
, pp. 2401-2407
-
-
George, S.1
Wang, Q.2
Heinrich, M.C.3
Corless, C.L.4
Zhu, M.5
Butrynski, J.E.6
Morgan, J.A.7
Wagner, A.J.8
Choy, E.9
Tap, W.D.10
Yap, J.T.11
Van den Abbeele, A.D.12
Manola, J.B.13
Solomon, S.M.14
Fletcher, J.A.15
von Mehren, M.16
Demetri, G.D.17
-
86
-
-
85007560261
-
Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial
-
COI: 1:CAS:528:DC%2BC28XitVajsrrN, PID: 27932229
-
Bruix J, Qin S, Merle P, Granito A, Huang YH, Bodoky G, Pracht M, Yokosuka O, Rosmorduc O, Breder V, Gerolami R, Masi G, Ross PJ, Song T, Bronowicki JP, Ollivier-Hourmand I, Kudo M, Cheng AL, Llovet JM, Finn RS, LeBerre MA, Baumhauer A, Meinhardt G, Han G, Investigators R (2017) Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 389(10064):56–66. doi:10.1016/S0140-6736(16)32453-9
-
(2017)
Lancet
, vol.389
, Issue.10064
, pp. 56-66
-
-
Bruix, J.1
Qin, S.2
Merle, P.3
Granito, A.4
Huang, Y.H.5
Bodoky, G.6
Pracht, M.7
Yokosuka, O.8
Rosmorduc, O.9
Breder, V.10
Gerolami, R.11
Masi, G.12
Ross, P.J.13
Song, T.14
Bronowicki, J.P.15
Ollivier-Hourmand, I.16
Kudo, M.17
Cheng, A.L.18
Llovet, J.M.19
Finn, R.S.20
LeBerre, M.A.21
Baumhauer, A.22
Meinhardt, G.23
Han, G.24
Investigators, R.25
more..
-
87
-
-
84872921660
-
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
-
COI: 1:CAS:528:DC%2BC38Xhslarsr%2FE, PID: 23177514
-
Grothey A, Van Cutsem E, Sobrero A, Siena S, Falcone A, Ychou M, Humblet Y, Bouche O, Mineur L, Barone C, Adenis A, Tabernero J, Yoshino T, Lenz HJ, Goldberg RM, Sargent DJ, Cihon F, Cupit L, Wagner A, Laurent D, Group CS (2013) Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 381(9863):303–312. doi:10.1016/S0140-6736(12)61900-X
-
(2013)
Lancet
, vol.381
, Issue.9863
, pp. 303-312
-
-
Grothey, A.1
Van Cutsem, E.2
Sobrero, A.3
Siena, S.4
Falcone, A.5
Ychou, M.6
Humblet, Y.7
Bouche, O.8
Mineur, L.9
Barone, C.10
Adenis, A.11
Tabernero, J.12
Yoshino, T.13
Lenz, H.J.14
Goldberg, R.M.15
Sargent, D.J.16
Cihon, F.17
Cupit, L.18
Wagner, A.19
Laurent, D.20
Group, C.S.21
more..
-
88
-
-
84655175698
-
Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial
-
COI: 1:CAS:528:DC%2BC38XisFGrsb0%3D, PID: 22025146
-
Wells SA Jr, Robinson BG, Gagel RF, Dralle H, Fagin JA, Santoro M, Baudin E, Elisei R, Jarzab B, Vasselli JR, Read J, Langmuir P, Ryan AJ, Schlumberger MJ (2012) Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J Clin Oncol 30(2):134–141. doi:10.1200/JCO.2011.35.5040
-
(2012)
J Clin Oncol
, vol.30
, Issue.2
, pp. 134-141
-
-
Wells, S.A.1
Robinson, B.G.2
Gagel, R.F.3
Dralle, H.4
Fagin, J.A.5
Santoro, M.6
Baudin, E.7
Elisei, R.8
Jarzab, B.9
Vasselli, J.R.10
Read, J.11
Langmuir, P.12
Ryan, A.J.13
Schlumberger, M.J.14
-
89
-
-
77957359933
-
Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study
-
COI: 1:CAS:528:DC%2BC3cXht1ertLjO, PID: 20851682
-
Bible KC, Suman VJ, Molina JR, Smallridge RC, Maples WJ, Menefee ME, Rubin J, Sideras K, Morris JC 3rd, McIver B, Burton JK, Webster KP, Bieber C, Traynor AM, Flynn PJ, Goh BC, Tang H, Ivy SP, Erlichman C, Endocrine Malignancies Disease Oriented G, Mayo Clinic Cancer C, Mayo Phase C (2010) Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study. Lancet Oncol 11(10):962–972. doi:10.1016/S1470-2045(10)70203-5
-
(2010)
Lancet Oncol
, vol.11
, Issue.10
, pp. 962-972
-
-
Bible, K.C.1
Suman, V.J.2
Molina, J.R.3
Smallridge, R.C.4
Maples, W.J.5
Menefee, M.E.6
Rubin, J.7
Sideras, K.8
Morris, J.C.9
McIver, B.10
Burton, J.K.11
Webster, K.P.12
Bieber, C.13
Traynor, A.M.14
Flynn, P.J.15
Goh, B.C.16
Tang, H.17
Ivy, S.P.18
Erlichman, C.19
-
90
-
-
84899711381
-
Overall survival in renal-cell carcinoma with pazopanib versus sunitinib
-
COI: 1:CAS:528:DC%2BC2cXotVemtLw%3D, PID: 24785224
-
Motzer RJ, Hutson TE, McCann L, Deen K, Choueiri TK (2014) Overall survival in renal-cell carcinoma with pazopanib versus sunitinib. N Engl J Med 370(18):1769–1770. doi:10.1056/NEJMc1400731
-
(2014)
N Engl J Med
, vol.370
, Issue.18
, pp. 1769-1770
-
-
Motzer, R.J.1
Hutson, T.E.2
McCann, L.3
Deen, K.4
Choueiri, T.K.5
-
91
-
-
84955253186
-
Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial
-
COI: 1:CAS:528:DC%2BC2MXhs1yks7zF, PID: 26482279
-
Motzer RJ, Hutson TE, Glen H, Michaelson MD, Molina A, Eisen T, Jassem J, Zolnierek J, Maroto JP, Mellado B, Melichar B, Tomasek J, Kremer A, Kim HJ, Wood K, Dutcus C, Larkin J (2015) Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial. Lancet Oncol 16(15):1473–1482. doi:10.1016/S1470-2045(15)00290-9
-
(2015)
Lancet Oncol
, vol.16
, Issue.15
, pp. 1473-1482
-
-
Motzer, R.J.1
Hutson, T.E.2
Glen, H.3
Michaelson, M.D.4
Molina, A.5
Eisen, T.6
Jassem, J.7
Zolnierek, J.8
Maroto, J.P.9
Mellado, B.10
Melichar, B.11
Tomasek, J.12
Kremer, A.13
Kim, H.J.14
Wood, K.15
Dutcus, C.16
Larkin, J.17
-
92
-
-
84946552683
-
Cabozantinib versus everolimus in advanced renal-cell carcinoma
-
COI: 1:CAS:528:DC%2BC28XnvFCktLY%3D, PID: 26406150
-
Choueiri TK, Escudier B, Powles T, Mainwaring PN, Rini BI, Donskov F, Hammers H, Hutson TE, Lee JL, Peltola K, Roth BJ, Bjarnason GA, Geczi L, Keam B, Maroto P, Heng DY, Schmidinger M, Kantoff PW, Borgman-Hagey A, Hessel C, Scheffold C, Schwab GM, Tannir NM, Motzer RJ, Investigators M (2015) Cabozantinib versus everolimus in advanced renal-cell carcinoma. N Engl J Med 373(19):1814–1823. doi:10.1056/NEJMoa1510016
-
(2015)
N Engl J Med
, vol.373
, Issue.19
, pp. 1814-1823
-
-
Choueiri, T.K.1
Escudier, B.2
Powles, T.3
Mainwaring, P.N.4
Rini, B.I.5
Donskov, F.6
Hammers, H.7
Hutson, T.E.8
Lee, J.L.9
Peltola, K.10
Roth, B.J.11
Bjarnason, G.A.12
Geczi, L.13
Keam, B.14
Maroto, P.15
Heng, D.Y.16
Schmidinger, M.17
Kantoff, P.W.18
Borgman-Hagey, A.19
Hessel, C.20
Scheffold, C.21
Schwab, G.M.22
Tannir, N.M.23
Motzer, R.J.24
Investigators, M.25
more..
-
93
-
-
84890571003
-
Cabozantinib in progressive medullary thyroid cancer
-
COI: 1:CAS:528:DC%2BC3sXhsl2hsrbI, PID: 24002501
-
Elisei R, Schlumberger MJ, Muller SP, Schoffski P, Brose MS, Shah MH, Licitra L, Jarzab B, Medvedev V, Kreissl MC, Niederle B, Cohen EE, Wirth LJ, Ali H, Hessel C, Yaron Y, Ball D, Nelkin B, Sherman SI (2013) Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol 31(29):3639–3646. doi:10.1200/JCO.2012.48.4659
-
(2013)
J Clin Oncol
, vol.31
, Issue.29
, pp. 3639-3646
-
-
Elisei, R.1
Schlumberger, M.J.2
Muller, S.P.3
Schoffski, P.4
Brose, M.S.5
Shah, M.H.6
Licitra, L.7
Jarzab, B.8
Medvedev, V.9
Kreissl, M.C.10
Niederle, B.11
Cohen, E.E.12
Wirth, L.J.13
Ali, H.14
Hessel, C.15
Yaron, Y.16
Ball, D.17
Nelkin, B.18
Sherman, S.I.19
-
94
-
-
79959936054
-
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer
-
COI: 1:CAS:528:DC%2BC3MXpvFWltbY%3D, PID: 21606412
-
Kurzrock R, Sherman SI, Ball DW, Forastiere AA, Cohen RB, Mehra R, Pfister DG, Cohen EE, Janisch L, Nauling F, Hong DS, Ng CS, Ye L, Gagel RF, Frye J, Muller T, Ratain MJ, Salgia R (2011) Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. J Clin Oncol 29(19):2660–2666. doi:10.1200/JCO.2010.32.4145
-
(2011)
J Clin Oncol
, vol.29
, Issue.19
, pp. 2660-2666
-
-
Kurzrock, R.1
Sherman, S.I.2
Ball, D.W.3
Forastiere, A.A.4
Cohen, R.B.5
Mehra, R.6
Pfister, D.G.7
Cohen, E.E.8
Janisch, L.9
Nauling, F.10
Hong, D.S.11
Ng, C.S.12
Ye, L.13
Gagel, R.F.14
Frye, J.15
Muller, T.16
Ratain, M.J.17
Salgia, R.18
-
95
-
-
84892852372
-
Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial
-
COI: 1:CAS:528:DC%2BC3sXhsFOns77J, PID: 24094768
-
Fuchs CS, Tomasek J, Yong CJ, Dumitru F, Passalacqua R, Goswami C, Safran H, dos Santos LV, Aprile G, Ferry DR, Melichar B, Tehfe M, Topuzov E, Zalcberg JR, Chau I, Campbell W, Sivanandan C, Pikiel J, Koshiji M, Hsu Y, Liepa AM, Gao L, Schwartz JD, Tabernero J, Investigators RT (2014) Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet 383(9911):31–39. doi:10.1016/S0140-6736(13)61719-5
-
(2014)
Lancet
, vol.383
, Issue.9911
, pp. 31-39
-
-
Fuchs, C.S.1
Tomasek, J.2
Yong, C.J.3
Dumitru, F.4
Passalacqua, R.5
Goswami, C.6
Safran, H.7
dos Santos, L.V.8
Aprile, G.9
Ferry, D.R.10
Melichar, B.11
Tehfe, M.12
Topuzov, E.13
Zalcberg, J.R.14
Chau, I.15
Campbell, W.16
Sivanandan, C.17
Pikiel, J.18
Koshiji, M.19
Hsu, Y.20
Liepa, A.M.21
Gao, L.22
Schwartz, J.D.23
Tabernero, J.24
Investigators, R.T.25
more..
-
96
-
-
84906903314
-
Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial
-
COI: 1:CAS:528:DC%2BC2cXpslCntrc%3D, PID: 24933332
-
Garon EB, Ciuleanu TE, Arrieta O, Prabhash K, Syrigos KN, Goksel T, Park K, Gorbunova V, Kowalyszyn RD, Pikiel J, Czyzewicz G, Orlov SV, Lewanski CR, Thomas M, Bidoli P, Dakhil S, Gans S, Kim JH, Grigorescu A, Karaseva N, Reck M, Cappuzzo F, Alexandris E, Sashegyi A, Yurasov S, Perol M (2014) Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial. Lancet 384(9944):665–673. doi:10.1016/S0140-6736(14)60845-X
-
(2014)
Lancet
, vol.384
, Issue.9944
, pp. 665-673
-
-
Garon, E.B.1
Ciuleanu, T.E.2
Arrieta, O.3
Prabhash, K.4
Syrigos, K.N.5
Goksel, T.6
Park, K.7
Gorbunova, V.8
Kowalyszyn, R.D.9
Pikiel, J.10
Czyzewicz, G.11
Orlov, S.V.12
Lewanski, C.R.13
Thomas, M.14
Bidoli, P.15
Dakhil, S.16
Gans, S.17
Kim, J.H.18
Grigorescu, A.19
Karaseva, N.20
Reck, M.21
Cappuzzo, F.22
Alexandris, E.23
Sashegyi, A.24
Yurasov, S.25
Perol, M.26
more..
-
97
-
-
84908139963
-
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial
-
COI: 1:CAS:528:DC%2BC2cXhs1SqurvJ, PID: 25240821
-
Wilke H, Muro K, Van Cutsem E, Oh SC, Bodoky G, Shimada Y, Hironaka S, Sugimoto N, Lipatov O, Kim TY, Cunningham D, Rougier P, Komatsu Y, Ajani J, Emig M, Carlesi R, Ferry D, Chandrawansa K, Schwartz JD, Ohtsu A, Group RS (2014) Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial. Lancet Oncol 15(11):1224–1235. doi:10.1016/S1470-2045(14)70420-6
-
(2014)
Lancet Oncol
, vol.15
, Issue.11
, pp. 1224-1235
-
-
Wilke, H.1
Muro, K.2
Van Cutsem, E.3
Oh, S.C.4
Bodoky, G.5
Shimada, Y.6
Hironaka, S.7
Sugimoto, N.8
Lipatov, O.9
Kim, T.Y.10
Cunningham, D.11
Rougier, P.12
Komatsu, Y.13
Ajani, J.14
Emig, M.15
Carlesi, R.16
Ferry, D.17
Chandrawansa, K.18
Schwartz, J.D.19
Ohtsu, A.20
Group, R.S.21
more..
-
98
-
-
84961266836
-
Cediranib in patients with relapsed platinum-sensitive ovarian cancer (ICON6): a randomised, double-blind, placebo-controlled phase 3 trial
-
COI: 1:CAS:528:DC%2BC28XktFKmsb0%3D, PID: 27025186
-
Ledermann JA, Embleton AC, Raja F, Perren TJ, Jayson GC, Rustin GJ, Kaye SB, Hirte H, Eisenhauer E, Vaughan M, Friedlander M, Gonzalez-Martin A, Stark D, Clark E, Farrelly L, Swart AM, Cook A, Kaplan RS, Parmar MK, collaborators I (2016) Cediranib in patients with relapsed platinum-sensitive ovarian cancer (ICON6): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 387(10023):1066–1074. doi:10.1016/S0140-6736(15)01167-8
-
(2016)
Lancet
, vol.387
, Issue.10023
, pp. 1066-1074
-
-
Ledermann, J.A.1
Embleton, A.C.2
Raja, F.3
Perren, T.J.4
Jayson, G.C.5
Rustin, G.J.6
Kaye, S.B.7
Hirte, H.8
Eisenhauer, E.9
Vaughan, M.10
Friedlander, M.11
Gonzalez-Martin, A.12
Stark, D.13
Clark, E.14
Farrelly, L.15
Swart, A.M.16
Cook, A.17
Kaplan, R.S.18
Parmar, M.K.19
collaborators, I.20
more..
-
99
-
-
84867115561
-
Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: a double-blind, randomized phase III study (HORIZON III)
-
COI: 1:CAS:528:DC%2BC38XhslSkur3P, PID: 22965961
-
Schmoll HJ, Cunningham D, Sobrero A, Karapetis CS, Rougier P, Koski SL, Kocakova I, Bondarenko I, Bodoky G, Mainwaring P, Salazar R, Barker P, Mookerjee B, Robertson J, Van Cutsem E (2012) Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: a double-blind, randomized phase III study (HORIZON III). J Clin Oncol 30(29):3588–3595. doi:10.1200/JCO.2012.42.5355
-
(2012)
J Clin Oncol
, vol.30
, Issue.29
, pp. 3588-3595
-
-
Schmoll, H.J.1
Cunningham, D.2
Sobrero, A.3
Karapetis, C.S.4
Rougier, P.5
Koski, S.L.6
Kocakova, I.7
Bondarenko, I.8
Bodoky, G.9
Mainwaring, P.10
Salazar, R.11
Barker, P.12
Mookerjee, B.13
Robertson, J.14
Van Cutsem, E.15
-
100
-
-
84927173477
-
Cediranib aims for a comeback
-
Schmidt C (2015) Cediranib aims for a comeback. J Natl Cancer Inst. doi:10.1093/jnci/djv068
-
(2015)
J Natl Cancer Inst
-
-
Schmidt, C.1
-
101
-
-
84903901969
-
Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions
-
COI: 1:CAS:528:DC%2BC2cXpsVGrtrk%3D, PID: 24482243
-
Vasudev NS, Reynolds AR (2014) Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions. Angiogenesis 17(3):471–494. doi:10.1007/s10456-014-9420-y
-
(2014)
Angiogenesis
, vol.17
, Issue.3
, pp. 471-494
-
-
Vasudev, N.S.1
Reynolds, A.R.2
-
102
-
-
79952741178
-
Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation
-
COI: 1:CAS:528:DC%2BC3MXkslagt7k%3D, PID: 21269250
-
Mas-Moruno C, Rechenmacher F, Kessler H (2010) Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation. Anticancer Agents Med Chem 10(10):753–768
-
(2010)
Anticancer Agents Med Chem
, vol.10
, Issue.10
, pp. 753-768
-
-
Mas-Moruno, C.1
Rechenmacher, F.2
Kessler, H.3
-
103
-
-
61649116978
-
Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway
-
PID: 19114005
-
Oliveira-Ferrer L, Hauschild J, Fiedler W, Bokemeyer C, Nippgen J, Celik I, Schuch G (2008) Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway. J Exp Clin Cancer Res 27:86. doi:10.1186/1756-9966-27-86
-
(2008)
J Exp Clin Cancer Res
, vol.27
, pp. 86
-
-
Oliveira-Ferrer, L.1
Hauschild, J.2
Fiedler, W.3
Bokemeyer, C.4
Nippgen, J.5
Celik, I.6
Schuch, G.7
-
104
-
-
84908563697
-
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial
-
COI: 1:CAS:528:DC%2BC2cXhsVSmt73E, PID: 25163906
-
Stupp R, Hegi ME, Gorlia T, Erridge SC, Perry J, Hong YK, Aldape KD, Lhermitte B, Pietsch T, Grujicic D, Steinbach JP, Wick W, Tarnawski R, Nam DH, Hau P, Weyerbrock A, Taphoorn MJ, Shen CC, Rao N, Thurzo L, Herrlinger U, Gupta T, Kortmann RD, Adamska K, McBain C, Brandes AA, Tonn JC, Schnell O, Wiegel T, Kim CY, Nabors LB, Reardon DA, van den Bent MJ, Hicking C, Markivskyy A, Picard M, Weller M, European Organisation for R, Treatment of C, Canadian Brain Tumor C, team Cs (2014) Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 15(10):1100–1108. doi:10.1016/S1470-2045(14)70379-1
-
(2014)
Lancet Oncol
, vol.15
, Issue.10
, pp. 1100-1108
-
-
Stupp, R.1
Hegi, M.E.2
Gorlia, T.3
Erridge, S.C.4
Perry, J.5
Hong, Y.K.6
Aldape, K.D.7
Lhermitte, B.8
Pietsch, T.9
Grujicic, D.10
Steinbach, J.P.11
Wick, W.12
Tarnawski, R.13
Nam, D.H.14
Hau, P.15
Weyerbrock, A.16
Taphoorn, M.J.17
Shen, C.C.18
Rao, N.19
Thurzo, L.20
Herrlinger, U.21
Gupta, T.22
Kortmann, R.D.23
Adamska, K.24
McBain, C.25
Brandes, A.A.26
Tonn, J.C.27
Schnell, O.28
Wiegel, T.29
Kim, C.Y.30
Nabors, L.B.31
Reardon, D.A.32
van den Bent, M.J.33
Hicking, C.34
Markivskyy, A.35
Picard, M.36
Weller, M.37
more..
-
105
-
-
77955347059
-
AMG-386, a selective angiopoietin-1/-2-neutralizing peptibody for the potential treatment of cancer
-
COI: 1:CAS:528:DC%2BC3cXhtlaktL%2FK, PID: 20677100
-
Neal J, Wakelee H (2010) AMG-386, a selective angiopoietin-1/-2-neutralizing peptibody for the potential treatment of cancer. Curr Opin Mol Ther 12(4):487–495
-
(2010)
Curr Opin Mol Ther
, vol.12
, Issue.4
, pp. 487-495
-
-
Neal, J.1
Wakelee, H.2
-
106
-
-
77958042477
-
Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody
-
COI: 1:CAS:528:DC%2BC3cXht1Khtr3I, PID: 20937592
-
Coxon A, Bready J, Min H, Kaufman S, Leal J, Yu D, Lee TA, Sun JR, Estrada J, Bolon B, McCabe J, Wang L, Rex K, Caenepeel S, Hughes P, Cordover D, Kim H, Han SJ, Michaels ML, Hsu E, Shimamoto G, Cattley R, Hurh E, Nguyen L, Wang SX, Ndifor A, Hayward IJ, Falcon BL, McDonald DM, Li L, Boone T, Kendall R, Radinsky R, Oliner JD (2010) Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody. Mol Cancer Ther 9(10):2641–2651. doi:10.1158/1535-7163.MCT-10-0213
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.10
, pp. 2641-2651
-
-
Coxon, A.1
Bready, J.2
Min, H.3
Kaufman, S.4
Leal, J.5
Yu, D.6
Lee, T.A.7
Sun, J.R.8
Estrada, J.9
Bolon, B.10
McCabe, J.11
Wang, L.12
Rex, K.13
Caenepeel, S.14
Hughes, P.15
Cordover, D.16
Kim, H.17
Han, S.J.18
Michaels, M.L.19
Hsu, E.20
Shimamoto, G.21
Cattley, R.22
Hurh, E.23
Nguyen, L.24
Wang, S.X.25
Ndifor, A.26
Hayward, I.J.27
Falcon, B.L.28
McDonald, D.M.29
Li, L.30
Boone, T.31
Kendall, R.32
Radinsky, R.33
Oliner, J.D.34
more..
-
107
-
-
84903517779
-
Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial
-
COI: 1:CAS:528:DC%2BC2cXhtVamsLbJ, PID: 24950985
-
Monk BJ, Poveda A, Vergote I, Raspagliesi F, Fujiwara K, Bae DS, Oaknin A, Ray-Coquard I, Provencher DM, Karlan BY, Lhomme C, Richardson G, Rincon DG, Coleman RL, Herzog TJ, Marth C, Brize A, Fabbro M, Redondo A, Bamias A, Tassoudji M, Navale L, Warner DJ, Oza AM (2014) Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial. Lancet Oncol 15(8):799–808. doi:10.1016/S1470-2045(14)70244-X
-
(2014)
Lancet Oncol
, vol.15
, Issue.8
, pp. 799-808
-
-
Monk, B.J.1
Poveda, A.2
Vergote, I.3
Raspagliesi, F.4
Fujiwara, K.5
Bae, D.S.6
Oaknin, A.7
Ray-Coquard, I.8
Provencher, D.M.9
Karlan, B.Y.10
Lhomme, C.11
Richardson, G.12
Rincon, D.G.13
Coleman, R.L.14
Herzog, T.J.15
Marth, C.16
Brize, A.17
Fabbro, M.18
Redondo, A.19
Bamias, A.20
Tassoudji, M.21
Navale, L.22
Warner, D.J.23
Oza, A.M.24
more..
-
108
-
-
84896713052
-
Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: an open-label, randomised phase 3 trial
-
COI: 1:CAS:528:DC%2BC2cXis1Cks7c%3D, PID: 24556040
-
Motzer RJ, Porta C, Vogelzang NJ, Sternberg CN, Szczylik C, Zolnierek J, Kollmannsberger C, Rha SY, Bjarnason GA, Melichar B, De Giorgi U, Grunwald V, Davis ID, Lee JL, Esteban E, Urbanowitz G, Cai C, Squires M, Marker M, Shi MM, Escudier B (2014) Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: an open-label, randomised phase 3 trial. Lancet Oncol 15(3):286–296. doi:10.1016/S1470-2045(14)70030-0
-
(2014)
Lancet Oncol
, vol.15
, Issue.3
, pp. 286-296
-
-
Motzer, R.J.1
Porta, C.2
Vogelzang, N.J.3
Sternberg, C.N.4
Szczylik, C.5
Zolnierek, J.6
Kollmannsberger, C.7
Rha, S.Y.8
Bjarnason, G.A.9
Melichar, B.10
De Giorgi, U.11
Grunwald, V.12
Davis, I.D.13
Lee, J.L.14
Esteban, E.15
Urbanowitz, G.16
Cai, C.17
Squires, M.18
Marker, M.19
Shi, M.M.20
Escudier, B.21
more..
-
109
-
-
84862145477
-
A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma
-
Sivanand S, Pena-Llopis S, Zhao H, Kucejova B, Spence P, Pavia-Jimenez A, Yamasaki T, McBride DJ, Gillen J, Wolff NC, Morlock L, Lotan Y, Raj GV, Sagalowsky A, Margulis V, Cadeddu JA, Ross MT, Bentley DR, Kabbani W, Xie XJ, Kapur P, Williams NS, Brugarolas J (2012) A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma. Sci Transl Med 4(137):137ra175. doi:10.1126/scitranslmed.3003643
-
(2012)
Sci Transl Med
, vol.4
, Issue.137
, pp. 137ra175
-
-
Sivanand, S.1
Pena-Llopis, S.2
Zhao, H.3
Kucejova, B.4
Spence, P.5
Pavia-Jimenez, A.6
Yamasaki, T.7
McBride, D.J.8
Gillen, J.9
Wolff, N.C.10
Morlock, L.11
Lotan, Y.12
Raj, G.V.13
Sagalowsky, A.14
Margulis, V.15
Cadeddu, J.A.16
Ross, M.T.17
Bentley, D.R.18
Kabbani, W.19
Xie, X.J.20
Kapur, P.21
Williams, N.S.22
Brugarolas, J.23
more..
-
110
-
-
58149175849
-
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
-
COI: 1:CAS:528:DC%2BD1cXhtF2nurvK, PID: 18829493
-
Huynh H, Ngo VC, Fargnoli J, Ayers M, Soo KC, Koong HN, Thng CH, Ong HS, Chung A, Chow P, Pollock P, Byron S, Tran E (2008) Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res 14(19):6146–6153. doi:10.1158/1078-0432.CCR-08-0509
-
(2008)
Clin Cancer Res
, vol.14
, Issue.19
, pp. 6146-6153
-
-
Huynh, H.1
Ngo, V.C.2
Fargnoli, J.3
Ayers, M.4
Soo, K.C.5
Koong, H.N.6
Thng, C.H.7
Ong, H.S.8
Chung, A.9
Chow, P.10
Pollock, P.11
Byron, S.12
Tran, E.13
-
111
-
-
84890274647
-
Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study
-
COI: 1:CAS:528:DC%2BC3sXhs12mt7%2FN, PID: 23980084
-
Johnson PJ, Qin S, Park JW, Poon RT, Raoul JL, Philip PA, Hsu CH, Hu TH, Heo J, Xu J, Lu L, Chao Y, Boucher E, Han KH, Paik SW, Robles-Avina J, Kudo M, Yan L, Sobhonslidsuk A, Komov D, Decaens T, Tak WY, Jeng LB, Liu D, Ezzeddine R, Walters I, Cheng AL (2013) Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study. J Clin Oncol 31(28):3517–3524. doi:10.1200/JCO.2012.48.4410
-
(2013)
J Clin Oncol
, vol.31
, Issue.28
, pp. 3517-3524
-
-
Johnson, P.J.1
Qin, S.2
Park, J.W.3
Poon, R.T.4
Raoul, J.L.5
Philip, P.A.6
Hsu, C.H.7
Hu, T.H.8
Heo, J.9
Xu, J.10
Lu, L.11
Chao, Y.12
Boucher, E.13
Han, K.H.14
Paik, S.W.15
Robles-Avina, J.16
Kudo, M.17
Yan, L.18
Sobhonslidsuk, A.19
Komov, D.20
Decaens, T.21
Tak, W.Y.22
Jeng, L.B.23
Liu, D.24
Ezzeddine, R.25
Walters, I.26
Cheng, A.L.27
more..
-
112
-
-
84922252607
-
Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma: a randomized phase III trial
-
COI: 1:CAS:528:DC%2BC2cXhvVansbbP, PID: 24996197
-
Kudo M, Han G, Finn RS, Poon RT, Blanc JF, Yan L, Yang J, Lu L, Tak WY, Yu X, Lee JH, Lin SM, Wu C, Tanwandee T, Shao G, Walters IB, Dela Cruz C, Poulart V, Wang JH (2014) Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma: a randomized phase III trial. Hepatology 60(5):1697–1707. doi:10.1002/hep.27290
-
(2014)
Hepatology
, vol.60
, Issue.5
, pp. 1697-1707
-
-
Kudo, M.1
Han, G.2
Finn, R.S.3
Poon, R.T.4
Blanc, J.F.5
Yan, L.6
Yang, J.7
Lu, L.8
Tak, W.Y.9
Yu, X.10
Lee, J.H.11
Lin, S.M.12
Wu, C.13
Tanwandee, T.14
Shao, G.15
Walters, I.B.16
Dela Cruz, C.17
Poulart, V.18
Wang, J.H.19
-
113
-
-
84885587718
-
Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study
-
COI: 1:CAS:528:DC%2BC3sXhs12mt77E, PID: 23980090
-
Llovet JM, Decaens T, Raoul JL, Boucher E, Kudo M, Chang C, Kang YK, Assenat E, Lim HY, Boige V, Mathurin P, Fartoux L, Lin DY, Bruix J, Poon RT, Sherman M, Blanc JF, Finn RS, Tak WY, Chao Y, Ezzeddine R, Liu D, Walters I, Park JW (2013) Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study. J Clin Oncol 31(28):3509–3516. doi:10.1200/JCO.2012.47.3009
-
(2013)
J Clin Oncol
, vol.31
, Issue.28
, pp. 3509-3516
-
-
Llovet, J.M.1
Decaens, T.2
Raoul, J.L.3
Boucher, E.4
Kudo, M.5
Chang, C.6
Kang, Y.K.7
Assenat, E.8
Lim, H.Y.9
Boige, V.10
Mathurin, P.11
Fartoux, L.12
Lin, D.Y.13
Bruix, J.14
Poon, R.T.15
Sherman, M.16
Blanc, J.F.17
Finn, R.S.18
Tak, W.Y.19
Chao, Y.20
Ezzeddine, R.21
Liu, D.22
Walters, I.23
Park, J.W.24
more..
-
114
-
-
84931271695
-
The great escape; the hallmarks of resistance to antiangiogenic therapy
-
PID: 25769965
-
van Beijnum JR, Nowak-Sliwinska P, Huijbers EJ, Thijssen VL, Griffioen AW (2015) The great escape; the hallmarks of resistance to antiangiogenic therapy. Pharmacol Rev 67(2):441–461. doi:10.1124/pr.114.010215
-
(2015)
Pharmacol Rev
, vol.67
, Issue.2
, pp. 441-461
-
-
van Beijnum, J.R.1
Nowak-Sliwinska, P.2
Huijbers, E.J.3
Thijssen, V.L.4
Griffioen, A.W.5
-
115
-
-
82555189379
-
Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance
-
COI: 1:CAS:528:DC%2BC3MXhsFCmtrjM, PID: 21980135
-
Gotink KJ, Broxterman HJ, Labots M, de Haas RR, Dekker H, Honeywell RJ, Rudek MA, Beerepoot LV, Musters RJ, Jansen G, Griffioen AW, Assaraf YG, Pili R, Peters GJ, Verheul HM (2011) Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance. Clin Cancer Res 17(23):7337–7346. doi:10.1158/1078-0432.CCR-11-1667
-
(2011)
Clin Cancer Res
, vol.17
, Issue.23
, pp. 7337-7346
-
-
Gotink, K.J.1
Broxterman, H.J.2
Labots, M.3
de Haas, R.R.4
Dekker, H.5
Honeywell, R.J.6
Rudek, M.A.7
Beerepoot, L.V.8
Musters, R.J.9
Jansen, G.10
Griffioen, A.W.11
Assaraf, Y.G.12
Pili, R.13
Peters, G.J.14
Verheul, H.M.15
-
116
-
-
70350225520
-
Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer
-
COI: 1:CAS:528:DC%2BD1MXht1ynurnK, PID: 19826039
-
Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK (2009) Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res 69(20):7905–7910. doi:10.1158/0008-5472.CAN-09-2099
-
(2009)
Cancer Res
, vol.69
, Issue.20
, pp. 7905-7910
-
-
Xu, L.1
Duda, D.G.2
di Tomaso, E.3
Ancukiewicz, M.4
Chung, D.C.5
Lauwers, G.Y.6
Samuel, R.7
Shellito, P.8
Czito, B.G.9
Lin, P.C.10
Poleski, M.11
Bentley, R.12
Clark, J.W.13
Willett, C.G.14
Jain, R.K.15
-
117
-
-
84995766806
-
Understanding and targeting resistance to anti-angiogenic therapies
-
COI: 1:CAS:528:DC%2BC2cXht1Sku7jN, PID: 23997938
-
Clarke JM, Hurwitz HI (2013) Understanding and targeting resistance to anti-angiogenic therapies. J Gastrointest Oncol 4(3):253–263. doi:10.3978/j.issn.2078-6891.2013.036
-
(2013)
J Gastrointest Oncol
, vol.4
, Issue.3
, pp. 253-263
-
-
Clarke, J.M.1
Hurwitz, H.I.2
-
118
-
-
0035887011
-
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
COI: 1:CAS:528:DC%2BD3MXnvVWksb4%3D, PID: 11641274
-
Mahon PC, Hirota K, Semenza GL (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15(20):2675–2686. doi:10.1101/gad.924501
-
(2001)
Genes Dev
, vol.15
, Issue.20
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
119
-
-
7944224442
-
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
-
COI: 1:CAS:528:DC%2BD2cXhtVGlurjN, PID: 15542432
-
Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS (2004) Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6(5):485–495. doi:10.1016/j.ccr.2004.09.026
-
(2004)
Cancer Cell
, vol.6
, Issue.5
, pp. 485-495
-
-
Tang, N.1
Wang, L.2
Esko, J.3
Giordano, F.J.4
Huang, Y.5
Gerber, H.P.6
Ferrara, N.7
Johnson, R.S.8
-
120
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
COI: 1:CAS:528:DyaK1MXnslygsr0%3D, PID: 10582706
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW (1999) Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59(22):5830–5835
-
(1999)
Cancer Res
, vol.59
, Issue.22
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
-
121
-
-
5444225991
-
Expansion of myeloid immune suppressor Gr+ CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
-
COI: 1:CAS:528:DC%2BD2cXpsF2rtLo%3D, PID: 15488763
-
Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, Matrisian LM, Carbone DP, Lin PC (2004) Expansion of myeloid immune suppressor Gr+ CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 6(4):409–421. doi:10.1016/j.ccr.2004.08.031
-
(2004)
Cancer Cell
, vol.6
, Issue.4
, pp. 409-421
-
-
Yang, L.1
DeBusk, L.M.2
Fukuda, K.3
Fingleton, B.4
Green-Jarvis, B.5
Shyr, Y.6
Matrisian, L.M.7
Carbone, D.P.8
Lin, P.C.9
-
122
-
-
84960431096
-
Role of the tumor stroma in resistance to anti-angiogenic therapy
-
PID: 27155374
-
Huijbers EJ, van Beijnum JR, Thijssen VL, Sabrkhany S, Nowak-Sliwinska P, Griffioen AW (2016) Role of the tumor stroma in resistance to anti-angiogenic therapy. Drug Resist Updat 25:26–37. doi:10.1016/j.drup.2016.02.002
-
(2016)
Drug Resist Updat
, vol.25
, pp. 26-37
-
-
Huijbers, E.J.1
van Beijnum, J.R.2
Thijssen, V.L.3
Sabrkhany, S.4
Nowak-Sliwinska, P.5
Griffioen, A.W.6
-
123
-
-
78651109040
-
C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells
-
COI: 1:CAS:528:DC%2BC3MXms1KhtA%3D%3D, PID: 21173223
-
Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK (2011) C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells. Proc Natl Acad Sci USA 108(1):302–307. doi:10.1073/pnas.1016917108
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.1
, pp. 302-307
-
-
Hiratsuka, S.1
Duda, D.G.2
Huang, Y.3
Goel, S.4
Sugiyama, T.5
Nagasawa, T.6
Fukumura, D.7
Jain, R.K.8
-
124
-
-
84928207236
-
CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice
-
COI: 1:CAS:528:DC%2BC2MXmslWlsb8%3D, PID: 25529917
-
Chen Y, Ramjiawan RR, Reiberger T, Ng MR, Hato T, Huang Y, Ochiai H, Kitahara S, Unan EC, Reddy TP, Fan C, Huang P, Bardeesy N, Zhu AX, Jain RK, Duda DG (2015) CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice. Hepatology 61(5):1591–1602. doi:10.1002/hep.27665
-
(2015)
Hepatology
, vol.61
, Issue.5
, pp. 1591-1602
-
-
Chen, Y.1
Ramjiawan, R.R.2
Reiberger, T.3
Ng, M.R.4
Hato, T.5
Huang, Y.6
Ochiai, H.7
Kitahara, S.8
Unan, E.C.9
Reddy, T.P.10
Fan, C.11
Huang, P.12
Bardeesy, N.13
Zhu, A.X.14
Jain, R.K.15
Duda, D.G.16
-
125
-
-
77952673621
-
Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates
-
COI: 1:CAS:528:DC%2BC3cXhtV2ntrzN, PID: 21779425
-
Loges S, Schmidt T, Carmeliet P (2010) Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates. Genes Cancer 1(1):12–25. doi:10.1177/1947601909356574
-
(2010)
Genes Cancer
, vol.1
, Issue.1
, pp. 12-25
-
-
Loges, S.1
Schmidt, T.2
Carmeliet, P.3
-
126
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
COI: 1:CAS:528:DC%2BD1cXovV2lsrk%3D, PID: 18650835
-
Bergers G, Hanahan D (2008) Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8(8):592–603. doi:10.1038/nrc2442
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
127
-
-
84937940827
-
An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis
-
COI: 1:CAS:528:DC%2BC2MXhtFyksrfI, PID: 26203823
-
Reiberger T, Chen Y, Ramjiawan RR, Hato T, Fan C, Samuel R, Roberge S, Huang P, Lauwers GY, Zhu AX, Bardeesy N, Jain RK, Duda DG (2015) An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis. Nat Protoc 10(8):1264–1274. doi:10.1038/nprot.2015.080
-
(2015)
Nat Protoc
, vol.10
, Issue.8
, pp. 1264-1274
-
-
Reiberger, T.1
Chen, Y.2
Ramjiawan, R.R.3
Hato, T.4
Fan, C.5
Samuel, R.6
Roberge, S.7
Huang, P.8
Lauwers, G.Y.9
Zhu, A.X.10
Bardeesy, N.11
Jain, R.K.12
Duda, D.G.13
-
128
-
-
33845466231
-
Monocyte/macrophage infiltration in tumors: modulators of angiogenesis
-
COI: 1:CAS:528:DC%2BD28XhtlSisLjN, PID: 16997855
-
Dirkx AE, Oude Egbrink MG, Wagstaff J, Griffioen AW (2006) Monocyte/macrophage infiltration in tumors: modulators of angiogenesis. J Leukoc Biol 80(6):1183–1196. doi:10.1189/jlb.0905495
-
(2006)
J Leukoc Biol
, vol.80
, Issue.6
, pp. 1183-1196
-
-
Dirkx, A.E.1
Oude Egbrink, M.G.2
Wagstaff, J.3
Griffioen, A.W.4
-
129
-
-
0033580889
-
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
-
COI: 1:CAS:528:DyaK1MXktVWntrY%3D, PID: 10373119
-
Holash J, Maisonpierre PC, Compton D, Boland P, Alexander CR, Zagzag D, Yancopoulos GD, Wiegand SJ (1999) Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284(5422):1994–1998
-
(1999)
Science
, vol.284
, Issue.5422
, pp. 1994-1998
-
-
Holash, J.1
Maisonpierre, P.C.2
Compton, D.3
Boland, P.4
Alexander, C.R.5
Zagzag, D.6
Yancopoulos, G.D.7
Wiegand, S.J.8
-
130
-
-
0033822622
-
Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
-
COI: 1:CAS:528:DC%2BD3cXntVCjtb8%3D, PID: 11005565
-
Rubenstein JL, Kim J, Ozawa T, Zhang M, Westphal M, Deen DF, Shuman MA (2000) Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia 2(4):306–314
-
(2000)
Neoplasia
, vol.2
, Issue.4
, pp. 306-314
-
-
Rubenstein, J.L.1
Kim, J.2
Ozawa, T.3
Zhang, M.4
Westphal, M.5
Deen, D.F.6
Shuman, M.A.7
-
131
-
-
84992401796
-
Co-option of liver vessels and not sprouting angiogenesis drives acquired sorafenib resistance in hepatocellular carcinoma
-
PID: 27059374
-
Kuczynski EA, Yin M, Bar-Zion A, Lee CR, Butz H, Man S, Daley F, Vermeulen PB, Yousef GM, Foster FS, Reynolds AR, Kerbel RS (2016) Co-option of liver vessels and not sprouting angiogenesis drives acquired sorafenib resistance in hepatocellular carcinoma. J Natl Cancer Inst. doi:10.1093/jnci/djw030
-
(2016)
J Natl Cancer Inst
-
-
Kuczynski, E.A.1
Yin, M.2
Bar-Zion, A.3
Lee, C.R.4
Butz, H.5
Man, S.6
Daley, F.7
Vermeulen, P.B.8
Yousef, G.M.9
Foster, F.S.10
Reynolds, A.R.11
Kerbel, R.S.12
-
132
-
-
84991735476
-
Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases
-
COI: 1:CAS:528:DC%2BC28Xhs1yktb3P, PID: 27748747
-
Frentzas S, Simoneau E, Bridgeman VL, Vermeulen PB, Foo S, Kostaras E, Nathan MR, Wotherspoon A, Gao ZH, Shi Y, Van den Eynden G, Daley F, Peckitt C, Tan X, Salman A, Lazaris A, Gazinska P, Berg TJ, Eltahir Z, Ritsma L, van Rheenen J, Khashper A, Brown G, Nystrom H, Sund M, Van Laere S, Loyer E, Dirix L, Cunningham D, Metrakos P, Reynolds AR (2016) Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases. Nat Med 22(11):1294–1302. doi:10.1038/nm.4197
-
(2016)
Nat Med
, vol.22
, Issue.11
, pp. 1294-1302
-
-
Frentzas, S.1
Simoneau, E.2
Bridgeman, V.L.3
Vermeulen, P.B.4
Foo, S.5
Kostaras, E.6
Nathan, M.R.7
Wotherspoon, A.8
Gao, Z.H.9
Shi, Y.10
Van den Eynden, G.11
Daley, F.12
Peckitt, C.13
Tan, X.14
Salman, A.15
Lazaris, A.16
Gazinska, P.17
Berg, T.J.18
Eltahir, Z.19
Ritsma, L.20
van Rheenen, J.21
Khashper, A.22
Brown, G.23
Nystrom, H.24
Sund, M.25
Van Laere, S.26
Loyer, E.27
Dirix, L.28
Cunningham, D.29
Metrakos, P.30
Reynolds, A.R.31
more..
-
133
-
-
84938646876
-
Investigation of the lack of angiogenesis in the formation of lymph node metastases
-
Jeong HS, Jones D, Liao S, Wattson DA, Cui CH, Duda DG, Willett CG, Jain RK, Padera TP (2015) Investigation of the lack of angiogenesis in the formation of lymph node metastases. J Natl Cancer Inst. doi:10.1093/jnci/djv155
-
(2015)
J Natl Cancer Inst
-
-
Jeong, H.S.1
Jones, D.2
Liao, S.3
Wattson, D.A.4
Cui, C.H.5
Duda, D.G.6
Willett, C.G.7
Jain, R.K.8
Padera, T.P.9
-
134
-
-
33947378293
-
Hypoxia influences vasculogenic mimicry channel formation and tumor invasion-related protein expression in melanoma
-
COI: 1:CAS:528:DC%2BD2sXjsVektbw%3D, PID: 16997457
-
Sun B, Zhang D, Zhang S, Zhang W, Guo H, Zhao X (2007) Hypoxia influences vasculogenic mimicry channel formation and tumor invasion-related protein expression in melanoma. Cancer Lett 249(2):188–197. doi:10.1016/j.canlet.2006.08.016
-
(2007)
Cancer Lett
, vol.249
, Issue.2
, pp. 188-197
-
-
Sun, B.1
Zhang, D.2
Zhang, S.3
Zhang, W.4
Guo, H.5
Zhao, X.6
-
135
-
-
33947590737
-
Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis, and short survival in patients with hepatocellular carcinoma
-
COI: 1:CAS:528:DC%2BD2sXlvFyisro%3D, PID: 16969481
-
Sun B, Zhang S, Zhang D, Du J, Guo H, Zhao X, Zhang W, Hao X (2006) Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis, and short survival in patients with hepatocellular carcinoma. Oncol Rep 16(4):693–698
-
(2006)
Oncol Rep
, vol.16
, Issue.4
, pp. 693-698
-
-
Sun, B.1
Zhang, S.2
Zhang, D.3
Du, J.4
Guo, H.5
Zhao, X.6
Zhang, W.7
Hao, X.8
-
136
-
-
84863799908
-
Vasculogenic mimicry-potential target for glioblastoma therapy: an in vitro and in vivo study
-
COI: 1:CAS:528:DC%2BC38Xit1ejtLw%3D, PID: 21161444
-
Chen Y, Jing Z, Luo C, Zhuang M, Xia J, Chen Z, Wang Y (2012) Vasculogenic mimicry-potential target for glioblastoma therapy: an in vitro and in vivo study. Med Oncol 29(1):324–331. doi:10.1007/s12032-010-9765-z
-
(2012)
Med Oncol
, vol.29
, Issue.1
, pp. 324-331
-
-
Chen, Y.1
Jing, Z.2
Luo, C.3
Zhuang, M.4
Xia, J.5
Chen, Z.6
Wang, Y.7
-
137
-
-
29244473123
-
Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia
-
PID: 16357161
-
van der Schaft DW, Hillen F, Pauwels P, Kirschmann DA, Castermans K, Egbrink MG, Tran MG, Sciot R, Hauben E, Hogendoorn PC, Delattre O, Maxwell PH, Hendrix MJ, Griffioen AW (2005) Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia. Cancer Res 65(24):11520–11528. doi:10.1158/0008-5472.CAN-05-2468
-
(2005)
Cancer Res
, vol.65
, Issue.24
, pp. 11520-11528
-
-
van der Schaft, D.W.1
Hillen, F.2
Pauwels, P.3
Kirschmann, D.A.4
Castermans, K.5
Egbrink, M.G.6
Tran, M.G.7
Sciot, R.8
Hauben, E.9
Hogendoorn, P.C.10
Delattre, O.11
Maxwell, P.H.12
Hendrix, M.J.13
Griffioen, A.W.14
-
138
-
-
6944230090
-
Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cells
-
PID: 15467037
-
van der Schaft DW, Seftor RE, Seftor EA, Hess AR, Gruman LM, Kirschmann DA, Yokoyama Y, Griffioen AW, Hendrix MJ (2004) Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cells. J Natl Cancer Inst 96(19):1473–1477. doi:10.1093/jnci/djh267
-
(2004)
J Natl Cancer Inst
, vol.96
, Issue.19
, pp. 1473-1477
-
-
van der Schaft, D.W.1
Seftor, R.E.2
Seftor, E.A.3
Hess, A.R.4
Gruman, L.M.5
Kirschmann, D.A.6
Yokoyama, Y.7
Griffioen, A.W.8
Hendrix, M.J.9
-
139
-
-
0029986979
-
Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis
-
COI: 1:STN:280:DyaK283kvF2ksA%3D%3D, PID: 8778579
-
Patan S, Munn LL, Jain RK (1996) Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis. Microvasc Res 51(2):260–272. doi:10.1006/mvre.1996.0025
-
(1996)
Microvasc Res
, vol.51
, Issue.2
, pp. 260-272
-
-
Patan, S.1
Munn, L.L.2
Jain, R.K.3
-
140
-
-
0036022248
-
Optimality in the developing vascular system: branching remodeling by means of intussusception as an efficient adaptation mechanism
-
PID: 12203731
-
Djonov VG, Kurz H, Burri PH (2002) Optimality in the developing vascular system: branching remodeling by means of intussusception as an efficient adaptation mechanism. Dev Dyn 224(4):391–402. doi:10.1002/dvdy.10119
-
(2002)
Dev Dyn
, vol.224
, Issue.4
, pp. 391-402
-
-
Djonov, V.G.1
Kurz, H.2
Burri, P.H.3
-
141
-
-
53149098943
-
Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation
-
COI: 1:CAS:528:DC%2BD1cXht1CjtL%2FL, PID: 18787105
-
Hlushchuk R, Riesterer O, Baum O, Wood J, Gruber G, Pruschy M, Djonov V (2008) Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation. Am J Pathol 173(4):1173–1185. doi:10.2353/ajpath.2008.071131
-
(2008)
Am J Pathol
, vol.173
, Issue.4
, pp. 1173-1185
-
-
Hlushchuk, R.1
Riesterer, O.2
Baum, O.3
Wood, J.4
Gruber, G.5
Pruschy, M.6
Djonov, V.7
-
142
-
-
77949697909
-
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
-
COI: 1:CAS:528:DC%2BC3cXjtV2ns74%3D, PID: 20179352
-
Kioi M, Vogel H, Schultz G, Hoffman RM, Harsh GR, Brown JM (2010) Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest 120(3):694–705. doi:10.1172/JCI40283
-
(2010)
J Clin Invest
, vol.120
, Issue.3
, pp. 694-705
-
-
Kioi, M.1
Vogel, H.2
Schultz, G.3
Hoffman, R.M.4
Harsh, G.R.5
Brown, J.M.6
-
143
-
-
0038386470
-
Role of bone marrow-derived cells in tumor angiogenesis and treatment
-
COI: 1:CAS:528:DC%2BD3sXltlSms7s%3D, PID: 12842078
-
Jain RK, Duda DG (2003) Role of bone marrow-derived cells in tumor angiogenesis and treatment. Cancer Cell 3(6):515–516
-
(2003)
Cancer Cell
, vol.3
, Issue.6
, pp. 515-516
-
-
Jain, R.K.1
Duda, D.G.2
-
144
-
-
84868595744
-
Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases
-
COI: 1:CAS:528:DC%2BC38Xhslyiu7zP, PID: 23071298
-
Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK (2012) Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Proc Natl Acad Sci USA 109(45):E3119–E3127. doi:10.1073/pnas.1216078109
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.45
, pp. E3119-E3127
-
-
Kodack, D.P.1
Chung, E.2
Yamashita, H.3
Incio, J.4
Duyverman, A.M.5
Song, Y.6
Farrar, C.T.7
Huang, Y.8
Ager, E.9
Kamoun, W.10
Goel, S.11
Snuderl, M.12
Lussiez, A.13
Hiddingh, L.14
Mahmood, S.15
Tannous, B.A.16
Eichler, A.F.17
Fukumura, D.18
Engelman, J.A.19
Jain, R.K.20
more..
-
145
-
-
1442290142
-
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
-
COI: 1:CAS:528:DC%2BD2cXht1Gjtrg%3D, PID: 14657001
-
Erber R, Thurnher A, Katsen AD, Groth G, Kerger H, Hammes HP, Menger MD, Ullrich A, Vajkoczy P (2004) Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J 18(2):338–340. doi:10.1096/fj.03-0271fje
-
(2004)
FASEB J
, vol.18
, Issue.2
, pp. 338-340
-
-
Erber, R.1
Thurnher, A.2
Katsen, A.D.3
Groth, G.4
Kerger, H.5
Hammes, H.P.6
Menger, M.D.7
Ullrich, A.8
Vajkoczy, P.9
-
146
-
-
80053159303
-
The parallel lives of angiogenesis and immunosuppression: cancer and other tales
-
COI: 1:CAS:528:DC%2BC3MXht1ajur7E, PID: 21941296
-
Motz GT, Coukos G (2011) The parallel lives of angiogenesis and immunosuppression: cancer and other tales. Nat Rev Immunol 11(10):702–711. doi:10.1038/nri3064
-
(2011)
Nat Rev Immunol
, vol.11
, Issue.10
, pp. 702-711
-
-
Motz, G.T.1
Coukos, G.2
-
147
-
-
84962013731
-
Resistance to antiangiogenic therapy is associated with an immunosuppressive tumor microenvironment in metastatic renal cell carcinoma
-
COI: 1:CAS:528:DC%2BC2MXhsFartL7E, PID: 26014097
-
Liu XD, Hoang A, Zhou L, Kalra S, Yetil A, Sun M, Ding Z, Zhang X, Bai S, German P, Tamboli P, Rao P, Karam JA, Wood C, Matin S, Zurita A, Bex A, Griffioen AW, Gao J, Sharma P, Tannir N, Sircar K, Jonasch E (2015) Resistance to antiangiogenic therapy is associated with an immunosuppressive tumor microenvironment in metastatic renal cell carcinoma. Cancer Immunol Res 3(9):1017–1029. doi:10.1158/2326-6066.CIR-14-0244
-
(2015)
Cancer Immunol Res
, vol.3
, Issue.9
, pp. 1017-1029
-
-
Liu, X.D.1
Hoang, A.2
Zhou, L.3
Kalra, S.4
Yetil, A.5
Sun, M.6
Ding, Z.7
Zhang, X.8
Bai, S.9
German, P.10
Tamboli, P.11
Rao, P.12
Karam, J.A.13
Wood, C.14
Matin, S.15
Zurita, A.16
Bex, A.17
Griffioen, A.W.18
Gao, J.19
Sharma, P.20
Tannir, N.21
Sircar, K.22
Jonasch, E.23
more..
-
148
-
-
84887419886
-
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation
-
COI: 1:CAS:528:DC%2BC3sXhvFCis7fI, PID: 24190997
-
Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen BR, Loeffler JS, Wen PY, Sorensen AG, Jain RK (2013) Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proc Natl Acad Sci USA 110(47):19059–19064. doi:10.1073/pnas.1318022110
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.47
, pp. 19059-19064
-
-
Batchelor, T.T.1
Gerstner, E.R.2
Emblem, K.E.3
Duda, D.G.4
Kalpathy-Cramer, J.5
Snuderl, M.6
Ancukiewicz, M.7
Polaskova, P.8
Pinho, M.C.9
Jennings, D.10
Plotkin, S.R.11
Chi, A.S.12
Eichler, A.F.13
Dietrich, J.14
Hochberg, F.H.15
Lu-Emerson, C.16
Iafrate, A.J.17
Ivy, S.P.18
Rosen, B.R.19
Loeffler, J.S.20
Wen, P.Y.21
Sorensen, A.G.22
Jain, R.K.23
more..
-
149
-
-
79956045735
-
Enhancement of T-cell-mediated antitumor response: angiostatic adjuvant to immunotherapy against cancer
-
COI: 1:CAS:528:DC%2BC3MXmtVGisbo%3D, PID: 21252159
-
Dings RP, Vang KB, Castermans K, Popescu F, Zhang Y, Oude Egbrink MG, Mescher MF, Farrar MA, Griffioen AW, Mayo KH (2011) Enhancement of T-cell-mediated antitumor response: angiostatic adjuvant to immunotherapy against cancer. Clin Cancer Res 17(10):3134–3145. doi:10.1158/1078-0432.CCR-10-2443
-
(2011)
Clin Cancer Res
, vol.17
, Issue.10
, pp. 3134-3145
-
-
Dings, R.P.1
Vang, K.B.2
Castermans, K.3
Popescu, F.4
Zhang, Y.5
Oude Egbrink, M.G.6
Mescher, M.F.7
Farrar, M.A.8
Griffioen, A.W.9
Mayo, K.H.10
-
150
-
-
84921047061
-
Pericytes: a double-edged sword in cancer therapy
-
COI: 1:CAS:528:DC%2BC2MXkvFGhtA%3D%3D, PID: 25143028
-
Meng MB, Zaorsky NG, Deng L, Wang HH, Chao J, Zhao LJ, Yuan ZY, Ping W (2015) Pericytes: a double-edged sword in cancer therapy. Future Oncol 11(1):169–179. doi:10.2217/fon.14.123
-
(2015)
Future Oncol
, vol.11
, Issue.1
, pp. 169-179
-
-
Meng, M.B.1
Zaorsky, N.G.2
Deng, L.3
Wang, H.H.4
Chao, J.5
Zhao, L.J.6
Yuan, Z.Y.7
Ping, W.8
-
151
-
-
19944422751
-
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
-
COI: 1:CAS:528:DC%2BD2MXktVantw%3D%3D, PID: 15607960
-
Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK (2004) Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 6(6):553–563. doi:10.1016/j.ccr.2004.10.011
-
(2004)
Cancer Cell
, vol.6
, Issue.6
, pp. 553-563
-
-
Winkler, F.1
Kozin, S.V.2
Tong, R.T.3
Chae, S.S.4
Booth, M.F.5
Garkavtsev, I.6
Xu, L.7
Hicklin, D.J.8
Fukumura, D.9
di Tomaso, E.10
Munn, L.L.11
Jain, R.K.12
-
152
-
-
84867902940
-
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
-
COI: 1:CAS:528:DC%2BC38XhvVSltLjK, PID: 23045683
-
Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC (2012) Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci USA 109(43):17561–17566. doi:10.1073/pnas.1215397109
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.43
, pp. 17561-17566
-
-
Huang, Y.1
Yuan, J.2
Righi, E.3
Kamoun, W.S.4
Ancukiewicz, M.5
Nezivar, J.6
Santosuosso, M.7
Martin, J.D.8
Martin, M.R.9
Vianello, F.10
Leblanc, P.11
Munn, L.L.12
Huang, P.13
Duda, D.G.14
Fukumura, D.15
Jain, R.K.16
Poznansky, M.C.17
-
153
-
-
55449084935
-
The T-cell receptor repertoire of regulatory T cells
-
COI: 1:CAS:528:DC%2BD1cXhsV2jsLjE, PID: 19128356
-
Pacholczyk R, Kern J (2008) The T-cell receptor repertoire of regulatory T cells. Immunology 125(4):450–458. doi:10.1111/j.1365-2567.2008.02992.x
-
(2008)
Immunology
, vol.125
, Issue.4
, pp. 450-458
-
-
Pacholczyk, R.1
Kern, J.2
-
154
-
-
73949088551
-
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
-
COI: 1:CAS:528:DC%2BD1MXhs1WlsbrP, PID: 20008522
-
Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH (2009) PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 206(13):3015–3029. doi:10.1084/jem.20090847
-
(2009)
J Exp Med
, vol.206
, Issue.13
, pp. 3015-3029
-
-
Francisco, L.M.1
Salinas, V.H.2
Brown, K.E.3
Vanguri, V.K.4
Freeman, G.J.5
Kuchroo, V.K.6
Sharpe, A.H.7
-
155
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BC28XjsFyitL0%3D, PID: 26412456
-
Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, Chow LQ, Vokes EE, Felip E, Holgado E, Barlesi F, Kohlhaufl M, Arrieta O, Burgio MA, Fayette J, Lena H, Poddubskaya E, Gerber DE, Gettinger SN, Rudin CM, Rizvi N, Crino L, Blumenschein GR Jr, Antonia SJ, Dorange C, Harbison CT, Graf Finckenstein F, Brahmer JR (2015) Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 373(17):1627–1639. doi:10.1056/NEJMoa1507643
-
(2015)
N Engl J Med
, vol.373
, Issue.17
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
Spigel, D.R.4
Steins, M.5
Ready, N.E.6
Chow, L.Q.7
Vokes, E.E.8
Felip, E.9
Holgado, E.10
Barlesi, F.11
Kohlhaufl, M.12
Arrieta, O.13
Burgio, M.A.14
Fayette, J.15
Lena, H.16
Poddubskaya, E.17
Gerber, D.E.18
Gettinger, S.N.19
Rudin, C.M.20
Rizvi, N.21
Crino, L.22
Blumenschein, G.R.23
Antonia, S.J.24
Dorange, C.25
Harbison, C.T.26
Graf Finckenstein, F.27
Brahmer, J.R.28
more..
-
156
-
-
84936791837
-
Nivolumab versus Docetaxel in advanced squamous-cell non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BC2MXht12qu7%2FJ, PID: 26028407
-
Brahmer J, Reckamp KL, Baas P, Crino L, Eberhardt WE, Poddubskaya E, Antonia S, Pluzanski A, Vokes EE, Holgado E, Waterhouse D, Ready N, Gainor J, Aren Frontera O, Havel L, Steins M, Garassino MC, Aerts JG, Domine M, Paz-Ares L, Reck M, Baudelet C, Harbison CT, Lestini B, Spigel DR (2015) Nivolumab versus Docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med 373(2):123–135. doi:10.1056/NEJMoa1504627
-
(2015)
N Engl J Med
, vol.373
, Issue.2
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
Crino, L.4
Eberhardt, W.E.5
Poddubskaya, E.6
Antonia, S.7
Pluzanski, A.8
Vokes, E.E.9
Holgado, E.10
Waterhouse, D.11
Ready, N.12
Gainor, J.13
Aren Frontera, O.14
Havel, L.15
Steins, M.16
Garassino, M.C.17
Aerts, J.G.18
Domine, M.19
Paz-Ares, L.20
Reck, M.21
Baudelet, C.22
Harbison, C.T.23
Lestini, B.24
Spigel, D.R.25
more..
-
157
-
-
84946607195
-
Nivolumab versus everolimus in advanced renal-cell carcinoma
-
COI: 1:CAS:528:DC%2BC28XjsFyhsrg%3D, PID: 26406148
-
Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, Castellano D, Choueiri TK, Gurney H, Donskov F, Bono P, Wagstaff J, Gauler TC, Ueda T, Tomita Y, Schutz FA, Kollmannsberger C, Larkin J, Ravaud A, Simon JS, Xu LA, Waxman IM, Sharma P, CheckMate I (2015) Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med 373(19):1803–1813. doi:10.1056/NEJMoa1510665
-
(2015)
N Engl J Med
, vol.373
, Issue.19
, pp. 1803-1813
-
-
Motzer, R.J.1
Escudier, B.2
McDermott, D.F.3
George, S.4
Hammers, H.J.5
Srinivas, S.6
Tykodi, S.S.7
Sosman, J.A.8
Procopio, G.9
Plimack, E.R.10
Castellano, D.11
Choueiri, T.K.12
Gurney, H.13
Donskov, F.14
Bono, P.15
Wagstaff, J.16
Gauler, T.C.17
Ueda, T.18
Tomita, Y.19
Schutz, F.A.20
Kollmannsberger, C.21
Larkin, J.22
Ravaud, A.23
Simon, J.S.24
Xu, L.A.25
Waxman, I.M.26
Sharma, P.27
CheckMate, I.28
more..
-
158
-
-
84925222119
-
Nivolumab in previously untreated melanoma without BRAF mutation
-
COI: 1:CAS:528:DC%2BC2MXisFGqsLg%3D, PID: 25399552
-
Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, Savage KJ, Hernberg MM, Lebbe C, Charles J, Mihalcioiu C, Chiarion-Sileni V, Mauch C, Cognetti F, Arance A, Schmidt H, Schadendorf D, Gogas H, Lundgren-Eriksson L, Horak C, Sharkey B, Waxman IM, Atkinson V, Ascierto PA (2015) Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 372(4):320–330. doi:10.1056/NEJMoa1412082
-
(2015)
N Engl J Med
, vol.372
, Issue.4
, pp. 320-330
-
-
Robert, C.1
Long, G.V.2
Brady, B.3
Dutriaux, C.4
Maio, M.5
Mortier, L.6
Hassel, J.C.7
Rutkowski, P.8
McNeil, C.9
Kalinka-Warzocha, E.10
Savage, K.J.11
Hernberg, M.M.12
Lebbe, C.13
Charles, J.14
Mihalcioiu, C.15
Chiarion-Sileni, V.16
Mauch, C.17
Cognetti, F.18
Arance, A.19
Schmidt, H.20
Schadendorf, D.21
Gogas, H.22
Lundgren-Eriksson, L.23
Horak, C.24
Sharkey, B.25
Waxman, I.M.26
Atkinson, V.27
Ascierto, P.A.28
more..
-
159
-
-
84994812847
-
Nivolumab for recurrent squamous-cell carcinoma of the head and neck
-
PID: 27718784
-
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML (2016) Nivolumab for recurrent squamous-cell carcinoma of the head and neck. N Engl J Med 375(19):1856–1867. doi:10.1056/NEJMoa1602252
-
(2016)
N Engl J Med
, vol.375
, Issue.19
, pp. 1856-1867
-
-
Ferris, R.L.1
Blumenschein, G.2
Fayette, J.3
Guigay, J.4
Colevas, A.D.5
Licitra, L.6
Harrington, K.7
Kasper, S.8
Vokes, E.E.9
Even, C.10
Worden, F.11
Saba, N.F.12
Iglesias Docampo, L.C.13
Haddad, R.14
Rordorf, T.15
Kiyota, N.16
Tahara, M.17
Monga, M.18
Lynch, M.19
Geese, W.J.20
Kopit, J.21
Shaw, J.W.22
Gillison, M.L.23
more..
-
160
-
-
85010904121
-
Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial
-
Sharma P, Retz M, Siefker-Radtke A, Baron A, Necchi A, Bedke J, Plimack ER, Vaena D, Grimm MO, Bracarda S, Arranz JA, Pal S, Ohyama C, Saci A, Qu X, Lambert A, Krishnan S, Azrilevich A, Galsky MD (2017) Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial. Lancet Oncol. doi:10.1016/S1470-2045(17)30065-7
-
(2017)
Lancet Oncol
-
-
Sharma, P.1
Retz, M.2
Siefker-Radtke, A.3
Baron, A.4
Necchi, A.5
Bedke, J.6
Plimack, E.R.7
Vaena, D.8
Grimm, M.O.9
Bracarda, S.10
Arranz, J.A.11
Pal, S.12
Ohyama, C.13
Saci, A.14
Qu, X.15
Lambert, A.16
Krishnan, S.17
Azrilevich, A.18
Galsky, M.D.19
-
161
-
-
58149483422
-
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
-
COI: 1:CAS:528:DC%2BD1MXhsFWktA%3D%3D, PID: 19074257
-
Yuan J, Gnjatic S, Li H, Powel S, Gallardo HF, Ritter E, Ku GY, Jungbluth AA, Segal NH, Rasalan TS, Manukian G, Xu Y, Roman RA, Terzulli SL, Heywood M, Pogoriler E, Ritter G, Old LJ, Allison JP, Wolchok JD (2008) CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit. Proc Natl Acad Sci USA 105(51):20410–20415. doi:10.1073/pnas.0810114105
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.51
, pp. 20410-20415
-
-
Yuan, J.1
Gnjatic, S.2
Li, H.3
Powel, S.4
Gallardo, H.F.5
Ritter, E.6
Ku, G.Y.7
Jungbluth, A.A.8
Segal, N.H.9
Rasalan, T.S.10
Manukian, G.11
Xu, Y.12
Roman, R.A.13
Terzulli, S.L.14
Heywood, M.15
Pogoriler, E.16
Ritter, G.17
Old, L.J.18
Allison, J.P.19
Wolchok, J.D.20
more..
-
162
-
-
79955719446
-
Sipuleucel-T (provenge) injection: the first immunotherapy agent (vaccine) for hormone-refractory prostate cancer
-
Anassi E, Ndefo UA (2011) Sipuleucel-T (provenge) injection: the first immunotherapy agent (vaccine) for hormone-refractory prostate cancer. Pharm Ther 36(4):197–202
-
(2011)
Pharm Ther
, vol.36
, Issue.4
, pp. 197-202
-
-
Anassi, E.1
Ndefo, U.A.2
-
163
-
-
84959577118
-
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
-
COI: 1:CAS:528:DC%2BC28XjslGmu7w%3D, PID: 26952546
-
Rosenberg JE, Hoffman-Censits J, Powles T, van der Heijden MS, Balar AV, Necchi A, Dawson N, O’Donnell PH, Balmanoukian A, Loriot Y, Srinivas S, Retz MM, Grivas P, Joseph RW, Galsky MD, Fleming MT, Petrylak DP, Perez-Gracia JL, Burris HA, Castellano D, Canil C, Bellmunt J, Bajorin D, Nickles D, Bourgon R, Frampton GM, Cui N, Mariathasan S, Abidoye O, Fine GD, Dreicer R (2016) Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet 387(10031):1909–1920. doi:10.1016/S0140-6736(16)00561-4
-
(2016)
Lancet
, vol.387
, Issue.10031
, pp. 1909-1920
-
-
Rosenberg, J.E.1
Hoffman-Censits, J.2
Powles, T.3
van der Heijden, M.S.4
Balar, A.V.5
Necchi, A.6
Dawson, N.7
O’Donnell, P.H.8
Balmanoukian, A.9
Loriot, Y.10
Srinivas, S.11
Retz, M.M.12
Grivas, P.13
Joseph, R.W.14
Galsky, M.D.15
Fleming, M.T.16
Petrylak, D.P.17
Perez-Gracia, J.L.18
Burris, H.A.19
Castellano, D.20
Canil, C.21
Bellmunt, J.22
Bajorin, D.23
Nickles, D.24
Bourgon, R.25
Frampton, G.M.26
Cui, N.27
Mariathasan, S.28
Abidoye, O.29
Fine, G.D.30
Dreicer, R.31
more..
-
164
-
-
77953747963
-
The PD-1 pathway in tolerance and autoimmunity
-
COI: 1:CAS:528:DC%2BC3cXovFaks7s%3D, PID: 20636820
-
Francisco LM, Sage PT, Sharpe AH (2010) The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 236:219–242. doi:10.1111/j.1600-065X.2010.00923.x
-
(2010)
Immunol Rev
, vol.236
, pp. 219-242
-
-
Francisco, L.M.1
Sage, P.T.2
Sharpe, A.H.3
-
165
-
-
84959865627
-
Regulation of PD-L1: a novel role of pro-survival signalling in cancer
-
COI: 1:STN:280:DC%2BC28rhtlansA%3D%3D, PID: 26681673
-
Chen J, Jiang CC, Jin L, Zhang XD (2016) Regulation of PD-L1: a novel role of pro-survival signalling in cancer. Ann Oncol 27(3):409–416. doi:10.1093/annonc/mdv615
-
(2016)
Ann Oncol
, vol.27
, Issue.3
, pp. 409-416
-
-
Chen, J.1
Jiang, C.C.2
Jin, L.3
Zhang, X.D.4
-
166
-
-
84941797037
-
Classifying cancers based on T-cell infiltration and PD-L1
-
COI: 1:CAS:528:DC%2BC2MXpt1Kksrs%3D, PID: 25977340
-
Teng MW, Ngiow SF, Ribas A, Smyth MJ (2015) Classifying cancers based on T-cell infiltration and PD-L1. Cancer Res 75(11):2139–2145. doi:10.1158/0008-5472.CAN-15-0255
-
(2015)
Cancer Res
, vol.75
, Issue.11
, pp. 2139-2145
-
-
Teng, M.W.1
Ngiow, S.F.2
Ribas, A.3
Smyth, M.J.4
-
167
-
-
84903208336
-
PD-1 pathway inhibitors: changing the landscape of cancer immunotherapy
-
PID: 24955707
-
Dolan DE, Gupta S (2014) PD-1 pathway inhibitors: changing the landscape of cancer immunotherapy. Cancer Control 21(3):231–237
-
(2014)
Cancer Control
, vol.21
, Issue.3
, pp. 231-237
-
-
Dolan, D.E.1
Gupta, S.2
-
168
-
-
85013080291
-
PD-1 and PD-L1 antibodies in cancer: current status and future directions
-
PID: 28213726
-
Balar AV, Weber JS (2017) PD-1 and PD-L1 antibodies in cancer: current status and future directions. Cancer Immunol Immunother. doi:10.1007/s00262-017-1954-6
-
(2017)
Cancer Immunol Immunother
-
-
Balar, A.V.1
Weber, J.S.2
-
169
-
-
84995489253
-
Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma: results from the phase Ib KEYNOTE-012 expansion cohort
-
Chow LQ, Haddad R, Gupta S, Mahipal A, Mehra R, Tahara M, Berger R, Eder JP, Burtness B, Lee SH, Keam B, Kang H, Muro K, Weiss J, Geva R, Lin CC, Chung HC, Meister A, Dolled-Filhart M, Pathiraja K, Cheng JD, Seiwert TY (2016) Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma: results from the phase Ib KEYNOTE-012 expansion cohort. J Clin Oncol. doi:10.1200/JCO.2016.68.1478
-
(2016)
J Clin Oncol
-
-
Chow, L.Q.1
Haddad, R.2
Gupta, S.3
Mahipal, A.4
Mehra, R.5
Tahara, M.6
Berger, R.7
Eder, J.P.8
Burtness, B.9
Lee, S.H.10
Keam, B.11
Kang, H.12
Muro, K.13
Weiss, J.14
Geva, R.15
Lin, C.C.16
Chung, H.C.17
Meister, A.18
Dolled-Filhart, M.19
Pathiraja, K.20
Cheng, J.D.21
Seiwert, T.Y.22
more..
-
170
-
-
58049202334
-
Phase I/II study of ipilimumab for patients with metastatic melanoma
-
COI: 1:CAS:528:DC%2BD1MXhs1Ggurc%3D, PID: 19018089
-
Weber JS, O’Day S, Urba W, Powderly J, Nichol G, Yellin M, Snively J, Hersh E (2008) Phase I/II study of ipilimumab for patients with metastatic melanoma. J Clin Oncol 26(36):5950–5956. doi:10.1200/JCO.2008.16.1927
-
(2008)
J Clin Oncol
, vol.26
, Issue.36
, pp. 5950-5956
-
-
Weber, J.S.1
O’Day, S.2
Urba, W.3
Powderly, J.4
Nichol, G.5
Yellin, M.6
Snively, J.7
Hersh, E.8
-
171
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
COI: 1:CAS:528:DC%2BC3cXhtVCrtrbN, PID: 20525992
-
Hodi FS, O’Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, Akerley W, van den Eertwegh AJ, Lutzky J, Lorigan P, Vaubel JM, Linette GP, Hogg D, Ottensmeier CH, Lebbe C, Peschel C, Quirt I, Clark JI, Wolchok JD, Weber JS, Tian J, Yellin MJ, Nichol GM, Hoos A, Urba WJ (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363(8):711–723. doi:10.1056/NEJMoa1003466
-
(2010)
N Engl J Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O’Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
Gonzalez, R.7
Robert, C.8
Schadendorf, D.9
Hassel, J.C.10
Akerley, W.11
van den Eertwegh, A.J.12
Lutzky, J.13
Lorigan, P.14
Vaubel, J.M.15
Linette, G.P.16
Hogg, D.17
Ottensmeier, C.H.18
Lebbe, C.19
Peschel, C.20
Quirt, I.21
Clark, J.I.22
Wolchok, J.D.23
Weber, J.S.24
Tian, J.25
Yellin, M.J.26
Nichol, G.M.27
Hoos, A.28
Urba, W.J.29
more..
-
172
-
-
75249100054
-
Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study
-
COI: 1:CAS:528:DC%2BC3cXhtlGgtbY%3D, PID: 20004617
-
Wolchok JD, Neyns B, Linette G, Negrier S, Lutzky J, Thomas L, Waterfield W, Schadendorf D, Smylie M, Guthrie T Jr, Grob JJ, Chesney J, Chin K, Chen K, Hoos A, O’Day SJ, Lebbe C (2010) Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol 11(2):155–164. doi:10.1016/S1470-2045(09)70334-1
-
(2010)
Lancet Oncol
, vol.11
, Issue.2
, pp. 155-164
-
-
Wolchok, J.D.1
Neyns, B.2
Linette, G.3
Negrier, S.4
Lutzky, J.5
Thomas, L.6
Waterfield, W.7
Schadendorf, D.8
Smylie, M.9
Guthrie, T.10
Grob, J.J.11
Chesney, J.12
Chin, K.13
Chen, K.14
Hoos, A.15
O’Day, S.J.16
Lebbe, C.17
-
173
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
COI: 1:CAS:528:DC%2BC3MXosVegtro%3D, PID: 21639810
-
Robert C, Thomas L, Bondarenko I, O’Day S, Weber J, Garbe C, Lebbe C, Baurain JF, Testori A, Grob JJ, Davidson N, Richards J, Maio M, Hauschild A, Miller WH Jr, Gascon P, Lotem M, Harmankaya K, Ibrahim R, Francis S, Chen TT, Humphrey R, Hoos A, Wolchok JD (2011) Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 364(26):2517–2526. doi:10.1056/NEJMoa1104621
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
O’Day, S.4
Weber, J.5
Garbe, C.6
Lebbe, C.7
Baurain, J.F.8
Testori, A.9
Grob, J.J.10
Davidson, N.11
Richards, J.12
Maio, M.13
Hauschild, A.14
Miller, W.H.15
Gascon, P.16
Lotem, M.17
Harmankaya, K.18
Ibrahim, R.19
Francis, S.20
Chen, T.T.21
Humphrey, R.22
Hoos, A.23
Wolchok, J.D.24
more..
-
174
-
-
84936147067
-
Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
-
PID: 26027431
-
Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, Schadendorf D, Dummer R, Smylie M, Rutkowski P, Ferrucci PF, Hill A, Wagstaff J, Carlino MS, Haanen JB, Maio M, Marquez-Rodas I, McArthur GA, Ascierto PA, Long GV, Callahan MK, Postow MA, Grossmann K, Sznol M, Dreno B, Bastholt L, Yang A, Rollin LM, Horak C, Hodi FS, Wolchok JD (2015) Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 373(1):23–34. doi:10.1056/NEJMoa1504030
-
(2015)
N Engl J Med
, vol.373
, Issue.1
, pp. 23-34
-
-
Larkin, J.1
Chiarion-Sileni, V.2
Gonzalez, R.3
Grob, J.J.4
Cowey, C.L.5
Lao, C.D.6
Schadendorf, D.7
Dummer, R.8
Smylie, M.9
Rutkowski, P.10
Ferrucci, P.F.11
Hill, A.12
Wagstaff, J.13
Carlino, M.S.14
Haanen, J.B.15
Maio, M.16
Marquez-Rodas, I.17
McArthur, G.A.18
Ascierto, P.A.19
Long, G.V.20
Callahan, M.K.21
Postow, M.A.22
Grossmann, K.23
Sznol, M.24
Dreno, B.25
Bastholt, L.26
Yang, A.27
Rollin, L.M.28
Horak, C.29
Hodi, F.S.30
Wolchok, J.D.31
more..
-
175
-
-
84873129546
-
CTLA-4 blockade in tumor models: an overview of preclinical and translational research
-
PID: 23390376
-
Grosso JF, Jure-Kunkel MN (2013) CTLA-4 blockade in tumor models: an overview of preclinical and translational research. Cancer Immun 13:5
-
(2013)
Cancer Immun
, vol.13
, pp. 5
-
-
Grosso, J.F.1
Jure-Kunkel, M.N.2
-
176
-
-
84955463999
-
The urgent need to recover MHC class I in cancers for effective immunotherapy
-
COI: 1:CAS:528:DC%2BC28Xlt1CltQ%3D%3D, PID: 26796069
-
Garrido F, Aptsiauri N, Doorduijn EM, Garcia Lora AM, van Hall T (2016) The urgent need to recover MHC class I in cancers for effective immunotherapy. Curr Opin Immunol 39:44–51. doi:10.1016/j.coi.2015.12.007
-
(2016)
Curr Opin Immunol
, vol.39
, pp. 44-51
-
-
Garrido, F.1
Aptsiauri, N.2
Doorduijn, E.M.3
Garcia Lora, A.M.4
van Hall, T.5
-
177
-
-
84880109398
-
Targeting the MHC class II antigen presentation pathway in cancer immunotherapy
-
PID: 23162758
-
Thibodeau J, Bourgeois-Daigneault MC, Lapointe R (2012) Targeting the MHC class II antigen presentation pathway in cancer immunotherapy. Oncoimmunology 1(6):908–916. doi:10.4161/onci.21205
-
(2012)
Oncoimmunology
, vol.1
, Issue.6
, pp. 908-916
-
-
Thibodeau, J.1
Bourgeois-Daigneault, M.C.2
Lapointe, R.3
-
178
-
-
84856831467
-
Major histocompatibility complex class i and tumour immuno-evasion: how to fool T cells and natural killer cells at one time
-
COI: 1:STN:280:DC%2BC383is1ahtA%3D%3D, PID: 22328841
-
Fruci D, Benevolo M, Cifaldi L, Lorenzi S, Lo Monaco E, Tremante E, Giacomini P (2012) Major histocompatibility complex class i and tumour immuno-evasion: how to fool T cells and natural killer cells at one time. Curr Oncol 19(1):39–41. doi:10.3747/co.19.945
-
(2012)
Curr Oncol
, vol.19
, Issue.1
, pp. 39-41
-
-
Fruci, D.1
Benevolo, M.2
Cifaldi, L.3
Lorenzi, S.4
Lo Monaco, E.5
Tremante, E.6
Giacomini, P.7
-
179
-
-
79961109805
-
Cancer immunotherapy: sipuleucel-T and beyond
-
PID: 21923608
-
Hammerstrom AE, Cauley DH, Atkinson BJ, Sharma P (2011) Cancer immunotherapy: sipuleucel-T and beyond. Pharmacotherapy 31(8):813–828. doi:10.1592/phco.31.8.813
-
(2011)
Pharmacotherapy
, vol.31
, Issue.8
, pp. 813-828
-
-
Hammerstrom, A.E.1
Cauley, D.H.2
Atkinson, B.J.3
Sharma, P.4
-
180
-
-
83055188639
-
T-cell-inducing vaccines—what’s the future
-
COI: 1:CAS:528:DC%2BC3MXhs12ntLzO, PID: 22044118
-
Gilbert SC (2012) T-cell-inducing vaccines—what’s the future. Immunology 135(1):19–26. doi:10.1111/j.1365-2567.2011.03517.x
-
(2012)
Immunology
, vol.135
, Issue.1
, pp. 19-26
-
-
Gilbert, S.C.1
-
181
-
-
84947744383
-
Pros and Cons of antigen-presenting cell targeted tumor vaccines
-
PID: 26583156
-
Goyvaerts C, Breckpot K (2015) Pros and Cons of antigen-presenting cell targeted tumor vaccines. J Immunol Res 2015:785634. doi:10.1155/2015/785634
-
(2015)
J Immunol Res
, vol.2015
, pp. 785634
-
-
Goyvaerts, C.1
Breckpot, K.2
-
182
-
-
0034554863
-
Immunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cells
-
COI: 1:CAS:528:DC%2BD3cXptVSiurc%3D, PID: 11099318
-
Small EJ, Fratesi P, Reese DM, Strang G, Laus R, Peshwa MV, Valone FH (2000) Immunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cells. J Clin Oncol 18(23):3894–3903. doi:10.1200/JCO.2000.18.23.3894
-
(2000)
J Clin Oncol
, vol.18
, Issue.23
, pp. 3894-3903
-
-
Small, E.J.1
Fratesi, P.2
Reese, D.M.3
Strang, G.4
Laus, R.5
Peshwa, M.V.6
Valone, F.H.7
-
183
-
-
84858780815
-
Cancer immunotherapy via dendritic cells
-
COI: 1:CAS:528:DC%2BC38XksVehtrY%3D, PID: 22437871
-
Palucka K, Banchereau J (2012) Cancer immunotherapy via dendritic cells. Nat Rev Cancer 12(4):265–277. doi:10.1038/nrc3258
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.4
, pp. 265-277
-
-
Palucka, K.1
Banchereau, J.2
-
184
-
-
33746012881
-
Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer
-
COI: 1:CAS:528:DC%2BD28XnslKhs7g%3D, PID: 16809734
-
Small EJ, Schellhammer PF, Higano CS, Redfern CH, Nemunaitis JJ, Valone FH, Verjee SS, Jones LA, Hershberg RM (2006) Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. J Clin Oncol 24(19):3089–3094. doi:10.1200/JCO.2005.04.5252
-
(2006)
J Clin Oncol
, vol.24
, Issue.19
, pp. 3089-3094
-
-
Small, E.J.1
Schellhammer, P.F.2
Higano, C.S.3
Redfern, C.H.4
Nemunaitis, J.J.5
Valone, F.H.6
Verjee, S.S.7
Jones, L.A.8
Hershberg, R.M.9
-
185
-
-
84975059616
-
Resistance mechanisms to immune-checkpoint blockade in cancer: tumor-intrinsic and -extrinsic factors
-
COI: 1:CAS:528:DC%2BC28XhtVKhs7nL, PID: 27332730
-
Pitt JM, Vetizou M, Daillere R, Roberti MP, Yamazaki T, Routy B, Lepage P, Boneca IG, Chamaillard M, Kroemer G, Zitvogel L (2016) Resistance mechanisms to immune-checkpoint blockade in cancer: tumor-intrinsic and -extrinsic factors. Immunity 44(6):1255–1269. doi:10.1016/j.immuni.2016.06.001
-
(2016)
Immunity
, vol.44
, Issue.6
, pp. 1255-1269
-
-
Pitt, J.M.1
Vetizou, M.2
Daillere, R.3
Roberti, M.P.4
Yamazaki, T.5
Routy, B.6
Lepage, P.7
Boneca, I.G.8
Chamaillard, M.9
Kroemer, G.10
Zitvogel, L.11
-
186
-
-
0030700761
-
Endothelial CD34 is suppressed in human malignancies: role of angiogenic factors
-
COI: 1:CAS:528:DyaK2sXnt1eksL8%3D, PID: 9461038
-
Hellwig SM, Damen CA, van Adrichem NP, Blijham GH, Groenewegen G, Griffioen AW (1997) Endothelial CD34 is suppressed in human malignancies: role of angiogenic factors. Cancer Lett 120(2):203–211
-
(1997)
Cancer Lett
, vol.120
, Issue.2
, pp. 203-211
-
-
Hellwig, S.M.1
Damen, C.A.2
van Adrichem, N.P.3
Blijham, G.H.4
Groenewegen, G.5
Griffioen, A.W.6
-
187
-
-
0029788738
-
Endoglin/CD 105 may not be an optimal tumor endothelial treatment target
-
COI: 1:STN:280:DyaK2s%2Fis1Wmtg%3D%3D, PID: 8872333
-
Griffioen AW, Damen CA, Blijham GH, Groenewegen G (1996) Endoglin/CD 105 may not be an optimal tumor endothelial treatment target. Breast Cancer Res Treat 39(2):239–242
-
(1996)
Breast Cancer Res Treat
, vol.39
, Issue.2
, pp. 239-242
-
-
Griffioen, A.W.1
Damen, C.A.2
Blijham, G.H.3
Groenewegen, G.4
-
188
-
-
0030044629
-
Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors
-
COI: 1:CAS:528:DyaK28XhtlKktrs%3D, PID: 8640769
-
Griffioen AW, Damen CA, Martinotti S, Blijham GH, Groenewegen G (1996) Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors. Cancer Res 56(5):1111–1117
-
(1996)
Cancer Res
, vol.56
, Issue.5
, pp. 1111-1117
-
-
Griffioen, A.W.1
Damen, C.A.2
Martinotti, S.3
Blijham, G.H.4
Groenewegen, G.5
-
189
-
-
4043184065
-
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
-
COI: 1:CAS:528:DC%2BD2cXmtFWrtr0%3D, PID: 15235597
-
Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME, Capla JM, Galiano RD, Levine JP, Gurtner GC (2004) Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10(8):858–864. doi:10.1038/nm1075
-
(2004)
Nat Med
, vol.10
, Issue.8
, pp. 858-864
-
-
Ceradini, D.J.1
Kulkarni, A.R.2
Callaghan, M.J.3
Tepper, O.M.4
Bastidas, N.5
Kleinman, M.E.6
Capla, J.M.7
Galiano, R.D.8
Levine, J.P.9
Gurtner, G.C.10
-
190
-
-
79960393113
-
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
-
COI: 1:CAS:528:DC%2BC3MXovFegs7g%3D, PID: 21753853
-
Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, Gimotty PA, Gilks CB, Lal P, Zhang L, Coukos G (2011) Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 475(7355):226–230. doi:10.1038/nature10169
-
(2011)
Nature
, vol.475
, Issue.7355
, pp. 226-230
-
-
Facciabene, A.1
Peng, X.2
Hagemann, I.S.3
Balint, K.4
Barchetti, A.5
Wang, L.P.6
Gimotty, P.A.7
Gilks, C.B.8
Lal, P.9
Zhang, L.10
Coukos, G.11
-
191
-
-
85014835509
-
Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors
-
PID: 28276530
-
Chen Y, Liu YC, Sung YC, Ramjiawan RR, Lin TT, Chang CC, Jeng KS, Chang CF, Liu CH, Gao DY, Hsu FF, Duyverman AM, Kitahara S, Huang P, Dima S, Popescu I, Flaherty KT, Zhu AX, Bardeesy N, Jain RK, Benes CH, Duda DG (2017) Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors. Sci Rep 7:44123. doi:10.1038/srep44123
-
(2017)
Sci Rep
, vol.7
, pp. 44123
-
-
Chen, Y.1
Liu, Y.C.2
Sung, Y.C.3
Ramjiawan, R.R.4
Lin, T.T.5
Chang, C.C.6
Jeng, K.S.7
Chang, C.F.8
Liu, C.H.9
Gao, D.Y.10
Hsu, F.F.11
Duyverman, A.M.12
Kitahara, S.13
Huang, P.14
Dima, S.15
Popescu, I.16
Flaherty, K.T.17
Zhu, A.X.18
Bardeesy, N.19
Jain, R.K.20
Benes, C.H.21
Duda, D.G.22
more..
-
192
-
-
84899753178
-
PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
-
COI: 1:CAS:528:DC%2BC2cXotVCjs7w%3D, PID: 24778419
-
Noman MZ, Desantis G, Janji B, Hasmim M, Karray S, Dessen P, Bronte V, Chouaib S (2014) PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med 211(5):781–790. doi:10.1084/jem.20131916
-
(2014)
J Exp Med
, vol.211
, Issue.5
, pp. 781-790
-
-
Noman, M.Z.1
Desantis, G.2
Janji, B.3
Hasmim, M.4
Karray, S.5
Dessen, P.6
Bronte, V.7
Chouaib, S.8
-
193
-
-
84922214829
-
Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions
-
COI: 1:CAS:528:DC%2BC2cXhvVansbnF, PID: 24912948
-
Hato T, Goyal L, Greten TF, Duda DG, Zhu AX (2014) Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions. Hepatology 60(5):1776–1782. doi:10.1002/hep.27246
-
(2014)
Hepatology
, vol.60
, Issue.5
, pp. 1776-1782
-
-
Hato, T.1
Goyal, L.2
Greten, T.F.3
Duda, D.G.4
Zhu, A.X.5
-
194
-
-
33845343558
-
Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy
-
COI: 1:CAS:528:DC%2BD28Xht1elsLzE, PID: 17121902
-
Li B, Lalani AS, Harding TC, Luan B, Koprivnikar K, Huan T, Prell R, VanRoey MJ, Simmons AD, Jooss K (2006) Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy. Clin Cancer Res 12(22):6808–6816. doi:10.1158/1078-0432.CCR-06-1558
-
(2006)
Clin Cancer Res
, vol.12
, Issue.22
, pp. 6808-6816
-
-
Li, B.1
Lalani, A.S.2
Harding, T.C.3
Luan, B.4
Koprivnikar, K.5
Huan, T.6
Prell, R.7
VanRoey, M.J.8
Simmons, A.D.9
Jooss, K.10
-
195
-
-
77957061892
-
Combining antiangiogenic therapy with immunotherapy exerts better therapeutical effects on large tumors in a woodchuck hepatoma model
-
COI: 1:CAS:528:DC%2BC3cXhtVKqs7rI, PID: 20679198
-
Huang KW, Wu HL, Lin HL, Liang PC, Chen PJ, Chen SH, Lee HI, Su PY, Wu WH, Lee PH, Hwang LH, Chen DS (2010) Combining antiangiogenic therapy with immunotherapy exerts better therapeutical effects on large tumors in a woodchuck hepatoma model. Proc Natl Acad Sci USA 107(33):14769–14774. doi:10.1073/pnas.1009534107
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.33
, pp. 14769-14774
-
-
Huang, K.W.1
Wu, H.L.2
Lin, H.L.3
Liang, P.C.4
Chen, P.J.5
Chen, S.H.6
Lee, H.I.7
Su, P.Y.8
Wu, W.H.9
Lee, P.H.10
Hwang, L.H.11
Chen, D.S.12
-
196
-
-
84964313298
-
Bevacizumab plus ipilimumab in patients with metastatic melanoma
-
COI: 1:CAS:528:DC%2BC2cXhtFWgtr3O, PID: 24838938
-
Hodi FS, Lawrence D, Lezcano C, Wu X, Zhou J, Sasada T, Zeng W, Giobbie-Hurder A, Atkins MB, Ibrahim N, Friedlander P, Flaherty KT, Murphy GF, Rodig S, Velazquez EF, Mihm MC Jr, Russell S, DiPiro PJ, Yap JT, Ramaiya N, Van den Abbeele AD, Gargano M, McDermott D (2014) Bevacizumab plus ipilimumab in patients with metastatic melanoma. Cancer Immunol Res 2(7):632–642. doi:10.1158/2326-6066.CIR-14-0053
-
(2014)
Cancer Immunol Res
, vol.2
, Issue.7
, pp. 632-642
-
-
Hodi, F.S.1
Lawrence, D.2
Lezcano, C.3
Wu, X.4
Zhou, J.5
Sasada, T.6
Zeng, W.7
Giobbie-Hurder, A.8
Atkins, M.B.9
Ibrahim, N.10
Friedlander, P.11
Flaherty, K.T.12
Murphy, G.F.13
Rodig, S.14
Velazquez, E.F.15
Mihm, M.C.16
Russell, S.17
DiPiro, P.J.18
Yap, J.T.19
Ramaiya, N.20
Van den Abbeele, A.D.21
Gargano, M.22
McDermott, D.23
more..
-
197
-
-
84984870923
-
Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma
-
COI: 1:CAS:528:DC%2BC28XhsVKjsbnI, PID: 27571927
-
Wallin JJ, Bendell JC, Funke R, Sznol M, Korski K, Jones S, Hernandez G, Mier J, He X, Hodi FS, Denker M, Leveque V, Canamero M, Babitski G, Koeppen H, Ziai J, Sharma N, Gaire F, Chen DS, Waterkamp D, Hegde PS, McDermott DF (2016) Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma. Nat Commun 7:12624. doi:10.1038/ncomms12624
-
(2016)
Nat Commun
, vol.7
, pp. 12624
-
-
Wallin, J.J.1
Bendell, J.C.2
Funke, R.3
Sznol, M.4
Korski, K.5
Jones, S.6
Hernandez, G.7
Mier, J.8
He, X.9
Hodi, F.S.10
Denker, M.11
Leveque, V.12
Canamero, M.13
Babitski, G.14
Koeppen, H.15
Ziai, J.16
Sharma, N.17
Gaire, F.18
Chen, D.S.19
Waterkamp, D.20
Hegde, P.S.21
McDermott, D.F.22
more..
-
198
-
-
84994193774
-
Phase II and phase III failures: 2013–2015
-
COI: 1:CAS:528:DC%2BC28XhslynsLvN, PID: 27811931
-
Harrison RK (2016) Phase II and phase III failures: 2013–2015. Nat Rev Drug Discov 15(12):817–818. doi:10.1038/nrd.2016.184
-
(2016)
Nat Rev Drug Discov
, vol.15
, Issue.12
, pp. 817-818
-
-
Harrison, R.K.1
-
199
-
-
84945563895
-
Failures in Phase III: causes and consequences
-
COI: 1:CAS:528:DC%2BC2MXhs1yltr%2FE, PID: 26473191
-
Seruga B, Ocana A, Amir E, Tannock IF (2015) Failures in Phase III: causes and consequences. Clin Cancer Res 21(20):4552–4560. doi:10.1158/1078-0432.CCR-15-0124
-
(2015)
Clin Cancer Res
, vol.21
, Issue.20
, pp. 4552-4560
-
-
Seruga, B.1
Ocana, A.2
Amir, E.3
Tannock, I.F.4
-
200
-
-
84912096468
-
Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia
-
COI: 1:CAS:528:DC%2BC2cXhvFSmt73F, PID: 25517747
-
Jain RK (2014) Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell 26(5):605–622. doi:10.1016/j.ccell.2014.10.006
-
(2014)
Cancer Cell
, vol.26
, Issue.5
, pp. 605-622
-
-
Jain, R.K.1
-
201
-
-
84904323068
-
The role of mechanical forces in tumor growth and therapy
-
COI: 1:CAS:528:DC%2BC2cXhsVKgt7%2FJ, PID: 25014786
-
Jain RK, Martin JD, Stylianopoulos T (2014) The role of mechanical forces in tumor growth and therapy. Annu Rev Biomed Eng 16:321–346. doi:10.1146/annurev-bioeng-071813-105259
-
(2014)
Annu Rev Biomed Eng
, vol.16
, pp. 321-346
-
-
Jain, R.K.1
Martin, J.D.2
Stylianopoulos, T.3
-
202
-
-
85019380720
-
Current trends in multidrug optimization
-
Weiss A, Nowak-Sliwinska P (2016) Current trends in multidrug optimization. J Lab Autom. doi:10.1177/2472630316682338
-
(2016)
J Lab Autom
-
-
Weiss, A.1
Nowak-Sliwinska, P.2
-
203
-
-
84961318149
-
Optimization of drug combinations using feedback system control
-
COI: 1:CAS:528:DC%2BC28XlvVGrtw%3D%3D, PID: 26766116
-
Nowak-Sliwinska P, Weiss A, Ding X, Dyson PJ, van den Bergh H, Griffioen AW, Ho CM (2016) Optimization of drug combinations using feedback system control. Nat Protoc 11(2):302–315. doi:10.1038/nprot.2016.017
-
(2016)
Nat Protoc
, vol.11
, Issue.2
, pp. 302-315
-
-
Nowak-Sliwinska, P.1
Weiss, A.2
Ding, X.3
Dyson, P.J.4
van den Bergh, H.5
Griffioen, A.W.6
Ho, C.M.7
|