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Volumn 66, Issue 5, 2017, Pages 551-564

PD-1 and PD-L1 antibodies in cancer: current status and future directions

Author keywords

Biomarkers; Checkpoint inhibitors; Immunotherapy; Microbiome; PD 1; PD L1

Indexed keywords

BIOLOGICAL MARKER; BLOCKING ANTIBODY; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; CD274 PROTEIN, HUMAN; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN;

EID: 85013080291     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-017-1954-6     Document Type: Review
Times cited : (264)

References (95)
  • 1
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • COI: 1:CAS:528:DyaK3sXkslShtbs%3D, PID: 1396582
    • Ishida Y, Agata Y, Shibahara K, Honjo T (1992) Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 11(11):3887–3895
    • (1992) EMBO J , vol.11 , Issue.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 2
    • 0030005099 scopus 로고    scopus 로고
    • Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
    • COI: 1:CAS:528:DyaK28Xjt1Kmurw%3D, PID: 8671665
    • Agata Y, Kawasaki A, Nishimura H, Ishida Y, Tsubata T, Yagita H, Honjo T (1996) Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol 8(5):765–772
    • (1996) Int Immunol , vol.8 , Issue.5 , pp. 765-772
    • Agata, Y.1    Kawasaki, A.2    Nishimura, H.3    Ishida, Y.4    Tsubata, T.5    Yagita, H.6    Honjo, T.7
  • 3
    • 0031562690 scopus 로고    scopus 로고
    • Activation-induced expression of human programmed death-1 gene in T-lymphocytes
    • COI: 1:CAS:528:DyaK2sXisVCqsrc%3D, PID: 9141617
    • Vibhakar R, Juan G, Traganos F, Darzynkiewicz Z, Finger LR (1997) Activation-induced expression of human programmed death-1 gene in T-lymphocytes. Exp Cell Res 232(1):25–28. doi:10.1006/excr.1997.3493
    • (1997) Exp Cell Res , vol.232 , Issue.1 , pp. 25-28
    • Vibhakar, R.1    Juan, G.2    Traganos, F.3    Darzynkiewicz, Z.4    Finger, L.R.5
  • 4
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • COI: 1:CAS:528:DyaK1MXlvVShsb8%3D, PID: 10485649
    • Nishimura H, Nose M, Hiai H, Minato N, Honjo T (1999) Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11(2):141–151
    • (1999) Immunity , vol.11 , Issue.2 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 5
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • COI: 1:CAS:528:DC%2BD28XhtFyktL0%3D, PID: 16382236
    • Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R (2006) Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439(7077):682–687. doi:10.1038/nature04444
    • (2006) Nature , vol.439 , Issue.7077 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3    Zhu, B.4    Allison, J.P.5    Sharpe, A.H.6    Freeman, G.J.7    Ahmed, R.8
  • 7
    • 34848900497 scopus 로고    scopus 로고
    • Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs
    • COI: 1:CAS:528:DC%2BD2sXhtFSrtrrP, PID: 17898045
    • Wong RM, Scotland RR, Lau RL, Wang C, Korman AJ, Kast WM, Weber JS (2007) Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs. Int Immunol 19(10):1223–1234. doi:10.1093/intimm/dxm091
    • (2007) Int Immunol , vol.19 , Issue.10 , pp. 1223-1234
    • Wong, R.M.1    Scotland, R.R.2    Lau, R.L.3    Wang, C.4    Korman, A.J.5    Kast, W.M.6    Weber, J.S.7
  • 8
    • 70350234729 scopus 로고    scopus 로고
    • Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions
    • COI: 1:CAS:528:DC%2BD1MXht1ynurfK, PID: 19826049
    • Wu K, Kryczek I, Chen L, Zou W, Welling TH (2009) Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions. Cancer Res 69(20):8067–8075. doi:10.1158/0008-5472.CAN-09-0901
    • (2009) Cancer Res , vol.69 , Issue.20 , pp. 8067-8075
    • Wu, K.1    Kryczek, I.2    Chen, L.3    Zou, W.4    Welling, T.H.5
  • 9
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • COI: 1:CAS:528:DC%2BD1MXhtVyiur3K, PID: 19423728
    • Ahmadzadeh M, Johnson LA, Heemskerk B, Wunderlich JR, Dudley ME, White DE, Rosenberg SA (2009) Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 114(8):1537–1544. doi:10.1182/blood-2008-12-195792
    • (2009) Blood , vol.114 , Issue.8 , pp. 1537-1544
    • Ahmadzadeh, M.1    Johnson, L.A.2    Heemskerk, B.3    Wunderlich, J.R.4    Dudley, M.E.5    White, D.E.6    Rosenberg, S.A.7
  • 10
    • 77957723967 scopus 로고    scopus 로고
    • Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
    • COI: 1:CAS:528:DC%2BC3cXht1Cms73N, PID: 20819923
    • Fourcade J, Sun Z, Benallaoua M, Guillaume P, Luescher IF, Sander C, Kirkwood JM, Kuchroo V, Zarour HM (2010) Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med 207(10):2175–2186. doi:10.1084/jem.20100637
    • (2010) J Exp Med , vol.207 , Issue.10 , pp. 2175-2186
    • Fourcade, J.1    Sun, Z.2    Benallaoua, M.3    Guillaume, P.4    Luescher, I.F.5    Sander, C.6    Kirkwood, J.M.7    Kuchroo, V.8    Zarour, H.M.9
  • 12
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, Chen S, Klein AP, Pardoll DM, Topalian SL, Chen L (2012) Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 4(127):127ra137. doi:10.1126/scitranslmed.3003689
    • (2012) Sci Transl Med , vol.4 , Issue.127 , pp. 127ra137
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3    Xu, H.4    Sharma, R.5    McMiller, T.L.6    Chen, S.7    Klein, A.P.8    Pardoll, D.M.9    Topalian, S.L.10    Chen, L.11
  • 13
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells
    • PID: 23986400
    • Spranger S, Spaapen RM, Zha Y, Williams J, Meng Y, Ha TT, Gajewski TF (2013) Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. Sci Transl Med 5(200):200ra116. doi:10.1126/scitranslmed.3006504
    • (2013) Sci Transl Med , vol.5 , Issue.200 , pp. 200ra116
    • Spranger, S.1    Spaapen, R.M.2    Zha, Y.3    Williams, J.4    Meng, Y.5    Ha, T.T.6    Gajewski, T.F.7
  • 16
    • 84941711371 scopus 로고    scopus 로고
    • Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future
    • PID: 26325035
    • Chen L, Han X (2015) Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. J Clin Invest 125(9):3384–3391. doi:10.1172/JCI80011
    • (2015) J Clin Invest , vol.125 , Issue.9 , pp. 3384-3391
    • Chen, L.1    Han, X.2
  • 17
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • COI: 1:CAS:528:DC%2BD2sXosFeqtrk%3D, PID: 17629517
    • Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ (2007) Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 27(1):111–122. doi:10.1016/j.immuni.2007.05.016
    • (2007) Immunity , vol.27 , Issue.1 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3    Sharpe, A.H.4    Freeman, G.J.5
  • 19
    • 0038796692 scopus 로고    scopus 로고
    • B7-H1 pathway and its role in the evasion of tumor immunity
    • COI: 1:CAS:528:DC%2BD3sXjvVSltrs%3D
    • Dong H, Chen L (2003) B7-H1 pathway and its role in the evasion of tumor immunity. J Mol Med (Berl) 81(5):281–287. doi:10.1007/s00109-003-0430-2
    • (2003) J Mol Med (Berl) , vol.81 , Issue.5 , pp. 281-287
    • Dong, H.1    Chen, L.2
  • 20
    • 43549115533 scopus 로고    scopus 로고
    • B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
    • COI: 1:CAS:528:DC%2BD1cXktlWmsbs%3D, PID: 18223165
    • Azuma T, Yao S, Zhu G, Flies AS, Flies SJ, Chen L (2008) B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 111(7):3635–3643. doi:10.1182/blood-2007-11-123141
    • (2008) Blood , vol.111 , Issue.7 , pp. 3635-3643
    • Azuma, T.1    Yao, S.2    Zhu, G.3    Flies, A.S.4    Flies, S.J.5    Chen, L.6
  • 29
    • 84980602745 scopus 로고    scopus 로고
    • Efficacy and Safety of Nivolumab in patients with BRAF V600 mutant and BRAF Wild-Type Advanced Melanoma: a pooled analysis of 4 clinical trials
    • PID: 26181250
    • Larkin J, Lao CD, Urba WJ, McDermott DF, Horak C, Jiang J, Wolchok JD (2015) Efficacy and Safety of Nivolumab in patients with BRAF V600 mutant and BRAF Wild-Type Advanced Melanoma: a pooled analysis of 4 clinical trials. JAMA Oncol 1(4):433–440. doi:10.1001/jamaoncol.2015.1184
    • (2015) JAMA Oncol , vol.1 , Issue.4 , pp. 433-440
    • Larkin, J.1    Lao, C.D.2    Urba, W.J.3    McDermott, D.F.4    Horak, C.5    Jiang, J.6    Wolchok, J.D.7
  • 41
    • 84928917822 scopus 로고    scopus 로고
    • Pooled analysis of long-term survival data from phase II and phase III trials of Ipilimumab in unresectable or metastatic melanoma
    • COI: 1:CAS:528:DC%2BC2MXhsFKmt7zP, PID: 25667295
    • Schadendorf D, Hodi FS, Robert C, Weber JS, Margolin K, Hamid O, Patt D, Chen TT, Berman DM, Wolchok JD (2015) Pooled analysis of long-term survival data from phase II and phase III trials of Ipilimumab in unresectable or metastatic melanoma. J Clin Oncol 33(17):1889–1894. doi:10.1200/JCO.2014.56.2736
    • (2015) J Clin Oncol , vol.33 , Issue.17 , pp. 1889-1894
    • Schadendorf, D.1    Hodi, F.S.2    Robert, C.3    Weber, J.S.4    Margolin, K.5    Hamid, O.6    Patt, D.7    Chen, T.T.8    Berman, D.M.9    Wolchok, J.D.10
  • 54
    • 77951626194 scopus 로고    scopus 로고
    • Prognostic factors in patients with advanced transitional cell carcinoma of the urothelial tract experiencing treatment failure with platinum-containing regimens
    • PID: 20231682
    • Bellmunt J, Choueiri TK, Fougeray R, Schutz FA, Salhi Y, Winquist E, Culine S, von der Maase H, Vaughn DJ, Rosenberg JE (2010) Prognostic factors in patients with advanced transitional cell carcinoma of the urothelial tract experiencing treatment failure with platinum-containing regimens. J Clin Oncol 28(11):1850–1855. doi:10.1200/JCO.2009.25.4599
    • (2010) J Clin Oncol , vol.28 , Issue.11 , pp. 1850-1855
    • Bellmunt, J.1    Choueiri, T.K.2    Fougeray, R.3    Schutz, F.A.4    Salhi, Y.5    Winquist, E.6    Culine, S.7    von der Maase, H.8    Vaughn, D.J.9    Rosenberg, J.E.10
  • 58
    • 85018001858 scopus 로고    scopus 로고
    • DP P Updated efficacy from IMvigor210: Atezolizumab in platinum-treated locally advanced/metastatic urothelial carcinoma (mUC). In: ASCO Annual Meeting
    • Dreicer R, Hoffman-Censits J, Flaig T, Grande E, Balmanoukian A, von Amsberg G, Theodore C, Chowdhury S, Bracarda S, Clement JM, Yu E, Kalebasty AR, Niegisch G, Culine S GM, Ding B, Mariathasan S, Legrand F, Abidoye OO, , Chicago, IL, 34, 2016 (suppl)
    • Dreicer R, Hoffman-Censits J, Flaig T, Grande E, Balmanoukian A, von Amsberg G, Theodore C, Chowdhury S, Bracarda S, Clement JM, Yu E, Kalebasty AR, Niegisch G, Culine S GM, Ding B, Mariathasan S, Legrand F, Abidoye OO, DP P Updated efficacy from IMvigor210: Atezolizumab in platinum-treated locally advanced/metastatic urothelial carcinoma (mUC). In: ASCO Annual Meeting, Chicago, IL, 2016. J Clin Oncol 34, 2016 (suppl; abstr 4515)
    • (2016) J Clin Oncol
  • 59
    • 84960085003 scopus 로고    scopus 로고
    • Second-line single-agent versus doublet chemotherapy as salvage therapy for metastatic urothelial cancer: a systematic review and meta-analysis
    • COI: 1:STN:280:DC%2BC28zjvVSlsg%3D%3D, PID: 26487582
    • Raggi D, Miceli R, Sonpavde G, Giannatempo P, Mariani L, Galsky MD, Bellmunt J, Necchi A (2016) Second-line single-agent versus doublet chemotherapy as salvage therapy for metastatic urothelial cancer: a systematic review and meta-analysis. Ann Oncol 27(1):49–61. doi:10.1093/annonc/mdv509
    • (2016) Ann Oncol , vol.27 , Issue.1 , pp. 49-61
    • Raggi, D.1    Miceli, R.2    Sonpavde, G.3    Giannatempo, P.4    Mariani, L.5    Galsky, M.D.6    Bellmunt, J.7    Necchi, A.8
  • 62
    • 84855583390 scopus 로고    scopus 로고
    • Randomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC study 30986
    • PID: 22162575
    • De Santis M, Bellmunt J, Mead G, Kerst JM, Leahy M, Maroto P, Gil T, Marreaud S, Daugaard G, Skoneczna I, Collette S, Lorent J, de Wit R, Sylvester R (2012) Randomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC study 30986. J Clin Oncol 30(2):191–199. doi:10.1200/JCO.2011.37.3571
    • (2012) J Clin Oncol , vol.30 , Issue.2 , pp. 191-199
    • De Santis, M.1    Bellmunt, J.2    Mead, G.3    Kerst, J.M.4    Leahy, M.5    Maroto, P.6    Gil, T.7    Marreaud, S.8    Daugaard, G.9    Skoneczna, I.10    Collette, S.11    Lorent, J.12    de Wit, R.13    Sylvester, R.14
  • 66
    • 48249117436 scopus 로고    scopus 로고
    • High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma: a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006
    • COI: 1:CAS:528:DC%2BD1cXpt1Orsb4%3D, PID: 18457330
    • Klapper JA, Downey SG, Smith FO, Yang JC, Hughes MS, Kammula US, Sherry RM, Royal RE, Steinberg SM, Rosenberg S (2008) High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma: a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006. Cancer 113(2):293–301. doi:10.1002/cncr.23552
    • (2008) Cancer , vol.113 , Issue.2 , pp. 293-301
    • Klapper, J.A.1    Downey, S.G.2    Smith, F.O.3    Yang, J.C.4    Hughes, M.S.5    Kammula, U.S.6    Sherry, R.M.7    Royal, R.E.8    Steinberg, S.M.9    Rosenberg, S.10
  • 68
    • 84962497081 scopus 로고    scopus 로고
    • Atezolizumab, an anti-programmed death-ligand 1 antibody, in metastatic renal cell carcinoma: long-term safety, clinical activity, and immune correlates from a phase Ia study
    • COI: 1:CAS:528:DC%2BC2sXhslOhtQ%3D%3D, PID: 26755520
    • McDermott DF, Sosman JA, Sznol M, Massard C, Gordon MS, Hamid O, Powderly JD, Infante JR, Fasso M, Wang YV, Zou W, Hegde PS, Fine GD, Powles T (2016) Atezolizumab, an anti-programmed death-ligand 1 antibody, in metastatic renal cell carcinoma: long-term safety, clinical activity, and immune correlates from a phase Ia study. J Clin Oncol 34(8):833–842. doi:10.1200/JCO.2015.63.7421
    • (2016) J Clin Oncol , vol.34 , Issue.8 , pp. 833-842
    • McDermott, D.F.1    Sosman, J.A.2    Sznol, M.3    Massard, C.4    Gordon, M.S.5    Hamid, O.6    Powderly, J.D.7    Infante, J.R.8    Fasso, M.9    Wang, Y.V.10    Zou, W.11    Hegde, P.S.12    Fine, G.D.13    Powles, T.14
  • 70
    • 84973547996 scopus 로고    scopus 로고
    • Quality of life in patients with advanced renal cell carcinoma given nivolumab versus everolimus in CheckMate 025: a randomised, open-label, phase 3 trial
    • COI: 1:CAS:528:DC%2BC28XpslyjsL4%3D, PID: 27283863
    • Cella D, Grunwald V, Nathan P, Doan J, Dastani H, Taylor F, Bennett B, DeRosa M, Berry S, Broglio K, Berghorn E, Motzer RJ (2016) Quality of life in patients with advanced renal cell carcinoma given nivolumab versus everolimus in CheckMate 025: a randomised, open-label, phase 3 trial. Lancet Oncol 17(7):994–1003. doi:10.1016/S1470-2045(16)30125-5
    • (2016) Lancet Oncol , vol.17 , Issue.7 , pp. 994-1003
    • Cella, D.1    Grunwald, V.2    Nathan, P.3    Doan, J.4    Dastani, H.5    Taylor, F.6    Bennett, B.7    DeRosa, M.8    Berry, S.9    Broglio, K.10    Berghorn, E.11    Motzer, R.J.12
  • 76
    • 84991235797 scopus 로고    scopus 로고
    • Correlation of peripheral and intratumoral T-cell receptor (TCR) clonality with clinical outcomes in patients with metastatic urothelial cancer (mUC) treated with atezolizumab
    • In: ASCO Annual Meeting, Chicago, IL, 34
    • Funt SCA, Yusko E, Vignali M, Benzeno S, Boyd ME, Meredith MM, Kania BE, Cipolla CK, Regazzi AM, Robins H, Iyer G, Rosenberg JE, Bajorin DF (2016) Correlation of peripheral and intratumoral T-cell receptor (TCR) clonality with clinical outcomes in patients with metastatic urothelial cancer (mUC) treated with atezolizumab. In: ASCO Annual Meeting, Chicago, IL, 2016. vol J Clin Oncol 34, 2016 (suppl; abstr 3005)
    • (2016) J Clin Oncol
    • Funt, S.C.A.1    Yusko, E.2    Vignali, M.3    Benzeno, S.4    Boyd, M.E.5    Meredith, M.M.6    Kania, B.E.7    Cipolla, C.K.8    Regazzi, A.M.9    Robins, H.10    Iyer, G.11    Rosenberg, J.E.12    Bajorin, D.F.13
  • 79
    • 84978179559 scopus 로고    scopus 로고
    • A comparative study of PD-L1 diagnostic assays and the classification of patients as PD-L1 positive and PD-L1 negative
    • Ratcliffe MJSA, Midha A, Barker C, Scorer P, Walker J (2016) A comparative study of PD-L1 diagnostic assays and the classification of patients as PD-L1 positive and PD-L1 negative. In: AACR Annual Meeting, New Orleans, LA, 2016. LB-094
    • (2016) AACR Annual Meeting LB-094
    • Ratcliffe, M.J.S.A.1    Midha, A.2    Barker, C.3    Scorer, P.4    Walker, J.5
  • 80
    • 84940372582 scopus 로고    scopus 로고
    • The next hurdle in cancer immunotherapy: overcoming the non-T-cell-inflamed tumor microenvironment
    • PID: 26320069
    • Gajewski TF (2015) The next hurdle in cancer immunotherapy: overcoming the non-T-cell-inflamed tumor microenvironment. Semin Oncol 42(4):663–671. doi:10.1053/j.seminoncol.2015.05.011
    • (2015) Semin Oncol , vol.42 , Issue.4 , pp. 663-671
    • Gajewski, T.F.1
  • 81
    • 84936953099 scopus 로고    scopus 로고
    • Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity
    • COI: 1:CAS:528:DC%2BC2MXhtFaitrrL, PID: 25970248
    • Spranger S, Bao R, Gajewski TF (2015) Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature 523(7559):231–235. doi:10.1038/nature14404
    • (2015) Nature , vol.523 , Issue.7559 , pp. 231-235
    • Spranger, S.1    Bao, R.2    Gajewski, T.F.3
  • 84
    • 84979763259 scopus 로고    scopus 로고
    • Molecular drivers of the non-t-cell-inflamed tumor microenvironment in urothelial bladder cancer
    • COI: 1:CAS:528:DC%2BC28XhtVyitLnK, PID: 27197067
    • Sweis RF, Spranger S, Bao R, Paner GP, Stadler WM, Steinberg G, Gajewski TF (2016) Molecular drivers of the non-t-cell-inflamed tumor microenvironment in urothelial bladder cancer. Cancer Immunol Res 4(7):563–568. doi:10.1158/2326-6066.CIR-15-0274
    • (2016) Cancer Immunol Res , vol.4 , Issue.7 , pp. 563-568
    • Sweis, R.F.1    Spranger, S.2    Bao, R.3    Paner, G.P.4    Stadler, W.M.5    Steinberg, G.6    Gajewski, T.F.7
  • 85
    • 26244467481 scopus 로고    scopus 로고
    • All the peptides that fit: the beginning, the middle, and the end of the MHC class I antigen-processing pathway
    • COI: 1:CAS:528:DC%2BD2MXhtFOqtL7M, PID: 16181325
    • Shastri N, Cardinaud S, Schwab SR, Serwold T, Kunisawa J (2005) All the peptides that fit: the beginning, the middle, and the end of the MHC class I antigen-processing pathway. Immunol Rev 207:31–41. doi:10.1111/j.0105-2896.2005.00321.x
    • (2005) Immunol Rev , vol.207 , pp. 31-41
    • Shastri, N.1    Cardinaud, S.2    Schwab, S.R.3    Serwold, T.4    Kunisawa, J.5
  • 92
    • 84962788254 scopus 로고    scopus 로고
    • Microbiome and anticancer immunosurveillance
    • COI: 1:CAS:528:DC%2BC28Xlslers7Y%3D, PID: 27058662
    • Zitvogel L, Ayyoub M, Routy B, Kroemer G (2016) Microbiome and anticancer immunosurveillance. Cell 165(2):276–287. doi:10.1016/j.cell.2016.03.001
    • (2016) Cell , vol.165 , Issue.2 , pp. 276-287
    • Zitvogel, L.1    Ayyoub, M.2    Routy, B.3    Kroemer, G.4
  • 93
    • 84947773168 scopus 로고    scopus 로고
    • Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors
    • COI: 1:CAS:528:DC%2BC2MXhvFWlsb3M, PID: 26590829
    • Derer A, Frey B, Fietkau R, Gaipl US (2016) Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors. Cancer Immunol Immunother 65(7):779–786. doi:10.1007/s00262-015-1771-8
    • (2016) Cancer Immunol Immunother , vol.65 , Issue.7 , pp. 779-786
    • Derer, A.1    Frey, B.2    Fietkau, R.3    Gaipl, U.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.