Role of the tumor stroma in resistance to anti-angiogenic therapy

Drug Resistance Updates

Volumn 25, Issue , 2016, Pages 26-37

  Huijbers, Elisabeth J M ^a   Van Beijnum, Judy R ^a   Thijssen, Victor L ^a   Sabrkhany, Siamack ^b   Nowak Sliwinska, Patrycja ^a   Griffioen, Arjan W ^a  

^a University of Amsterdam   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Angiogenesis; Anti angiogenic therapy; Resistance; Stroma; Tumor

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT;

ANTIANGIOGENIC THERAPY; ARTICLE; BONE MARROW CELL; CANCER GROWTH; CANCER RESISTANCE; CELL DIFFERENTIATION; CYTOKINE RELEASE; DENDRITIC CELL; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; EOSINOPHIL; ERYTHROCYTE; FIBROBLAST; GIANT CELL TUMOR; GLYCOSYLATION; GRANULOCYTE; HEMOSTASIS; HUMAN; HYPOXIA; LYMPHOID CELL; MACROPHAGE; MAST CELL; MONOCYTE; NEOPLASM; NEUTROPHIL; NONHUMAN; PERICYTE; PHASE 1 CLINICAL TRIAL (TOPIC); PHENOTYPE; PRIORITY JOURNAL; SOLID TUMOR; STROMA; STROMA CELL; SUPPRESSOR CELL; THROMBOCYTE; THROMBOSIS; TUMOR ASSOCIATED LEUKOCYTE; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; TUMOR STROMA; TUMOR VASCULARIZATION; ANIMAL; DRUG RESISTANCE; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; SURVIVAL; VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, NEOPLASM; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; STROMAL CELLS; SURVIVAL;

EID: 84960431096     PISSN: 13687646     EISSN: 15322084     Source Type: Journal    
DOI: 10.1016/j.drup.2016.02.002     Document Type: Article

References (204)

1. A. Abramsson, P. Lindblom, and C. Betsholtz Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors J Clin. Invest. 112 2003 1142 1151
2. Y. Adar, M. Stark, E.E. Bram, P. Nowak-Sliwinska, H. van den Bergh, G. Szewczyk, T. Sarna, A. Skladanowski, A.W. Griffioen, and Y.G. Assaraf Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers Cell Death Dis. 3 2012 e293
3. B. Ahmed, L.I. Van Eijk, J.C. Bouma-Ter Steege, D.W. Van Der Schaft, A.M. Van Esch, S.R. Joosten-Achjanie, P. Lambin, W. Landuyt, and A.W. Griffioen Vascular targeting effect of combretastatin A-4 phosphate dominates the inherent angiogenesis inhibitory activity Int. J. Cancer 105 2003 20 25
4. W.C. Aird Endothelial cell heterogeneity Cold Spring Harb. Perspect. Med. 2 2012 a006429
5. K. Akiyama, N. Ohga, Y. Hida, T. Kawamoto, Y. Sadamoto, S. Ishikawa, N. Maishi, T. Akino, M. Kondoh, and et al. Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment Am. J. Pathol. 180 2012 1283 1293
6. M. Ammendola, I. Marech, G. Sammarco, V. Zuccalà, M. Luposella, N. Zizzo, R. Patruno, A. Crovace, E. Ruggieri, and et al. Infiltrating mast cells correlate with angiogenesis in bone metastases from gastric cancer patients Int. J. Mol. Sci. 16 2015 3237 3250
7. C. Anderberg, and K. Pietras On the origin of cancer-associated fibroblasts Cell Cycle 8 2009 1461 1462
8. A.S. Arbab Activation of alternative pathways of angiogenesis and involvement of stem cells following anti-angiogenesis treatment in glioma Histol. Histopathol. 27 2012 549 557
9. T. Asahara, T. Murohara, A. Sullivan, M. Silver, R. van der Zee, T. Li, B. Witzenbichler, G. Schatteman, and J.M. Isner Isolation of putative progenitor endothelial cells for angiogenesis Science 275 1997 964 967
10. J.A. Baron, B.F. Cole, R.S. Sandler, R.W. Haile, D. Ahnen, R. Bresalier, G. McKeown-Eyssen, R.W. Summers, R. Rothstein, and et al. A randomized trial of aspirin to prevent colorectal adenomas N. Engl. J. Med. 348 2003 891 899
11. C.A. Behm, and K.S. Ovington The role of eosinophils in parasitic helminth infections: insights from genetically modified mice Parasitol. Today 16 2000 202 209
12. G. Bergers, and D. Hanahan Modes of resistance to anti-angiogenic therapy Nat. Rev. Cancer 8 2008 592 603
13. G. Bergers, R. Brekken, G. McMahon, T.H. Vu, T. Itoh, K. Tamaki, K. Tanzawa, P. Thorpe, S. Itohara, and et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis Nat. Cell Biol. 2 2000 737 744
14. G. Bergers, S. Song, N. Meyer-Morse, E. Bergsland, and D. Hanahan Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors J. Clin. Invest. 111 2003 1287 1295
15. N.A. Bhowmick, E.G. Neilson, and H.L. Moses Stromal fibroblasts in cancer initiation and progression Nature 432 2004 332 337
16. S.C. Bischoff Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data Nat. Rev. Immunol. 7 2007 93 104
17. C.C. Bleul, M. Farzan, H. Choe, C. Parolin, I. Clark-Lewis, J. Sodroski, and T.A. Springer The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry Nature 382 1996 829 833
18. J.A. Burger, and A. Peled CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers Leukemia 23 2009 43 52
19. A. Burlacu, G. Grigorescu, A.M. Rosca, M.B. Preda, and M. Simionescu Factors secreted by mesenchymal stem cells and endothelial progenitor cells have complementary effects on angiogenesis in vitro Stem Cells Dev. 22 2013 643 653
20. J.M. Burns, B.C. Summers, Y. Wang, A. Melikian, R. Berahovich, Z. Miao, M.E. Penfold, M.J. Sunshine, D.R. Littman, and et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development J. Exp. Med. 203 2006 2201 2213
21. M. Cao, Y. Xu, J.I. Youn, R. Cabrera, X. Zhang, D. Gabrilovich, D.R. Nelson, and C. Liu Kinase inhibitor Sorafenib modulates immunosuppressive cell populations in a murine liver cancer model Lab. Investig. 91 2011 598 608
22. P. Carmeliet, and R.K. Jain Molecular mechanisms and clinical applications of angiogenesis Nature 473 2011 298 307
23. J. Cedervall, A. Dimberg, and A.K. Olsson Tumor-induced local and systemic impact on blood vessel function Mediat. Inflamm. 2015 2015 418290
24. D.J. Ceradini, A.R. Kulkarni, M.J. Callaghan, O.M. Tepper, N. Bastidas, M.E. Kleinman, J.M. Capla, R.D. Galiano, J.P. Levine, and G.C. Gurtner Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 Nat. Med. 10 2004 858 864
25. L. Cheng, Z. Huang, W. Zhou, Q. Wu, S. Donnola, J.K. Liu, X. Fang, A.E. Sloan, Y. Mao, and et al. Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth Cell 153 2013 139 152
26. A.S. Chung, X. Wu, G. Zhuang, H. Ngu, I. Kasman, J. Zhang, J.M. Vernes, Z. Jiang, Y.G. Meng, and et al. An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy Nat. Med. 19 2013 1114 1123
27. P. Cirri, and P. Chiarugi Cancer associated fibroblasts: the dark side of the coin Am. J. Cancer Res. 1 2011 482 497
28. J.M. Clarke, and H.I. Hurwitz Understanding and targeting resistance to anti-angiogenic therapies J. Gastrointest. Oncol. 4 2013 253 263
29. S.B. Coffelt, C.E. Lewis, L. Naldini, J.M. Brown, N. Ferrara, and M. De Palma Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors Am. J. Pathol. 176 2010 1564 1576
30. S.B. Coffelt, A.O. Tal, A. Scholz, M. De Palma, S. Patel, C. Urbich, S.K. Biswas, C. Murdoch, K.H. Plate, and et al. Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions Cancer Res. 70 2010 5270 5280
31. V.G. Cooke, V.S. LeBleu, D. Keskin, Z. Khan, J.T. O'Connell, Y. Teng, M.B. Duncan, L. Xie, G. Maeda, and et al. Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway Cancer Cell 21 2012 66 81
32. L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867
33. Y. Crawford, and N. Ferrara Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies Trends Pharmacol. Sci. 30 2009 624 630
34. E. Crivellato, B. Nico, and D. Ribatti Mast cells and tumour angiogenesis: new insight from experimental carcinogenesis Cancer Lett. 269 2008 1 6
35. D.O. Croci, J.P. Cerliani, T. Dalotto-Moreno, S.P. Méndez-Huergo, I.D. Mascanfroni, S. Dergan-Dylon, M.A. Toscano, J.J. Caramelo, J.J. García-Vallejo, and et al. Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors Cell 156 2014 744 758
36. M. Czabanka, J. Bruenner, G. Parmaksiz, T. Broggini, M. Topalovic, S.H. Bayerl, G. Auf, I. Kremenetskaia, M. Nieminen, and et al. Combined temozolomide and sunitinib treatment leads to better tumour control but increased vascular resistance in O6-methylguanine methyltransferase-methylated gliomas Eur. J. Cancer 49 2013 2243 2252
37. B.P. Davis, and M.E. Rothenberg Eosinophils and cancer Cancer Immunol. Res. 2 2014 1 8
38. M. De Palma, and L. Naldini Tie2-expressing monocytes (TEMs): novel targets and vehicles of anticancer therapy? Biochim. Biophys. Acta 1796 2009 5 10
39. M. De Palma, M.A. Venneri, R. Galli, L. Sergi, L.S. Politi, M. Sampaolesi, and L. Naldini Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors Cancer Cell 8 2005 211 226
40. P. Dentelli, A. Rosso, C. Olgasi, G. Camussi, and M.F. Brizzi IL-3 is a novel target to interfere with tumor vasculature Oncogene 30 2011 4930 4940
41. E.I. Deryugina, E. Zajac, A. Juncker-Jensen, T.A. Kupriyanova, L. Welter, and J.P. Quigley Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment Neoplasia 16 2014 771 788
42. Y. Ding, N. Song, and Y. Luo Role of bone marrow-derived cells in angiogenesis: focus on macrophages and pericytes Cancer Microenviron. 5 2012 225 236
43. R.P. Dings, K.B. Vang, K. Castermans, F. Popescu, Y. Zhang, M.G. Oude Egbrink, M.F. Mescher, M.A. Farrar, A.W. Griffioen, and K.H. Mayo Enhancement of T-cell-mediated antitumor response: angiostatic adjuvant to immunotherapy against cancer Clin. Cancer Res. 17 2011 3134 3145
44. A.E. Dirkx, M.G. Oude Egbrink, J. Wagstaff, and A.W. Griffioen Monocyte/macrophage infiltration in tumors: modulators of angiogenesis J. Leukoc. Biol. 80 2006 1183 1196
45. D.G. Duda, S.V. Kozin, N.D. Kirkpatrick, L. Xu, D. Fukumura, and R.K. Jain CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies? Clin. Cancer Res. 17 2011 2074 2080
46. J.M. Ebos, C.R. Lee, J.G. Christensen, A.J. Mutsaers, and R.S. Kerbel Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy Proc. Natl. Acad. Sci. USA 104 2007 17069 17074
47. J.M. Ebos, C.R. Lee, W. Cruz-Munoz, G.A. Bjarnason, J.G. Christensen, and R.S. Kerbel Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis Cancer Cell 15 2009 232 239
48. M. Egeblad, E.S. Nakasone, and Z. Werb Tumors as organs: complex tissues that interface with the entire organism Dev. Cell 18 2010 884 901
49. J. Ehnfors, M. Kost-Alimova, N.L. Persson, A. Bergsmedh, J. Castro, T. Levchenko-Tegnebratt, L. Yang, T. Panaretakis, and L. Holmgren Horizontal transfer of tumor DNA to endothelial cells in vivo Cell Death Differ. 16 2009 749 757
50. N. Erez, M. Truitt, P. Olson, S.T. Arron, and D. Hanahan Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner Cancer Cell 17 2010 135 147
51. T.D. Eubank, R.D. Roberts, M. Khan, J.M. Curry, G.J. Nuovo, P. Kuppusamy, and C.B. Marsh Granulocyte macrophage colony-stimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophages Cancer Res. 69 2009 2133 2140
52. A. Fantin, J.M. Vieira, G. Gestri, L. Denti, Q. Schwarz, S. Prykhozhij, F. Peri, S.W. Wilson, and C. Ruhrberg Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction Blood 116 2010 829 840
53. J. Femel, E.J. Huijbers, F. Saupe, J. Cedervall, L. Zhang, P. Roswall, E. Larsson, H. Olofsson, K. Pietras, and et al. Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer Oncotarget 5 2014 12418 12427
54. W. Feng, M. Madajka, B.A. Kerr, G.H. Mahabeleshwar, S.W. Whiteheart, and T.V. Byzova A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing Blood 117 2011 3893 3902
55. J. Finke, J. Ko, B. Rini, P. Rayman, J. Ireland, and P. Cohen MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy Int. Immunopharmacol. 11 2011 856 861
56. J. Folkman Tumor angiogenesis: therapeutic implications N. Engl. J. Med. 285 1971 1182 1186
57. P. Foubert, G. Matrone, B. Souttou, C. Leré-Déan, V. Barateau, J. Plouët, S. Le Ricousse-Roussanne, B.I. Lévy, J.S. Silvestre, and G. Tobelem Coadministration of endothelial and smooth muscle progenitor cells enhances the efficiency of proangiogenic cell-based therapy Circ. Res. 103 2008 751 760
58. G. Francia, U. Emmenegger, and R.S. Kerbel Tumor-associated fibroblasts as "Trojan Horse" mediators of resistance to anti-VEGF therapy Cancer Cell 15 2009 3 5
59. D.I. Gabrilovich, S. Ostrand-Rosenberg, and V. Bronte Coordinated regulation of myeloid cells by tumours Nat. Rev. Immunol. 12 2012 253 268
60. K. Gabrusiewicz, D. Liu, N. Cortes-Santiago, M.B. Hossain, C.A. Conrad, K.D. Aldape, G.N. Fuller, F.C. Marini, M.M. Alonso, and et al. Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes Oncotarget 5 2014 2208 2220
61. G.J. Gasic, T.B. Gasic, and C.C. Stewart Antimetastatic effects associated with platelet reduction Proc. Natl. Acad. Sci. USA 61 1968 46 52
62. L.J. Gay, and B. Felding-Habermann Contribution of platelets to tumour metastasis Nat. Rev. Cancer 11 2011 123 134
63. K.J. Gotink, H.J. Broxterman, M. Labots, R.R. de Haas, H. Dekker, R.J. Honeywell, M.A. Rudek, L.V. Beerepoot, R.J. Musters, and et al. Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance Clin. Cancer Res. 17 2011 7337 7346
64. A.W. Griffioen, and G. Molema Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation Pharmacol. Rev. 52 2000 237 268
65. A.W. Griffioen, C.A. Damen, G.H. Blijham, and G. Groenewegen Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium Blood 88 1996 667 673
66. A.W. Griffioen, C.A. Damen, S. Martinotti, G.H. Blijham, and G. Groenewegen Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors Cancer Res. 56 1996 1111 1117
67. A.W. Griffioen, L.A. Mans, A.M. de Graaf, P. Nowak-Sliwinska, C.L. de Hoog, T.A. de Jong, F.A. Vyth-Dreese, J.R. van Beijnum, A. Bex, and E. Jonasch Rapid angiogenesis onset after discontinuation of sunitinib treatment of renal cell carcinoma patients Clin. Cancer Res. 18 2012 3961 3971
68. A.W. Griffioen, A. Weiss, R.H. Berndsen, U.K. Abdul, M.T. te Winkel, and P. Nowak-Sliwinska The emerging quest for the optimal angiostatic combination therapy Biochem. Soc. Trans. 42 2014 1608 1615
69. E. Hasnis, D. Alishekevitz, S. Gingis-Veltski, R. Bril, E. Fremder, T. Voloshin, Z. Raviv, A. Karban, and Y. Shaked Anti-Bv8 antibody and metronomic gemcitabine improve pancreatic adenocarcinoma treatment outcome following weekly gemcitabine therapy Neoplasia 16 2014 501 510
70. C. Hellberg, A. Ostman, and C.H. Heldin PDGF and vessel maturation Recent Results Cancer Res. 180 2010 103 114
71. M. Hellström, H. Gerhardt, M. Kalén, X. Li, U. Eriksson, H. Wolburg, and C. Betsholtz Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis J. Cell Biol. 153 2001 543 553
72. K. Hida, Y. Hida, D.N. Amin, A.F. Flint, D. Panigrahy, C.C. Morton, and M. Klagsbrun Tumor-associated endothelial cells with cytogenetic abnormalities Cancer Res. 64 2004 8249 8255
73. K. Hida, N. Maishi, Y. Sakurai, Y. Hida, and H. Harashima Heterogeneity of tumor endothelial cells and drug delivery Adv. Drug Deliv. Rev. 2015 10.1016/j.addr.2015.11.008 [Epub ahead of print]
74. F. Hillen, C.I. Baeten, A. van de Winkel, D. Creytens, D.W. van der Schaft, V. Winnepenninckx, and A.W. Griffioen Leukocyte infiltration and tumor cell plasticity are parameters of aggressiveness in primary cutaneous melanoma Cancer Immunol. Immunother. 57 2008 97 106
75. K.K. Hirschi, S.A. Rohovsky, L.H. Beck, S.R. Smith, and P.A. D'Amore Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact Circ. Res. 84 1999 298 305
76. K.A. Hotchkiss, A.W. Ashton, R.S. Klein, M.L. Lenzi, G.H. Zhu, and E.L. Schwartz Mechanisms by which tumor cells and monocytes expressing the angiogenic factor thymidine phosphorylase mediate human endothelial cell migration Cancer Res. 63 2003 527 533
77. B. Ho-Tin-Noé, T. Goerge, S.M. Cifuni, D. Duerschmied, and D.D. Wagner Platelet granule secretion continuously prevents intratumor hemorrhage Cancer Res. 68 2008 6851 6858
78. Y. Hou, Y. Wu, S.M. Farooq, X. Guan, S. Wang, Y. Liu, J.J. Oblak, J. Holcomb, Y. Jiang, and et al. A critical role of CXCR2 PDZ-mediated interactions in endothelial progenitor cell homing and angiogenesis Stem Cell Res. 14 2015 133 143
79. L. Huang, C. Hu, M. Di Benedetto, R. Varin, J. Liu, L. Wang, J.P. Vannier, J. Jin, A. Janin, and et al. Induction of multiple drug resistance in HMEC-1 endothelial cells after long-term exposure to sunitinib Onco Target. Ther. 7 2014 2249 2255
80. L. Huang, C. Perrault, J. Coelho-Martins, C. Hu, C. Dulong, M. Varna, J. Liu, J. Jin, C. Soria, and et al. Induction of acquired drug resistance in endothelial cells and its involvement in anticancer therapy J. Hematol. Oncol. 6 2013 49
81. S. Huang, M. Van Arsdall, S. Tedjarati, M. McCarty, W. Wu, R. Langley, and I.J. Fidler Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice J. Natl. Cancer Inst. 94 2002 1134 1142
82. E.J. Huijbers, M. Ringvall, J. Femel, S. Kalamajski, A. Lukinius, M. Abrink, L. Hellman, and A.K. Olsson Vaccination against the extra domain-B of fibronectin as a novel tumor therapy FASEB J. 24 2010 4535 4544
83. R.K. Jain, and M.F. Booth What brings pericytes to tumor vessels? J. Clin. Invest. 112 2003 1134 1136
84. R.K. Jain, D.G. Duda, J.W. Clark, and J.S. Loeffler Lessons from phase III clinical trials on anti-VEGF therapy for cancer Nat. Clin. Pract. Oncol. 3 2006 24 40
85. G.C. Jayson, R. Kerbel, L.M. Ellis, and A.L. Harris Antiangiogenic therapy in oncology: current status and future directions Lancet 2016 10.1016/S0140-6736(15)01088-0 [Epub ahead of print]
86. K. Kashima, M. Watanabe, Y. Sato, J. Hata, N. Ishii, and Y. Aoki Inhibition of metastasis of rhabdomyosarcoma by a novel neutralizing antibody to CXC chemokine receptor-4 Cancer Sci. 105 2014 1343 1350
87. H. Kawamoto, and N. Minato Myeloid cells Int. J. Biochem. Cell Biol. 36 2004 1374 1379
88. A.A. Keskinov, and M.R. Shurin Myeloid regulatory cells in tumor spreading and metastasis Immunobiology 220 2015 236 242
89. Y. Kinugasa, T. Matsui, and N. Takakura CD44 expressed on cancer-associated fibroblasts is a functional molecule supporting the stemness and drug resistance of malignant cancer cells in the tumor microenvironment Stem Cells 32 2014 145 156
90. J.S. Ko, A.H. Zea, B.I. Rini, J.L. Ireland, P. Elson, P. Cohen, A. Golshayan, P.A. Rayman, L. Wood, and et al. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients Clin. Cancer Res. 15 2009 2148 2157
91. S. Kumar, R.B. Mokhtari, I.D. Oliveira, S. Islam, S.R. Toledo, H. Yeger, and S. Baruchel Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts Transl. Oncol. 6 2013 493 503
92. M. Labelle, S. Begum, and R.O. Hynes Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis Cancer Cell 20 2011 576 590
93. C. Lamagna, and G. Bergers The bone marrow constitutes a reservoir of pericyte progenitors J. Leukoc. Biol. 80 2006 677 681
94. H. Langer, A.E. May, K. Daub, U. Heinzmann, P. Lang, M. Schumm, D. Vestweber, S. Massberg, T. Schönberger, and et al. Adherent platelets recruit and induce differentiation of murine embryonic endothelial progenitor cells to mature endothelial cells in vitro Circ. Res. 98 2006 e2 e10
95. E. Lanitis, M. Irving, and G. Coukos Targeting the tumor vasculature to enhance T cell activity Curr. Opin. Immunol. 33 2015 55 63
96. J. Laurent, C. Touvrey, F. Botta, F. Kuonen, and C. Ruegg Emerging paradigms and questions on pro-angiogenic bone marrow-derived myelomonocytic cells Int. J. Dev. Biol. 55 2011 527 534
97. J. LeCouter, C. Zlot, M. Tejada, F. Peale, and N. Ferrara Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization Proc. Natl. Acad. Sci. USA 101 2004 16813 16818
98. W.P. Leenders, B. Küsters, K. Verrijp, C. Maass, P. Wesseling, A. Heerschap, D. Ruiter, A. Ryan, and R. de Waal Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option Clin. Cancer Res. 10 2004 6222 6230
99. R. Li, M. Ren, N. Chen, M. Luo, X. Deng, J. Xia, G. Yu, J. Liu, B. He, and et al. Presence of intratumoral platelets is associated with tumor vessel structure and metastasis BMC Cancer 14 2014 167
100. E.Y. Lin, J.F. Li, L. Gnatovskiy, Y. Deng, L. Zhu, D.A. Grzesik, H. Qian, X.N. Xue, and J.W. Pollard Macrophages regulate the angiogenic switch in a mouse model of breast cancer Cancer Res. 66 2006 11238 11246
101. B.Y. Liu, I. Soloviev, P. Chang, J. Lee, X. Huang, C. Zhong, N. Ferrara, P. Polakis, and C. Sakanaka Stromal cell-derived factor-1/CXCL12 contributes to MMTV-Wnt1 tumor growth involving Gr1 + CD11b + cells PLoS One 5 2010 e8611
102. X. Liu, H. Jin, G. Zhang, X. Lin, C. Chen, J. Sun, Y. Zhang, Q. Zhang, and J. Yu Intratumor IL-17-positive mast cells are the major source of the IL-17 that is predictive of survival in gastric cancer patients PLoS One 9 2014 e106834
103. X.D. Liu, A. Hoang, L. Zhou, S. Kalra, A. Yetil, M. Sun, Z. Ding, X. Zhang, S. Bai, and et al. Resistance to antiangiogenic therapy is associated with an immunosuppressive tumor microenvironment in metastatic renal cell carcinoma Cancer Immunol. Res. 3 2015 1017 1029
104. C. Lu-Emerson, M. Snuderl, N.D. Kirkpatrick, J. Goveia, C. Davidson, Y. Huang, L. Riedemann, J. Taylor, P. Ivy, and et al. Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma Neuro Oncol. 15 2013 1079 1087
105. H. Luo, G. Tu, Z. Liu, and M. Liu Cancer-associated fibroblasts: a multifaceted driver of breast cancer progression Cancer Lett. 361 2 2015 155 163
106. T.T. Maciel, I.C. Moura, and O. Hermine The role of mast cells in cancers F1000Prime Rep. 7 2015 09
107. S. Maltby, K. Khazaie, and K.M. McNagny Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation Biochim. Biophys. Acta 1796 2009 19 26
108. E. Maniati, R. Soper, and T. Hagemann Up for mischief? IL-17/Th17 in the tumour microenvironment Oncogene 29 2010 5653 5662
109. A. Mantovani, and M. Locati Tumor-associated macrophages as a paradigm of macrophage plasticity, diversity, and polarization: lessons and open questions Arterioscler. Thromb. Vasc. Biol. 33 2013 1478 1483
110. A. Mantovani, S.K. Biswas, M.R. Galdiero, A. Sica, and M. Locati Macrophage plasticity and polarization in tissue repair and remodelling J. Pathol. 229 2013 176 185
111. A. Mantovani, A. Sica, P. Allavena, C. Garlanda, and M. Locati Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation Hum. Immunol. 70 2009 325 330
112. A. Mantovani, S. Sozzani, M. Locati, P. Allavena, and A. Sica Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes Trends Immunol. 23 2002 549 555
113. K. Maruyama, Y. Mori, S. Murasawa, H. Masaki, N. Takahashi, Y. Tsutusmi, Y. Moriguchi, Y. Shibazaki, Y. Tanaka, and et al. Interleukin-1 beta upregulates cardiac expression of vascular endothelial growth factor and its receptor KDR/flk-1 via activation of protein tyrosine kinases J. Mol. Cell Cardiol. 31 1999 607 617
114. S. Massberg, I. Konrad, K. Schürzinger, M. Lorenz, S. Schneider, D. Zohlnhoefer, K. Hoppe, M. Schiemann, E. Kennerknecht, and et al. Platelets secrete stromal cell-derived factor 1 alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo J. Exp. Med. 203 2006 1221 1233
115. R. Mazzieri, F. Pucci, D. Moi, E. Zonari, A. Ranghetti, A. Berti, L.S. Politi, B. Gentner, J.L. Brown, and et al. Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells Cancer Cell 19 2011 512 526
116. K.L. Meadows, and H.I. Hurwitz Anti-VEGF therapies in the clinic Cold Spring Harb. Perspect. Med. 2 10 2012 10.1101/cshperspect.a006577
117. C. Melani, S. Sangaletti, F.M. Barazzetta, Z. Werb, and M.P. Colombo Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma Cancer Res. 67 2007 11438 11446
118. R.J. Melder, G.C. Koenig, B.P. Witwer, N. Safabakhsh, L.L. Munn, and R.K. Jain During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium Nat. Med. 2 1996 992 997
119. M. Moschetta, Y. Mishima, I. Sahin, S. Manier, S. Glavey, A. Vacca, A.M. Roccaro, and I.M. Ghobrial Role of endothelial progenitor cells in cancer progression Biochim. Biophys. Acta 1846 2014 26 39
120. C. Murdoch, M. Muthana, S.B. Coffelt, and C.E. Lewis The role of myeloid cells in the promotion of tumour angiogenesis Nat. Rev. Cancer 8 2008 618 631
121. C. Murdoch, S. Tazzyman, S. Webster, and C.E. Lewis Expression of Tie-2 by human monocytes and their responses to angiopoietin-2 J. Immunol. 178 2007 7405 7411
122. S. Nakao, T. Kuwano, C. Tsutsumi-Miyahara, S. Ueda, Y.N. Kimura, S. Hamano, K.H. Sonoda, Y. Saijo, T. Nukiwa, and et al. Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth J. Clin. Invest. 115 2005 2979 2991
123. P. Nowak-Sliwinska, A. Weiss, J.R. van Beijnum, T.J. Wong, W.W. Kilarski, G. Szewczyk, H.M. Verheul, T. Sarna, H. van den Bergh, and A.W. Griffioen Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition Cell Death Dis. 6 2015 e1641
124. H. Nozawa, C. Chiu, and D. Hanahan Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis Proc. Natl. Acad. Sci. USA 103 2006 12493 12498
125. N. Obermajer, R. Muthuswamy, K. Odunsi, R.P. Edwards, and P. Kalinski PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment Cancer Res. 71 2011 7463 7470
126. P.A. O'Connell, A.P. Surette, R.S. Liwski, P. Svenningsson, and D.M. Waisman S100A10 regulates plasminogen-dependent macrophage invasion Blood 116 2010 1136 1146
127. Y. Ohki, B. Heissig, Y. Sato, H. Akiyama, Z. Zhu, D.J. Hicklin, K. Shimada, H. Ogawa, H. Daida, and et al. Granulocyte colony-stimulating factor promotes neovascularization by releasing vascular endothelial growth factor from neutrophils FASEB J. 19 2005 2005 2007
128. A. Orimo, P.B. Gupta, D.C. Sgroi, F. Arenzana-Seisdedos, T. Delaunay, R. Naeem, V.J. Carey, A.L. Richardson, and R.A. Weinberg Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion Cell 121 2005 335 348
129. A. Orlidge, and P.A. D'Amore Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells J. Cell Biol. 105 1987 1455 1462
130. T. Oyama, S. Ran, T. Ishida, S. Nadaf, L. Kerr, D.P. Carbone, and D.I. Gabrilovich Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells J. Immunol. 160 1998 1224 1232
131. M. Paez-Ribes, E. Allen, J. Hudock, T. Takeda, H. Okuyama, F. Vinals, M. Inoue, G. Bergers, D. Hanahan, and O. Casanovas Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis Cancer Cell 15 2009 220 231
132. Y.W. Paulis, P.M. Soetekouw, H.M. Verheul, V.C. Tjan-Heijnen, and A.W. Griffioen Signalling pathways in vasculogenic mimicry Biochim. Biophys. Acta 1806 2010 18 28
133. K.D. Phipps, A.P. Surette, P.A. O'Connell, and D.M. Waisman Plasminogen receptor S100A10 is essential for the migration of tumor-promoting macrophages into tumor sites Cancer Res. 71 2011 6676 6683
134. Y. Piao, J. Liang, L. Holmes, A.J. Zurita, V. Henry, J.V. Heymach, and J.F. de Groot Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype Neuro Oncol. 14 2012 1379 1392
135. K. Pietras, and D. Hanahan A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer J. Clin. Oncol. 23 2005 939 952
136. M. Potente, H. Gerhardt, and P. Carmeliet Basic and therapeutic aspects of angiogenesis Cell 146 2011 873 887
137. A.R. Prisco, M.R. Prisco, B.E. Carlson, and A.S. Greene TNFα increases endothelial progenitor cell adhesion to the endothelium by increasing bond expression and affinity Am. J. Physiol. Heart Circ. Physiol. 308 11 2015 H1368 H1381 (ajpheart.00496.2014)
138. F. Pucci, M.A. Venneri, D. Biziato, A. Nonis, D. Moi, A. Sica, C. Di Serio, L. Naldini, and M. De Palma A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships Blood 114 2009 901 914
139. G. Pula, U. Mayr, C. Evans, M. Prokopi, D.S. Vara, X. Yin, Z. Astroulakis, Q. Xiao, J. Hill, and et al. Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures Circ. Res. 104 2009 32 40
140. B.Z. Qian, J. Li, H. Zhang, T. Kitamura, J. Zhang, L.R. Campion, E.A. Kaiser, L.A. Snyder, and J.W. Pollard CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis Nature 475 2011 222 225
141. A. Ricciardi, A.R. Elia, P. Cappello, M. Puppo, C. Vanni, P. Fardin, A. Eva, D. Munroe, X. Wu, and et al. Transcriptome of hypoxic immature dendritic cells: modulation of chemokine/receptor expression Mol. Cancer Res. 6 2008 175 185
142. C.H. Ries, M.A. Cannarile, S. Hoves, J. Benz, K. Wartha, V. Runza, F. Rey-Giraud, L.P. Pradel, F. Feuerhake, and et al. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy Cancer Cell 25 2014 846 859
143. N. Rigamonti, E. Kadioglu, I. Keklikoglou, C. Wyser Rmili, C.C. Leow, and M. De Palma Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade Cell Rep. 8 2014 696 706
144. L.B. Rivera, and G. Bergers Intertwined regulation of angiogenesis and immunity by myeloid cells Trends Immunol. 36 2015 240 249
145. L.B. Rivera, D. Meyronet, V. Hervieu, M.J. Frederick, E. Bergsland, and G. Bergers Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy Cell Rep. 11 2015 577 591
146. C.L. Roland, S.P. Dineen, K.D. Lynn, L.A. Sullivan, M.T. Dellinger, L. Sadegh, J.P. Sullivan, D.S. Shames, and R.A. Brekken Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts Mol. Cancer Ther. 8 2009 1761 1771
147. C.L. Roland, K.D. Lynn, J.E. Toombs, S.P. Dineen, D.G. Udugamasooriya, and R.A. Brekken Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer PLoS One 4 2009 e7669
148. P.M. Rothwell, M. Wilson, J.F. Price, J.F. Belch, T.W. Meade, and Z. Mehta Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials Lancet 379 2012 1591 1601
149. S. Sabrkhany, A.W. Griffioen, and M.G. Oude Egbrink The role of blood platelets in tumor angiogenesis Biochim. Biophys. Acta 1815 2011 189 196
150. S. Sabrkhany, A.W. Griffioen, H.M. Verheul, J.W. Heemskerk, M.G. Oude Egbrink, and M.J. Kuijpers Sunitinib is taken up by platelets and inhibits their function Angiogenesis 17 2014 771
151. S.K. Sandhu, K. Papadopoulos, P.C. Fong, A. Patnaik, C. Messiou, D. Olmos, G. Wang, B.J. Tromp, T.A. Puchalski, and et al. A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors Cancer Chemother. Pharmacol. 71 2013 1041 1050
152. R.S. Sandler, S. Halabi, J.A. Baron, S. Budinger, E. Paskett, R. Keresztes, N. Petrelli, J.M. Pipas, D.D. Karp, and et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer N. Engl. J. Med. 348 2003 883 890
153. Schmidt T., Carmeliet P., 2010. Nature. Blood-vessel formation: Bridges that guide and unite. England.
154. D. Schumacher, B. Strilic, K.K. Sivaraj, N. Wettschureck, and S. Offermanns Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor Cancer Cell 24 2013 130 137
155. M.A. Scott, J. Shen, K. Lam, Y. Yen, S. Shrestha, M. Mravic, G. Asatrian, C.G. Chung, C. Lugassy, and et al. Review of pericytes in tumor biology Int. J. Orthop. 2 2015 301 306
156. Y. Shaked, A. Ciarrocchi, M. Franco, C.R. Lee, S. Man, A.M. Cheung, D.J. Hicklin, D. Chaplin, F.S. Foster, and et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors Science 313 2006 1785 1787
157. D. Shepro, and N.M. Morel Pericyte physiology FASEB J. 7 1993 1031 1038
158. F. Shojaei, X. Wu, A.K. Malik, C. Zhong, M.E. Baldwin, S. Schanz, G. Fuh, H.P. Gerber, and N. Ferrara Tumor refractoriness to anti-VEGF treatment is mediated by CD11b + Gr1 + myeloid cells Nat Biotechnol. 25 2007 911 920
159. F. Shojaei, X. Wu, C. Zhong, L. Yu, X.H. Liang, J. Yao, D. Blanchard, C. Bais, F.V. Peale, and et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis Nature 450 2007 825 831
160. F. Shojaei, M. Singh, J.D. Thompson, and N. Ferrara Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression Proc. Natl. Acad. Sci. USA 105 2008 2640 2645
161. F. Shojaei, C. Zhong, X. Wu, L. Yu, and N. Ferrara Role of myeloid cells in tumor angiogenesis and growth Trends Cell Biol. 18 2008 372 378
162. R.K. Shrimali, Z. Yu, M.R. Theoret, D. Chinnasamy, N.P. Restifo, and S.A. Rosenberg Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer Cancer Res. 70 2010 6171 6180
163. A. Sica, and A. Mantovani Macrophage plasticity and polarization: in vivo veritas J. Clin. Invest. 122 2012 787 795
164. D.E. Sims The pericyte - a review Tissue Cell 18 1986 153 174
165. B. St Croix, C. Rago, V. Velculescu, G. Traverso, K.E. Romans, E. Montgomery, A. Lal, G.J. Riggins, C. Lengauer, and et al. Genes expressed in human tumor endothelium Science 289 2000 1197 1202
166. I.M. Stefansson, H.B. Salvesen, and L.A. Akslen Vascular proliferation is important for clinical progress of endometrial cancer Cancer Res. 66 2006 3303 3309
167. O. Stoeltzing, S.A. Ahmad, W. Liu, M.F. McCarty, J.S. Wey, A.A. Parikh, F. Fan, N. Reinmuth, M. Kawaguchi, and et al. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors Cancer Res. 63 2003 3370 3377
168. A.N. Stratman, K.M. Malotte, R.D. Mahan, M.J. Davis, and G.E. Davis Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation Blood 114 2009 5091 5101
169. A.N. Stratman, A.E. Schwindt, K.M. Malotte, and G.E. Davis Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization Blood 116 2010 4720 4730
170. A.N. Stratman, M.J. Davis, and G.E. Davis VEGF and FGF prime vascular tube morphogenesis and sprouting directed by hematopoietic stem cell cytokines Blood 117 2011 3709 3719
171. B. Streubel, A. Chott, D. Huber, M. Exner, U. Jäger, O. Wagner, and I. Schwarzinger Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas N. Engl. J. Med. 351 2004 250 259
172. X. Sun, G. Cheng, M. Hao, J. Zheng, X. Zhou, J. Zhang, R.S. Taichman, K.J. Pienta, and J. Wang CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression Cancer Metastasis Rev. 29 2010 709 722
173. M. Taylor, F. Billiot, V. Marty, V. Rouffiac, P. Cohen, E. Tournay, P. Opolon, F. Louache, G. Vassal, and et al. Reversing resistance to vascular-disrupting agents by blocking late mobilization of circulating endothelial progenitor cells Cancer Discov. 2 2012 434 449
174. O.M. Tepper, J.M. Capla, R.D. Galiano, D.J. Ceradini, M.J. Callaghan, M.E. Kleinman, and G.C. Gurtner Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow-derived cells Blood 105 2005 1068 1077
175. V.L. Thijssen, R. Postel, R.J. Brandwijk, R.P. Dings, I. Nesmelova, S. Satijn, N. Verhofstad, Y. Nakabeppu, L.G. Baum, and et al. Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy Proc. Natl. Acad. Sci. USA 103 2006 15975 15980
176. V.L. Thijssen, G.A. Rabinovich, and A.W. Griffioen Vascular galectins: regulators of tumor progression and targets for cancer therapy Cytokine Growth Factor Rev. 24 2013 547 558
177. V.L. Thijssen, J.R. van Beijnum, K.H. Mayo, and A.W. Griffioen Identification of novel drug targets for angiostatic cancer therapy: it takes two to tango Curr. Pharm. Des. 13 2007 3576 3583
178. M. Thomas, Y. Kienast, W. Scheuer, M. Bähner, K. Kaluza, C. Gassner, F. Herting, U. Brinkmann, S. Seeber, and et al. A novel angiopoietin-2 selective fully human antibody with potent anti-tumoral and anti-angiogenic efficacy and superior side effect profile compared to Pan-Angiopoietin-1/-2 inhibitors PLoS One 8 2013 e54923
179. J. Tran, Z. Master, J.L. Yu, J. Rak, D.J. Dumont, and R.S. Kerbel A role for survivin in chemoresistance of endothelial cells mediated by VEGF Proc. Natl. Acad. Sci. USA 99 2002 4349 4354
180. C. Tripathi, B.N. Tewari, R.K. Kanchan, K.S. Baghel, N. Nautiyal, R. Shrivastava, H. Kaur, M.L. Bhatt, and S. Bhadauria Macrophages are recruited to hypoxic tumor areas and acquire a pro-angiogenic M2-polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin Oncotarget 5 2014 5350 5368
181. S.S. Tykodi PD-1 as an emerging therapeutic target in renal cell carcinoma: current evidence Onco Targets Ther. 7 2014 1349 1359
182. T. Valković, F. Dobrila, M. Melato, F. Sasso, C. Rizzardi, and N. Jonjić Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma Virchows Arch. 440 2002 583 588
183. J.R. van Beijnum, and A.W. Griffioen In silico analysis of angiogenesis associated gene expression identifies angiogenic stage related profiles Biochim. Biophys. Acta 1755 2005 121 134
184. J.R. van Beijnum, R.P. Dings, E. van der Linden, B.M. Zwaans, F.C. Ramaekers, K.H. Mayo, and A.W. Griffioen Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature Blood 108 2006 2339 2348
185. J.R. van Beijnum, P. Nowak-Sliwinska, E.J. Huijbers, V.L. Thijssen, and A.W. Griffioen The great escape: the hallmarks of resistance to antiangiogenic therapy Pharmacol. Rev. 67 2015 441 461
186. J.R. van Beijnum, P. Nowak-Sliwinska, E. van den Boezem, P. Hautvast, W.A. Buurman, and A.W. Griffioen Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1 Oncogene 32 2013 363 374
187. H. van Cruijsen, A.A. van der Veldt, L. Vroling, D. Oosterhoff, H.J. Broxterman, R.J. Scheper, G. Giaccone, J.B. Haanen, A.J. van den Eertwegh, and et al. Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c + dendritic cell frequency predicts progression-free survival Clin. Cancer Res. 14 2008 5884 5892
188. D.W. van der Schaft, F. Hillen, P. Pauwels, D.A. Kirschmann, K. Castermans, M.G. Egbrink, M.G. Tran, R. Sciot, E. Hauben, and et al. Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia Cancer Res. 65 2005 11520 11528
189. N.S. Vasudev, and A.R. Reynolds Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions Angiogenesis 17 2014 471 494
190. J.D. Veltman, M.E. Lambers, M. van Nimwegen, R.W. Hendriks, H.C. Hoogsteden, J.P. Hegmans, and J.G. Aerts Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma Br. J. Cancer 103 2010 629 641
191. M.A. Venneri, M. De Palma, M. Ponzoni, F. Pucci, C. Scielzo, E. Zonari, R. Mazzieri, C. Doglioni, and L. Naldini Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer Blood 109 2007 5276 5285
192. C. Verdelli, L. Avagliano, P. Creo, V. Guarnieri, A. Scillitani, L. Vicentini, G.B. Steffano, E. Beretta, L. Soldati, and et al. Tumour-associated fibroblasts contribute to neoangiogenesis in human parathyroid neoplasia Endocr. Relat. Cancer 22 2015 87 98
193. H.M. Verheul, M.P. Lolkema, D.Z. Qian, Y.H. Hilkes, E. Liapi, J.W. Akkerman, R. Pili, and E.E. Voest Platelets take up the monoclonal antibody bevacizumab Clin. Cancer Res. 13 2007 5341 5347
194. D. Vyas, S. Gupt, V. Dixit, K. Anita, and S. Kaur To study the effect of curcumin on the growth properties of circulating endothelial progenitor cells In Vitro Cell Dev. Biol. Anim. 51 5 2015 488 494
195. A.F. Welford, D. Biziato, S.B. Coffelt, S. Nucera, M. Fisher, F. Pucci, C. Di Serio, L. Naldini, M. De Palma, and et al. TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice J. Clin. Invest. 121 2011 1969 1973
196. X. Xian, J. Hakansson, A. Stahlberg, P. Lindblom, C. Betsholtz, H. Gerhardt, and H. Semb Pericytes limit tumor cell metastasis J. Clin. Invest. 116 2006 642 651
197. H. Xin, C. Zhang, A. Herrmann, Y. Du, R. Figlin, and H. Yu Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells Cancer Res. 69 2009 2506 2513
198. Y.Q. Xiong, H.C. Sun, W. Zhang, X.D. Zhu, P.Y. Zhuang, J.B. Zhang, L. Wang, W.Z. Wu, L.X. Qin, and Z.Y. Tang Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells Clin. Cancer Res. 15 2009 4838 4846
199. J. Yamaguchi, K.F. Kusano, O. Masuo, A. Kawamoto, M. Silver, S. Murasawa, M. Bosch-Marce, H. Masuda, D.W. Losordo, and et al. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization Circulation 107 2003 1322 1328
200. X. Yan, S. Cai, X. Xiong, W. Sun, X. Dai, S. Chen, Q. Ye, Z. Song, Q. Jiang, and Z. Xu Chemokine receptor CXCR7 mediates human endothelial progenitor cells survival, angiogenesis, but not proliferation J. Cell Biochem. 113 2012 1437 1446
201. L. Zhang, J.R. Conejo-Garcia, D. Katsaros, P.A. Gimotty, M. Massobrio, G. Regnani, A. Makrigiannakis, H. Gray, K. Schlienger, and et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer N. Engl. J. Med. 348 2003 203 213
202. B. Zhitomirsky, and Y.G. Assaraf Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Oncotarget 6 2015 1143 1156
203. B. Zhitomirsky, and Y.G. Assaraf Lysosomes as mediators of drug resistance in cancer Drug Resist. Updat. 24 2016 23 33
204. C. Zhong, X. Qu, M. Tan, Y.G. Meng, and N. Ferrara Characterization and regulation of bv8 in human blood cells Clin. Cancer Res. 15 2009 2675 2684