메뉴 건너뛰기




Volumn 396, Issue , 2017, Pages 117-129

Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition

Author keywords

Breast cancer; EMT; Genome scale models; Metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID TRANSPORTER; GLUTATHIONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

EID: 85016312795     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2017.03.019     Document Type: Article
Times cited : (46)

References (64)
  • 1
    • 67651005404 scopus 로고    scopus 로고
    • EMT: when epithelial cells decide to become mesenchymal-like cells
    • [1] Kalluri, R., EMT: when epithelial cells decide to become mesenchymal-like cells. J. Clin. Invest. 119 (2009), 1417–1419.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1417-1419
    • Kalluri, R.1
  • 2
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • [2] Kalluri, R., Weinberg, R.A., The basics of epithelial-mesenchymal transition. J. Clin. Invest. 119 (2009), 1420–1428.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 3
    • 67650996280 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
    • [3] Acloque, H., Adams, M.S., Fishwick, K., Bronner-Fraser, M., Nieto, M.A., Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J. Clin. Invest. 119 (2009), 1438–1449.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3    Bronner-Fraser, M.4    Nieto, M.A.5
  • 4
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • [4] Polyak, K., Weinberg, R.A., Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat. Rev. Cancer 9 (2009), 265–273.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 5
    • 0037331707 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma
    • [5] Petersen, O.W., Nielsen, H.L., Gudjonsson, T., Villadsen, R., Rank, F., Niebuhr, E., et al. Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am. J. Pathol. 162 (2003), 391–402.
    • (2003) Am. J. Pathol. , vol.162 , pp. 391-402
    • Petersen, O.W.1    Nielsen, H.L.2    Gudjonsson, T.3    Villadsen, R.4    Rank, F.5    Niebuhr, E.6
  • 7
    • 84876434755 scopus 로고    scopus 로고
    • Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer
    • [7] Dong, C., Yuan, T., Wu, Y., Wang, Y., Fan, T.W., Miriyala, S., et al. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell 23 (2013), 316–331.
    • (2013) Cancer Cell , vol.23 , pp. 316-331
    • Dong, C.1    Yuan, T.2    Wu, Y.3    Wang, Y.4    Fan, T.W.5    Miriyala, S.6
  • 8
    • 84855743864 scopus 로고    scopus 로고
    • Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways
    • [8] Hanai, J., Doro, N., Sasaki, A.T., Kobayashi, S., Cantley, L.C., Seth, P., et al. Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. J. Cell. Physiol. 227 (2012), 1709–1720.
    • (2012) J. Cell. Physiol. , vol.227 , pp. 1709-1720
    • Hanai, J.1    Doro, N.2    Sasaki, A.T.3    Kobayashi, S.4    Cantley, L.C.5    Seth, P.6
  • 9
    • 84907302546 scopus 로고    scopus 로고
    • Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition
    • [9] Shaul, Y.D., Freinkman, E., Comb, W.C., Cantor, J.R., Tam, W.L., Thiru, P., et al. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell 158 (2014), 1094–1109.
    • (2014) Cell , vol.158 , pp. 1094-1109
    • Shaul, Y.D.1    Freinkman, E.2    Comb, W.C.3    Cantor, J.R.4    Tam, W.L.5    Thiru, P.6
  • 10
    • 84930227327 scopus 로고    scopus 로고
    • Using genome-scale models to predict biological capabilities
    • [10] O'Brien, E.J., Monk, J.M., Palsson, B.O., Using genome-scale models to predict biological capabilities. Cell 161 (2015), 971–987.
    • (2015) Cell , vol.161 , pp. 971-987
    • O'Brien, E.J.1    Monk, J.M.2    Palsson, B.O.3
  • 11
    • 84952659166 scopus 로고    scopus 로고
    • Systems Biology: Constraint-based Reconstruction and Analysis
    • Cambridge University Press
    • [11] Palsson, B.O., Systems Biology: Constraint-based Reconstruction and Analysis. 2015, Cambridge University Press.
    • (2015)
    • Palsson, B.O.1
  • 12
    • 84907379295 scopus 로고    scopus 로고
    • A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration
    • [12] Yizhak, K., Le Devedec, S.E., Rogkoti, V.M., Baenke, F., de Boer, V.C., Frezza, C., et al. A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration. Mol. Syst. Biol., 10, 2014, 744.
    • (2014) Mol. Syst. Biol. , vol.10 , pp. 744
    • Yizhak, K.1    Le Devedec, S.E.2    Rogkoti, V.M.3    Baenke, F.4    de Boer, V.C.5    Frezza, C.6
  • 15
    • 84912534464 scopus 로고    scopus 로고
    • Comprehensive metabolomic study of platelets reveals the expression of discrete metabolic phenotypes during storage
    • [15] Paglia, G., Sigurjonsson, O.E., Rolfsson, O., Valgeirsdottir, S., Hansen, M.B., Brynjolfsson, S., et al. Comprehensive metabolomic study of platelets reveals the expression of discrete metabolic phenotypes during storage. Transfusion 54 (2014), 2911–2923.
    • (2014) Transfusion , vol.54 , pp. 2911-2923
    • Paglia, G.1    Sigurjonsson, O.E.2    Rolfsson, O.3    Valgeirsdottir, S.4    Hansen, M.B.5    Brynjolfsson, S.6
  • 16
    • 84861420588 scopus 로고    scopus 로고
    • Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
    • [16] Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A.L., et al. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336 (2012), 1040–1044.
    • (2012) Science , vol.336 , pp. 1040-1044
    • Jain, M.1    Nilsson, R.2    Sharma, S.3    Madhusudhan, N.4    Kitami, T.5    Souza, A.L.6
  • 18
    • 84896701551 scopus 로고    scopus 로고
    • Fast reconstruction of compact context-specific metabolic network models
    • [18] Vlassis, N., Pacheco, M.P., Sauter, T., Fast reconstruction of compact context-specific metabolic network models. PLoS Comput. Biol., 10, 2014, e1003424.
    • (2014) PLoS Comput. Biol. , vol.10 , pp. e1003424
    • Vlassis, N.1    Pacheco, M.P.2    Sauter, T.3
  • 19
    • 0022493181 scopus 로고
    • Fat synthesis in adipose tissue. An examination of stoichiometric constraints
    • [19] Fell, D.A., Small, J.R., Fat synthesis in adipose tissue. An examination of stoichiometric constraints. Biochem. J. 238 (1986), 781–786.
    • (1986) Biochem. J. , vol.238 , pp. 781-786
    • Fell, D.A.1    Small, J.R.2
  • 20
    • 0026516223 scopus 로고
    • Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism
    • [20] Savinell, J.M., Palsson, B.O., Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism. J. Theor. Biol. 154 (1992), 421–454.
    • (1992) J. Theor. Biol. , vol.154 , pp. 421-454
    • Savinell, J.M.1    Palsson, B.O.2
  • 21
    • 65549092780 scopus 로고    scopus 로고
    • Use of randomized sampling for analysis of metabolic networks
    • [21] Schellenberger, J., Palsson, B.O., Use of randomized sampling for analysis of metabolic networks. J. Biol. Chem. 284 (2009), 5457–5461.
    • (2009) J. Biol. Chem. , vol.284 , pp. 5457-5461
    • Schellenberger, J.1    Palsson, B.O.2
  • 23
    • 77954167982 scopus 로고    scopus 로고
    • Transcriptional crosstalk between TGF-beta and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes
    • [23] Fuxe, J., Vincent, T., Garcia de Herreros, A., Transcriptional crosstalk between TGF-beta and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes. Cell Cycle 9 (2010), 2363–2374.
    • (2010) Cell Cycle , vol.9 , pp. 2363-2374
    • Fuxe, J.1    Vincent, T.2    Garcia de Herreros, A.3
  • 24
    • 84898999261 scopus 로고    scopus 로고
    • Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition
    • [24] Kolesnikoff, N., Attema, J.L., Roslan, S., Bert, A.G., Schwarz, Q.P., Gregory, P.A., et al. Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition. J. Biol. Chem. 289 (2014), 11194–11205.
    • (2014) J. Biol. Chem. , vol.289 , pp. 11194-11205
    • Kolesnikoff, N.1    Attema, J.L.2    Roslan, S.3    Bert, A.G.4    Schwarz, Q.P.5    Gregory, P.A.6
  • 25
    • 79151483638 scopus 로고    scopus 로고
    • An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
    • [25] Gyorffy, B., Lanczky, A., Eklund, A.C., Denkert, C., Budczies, J., Li, Q., et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res. Treat. 123 (2010), 725–731.
    • (2010) Breast Cancer Res. Treat. , vol.123 , pp. 725-731
    • Gyorffy, B.1    Lanczky, A.2    Eklund, A.C.3    Denkert, C.4    Budczies, J.5    Li, Q.6
  • 26
    • 84921894076 scopus 로고    scopus 로고
    • Mitochondrial phospholipids: role in mitochondrial function
    • [26] Mejia, E.M., Hatch, G.M., Mitochondrial phospholipids: role in mitochondrial function. J. Bioenerg. Biomembr. 48 (2016), 99–112.
    • (2016) J. Bioenerg. Biomembr. , vol.48 , pp. 99-112
    • Mejia, E.M.1    Hatch, G.M.2
  • 28
    • 84906936187 scopus 로고    scopus 로고
    • OPINION Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression
    • [28] Buchheit, C.L., Weigel, K.J., Schafer, Z.T., OPINION Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression. Nat. Rev. Cancer 14 (2014), 632–641.
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 632-641
    • Buchheit, C.L.1    Weigel, K.J.2    Schafer, Z.T.3
  • 29
    • 0041355315 scopus 로고    scopus 로고
    • Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin
    • [29] Hardy, S., El-Assaad, W., Przybytkowski, E., Joly, E., Prentki, M., Langelier, Y., Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin. J. Biol. Chem. 278 (2003), 31861–31870.
    • (2003) J. Biol. Chem. , vol.278 , pp. 31861-31870
    • Hardy, S.1    El-Assaad, W.2    Przybytkowski, E.3    Joly, E.4    Prentki, M.5    Langelier, Y.6
  • 30
    • 84947648620 scopus 로고    scopus 로고
    • Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress
    • [30] Schug, Z.T., Peck, B., Jones, D.T., Zhang, Q., Grosskurth, S., Alam, I.S., et al. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell 27 (2015), 57–71.
    • (2015) Cancer Cell , vol.27 , pp. 57-71
    • Schug, Z.T.1    Peck, B.2    Jones, D.T.3    Zhang, Q.4    Grosskurth, S.5    Alam, I.S.6
  • 31
    • 84930377006 scopus 로고    scopus 로고
    • Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer
    • [31] Yizhak, K., Gaude, E., Le Devedec, S., Waldman, Y.Y., Stein, G.Y., van de Water, B., et al. Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer. eLife, 3, 2014.
    • (2014) eLife , vol.3
    • Yizhak, K.1    Gaude, E.2    Le Devedec, S.3    Waldman, Y.Y.4    Stein, G.Y.5    van de Water, B.6
  • 32
    • 84963722238 scopus 로고    scopus 로고
    • Candidate antimetastasis drugs suppress the metastatic capacity of breast cancer cells by reducing membrane fluidity
    • [32] Zhao, W., Prijic, S., Urban, B.C., Tisza, M.J., Zuo, Y., Li, L., et al. Candidate antimetastasis drugs suppress the metastatic capacity of breast cancer cells by reducing membrane fluidity. Cancer Res. 76 (2016), 2037–2049.
    • (2016) Cancer Res. , vol.76 , pp. 2037-2049
    • Zhao, W.1    Prijic, S.2    Urban, B.C.3    Tisza, M.J.4    Zuo, Y.5    Li, L.6
  • 33
    • 80053643585 scopus 로고    scopus 로고
    • The mechanisms by which polyamines accelerate tumor spread
    • [33] Soda, K., The mechanisms by which polyamines accelerate tumor spread. J. Exp. Clin. Cancer Res., 30, 2011, 95.
    • (2011) J. Exp. Clin. Cancer Res. , vol.30 , pp. 95
    • Soda, K.1
  • 34
    • 84919779591 scopus 로고    scopus 로고
    • Alteration of N-glycans and expression of their related glycogenes in the epithelial-mesenchymal transition of HCV29 bladder epithelial cells
    • [34] Guo, J., Li, X., Tan, Z., Lu, W., Yang, G., Guan, F., Alteration of N-glycans and expression of their related glycogenes in the epithelial-mesenchymal transition of HCV29 bladder epithelial cells. Molecules 19 (2014), 20073–20090.
    • (2014) Molecules , vol.19 , pp. 20073-20090
    • Guo, J.1    Li, X.2    Tan, Z.3    Lu, W.4    Yang, G.5    Guan, F.6
  • 35
    • 84960387090 scopus 로고    scopus 로고
    • Posttranslational modification of E-cadherin by core fucosylation regulates Src activation and induces epithelial-mesenchymal transition-like process in lung cancer cells
    • [35] Shao, K., Chen, Z.Y., Gautam, S., Deng, N.H., Zhou, Y., Wu, X.Z., Posttranslational modification of E-cadherin by core fucosylation regulates Src activation and induces epithelial-mesenchymal transition-like process in lung cancer cells. Glycobiology 26 (2016), 142–154.
    • (2016) Glycobiology , vol.26 , pp. 142-154
    • Shao, K.1    Chen, Z.Y.2    Gautam, S.3    Deng, N.H.4    Zhou, Y.5    Wu, X.Z.6
  • 41
    • 84867527044 scopus 로고    scopus 로고
    • Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer
    • [41] Jerby, L., Wolf, L., Denkert, C., Stein, G.Y., Hilvo, M., Oresic, M., et al. Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer. Cancer Res. 72 (2012), 5712–5720.
    • (2012) Cancer Res. , vol.72 , pp. 5712-5720
    • Jerby, L.1    Wolf, L.2    Denkert, C.3    Stein, G.Y.4    Hilvo, M.5    Oresic, M.6
  • 42
    • 84930008414 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induces similar metabolic alterations in two independent breast cancer cell lines
    • [42] Kondaveeti, Y., Guttilla Reed, I.K., White, B.A., Epithelial-mesenchymal transition induces similar metabolic alterations in two independent breast cancer cell lines. Cancer Lett. 364 (2015), 44–58.
    • (2015) Cancer Lett. , vol.364 , pp. 44-58
    • Kondaveeti, Y.1    Guttilla Reed, I.K.2    White, B.A.3
  • 43
    • 84894593599 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial-mesenchymal transition
    • [43] Lamouille, S., Xu, J., Derynck, R., Molecular mechanisms of epithelial-mesenchymal transition. Nat. Rev. Mol. Cell Biol. 15 (2014), 178–196.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 178-196
    • Lamouille, S.1    Xu, J.2    Derynck, R.3
  • 44
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • [44] Mani, S.A., Guo, W., Liao, M.J., Eaton, E.N., Ayyanan, A., Zhou, A.Y., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133 (2008), 704–715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 45
    • 84883621632 scopus 로고    scopus 로고
    • Protein kinase C alpha is a central signaling node and therapeutic target for breast cancer stem cells
    • [45] Tam, W.L., Lu, H., Buikhuisen, J., Soh, B.S., Lim, E., Reinhardt, F., et al. Protein kinase C alpha is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell 24 (2013), 347–364.
    • (2013) Cancer Cell , vol.24 , pp. 347-364
    • Tam, W.L.1    Lu, H.2    Buikhuisen, J.3    Soh, B.S.4    Lim, E.5    Reinhardt, F.6
  • 46
    • 79551649114 scopus 로고    scopus 로고
    • Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists
    • [46] Badve, S., Dabbs, D.J., Schnitt, S.J., Baehner, F.L., Decker, T., Eusebi, V., et al. Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists. Mod. Pathol. 24 (2011), 157–167.
    • (2011) Mod. Pathol. , vol.24 , pp. 157-167
    • Badve, S.1    Dabbs, D.J.2    Schnitt, S.J.3    Baehner, F.L.4    Decker, T.5    Eusebi, V.6
  • 47
    • 0037087738 scopus 로고    scopus 로고
    • Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties
    • [47] Gudjonsson, T., Villadsen, R., Nielsen, H.L., Ronnov-Jessen, L., Bissell, M.J., Petersen, O.W., Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev. 16 (2002), 693–706.
    • (2002) Genes Dev. , vol.16 , pp. 693-706
    • Gudjonsson, T.1    Villadsen, R.2    Nielsen, H.L.3    Ronnov-Jessen, L.4    Bissell, M.J.5    Petersen, O.W.6
  • 48
    • 34249315460 scopus 로고    scopus 로고
    • Down-regulation of phosphoglucose isomerase/autocrine motility factor results in mesenchymal-to-epithelial transition of human lung fibrosarcoma cells
    • [48] Funasaka, T., Hu, H., Yanagawa, T., Hogan, V., Raz, A., Down-regulation of phosphoglucose isomerase/autocrine motility factor results in mesenchymal-to-epithelial transition of human lung fibrosarcoma cells. Cancer Res. 67 (2007), 4236–4243.
    • (2007) Cancer Res. , vol.67 , pp. 4236-4243
    • Funasaka, T.1    Hu, H.2    Yanagawa, T.3    Hogan, V.4    Raz, A.5
  • 49
    • 84926319631 scopus 로고    scopus 로고
    • Epithelial-mesenchymal plasticity of breast cancer stem cells: implications for metastasis and therapeutic resistance
    • [49] Luo, M., Brooks, M., Wicha, M.S., Epithelial-mesenchymal plasticity of breast cancer stem cells: implications for metastasis and therapeutic resistance. Curr. Pharm. Des. 21 (2015), 1301–1310.
    • (2015) Curr. Pharm. Des. , vol.21 , pp. 1301-1310
    • Luo, M.1    Brooks, M.2    Wicha, M.S.3
  • 50
    • 84948429460 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
    • [50] Fischer, K.R., Durrans, A., Lee, S., Sheng, J., Li, F., Wong, S.T., et al. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature 527 (2015), 472–476.
    • (2015) Nature , vol.527 , pp. 472-476
    • Fischer, K.R.1    Durrans, A.2    Lee, S.3    Sheng, J.4    Li, F.5    Wong, S.T.6
  • 51
    • 84931098436 scopus 로고    scopus 로고
    • L-amino acid transporter 1 may be a prognostic marker for local progression of prostatic cancer under expectant management
    • [51] Yanagisawa, N., Satoh, T., Hana, K., Ichinoe, M., Nakada, N., Endou, H., et al. L-amino acid transporter 1 may be a prognostic marker for local progression of prostatic cancer under expectant management. Cancer Biomark. 15 (2015), 365–374.
    • (2015) Cancer Biomark. , vol.15 , pp. 365-374
    • Yanagisawa, N.1    Satoh, T.2    Hana, K.3    Ichinoe, M.4    Nakada, N.5    Endou, H.6
  • 53
    • 84911458266 scopus 로고    scopus 로고
    • Expression of L-type amino acid transporter 1 (LAT1) as a prognostic and therapeutic indicator in multiple myeloma
    • [53] Isoda, A., Kaira, K., Iwashina, M., Oriuchi, N., Tominaga, H., Nagamori, S., et al. Expression of L-type amino acid transporter 1 (LAT1) as a prognostic and therapeutic indicator in multiple myeloma. Cancer Sci. 105 (2014), 1496–1502.
    • (2014) Cancer Sci. , vol.105 , pp. 1496-1502
    • Isoda, A.1    Kaira, K.2    Iwashina, M.3    Oriuchi, N.4    Tominaga, H.5    Nagamori, S.6
  • 54
    • 84944160659 scopus 로고    scopus 로고
    • CD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma
    • [54] Toyoda, M., Kaira, K., Shino, M., Sakakura, K., Takahashi, K., Takayasu, Y., et al. CD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma. Head Neck 37 (2015), 1569–1574.
    • (2015) Head Neck , vol.37 , pp. 1569-1574
    • Toyoda, M.1    Kaira, K.2    Shino, M.3    Sakakura, K.4    Takahashi, K.5    Takayasu, Y.6
  • 55
    • 84885180699 scopus 로고    scopus 로고
    • Clinicopathological significance of L-type amino acid transporter 1 (LAT1) expression in patients with adenoid cystic carcinoma
    • [55] Kaira, K., Toyoda, M., Shino, M., Sakakura, K., Takahashi, K., Tominaga, H., et al. Clinicopathological significance of L-type amino acid transporter 1 (LAT1) expression in patients with adenoid cystic carcinoma. Pathol. Oncol. Res. 19 (2013), 649–656.
    • (2013) Pathol. Oncol. Res. , vol.19 , pp. 649-656
    • Kaira, K.1    Toyoda, M.2    Shino, M.3    Sakakura, K.4    Takahashi, K.5    Tominaga, H.6
  • 56
    • 71549140072 scopus 로고    scopus 로고
    • CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases
    • [56] Kaira, K., Oriuchi, N., Imai, H., Shimizu, K., Yanagitani, N., Sunaga, N., et al. CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases. Ann. Surg. Oncol. 16 (2009), 3473–3481.
    • (2009) Ann. Surg. Oncol. , vol.16 , pp. 3473-3481
    • Kaira, K.1    Oriuchi, N.2    Imai, H.3    Shimizu, K.4    Yanagitani, N.5    Sunaga, N.6
  • 57
    • 84856492407 scopus 로고    scopus 로고
    • Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis
    • [57] Furuya, M., Horiguchi, J., Nakajima, H., Kanai, Y., Oyama, T., Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis. Cancer Sci. 103 (2012), 382–389.
    • (2012) Cancer Sci. , vol.103 , pp. 382-389
    • Furuya, M.1    Horiguchi, J.2    Nakajima, H.3    Kanai, Y.4    Oyama, T.5
  • 59
    • 84867554554 scopus 로고    scopus 로고
    • Predicting drug targets and biomarkers of cancer via genome-scale metabolic modeling
    • [59] Jerby, L., Ruppin, E., Predicting drug targets and biomarkers of cancer via genome-scale metabolic modeling. Clin. Cancer Res. 18 (2012), 5572–5584.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 5572-5584
    • Jerby, L.1    Ruppin, E.2
  • 60
    • 84901306814 scopus 로고    scopus 로고
    • Systematic evaluation of methods for integration of transcriptomic data into constraint-based models of metabolism
    • [60] Machado, D., Herrgard, M., Systematic evaluation of methods for integration of transcriptomic data into constraint-based models of metabolism. Plos Comput. Biol., 10, 2014.
    • (2014) Plos Comput. Biol. , vol.10
    • Machado, D.1    Herrgard, M.2
  • 61
    • 84868678284 scopus 로고    scopus 로고
    • Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation
    • [61] Yu, M., Lin, G., Arshadi, N., Kalatskaya, I., Xue, B., Haider, S., et al. Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation. Mol. Cell. Biol. 32 (2012), 3913–3924.
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 3913-3924
    • Yu, M.1    Lin, G.2    Arshadi, N.3    Kalatskaya, I.4    Xue, B.5    Haider, S.6
  • 62
    • 84892909254 scopus 로고    scopus 로고
    • Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways
    • [62] Onodera, Y., Nam, J.M., Bissell, M.J., Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J. Clin. Invest. 124 (2014), 367–384.
    • (2014) J. Clin. Invest. , vol.124 , pp. 367-384
    • Onodera, Y.1    Nam, J.M.2    Bissell, M.J.3
  • 63
    • 84884974310 scopus 로고    scopus 로고
    • Mammalian cell metabolomics: experimental design and sample preparation
    • [63] Leon, Z., Garcia-Canaveras, J.C., Donato, M.T., Lahoz, A., Mammalian cell metabolomics: experimental design and sample preparation. Electrophoresis 34 (2013), 2762–2775.
    • (2013) Electrophoresis , vol.34 , pp. 2762-2775
    • Leon, Z.1    Garcia-Canaveras, J.C.2    Donato, M.T.3    Lahoz, A.4
  • 64
    • 84877863145 scopus 로고    scopus 로고
    • Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei
    • [64] Creek, D.J., Nijagal, B., Kim, D.H., Rojas, F., Matthews, K.R., Barrett, M.P., Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. Antimicrob. Agents Chemother. 57 (2013), 2768–2779.
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 2768-2779
    • Creek, D.J.1    Nijagal, B.2    Kim, D.H.3    Rojas, F.4    Matthews, K.R.5    Barrett, M.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.