A Novel Role for Tm7sf2 Gene in Regulating TNFα Expression

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Bellezza, Ilaria ^a   Roberti, Rita ^a   Gatticchi, Leonardo ^a   Del Sordo, Rachele ^a   Rambotti, Maria Grazia ^a   Marchetti, Maria Cristina ^a   Sidoni, Angelo ^a   Minelli, Alba ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 2ALPHA; LIVER X RECEPTOR; THAPSIGARGIN; TUMOR NECROSIS FACTOR ALPHA; TUNICAMYCIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELLULAR STRESS RESPONSE; CELLULAR STRESS SIGNAL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; EDEMA; EMBRYO; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST; GENE; GENE CONTROL; GENE FUNCTION; GENE INTERACTION; GENETIC CORRELATION; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT GENE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TM7SF2 GENE; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; APOPTOSIS; CHOLESTEROL; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; LIVER; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; ORPHAN NUCLEAR RECEPTORS; OXIDOREDUCTASES; PHAGOSOMES; STRESS, PHYSIOLOGICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84880743095     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068017     Document Type: Article

References (52)

1. Xu F, Rychnovsky SD, Belani JD, Hobbs HH, Cohen JC, et al. (2005) Dual roles for cholesterol in mammalian cells. Proc Natl Acad Sci U S A 102: 14551-14556.
2. Goldstein JL, Brown MS, (1990) Regulation of the mevalonate pathway. Nature 343: 425-430.
3. Schiavoni G, Bennati AM, Castelli M, Fazia MA, Beccari T, et al. (2010) Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box. Biochim Biophys Acta 1801: 587-592.
4. Bennati AM, Castelli M, Della Fazia MA, Beccari T, Caruso D, et al. (2006) Sterol dependent regulation of humanTM7SF2 gene expression: role of the encoded 3β-hydroxysterol Δ14-reductase in human cholesterol biosynthesis. Biochim Biophys Acta 1761: 677-685.
5. Harding HP, Zhang Y, Ron D, (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397: 271-274.
6. Kleizen B, Braakman I, (2004) Protein folding and quality control in the endoplasmic reticulum. Curr Opin Cell Biol 16: 343-349.
7. Scheuner D, Vander Mierde D, Song B, Flamez D, Creemers JW, et al. (2005) Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med 11: 757-764.
8. Xu C, Bailly-Maitre B, Reed JC, (2005b) Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115: 2656-2664.
9. Lin Y, Jamison S, Lin W, (2012) Interferon-γ activates nuclear factor-κ B in oligodendrocytes through a process mediated by the unfolded protein response. PLoS One 7: e36408.
10. Zhang K, Kaufman RJ, (2006) The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 66: S102-109.
11. Tsang KY, Chan D, Bateman JF, Cheah KS, (2010) In vivo cellular adaptation to ER stress: survival strategies with double-edged consequences. J Cell Sci 123: 2145-2154.
12. Muaddi H, Majumder M, Peidis P, Papadakis AI, Holcik M, et al. (2010) Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Mol Biol Cell 21: 3220-3231.
13. Sonenberg N, Hinnebusch AG, (2009) Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 136: 731-745.
14. Schröder M, (2008) Endoplasmic reticulum stress responses. Cell Mol Life Sci 65: 862-894.
15. Schröder M, Kaufman RJ, (2006) Divergent roles of IRE1alpha and PERK in the unfolded protein response. Curr Mol Med 6: 5-36.
16. Parmar VM, Schröder M, (2012) Sensing endoplasmic reticulum stress. Adv Exp Med Biol 738: 153-168.
17. Momoi T, (2004) Caspases involved in ER stress-mediated cell death. J Chem Neuroanat 28: 101-105.
18. Kitamura M, (2011) Control of NF-κB and inflammation by the unfolded protein response. Int Rev Immunol 30: 4-15.
19. Liu XD, Ko S, Xu Y, Fattah EA, Xiang Q, et al. (2012) Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress. J Biol Chem 287: 19687-19698.
20. Bennati AM, Schiavoni G, Franken S, Piobbico D, Della Fazia MA, et al. (2008) Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis. FEBS J 275: 5034-5047.
21. Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, et al. (2008) DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death Differ 15: 1875-1886.
22. Macala LJ, Yu RK, Ando S, (1983) Analysis of brain lipids by high performance thin-layer chromatography and densitometry. J Lipid Res 24: 1243-1250.
23. Silve S, Dupuy PH, Ferrara P, Loison G, (1998) Human lamin B receptor exhibits sterol C14-reductase activity in Saccharomyces cerevisiae. Biochim Biophys Acta 1392: 233-244.
24. Roberti R, Bennati AM, Galli G, Caruso D, Maras B, et al. (2002) Cloning and expression of sterol delta14-reductase from bovine liver. Eur J Biochem 269: 283-290.
25. Sala SG, Muñoz U, Bartolomé F, Bermelo F, Martín-Requero A, (2008) HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects. J Pharmacol Exp Ther 324: 352-359.
26. Winther AM, Liu H, Sonntag Y, Olesen C, le Maire M, et al. (2010) Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs. J Biol Chem 285: 28883-23892.
27. Huang L, Zhang R, Wu J, Chen J, Grosjean F, et al. (2011) Increased susceptibility to acute kidney injury due to endoplasmic reticulum stress in mice lacking tumor necrosis factor-α and its receptor 1. Kidney Int 79: 613-623.
28. Klionsky DJ, (2007) Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 8: 931-937.
29. Ganley IG, Wong PM, Gammoh N, Jiang X, (2011) Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell 42: 731-743.
30. Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, et al. (2003) Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol 23: 5651-5663.
31. Endo M, Oyadomari S, Suga M, Mori M, Gotoh T, (2005) The ER stress pathway involving CHOP is activated in the lungs of LPS-treated mice. J Biochem 138: 501-507.
32. Oyadomari S, Mori M, (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11: 381-389.
33. Wakabayashi N, Slocum SL, Skoko JJ, Shin S, Kensler TW, (2010) When NRF2 talks, who's listening? Antioxid Redox Signal 13: 1649-1663.
34. Bellezza I, Mierla AL, Minelli A, (2010) Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression. Cancers 2: 483-497.
35. Brigelius-Flohé R, Flohé L, (2011) Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal 15: 2335-2381.
36. Rzymski T, Paantjens A, Bod J, Harris AL, (2008) Multiple pathways are involved in the anoxia response of SKIP3 including HuR-regulated RNA stability, NF-kappaB and ATF4. Oncogene 27: 4532-4543.
37. Miyamoto N, Izumi H, Miyamoto R, Bin H, Kondo H, et al. (2011) Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE-19/HPV-16 cells. Invest Ophthalmol Vis Sci 52: 1226-1234.
38. Repa JJ, Mangelsdorf DJ, (2000) The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol 16: 459-481.
39. Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P, (2003) Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 9: 213-219.
40. Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, et al. (2005) Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 122: 707-721.
41. Bensinger SJ, Tontonoz P, (2008) Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature 454: 470-477.
42. Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, et al. (2008) LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 134: 97-111.
43. Dumont JE, Dremier S, Pirson I, Maenhaut C, (2002) Cross signaling, cell specificity, and physiology. Am J Physiol Cell Physiol 283: 2-28.
44. He CH, Gong P, Hu B, Stewart D, Choi ME, et al. (2001) Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. J Biol Chem 276: 20858-20865.
45. Zong ZH, Du ZX, Li N, Li C, Zhang Q, et al. (2012) Implication of Nrf2 and ATF4 in differential induction of CHOP by proteasome inhibition in thyroid cancer cells. Biochim Biophys Acta 1823: 1395-1404.
46. Lundvig DM, Immenschuh S, Wagener FA, (2012) Heme oxygenase, inflammation, and fibrosis: the good, the bad, and the ugly? Front Pharmacol 3: 81.
47. Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, et al. (2000) Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6: 1099-1108.
48. Su N, Kilberg MS, (2008) C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J Biol Chem 283: 35106-35117.
49. Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, et al. (2004) Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol 24: 10161-10168.
50. Landis MS, Patel HV, Capone JP, (2002) Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes. J Biol Chem 277: 4713-4721.
51. Fowler AJ, Sheu MY, Schmuth M, Kao J, Fluhr JW, et al. (2003) Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol 120: 246-255.
52. Im SS, Osborne TF, (2011) Liver x receptors in atherosclerosis and inflammation. Circ Res 108: 996-1001.