메뉴 건너뛰기




Volumn 129, Issue 4, 2017, Pages 424-447

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(22)  Döhner, Hartmut a   Estey, Elihu b   Grimwade, David c   Amadori, Sergio d   Appelbaum, Frederick R b   Büchner, Thomas e   Dombret, Hervé f   Ebert, Benjamin L g   Fenaux, Pierre h   Larson, Richard A i   Levine, Ross L j   Lo Coco, Francesco d   Naoe, Tomoki k   Niederwieser, Dietger l   Ossenkoppele, Gert J m   Sanz, Miguel n   Sierra, Jorge o   Tallman, Martin S j   Tien, Hwei Fang p   Wei, Andrew H q,r   more..


Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE DERIVATIVE; ANTILEUKEMIC AGENT; CYTARABINE; CYTARABINE PLUS DAUNORUBICIN; GEMTUZUMAB OZOGAMICIN; GUADECITABINE; MONOCLONAL ANTIBODY; PROTEIN KINASE INHIBITOR; PURINE DERIVATIVE; VOSAROXIN; ANTINEOPLASTIC AGENT;

EID: 85014879329     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-08-733196     Document Type: Review
Times cited : (4467)

References (299)
  • 1
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Döhner H, Estey EH, Amadori S, et al; European LeukemiaNet. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115(3):453-474.
    • (2010) Blood , vol.115 , Issue.3 , pp. 453-474
    • Döhner, H.1    Estey, E.H.2    Amadori, S.3
  • 3
    • 84974560145 scopus 로고    scopus 로고
    • The 2016 revision to the world health organization classification of myeloid neoplasms and acute leukemia
    • Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-2405.
    • (2016) Blood , vol.127 , Issue.20 , pp. 2391-2405
    • Arber, D.A.1    Orazi, A.2    Hasserjian, R.3
  • 5
    • 61949441174 scopus 로고    scopus 로고
    • Management of acute promyelocytic leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet
    • Sanz MA, Grimwade D, Tallman MS, et al. Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood. 2009; 113(9):1875-1891.
    • (2009) Blood , vol.113 , Issue.9 , pp. 1875-1891
    • Sanz, M.A.1    Grimwade, D.2    Tallman, M.S.3
  • 7
    • 84898494315 scopus 로고    scopus 로고
    • A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia
    • Gröschel S, Sanders MA, Hoogenboezem R, et al. A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. Cell. 2014; 157(2):369-381.
    • (2014) Cell. , vol.157 , Issue.2 , pp. 369-381
    • Gröschel, S.1    Sanders, M.A.2    Hoogenboezem, R.3
  • 8
    • 84898420078 scopus 로고    scopus 로고
    • A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression
    • Yamazaki H, Suzuki M, Otsuki A, et al. A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression. Cancer Cell. 2014;25(4): 415-427.
    • (2014) Cancer Cell. , vol.25 , Issue.4 , pp. 415-427
    • Yamazaki, H.1    Suzuki, M.2    Otsuki, A.3
  • 9
    • 84876790071 scopus 로고    scopus 로고
    • Does BCR/ABL1 positive acute myeloid leukaemia exist?
    • Nacheva EP, Grace CD, Brazma D, et al. Does BCR/ABL1 positive acute myeloid leukaemia exist? Br J Haematol. 2013;161(4):541-550.
    • (2013) Br J Haematol. , vol.161 , Issue.4 , pp. 541-550
    • Nacheva, E.P.1    Grace, C.D.2    Brazma, D.3
  • 10
    • 63849241865 scopus 로고    scopus 로고
    • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
    • Wouters BJ, Löwenberg B, Erpelinck-Verschueren CA, van Putten WL, Valk PJ, Delwel R. Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood. 2009;113(13): 3088-3091.
    • (2009) Blood , vol.113 , Issue.13 , pp. 3088-3091
    • Wouters, B.J.1    Löwenberg, B.2    Erpelinck-Verschueren, C.A.3    Van Putten, W.L.4    Valk, P.J.5    Delwel, R.6
  • 11
    • 64949122396 scopus 로고    scopus 로고
    • Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
    • Pabst T, Eyholzer M, Fos J, Mueller BU. Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis. Br J Cancer. 2009;100(8): 1343-1346.
    • (2009) Br J Cancer , vol.100 , Issue.8 , pp. 1343-1346
    • Pabst, T.1    Eyholzer, M.2    Fos, J.3    Mueller, B.U.4
  • 12
    • 68749110471 scopus 로고    scopus 로고
    • Reply to 'Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favorable prognosis'
    • Hou HA, Lin LI, Chen CY, Tien HF. Reply to 'Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favorable prognosis'. Br J Cancer. 2009;101(4): 738-740.
    • (2009) Br J Cancer , vol.101 , Issue.4 , pp. 738-740
    • Hou, H.A.1    Lin, L.I.2    Chen, C.Y.3    Tien, H.F.4
  • 13
    • 77954921625 scopus 로고    scopus 로고
    • Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: Impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations
    • Green CL, Koo KK, Hills RK, Burnett AK, Linch DC, Gale RE. Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations. J Clin Oncol. 2010;28(16):2739-2747.
    • (2010) J Clin Oncol. , vol.28 , Issue.16 , pp. 2739-2747
    • Green, C.L.1    Koo, K.K.2    Hills, R.K.3    Burnett, A.K.4    Linch, D.C.5    Gale, R.E.6
  • 14
    • 77449146413 scopus 로고    scopus 로고
    • Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome
    • Dufour A, Schneider F, Metzeler KH, et al. Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome. J Clin Oncol. 2010;28(4): 570-577.
    • (2010) J Clin Oncol. , vol.28 , Issue.4 , pp. 570-577
    • Dufour, A.1    Schneider, F.2    Metzeler, K.H.3
  • 15
    • 79952122978 scopus 로고    scopus 로고
    • Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: Further evidence for CEBPA double mutant AML as a distinctive disease entity
    • Taskesen E, Bullinger L, Corbacioglu A, et al. Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity. Blood. 2011;117(8): 2469-2475.
    • (2011) Blood , vol.117 , Issue.8 , pp. 2469-2475
    • Taskesen, E.1    Bullinger, L.2    Corbacioglu, A.3
  • 16
    • 84888032250 scopus 로고    scopus 로고
    • The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA
    • Schlenk RF, Taskesen E, van Norden Y, et al. The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA. Blood. 2013;122(9): 1576-1582.
    • (2013) Blood , vol.122 , Issue.9 , pp. 1576-1582
    • Schlenk, R.F.1    Taskesen, E.2    Van Norden, Y.3
  • 17
    • 77952578145 scopus 로고    scopus 로고
    • Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1)
    • Falini B, Macijewski K, Weiss T, et al. Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1). Blood. 2010;115(18):3776-3786.
    • (2010) Blood , vol.115 , Issue.18 , pp. 3776-3786
    • Falini, B.1    Macijewski, K.2    Weiss, T.3
  • 18
    • 78650676071 scopus 로고    scopus 로고
    • The prognostic value of multilineage dysplasia in de novo acute myeloid leukemia patients with intermediate-risk cytogenetics is dependent on NPM1 mutational status
    • Díaz-Beyá M, Rozman M, Pratcorona M, et al. The prognostic value of multilineage dysplasia in de novo acute myeloid leukemia patients with intermediate-risk cytogenetics is dependent on NPM1 mutational status. Blood. 2010;116(26): 6147-6148.
    • (2010) Blood , vol.116 , Issue.26 , pp. 6147-6148
    • Díaz-Beyá, M.1    Rozman, M.2    Pratcorona, M.3
  • 19
    • 84861214425 scopus 로고    scopus 로고
    • Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity
    • Bacher U, Schnittger S, Macijewski K, et al. Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity. Blood. 2012;119(20):4719-4722.
    • (2012) Blood , vol.119 , Issue.20 , pp. 4719-4722
    • Bacher, U.1    Schnittger, S.2    Macijewski, K.3
  • 20
    • 73949090504 scopus 로고    scopus 로고
    • AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: Prognostic implication and interaction with other gene alterations
    • Tang JL, Hou HA, Chen CY, et al. AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. Blood. 2009;114(26):5352-5361.
    • (2009) Blood , vol.114 , Issue.26 , pp. 5352-5361
    • Tang, J.L.1    Hou, H.A.2    Chen, C.Y.3
  • 21
    • 79954448043 scopus 로고    scopus 로고
    • RUNX1 mutations in acute myeloid leukemia: Results from a comprehensive genetic and clinical analysis from the AML study group
    • Gaidzik VI, Bullinger L, Schlenk RF, et al. RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group. J Clin Oncol. 2011;29(10):1364-1372.
    • (2011) J Clin Oncol. , vol.29 , Issue.10 , pp. 1364-1372
    • Gaidzik, V.I.1    Bullinger, L.2    Schlenk, R.F.3
  • 22
    • 84865720625 scopus 로고    scopus 로고
    • RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures
    • Mendler JH, Maharry K, Radmacher MD, et al. RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures. J Clin Oncol. 2012;30(25): 3109-3118.
    • (2012) J Clin Oncol. , vol.30 , Issue.25 , pp. 3109-3118
    • Mendler, J.H.1    Maharry, K.2    Radmacher, M.D.3
  • 23
    • 84973659562 scopus 로고    scopus 로고
    • RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features
    • Gaidzik VI, Teleanu V, Papaemmanuil E, et al. RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features. Leukemia. 2016;30(11): 2160-2168.
    • (2016) Leukemia , vol.30 , Issue.11 , pp. 2160-2168
    • Gaidzik, V.I.1    Teleanu, V.2    Papaemmanuil, E.3
  • 24
    • 84975127099 scopus 로고    scopus 로고
    • The new provisional WHO entity 'RUNX1 mutated AML' shows specific genetics but no prognostic influence of dysplasia
    • Haferlach T, Stengel A, Eckstein S, et al. The new provisional WHO entity 'RUNX1 mutated AML' shows specific genetics but no prognostic influence of dysplasia. Leukemia. 2016;30(10): 2109-2112.
    • (2016) Leukemia , vol.30 , Issue.10 , pp. 2109-2112
    • Haferlach, T.1    Stengel, A.2    Eckstein, S.3
  • 25
    • 70350637903 scopus 로고    scopus 로고
    • AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features
    • Haferlach C, Mecucci C, Schnittger S, et al. AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features. Blood. 2009;114(14):3024-3032.
    • (2009) Blood , vol.114 , Issue.14 , pp. 3024-3032
    • Haferlach, C.1    Mecucci, C.2    Schnittger, S.3
  • 26
    • 84878396116 scopus 로고    scopus 로고
    • Significance of FAB subclassification of "acute myeloid leukemia, NOS" in the 2008 WHO classification: Analysis of 5848 newly diagnosed patients
    • Walter RB, Othus M, Burnett AK, et al. Significance of FAB subclassification of "acute myeloid leukemia, NOS" in the 2008 WHO classification: analysis of 5848 newly diagnosed patients. Blood. 2013;121(13):2424-2431.
    • (2013) Blood , vol.121 , Issue.13 , pp. 2424-2431
    • Walter, R.B.1    Othus, M.2    Burnett, A.K.3
  • 27
    • 84990913391 scopus 로고    scopus 로고
    • How I diagnose and manage individuals at risk for inherited myeloid malignancies
    • Churpek JE, Godley LA. How I diagnose and manage individuals at risk for inherited myeloid malignancies. Blood. 2016;128(14):1800-1813.
    • (2016) Blood , vol.128 , Issue.14 , pp. 1800-1813
    • Churpek, J.E.1    Godley, L.A.2
  • 28
    • 84929167143 scopus 로고    scopus 로고
    • Inherited and somatic defects in DDX41 in myeloid neoplasms
    • Polprasert C, Schulze I, Sekeres MA, et al. Inherited and somatic defects in DDX41 in myeloid neoplasms. Cancer Cell. 2015;27(5): 658-670.
    • (2015) Cancer Cell. , vol.27 , Issue.5 , pp. 658-670
    • Polprasert, C.1    Schulze, I.2    Sekeres, M.A.3
  • 29
    • 84926216729 scopus 로고    scopus 로고
    • Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy
    • Zhang MY, Churpek JE, Keel SB, et al. Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. Nat Genet. 2015; 47(2):180-185.
    • (2015) Nat Genet. , vol.47 , Issue.2 , pp. 180-185
    • Zhang, M.Y.1    Churpek, J.E.2    Keel, S.B.3
  • 30
    • 84958205839 scopus 로고    scopus 로고
    • Germline RBBP6 mutations in familial myeloproliferative neoplasms
    • Harutyunyan AS, Giambruno R, Krendl C, et al. Germline RBBP6 mutations in familial myeloproliferative neoplasms. Blood. 2016; 127(3):362-365.
    • (2016) Blood , vol.127 , Issue.3 , pp. 362-365
    • Harutyunyan, A.S.1    Giambruno, R.2    Krendl, C.3
  • 31
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013;368(22):2059-2074.
    • (2013) N Engl J Med. , vol.368 , Issue.22 , pp. 2059-2074
  • 32
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010;363(25):2424-2433.
    • (2010) N Engl J Med. , vol.363 , Issue.25 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 33
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan XJ, Xu J, Gu ZH, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011;43(4): 309-315.
    • (2011) Nat Genet. , vol.43 , Issue.4 , pp. 309-315
    • Yan, X.J.1    Xu, J.2    Gu, Z.H.3
  • 34
    • 84864255882 scopus 로고    scopus 로고
    • The origin and evolution of mutations in acute myeloid leukemia
    • Welch JS, Ley TJ, Link DC, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 2012;150(2):264-278.
    • (2012) Cell. , vol.150 , Issue.2 , pp. 264-278
    • Welch, J.S.1    Ley, T.J.2    Link, D.C.3
  • 35
    • 84862776906 scopus 로고    scopus 로고
    • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    • Ding L, Ley TJ, Larson DE, et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012; 481(7382):506-510.
    • (2012) Nature , vol.481 , Issue.7382 , pp. 506-510
    • Ding, L.1    Ley, T.J.2    Larson, D.E.3
  • 36
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel JP, Gönen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012;366(12):1079-1089.
    • (2012) N Engl J Med. , vol.366 , Issue.12 , pp. 1079-1089
    • Patel, J.P.1    Gönen, M.2    Figueroa, M.E.3
  • 37
    • 84973879698 scopus 로고    scopus 로고
    • Genomic classification and prognosis in acute myeloid leukemia
    • Papaemmanuil E, Gerstung M, Bullinger L, et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med. 2016;374(23): 2209-2221.
    • (2016) N Engl J Med. , vol.374 , Issue.23 , pp. 2209-2221
    • Papaemmanuil, E.1    Gerstung, M.2    Bullinger, L.3
  • 38
    • 84865827060 scopus 로고    scopus 로고
    • Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia
    • Jan M, Snyder TM, Corces-Zimmerman MR, et al. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med. 2012;4(149): 149ra118.
    • (2012) Sci Transl Med. , vol.4 , Issue.149 , pp. 149ra118
    • Jan, M.1    Snyder, T.M.2    Corces-Zimmerman, M.R.3
  • 39
    • 84883730914 scopus 로고    scopus 로고
    • Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia
    • Krönke J, Bullinger L, Teleanu V, et al. Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia. Blood. 2013;122(1):100-108.
    • (2013) Blood , vol.122 , Issue.1 , pp. 100-108
    • Krönke, J.1    Bullinger, L.2    Teleanu, V.3
  • 40
    • 84894304555 scopus 로고    scopus 로고
    • Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
    • Corces-Zimmerman MR, Hong WJ, Weissman IL, Medeiros BC, Majeti R. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci USA. 2014; 111(7):2548-2553.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.7 , pp. 2548-2553
    • Corces-Zimmerman, M.R.1    Hong, W.J.2    Weissman, I.L.3    Medeiros, B.C.4    Majeti, R.5
  • 41
    • 84894245627 scopus 로고    scopus 로고
    • Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia [published correction appears in nature. 2014;508(7496):420]
    • Shlush LI, Zandi S, Mitchell A, et al; HALT Pan-Leukemia Gene Panel Consortium. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia [published correction appears in Nature. 2014;508(7496):420]. Nature. 2014; 506(7488):328-333.
    • (2014) Nature , vol.506 , Issue.7488 , pp. 328-333
    • Shlush, L.I.1    Zandi, S.2    Mitchell, A.3
  • 42
    • 84868208186 scopus 로고    scopus 로고
    • Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
    • Busque L, Patel JP, Figueroa ME, et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet. 2012;44(11):1179-1181.
    • (2012) Nat Genet. , vol.44 , Issue.11 , pp. 1179-1181
    • Busque, L.1    Patel, J.P.2    Figueroa, M.E.3
  • 43
    • 84920053873 scopus 로고    scopus 로고
    • Age-related clonal hematopoiesis associated with adverse outcomes
    • Jaiswal S, Fontanillas P, Flannick J, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014;371(26): 2488-2498.
    • (2014) N Engl J Med. , vol.371 , Issue.26 , pp. 2488-2498
    • Jaiswal, S.1    Fontanillas, P.2    Flannick, J.3
  • 44
    • 84930003179 scopus 로고    scopus 로고
    • Age-related mutations associated with clonal hematopoietic expansion and malignancies
    • Xie M, Lu C, Wang J, et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat Med. 2014; 20(12):1472-1478.
    • (2014) Nat Med. , vol.20 , Issue.12 , pp. 1472-1478
    • Xie, M.1    Lu, C.2    Wang, J.3
  • 45
    • 84920024296 scopus 로고    scopus 로고
    • Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
    • Genovese G, Kähler AK, Handsaker RE, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014;371(26):2477-2487.
    • (2014) N Engl J Med. , vol.371 , Issue.26 , pp. 2477-2487
    • Genovese, G.1    Kähler, A.K.2    Handsaker, R.E.3
  • 46
    • 84924620531 scopus 로고    scopus 로고
    • Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis
    • McKerrell T, Park N, Moreno T, et al; Understanding Society Scientific Group. Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis. Cell Reports. 2015;10(8): 1239-1245.
    • (2015) Cell Reports , vol.10 , Issue.8 , pp. 1239-1245
    • McKerrell, T.1    Park, N.2    Moreno, T.3
  • 47
    • 84937904208 scopus 로고    scopus 로고
    • Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
    • Steensma DP, Bejar R, Jaiswal S, et al. Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. Blood. 2015;126(1):9-16.
    • (2015) Blood , vol.126 , Issue.1 , pp. 9-16
    • Steensma, D.P.1    Bejar, R.2    Jaiswal, S.3
  • 48
    • 79954450713 scopus 로고    scopus 로고
    • Immunophenotyping of acute leukemia and lymphoproliferative disorders: A consensus proposal of the European LeukemiaNet work package 10
    • Béné MC, Nebe T, Bettelheim P, et al. Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10. Leukemia. 2011;25(4):567-574.
    • (2011) Leukemia , vol.25 , Issue.4 , pp. 567-574
    • Béné, M.C.1    Nebe, T.2    Bettelheim, P.3
  • 49
    • 77955914238 scopus 로고    scopus 로고
    • Refinement of cytogenetic classification in acute myeloid leukemia: Determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom medical research council trials
    • Grimwade D, Hills RK, Moorman AV, et al; National Cancer Research Institute Adult Leukaemia Working Group. Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood. 2010;116(3): 354-365.
    • (2010) Blood , vol.116 , Issue.3 , pp. 354-365
    • Grimwade, D.1    Hills, R.K.2    Moorman, A.V.3
  • 50
    • 84955451182 scopus 로고    scopus 로고
    • Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance
    • Grimwade D, Ivey A, Huntly BJ. Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance. Blood. 2016; 127(1):29-41.
    • (2016) Blood , vol.127 , Issue.1 , pp. 29-41
    • Grimwade, D.1    Ivey, A.2    Huntly, B.J.3
  • 51
    • 83455220210 scopus 로고    scopus 로고
    • NUP98 gene fusions and hematopoietic malignancies: Common themes and new biologic insights
    • Gough SM, Slape CI, Aplan PD. NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights. Blood. 2011;118(24):6247-6257.
    • (2011) Blood , vol.118 , Issue.24 , pp. 6247-6257
    • Gough, S.M.1    Slape, C.I.2    Aplan, P.D.3
  • 52
    • 80053354797 scopus 로고    scopus 로고
    • NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern
    • Hollink IH, van den Heuvel-Eibrink MM, Arentsen-Peters ST, et al. NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern. Blood. 2011;118(13): 3645-3656.
    • (2011) Blood , vol.118 , Issue.13 , pp. 3645-3656
    • Hollink, I.H.1    Van Den Heuvel-Eibrink, M.M.2    Arentsen-Peters, S.T.3
  • 53
    • 84875225956 scopus 로고    scopus 로고
    • Analysis of NUP98/NSD1 translocations in adult AML and MDS patients
    • Thol F, Kölking B, Hollink IH, et al. Analysis of NUP98/NSD1 translocations in adult AML and MDS patients. Leukemia. 2013;27(3):750-754.
    • (2013) Leukemia , vol.27 , Issue.3 , pp. 750-754
    • Thol, F.1    Kölking, B.2    Hollink, I.H.3
  • 54
    • 84869009858 scopus 로고    scopus 로고
    • An inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia
    • Gruber TA, Larson Gedman A, Zhang J, et al. An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell. 2012;22(5):683-697.
    • (2012) Cancer Cell. , vol.22 , Issue.5 , pp. 683-697
    • Gruber, T.A.1    Larson Gedman, A.2    Zhang, J.3
  • 55
    • 84977674608 scopus 로고    scopus 로고
    • Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies
    • McKerrell T, Moreno T, Ponstingl H, et al. Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies. Blood. 2016;128(1):e1-e9.
    • (2016) Blood , vol.128 , Issue.1 , pp. e1-e9
    • McKerrell, T.1    Moreno, T.2    Ponstingl, H.3
  • 56
    • 84993661482 scopus 로고    scopus 로고
    • Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting
    • He J, Abdel-Wahab O, Nahas MK, et al. Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting. Blood. 2016;127(24):3004-3014.
    • (2016) Blood , vol.127 , Issue.24 , pp. 3004-3014
    • He, J.1    Abdel-Wahab, O.2    Nahas, M.K.3
  • 57
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Gale RE, Green C, Allen C, et al; Medical Research Council Adult Leukaemia Working Party. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood. 2008;111(5):2776-2784.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3
  • 58
    • 84878344487 scopus 로고    scopus 로고
    • Favorable outcome of patients with acute myeloid leukemia harboring a low-allelic burden FLT3-ITD mutation and concomitant NPM1 mutation: Relevance to post-remission therapy
    • Pratcorona M, Brunet S, Nomdedéu J, et al; Grupo Cooperativo Para el Estudio y Tratamiento de las Leucemias Agudas Mieloblásticas. Favorable outcome of patients with acute myeloid leukemia harboring a low-allelic burden FLT3-ITD mutation and concomitant NPM1 mutation: relevance to post-remission therapy. Blood. 2013;121(14): 2734-2738.
    • (2013) Blood , vol.121 , Issue.14 , pp. 2734-2738
    • Pratcorona, M.1    Brunet, S.2    Nomdedéu, J.3
  • 59
    • 84914163645 scopus 로고    scopus 로고
    • Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation
    • Schlenk RF, Kayser S, Bullinger L, et al; German-Austrian AML Study Group. Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation. Blood. 2014;124(23):3441-3449.
    • (2014) Blood , vol.124 , Issue.23 , pp. 3441-3449
    • Schlenk, R.F.1    Kayser, S.2    Bullinger, L.3
  • 60
    • 84904124365 scopus 로고    scopus 로고
    • Impact of FLT3(ITD) mutant allele level on relapse risk in intermediate-risk acute myeloid leukemia
    • Linch DC, Hills RK, Burnett AK, Khwaja A, Gale RE. Impact of FLT3(ITD) mutant allele level on relapse risk in intermediate-risk acute myeloid leukemia. Blood. 2014;124(2):273-276.
    • (2014) Blood , vol.124 , Issue.2 , pp. 273-276
    • Linch, D.C.1    Hills, R.K.2    Burnett, A.K.3    Khwaja, A.4    Gale, R.E.5
  • 61
    • 84964735868 scopus 로고    scopus 로고
    • Midostaurin, a multi-targeted kinase inhibitor, improves overall survival when added to standard chemotherapy in adults age 18-60 with FLT3 mutant acute myeloid leukemia (AML): Results from a randomized, prospective, placebo-controlled, double-blind trial, CALGB 10603/RATIFY [abstract]
    • Stone RM, Mandrekar S, Laumann C, et al. Midostaurin, a multi-targeted kinase inhibitor, improves overall survival when added to standard chemotherapy in adults age 18-60 with FLT3 mutant acute myeloid leukemia (AML): results from a randomized, prospective, placebo-controlled, double-blind trial, CALGB 10603/RATIFY [abstract]. Blood. 2015;126(23). Abstract 6.
    • (2015) Blood , vol.126 , Issue.23 , pp. 6
    • Stone, R.M.1    Mandrekar, S.2    Laumann, C.3
  • 62
    • 84255176496 scopus 로고    scopus 로고
    • ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN favorable genetic category
    • Metzeler KH, Becker H, Maharry K, et al. ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category. Blood. 2011;118(26):6920-6929.
    • (2011) Blood , vol.118 , Issue.26 , pp. 6920-6929
    • Metzeler, K.H.1    Becker, H.2    Maharry, K.3
  • 63
    • 84857699307 scopus 로고    scopus 로고
    • Acquired mutations in ASXL1 in acute myeloid leukemia: Prevalence and prognostic value
    • Pratcorona M, Abbas S, Sanders MA, et al. Acquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic value. Haematologica. 2012;97(3):388-392.
    • (2012) Haematologica , vol.97 , Issue.3 , pp. 388-392
    • Pratcorona, M.1    Abbas, S.2    Sanders, M.A.3
  • 64
    • 84873568769 scopus 로고    scopus 로고
    • ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome
    • Schnittger S, Eder C, Jeromin S, et al. ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome. Leukemia. 2013;27(1):82-91.
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 82-91
    • Schnittger, S.1    Eder, C.2    Jeromin, S.3
  • 65
    • 84924662543 scopus 로고    scopus 로고
    • ASXL1 mutations in younger adult patients with acute myeloid leukemia: A study by the German-Austrian acute myeloid leukemia study group
    • Paschka P, Schlenk RF, Gaidzik VI, et al. ASXL1 mutations in younger adult patients with acute myeloid leukemia: a study by the German-Austrian Acute Myeloid Leukemia Study Group. Haematologica. 2015;100(3):324-330.
    • (2015) Haematologica , vol.100 , Issue.3 , pp. 324-330
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3
  • 66
    • 49349140725 scopus 로고    scopus 로고
    • Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype
    • Haferlach C, Dicker F, Herholz H, Schnittger S, Kern W, Haferlach T. Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype. Leukemia. 2008;22(8):1539-1541.
    • (2008) Leukemia , vol.22 , Issue.8 , pp. 1539-1541
    • Haferlach, C.1    Dicker, F.2    Herholz, H.3    Schnittger, S.4    Kern, W.5    Haferlach, T.6
  • 67
    • 58249122390 scopus 로고    scopus 로고
    • TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis
    • Bowen D, Groves MJ, Burnett AK, et al. TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis. Leukemia. 2009;23(1):203-206.
    • (2009) Leukemia , vol.23 , Issue.1 , pp. 203-206
    • Bowen, D.1    Groves, M.J.2    Burnett, A.K.3
  • 68
    • 84857734093 scopus 로고    scopus 로고
    • TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome
    • Rücker FG, Schlenk RF, Bullinger L, et al. TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood. 2012;119(9):2114-2121.
    • (2012) Blood , vol.119 , Issue.9 , pp. 2114-2121
    • Rücker, F.G.1    Schlenk, R.F.2    Bullinger, L.3
  • 69
    • 84928403338 scopus 로고    scopus 로고
    • Role of ASXL1 and TP53 mutations in the molecular classification and prognosis of acute myeloid leukemias with myelodysplasia-related changes
    • Devillier R, Mansat-De Mas V, Gelsi-Boyer V, et al. Role of ASXL1 and TP53 mutations in the molecular classification and prognosis of acute myeloid leukemias with myelodysplasia-related changes. Oncotarget. 2015;6(10):8388-8396.
    • (2015) Oncotarget. , vol.6 , Issue.10 , pp. 8388-8396
    • Devillier, R.1    Mansat-De Mas, V.2    Gelsi-Boyer, V.3
  • 70
    • 84964057179 scopus 로고    scopus 로고
    • Genetic alterations and their clinical implications in older patients with acute myeloid leukemia
    • Tsai CH, Hou HA, Tang JL, et al. Genetic alterations and their clinical implications in older patients with acute myeloid leukemia. Leukemia. 2016;30(7):1485-1492.
    • (2016) Leukemia , vol.30 , Issue.7 , pp. 1485-1492
    • Tsai, C.H.1    Hou, H.A.2    Tang, J.L.3
  • 71
    • 84948976984 scopus 로고    scopus 로고
    • Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia
    • Churpek JE, Pyrtel K, Kanchi KL, et al. Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia. Blood. 2015;126(22):2484-2490.
    • (2015) Blood , vol.126 , Issue.22 , pp. 2484-2490
    • Churpek, J.E.1    Pyrtel, K.2    Kanchi, K.L.3
  • 72
    • 85014920454 scopus 로고    scopus 로고
    • Bone marrow fibroblasts derived from vitally frozen mononuclear cells as a source for germ line DNA in acute myeloid leukemia (AML) [abstract]
    • 2606
    • Mujahed H, Stefan D, Lehmann S. Bone marrow fibroblasts derived from vitally frozen mononuclear cells as a source for germ line DNA in acute myeloid leukemia (AML) [abstract]. Blood. 2015;126(23). Abstract 2606.
    • (2015) Blood , vol.126 , Issue.23
    • Mujahed, H.1    Stefan, D.2    Lehmann, S.3
  • 73
    • 84982966112 scopus 로고    scopus 로고
    • Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia
    • Metzeler KH, Herold T, Rothenberg-Thurley M, et al; AMLCG Study Group. Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia. Blood. 2016;128(5): 686-698.
    • (2016) Blood , vol.128 , Issue.5 , pp. 686-698
    • Metzeler, K.H.1    Herold, T.2    Rothenberg-Thurley, M.3
  • 74
    • 81255175041 scopus 로고    scopus 로고
    • Prediction of early death after induction therapy for newly diagnosed acute myeloid leukemia with pretreatment risk scores: A novel paradigm for treatment assignment
    • Walter RB, Othus M, Borthakur G, et al. Prediction of early death after induction therapy for newly diagnosed acute myeloid leukemia with pretreatment risk scores: a novel paradigm for treatment assignment. J Clin Oncol. 2011; 29(33):4417-4423.
    • (2011) J Clin Oncol. , vol.29 , Issue.33 , pp. 4417-4423
    • Walter, R.B.1    Othus, M.2    Borthakur, G.3
  • 75
    • 85014924523 scopus 로고    scopus 로고
    • Genomics of acute myeloid leukemia diagnosis and pathways
    • In press
    • Bullinger L, Döhner K, Döhner H. Genomics of acute myeloid leukemia diagnosis and pathways. J Clin Oncol. In press.
    • J Clin Oncol.
    • Bullinger, L.1    Döhner, K.2    Döhner, H.3
  • 76
    • 84904903686 scopus 로고    scopus 로고
    • Translational implications of somatic genomics in acute myeloid leukaemia
    • Meyer SC, Levine RL. Translational implications of somatic genomics in acute myeloid leukaemia. Lancet Oncol. 2014;15(9):e382-e394.
    • (2014) Lancet Oncol. , vol.15 , Issue.9 , pp. e382-e394
    • Meyer, S.C.1    Levine, R.L.2
  • 77
    • 84952898317 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation improves survival in patients with acute myeloid leukemia characterized by a high allelic ratio of mutant FLT3-ITD
    • Ho AD, Schetelig J, Bochtler T, et al; Study Alliance Leukemia. Allogeneic stem cell transplantation improves survival in patients with acute myeloid leukemia characterized by a high allelic ratio of mutant FLT3-ITD. Biol Blood Marrow Transplant. 2016;22(3):462-469.
    • (2016) Biol Blood Marrow Transplant , vol.22 , Issue.3 , pp. 462-469
    • Ho, A.D.1    Schetelig, J.2    Bochtler, T.3
  • 78
    • 84888219405 scopus 로고    scopus 로고
    • Clinical and biological implications of driver mutations in myelodysplastic syndromes
    • quiz 3699
    • Papaemmanuil E, Gerstung M, Malcovati L, et al; Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood. 2013;122(22):3616-3627, quiz 3699.
    • (2013) Blood , vol.122 , Issue.22 , pp. 3616-3627
    • Papaemmanuil, E.1    Gerstung, M.2    Malcovati, L.3
  • 79
    • 84893772765 scopus 로고    scopus 로고
    • Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
    • Haferlach T, Nagata Y, Grossmann V, et al. Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia. 2014; 28(2):241-247.
    • (2014) Leukemia , vol.28 , Issue.2 , pp. 241-247
    • Haferlach, T.1    Nagata, Y.2    Grossmann, V.3
  • 80
    • 84901465471 scopus 로고    scopus 로고
    • Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling
    • Taskesen E, Havermans M, van Lom K, et al. Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling. Blood. 2014;123(21): 3327-3335.
    • (2014) Blood , vol.123 , Issue.21 , pp. 3327-3335
    • Taskesen, E.1    Havermans, M.2    Van Lom, K.3
  • 81
    • 84961554506 scopus 로고    scopus 로고
    • Acute myeloid leukemia ontogeny is defined by distinct somatic mutations
    • Lindsley RC, Mar BG, Mazzola E, et al. Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. Blood. 2015;125(9): 1367-1376.
    • (2015) Blood , vol.125 , Issue.9 , pp. 1367-1376
    • Lindsley, R.C.1    Mar, B.G.2    Mazzola, E.3
  • 82
    • 84883742034 scopus 로고    scopus 로고
    • Mutations and prognosis in primary myelofibrosis
    • Vannucchi AM, Lasho TL, Guglielmelli P, et al. Mutations and prognosis in primary myelofibrosis. Leukemia. 2013;27(9):1861-1869.
    • (2013) Leukemia , vol.27 , Issue.9 , pp. 1861-1869
    • Vannucchi, A.M.1    Lasho, T.L.2    Guglielmelli, P.3
  • 83
    • 84899480888 scopus 로고    scopus 로고
    • Core-binding factor acute myeloid leukemia: Can we improve on HiDAC consolidation?
    • Paschka P, Döhner K. Core-binding factor acute myeloid leukemia: can we improve on HiDAC consolidation? Hematology Am Soc Hematol Educ Program. 2013;2013:209-219.
    • (2013) Hematology Am Soc Hematol Educ Program , vol.2013 , pp. 209-219
    • Paschka, P.1    Döhner, K.2
  • 84
    • 84883742457 scopus 로고    scopus 로고
    • The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia
    • Allen C, Hills RK, Lamb K, et al. The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia. Leukemia. 2013;27(9):1891-1901.
    • (2013) Leukemia , vol.27 , Issue.9 , pp. 1891-1901
    • Allen, C.1    Hills, R.K.2    Lamb, K.3
  • 85
    • 84877930402 scopus 로고    scopus 로고
    • Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia
    • Jourdan E, Boissel N, Chevret S, et al; French AML Intergroup. Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia. Blood. 2013;121(12):2213-2223.
    • (2013) Blood , vol.121 , Issue.12 , pp. 2213-2223
    • Jourdan, E.1    Boissel, N.2    Chevret, S.3
  • 86
    • 84872056078 scopus 로고    scopus 로고
    • Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): A study of the German-Austrian AML study group (AMLSG)
    • Paschka P, Du J, Schlenk RF, et al. Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG). Blood. 2013;121(1):170-177.
    • (2013) Blood , vol.121 , Issue.1 , pp. 170-177
    • Paschka, P.1    Du, J.2    Schlenk, R.F.3
  • 87
    • 85015404714 scopus 로고    scopus 로고
    • Comprehensive mutational profiling of core binding factor acute myeloid leukemia
    • Duployez N, Marceau-Renaut A, Boissel N, et al. Comprehensive mutational profiling of core binding factor acute myeloid leukemia. Blood. 2016;127(20):2451-2459.
    • (2016) Blood , vol.127 , Issue.20 , pp. 2451-2459
    • Duployez, N.1    Marceau-Renaut, A.2    Boissel, N.3
  • 88
    • 84992753537 scopus 로고    scopus 로고
    • The genomic landscape of core-binding factor acute myeloid leukemias
    • Faber ZJ, Chen X, Gedman AL, et al. The genomic landscape of core-binding factor acute myeloid leukemias. Nat Genet. 2016;48(12): 1551-1556.
    • (2016) Nat Genet. , vol.48 , Issue.12 , pp. 1551-1556
    • Faber, Z.J.1    Chen, X.2    Gedman, A.L.3
  • 89
    • 84907344294 scopus 로고    scopus 로고
    • Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations
    • Micol JB, Duployez N, Boissel N, et al. Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations. Blood. 2014; 124(9):1445-1449.
    • (2014) Blood , vol.124 , Issue.9 , pp. 1445-1449
    • Micol, J.B.1    Duployez, N.2    Boissel, N.3
  • 90
    • 84976309535 scopus 로고    scopus 로고
    • Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors
    • Lavallée VP, Krosl J, Lemieux S, et al. Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors. Blood. 2016;127(24):3054-3061.
    • (2016) Blood , vol.127 , Issue.24 , pp. 3054-3061
    • Lavallée, V.P.1    Krosl, J.2    Lemieux, S.3
  • 91
    • 84913553522 scopus 로고    scopus 로고
    • Defining minimal residual disease in acute myeloid leukemia: Which platforms are ready for "prime time"?
    • Grimwade D, Freeman SD. Defining minimal residual disease in acute myeloid leukemia: which platforms are ready for "prime time"? Blood. 2014;124(23):3345-3355.
    • (2014) Blood , vol.124 , Issue.23 , pp. 3345-3355
    • Grimwade, D.1    Freeman, S.D.2
  • 92
    • 84923870731 scopus 로고    scopus 로고
    • MRD in AML: It is time to change the definition of remission
    • Ossenkoppele GJ, Schuurhuis GJ. MRD in AML: it is time to change the definition of remission. Best Pract Res Clin Haematol. 2014;27(3-4): 265-271.
    • (2014) Best Pract Res Clin Haematol. , vol.27 , Issue.3-4 , pp. 265-271
    • Ossenkoppele, G.J.1    Schuurhuis, G.J.2
  • 93
    • 77957703236 scopus 로고    scopus 로고
    • Cytogenetic and molecular diagnostic characterization combined to postconsolidation minimal residual disease assessment by flow cytometry improves risk stratification in adult acute myeloid leukemia
    • Buccisano F, Maurillo L, Spagnoli A, et al. Cytogenetic and molecular diagnostic characterization combined to postconsolidation minimal residual disease assessment by flow cytometry improves risk stratification in adult acute myeloid leukemia. Blood. 2010;116(13): 2295-2303.
    • (2010) Blood , vol.116 , Issue.13 , pp. 2295-2303
    • Buccisano, F.1    Maurillo, L.2    Spagnoli, A.3
  • 94
    • 84867603927 scopus 로고    scopus 로고
    • Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia
    • Inaba H, Coustan-Smith E, Cao X, et al. Comparative analysis of different approaches to measure treatment response in acute myeloid leukemia. J Clin Oncol. 2012;30(29):3625-3632.
    • (2012) J Clin Oncol. , vol.30 , Issue.29 , pp. 3625-3632
    • Inaba, H.1    Coustan-Smith, E.2    Cao, X.3
  • 95
    • 84865406961 scopus 로고    scopus 로고
    • Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: A report from children's oncology group
    • Loken MR, Alonzo TA, Pardo L, et al. Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: a report from Children's Oncology Group. Blood. 2012; 120(8):1581-1588.
    • (2012) Blood , vol.120 , Issue.8 , pp. 1581-1588
    • Loken, M.R.1    Alonzo, T.A.2    Pardo, L.3
  • 96
    • 84891692448 scopus 로고    scopus 로고
    • Prognostic relevance of treatment response measured by flow cytometric residual disease detection in older patients with acute myeloid leukemia
    • Freeman SD, Virgo P, Couzens S, et al. Prognostic relevance of treatment response measured by flow cytometric residual disease detection in older patients with acute myeloid leukemia. J Clin Oncol. 2013;31(32):4123-4131.
    • (2013) J Clin Oncol. , vol.31 , Issue.32 , pp. 4123-4131
    • Freeman, S.D.1    Virgo, P.2    Couzens, S.3
  • 97
    • 84891654526 scopus 로고    scopus 로고
    • High prognostic impact of flow cytometric minimal residual disease detection in acute myeloid leukemia: Data from the HOVON/SAKK AML 42A study
    • Terwijn M, van Putten WL, Kelder A, et al. High prognostic impact of flow cytometric minimal residual disease detection in acute myeloid leukemia: data from the HOVON/SAKK AML 42A study. J Clin Oncol. 2013;31(31):3889-3897.
    • (2013) J Clin Oncol. , vol.31 , Issue.31 , pp. 3889-3897
    • Terwijn, M.1    Van Putten, W.L.2    Kelder, A.3
  • 98
    • 84927127471 scopus 로고    scopus 로고
    • Relation of clinical response and minimal residual disease and their prognostic impact on outcome in acute myeloid leukemia
    • Chen X, Xie H, Wood BL, et al. Relation of clinical response and minimal residual disease and their prognostic impact on outcome in acute myeloid leukemia. J Clin Oncol. 2015;33(11): 1258-1264.
    • (2015) J Clin Oncol. , vol.33 , Issue.11 , pp. 1258-1264
    • Chen, X.1    Xie, H.2    Wood, B.L.3
  • 99
    • 84955437697 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for acute myeloid leukemia: Time to move toward a minimal residual disease-based definition of complete remission?
    • Araki D, Wood BL, Othus M, et al. Allogeneic hematopoietic cell transplantation for acute myeloid leukemia: time to move toward a minimal residual disease-based definition of complete remission? J Clin Oncol. 2016;34(4): 329-336.
    • (2016) J Clin Oncol. , vol.34 , Issue.4 , pp. 329-336
    • Araki, D.1    Wood, B.L.2    Othus, M.3
  • 100
    • 29144495901 scopus 로고    scopus 로고
    • The prognostic value of MLL-AF9 detection in patients with t(9;11)(p22;q23)-positive acute myeloid leukemia
    • Scholl C, Schlenk RF, Eiwen K, Döhner H, Fröhling S, Döhner K; AML Study Group. The prognostic value of MLL-AF9 detection in patients with t(9;11)(p22;q23)-positive acute myeloid leukemia. Haematologica. 2005;90(12): 1626-1634.
    • (2005) Haematologica , vol.90 , Issue.12 , pp. 1626-1634
    • Scholl, C.1    Schlenk, R.F.2    Eiwen, K.3    Döhner, H.4    Fröhling, S.5    Döhner, K.6
  • 101
    • 70349579540 scopus 로고    scopus 로고
    • Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML
    • Schnittger S, Kern W, Tschulik C, et al. Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML. Blood. 2009; 114(11):2220-2231.
    • (2009) Blood , vol.114 , Issue.11 , pp. 2220-2231
    • Schnittger, S.1    Kern, W.2    Tschulik, C.3
  • 102
    • 79960127726 scopus 로고    scopus 로고
    • Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: A study from the German-Austrian acute myeloid leukemia study group
    • Krönke J, Schlenk RF, Jensen KO, et al. Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study group. J Clin Oncol. 2011;29(19): 2709-2716.
    • (2011) J Clin Oncol. , vol.29 , Issue.19 , pp. 2709-2716
    • Krönke, J.1    Schlenk, R.F.2    Jensen, K.O.3
  • 103
    • 84883677161 scopus 로고    scopus 로고
    • The level of residual disease based on mutant NPM1 is an independent prognostic factor for relapse and survival in AML
    • Shayegi N, Kramer M, Bornhäuser M, et al; Study Alliance Leukemia (SAL). The level of residual disease based on mutant NPM1 is an independent prognostic factor for relapse and survival in AML. Blood. 2013;122(1):83-92.
    • (2013) Blood , vol.122 , Issue.1 , pp. 83-92
    • Shayegi, N.1    Kramer, M.2    Bornhäuser, M.3
  • 104
    • 84905169133 scopus 로고    scopus 로고
    • Molecular response assessment by quantitative real-time polymerase chain reaction after induction therapy in NPM1-mutated patients identifies those at high risk of relapse
    • Hubmann M, Köhnke T, Hoster E, et al. Molecular response assessment by quantitative real-time polymerase chain reaction after induction therapy in NPM1-mutated patients identifies those at high risk of relapse. Haematologica. 2014;99(8):1317-1325.
    • (2014) Haematologica , vol.99 , Issue.8 , pp. 1317-1325
    • Hubmann, M.1    Köhnke, T.2    Hoster, E.3
  • 105
    • 84906266071 scopus 로고    scopus 로고
    • MRD assessed by WT1 and NPM1 transcript levels identifies distinct outcomes in AML patients and is influenced by gemtuzumab ozogamicin
    • Lambert J, Lambert J, Nibourel O, et al. MRD assessed by WT1 and NPM1 transcript levels identifies distinct outcomes in AML patients and is influenced by gemtuzumab ozogamicin. Oncotarget. 2014;5(15):6280-6288.
    • (2014) Oncotarget , vol.5 , Issue.15 , pp. 6280-6288
    • Lambert, J.1    Lambert, J.2    Nibourel, O.3
  • 106
    • 84956917285 scopus 로고    scopus 로고
    • Assessment of minimal residual disease in standard-risk AML
    • Ivey A, Hills RK, Simpson MA, et al; UK National Cancer Research Institute AML Working Group. Assessment of minimal residual disease in standard-risk AML. N Engl J Med. 2016;374(5): 422-433.
    • (2016) N Engl J Med. , vol.374 , Issue.5 , pp. 422-433
    • Ivey, A.1    Hills, R.K.2    Simpson, M.A.3
  • 107
    • 77957287616 scopus 로고    scopus 로고
    • Prognostic impact of minimal residual disease in CBFB-MYH11-positive acute myeloid leukemia
    • Corbacioglu A, Scholl C, Schlenk RF, et al. Prognostic impact of minimal residual disease in CBFB-MYH11-positive acute myeloid leukemia. J Clin Oncol. 2010;28(23):3724-3729.
    • (2010) J Clin Oncol. , vol.28 , Issue.23 , pp. 3724-3729
    • Corbacioglu, A.1    Scholl, C.2    Schlenk, R.F.3
  • 108
    • 84867297401 scopus 로고    scopus 로고
    • Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: Results of the United Kingdom MRC AML-15 trial
    • Yin JA, O'Brien MA, Hills RK, Daly SB, Wheatley K, Burnett AK. Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: results of the United Kingdom MRC AML-15 trial. Blood. 2012;120(14): 2826-2835.
    • (2012) Blood , vol.120 , Issue.14 , pp. 2826-2835
    • Yin, J.A.1    O'Brien, M.A.2    Hills, R.K.3    Daly, S.B.4    Wheatley, K.5    Burnett, A.K.6
  • 109
    • 84880991962 scopus 로고    scopus 로고
    • MRD-directed risk stratification treatment May improve outcomes of t(8;21) AML in the first complete remission: Results from the AML05 multicenter trial
    • Zhu HH, Zhang XH, Qin YZ, et al. MRD-directed risk stratification treatment may improve outcomes of t(8;21) AML in the first complete remission: results from the AML05 multicenter trial. Blood. 2013;121(20):4056-4062.
    • (2013) Blood , vol.121 , Issue.20 , pp. 4056-4062
    • Zhu, H.H.1    Zhang, X.H.2    Qin, Y.Z.3
  • 110
    • 84891855434 scopus 로고    scopus 로고
    • Monitoring of residual disease by next-generation deep-sequencing of RUNX1 mutations can identify acute myeloid leukemia patients with resistant disease
    • Kohlmann A, Nadarajah N, Alpermann T, et al. Monitoring of residual disease by next-generation deep-sequencing of RUNX1 mutations can identify acute myeloid leukemia patients with resistant disease. Leukemia. 2014; 28(1):129-137.
    • (2014) Leukemia , vol.28 , Issue.1 , pp. 129-137
    • Kohlmann, A.1    Nadarajah, N.2    Alpermann, T.3
  • 111
    • 84940545016 scopus 로고    scopus 로고
    • Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia
    • Klco JM, Miller CA, Griffith M, et al. Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia. JAMA. 2015;314(8):811-822.
    • (2015) JAMA , vol.314 , Issue.8 , pp. 811-822
    • Klco, J.M.1    Miller, C.A.2    Griffith, M.3
  • 112
    • 84916229685 scopus 로고    scopus 로고
    • Persistence of DNMT3A mutations at long-term remission in adult patients with AML
    • Pløen GG, Nederby L, Guldberg P, et al. Persistence of DNMT3A mutations at long-term remission in adult patients with AML. Br J Haematol. 2014;167(4):478-486.
    • (2014) Br J Haematol. , vol.167 , Issue.4 , pp. 478-486
    • Pløen, G.G.1    Nederby, L.2    Guldberg, P.3
  • 113
    • 85014936312 scopus 로고    scopus 로고
    • Monitoring of minimal residual disease (MRD) of DNMT3A mutations (DNMT3Amut) in acute myeloid leukemia (AML): A study of the AML study group (AMLSG) [abstract]
    • 226
    • Gaidzik V, Weber D, Paschka P, et al. Monitoring of minimal residual disease (MRD) of DNMT3A mutations (DNMT3Amut) in acute myeloid leukemia (AML): a study of the AML Study Group (AMLSG) [abstract]. Blood. 2015; 126(23). Abstract 226.
    • (2015) Blood , vol.126 , Issue.23
    • Gaidzik, V.1    Weber, D.2    Paschka, P.3
  • 114
    • 84871774636 scopus 로고    scopus 로고
    • Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia
    • Mrózek K, Marcucci G, Nicolet D, et al. Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia. J Clin Oncol. 2012; 30(36):4515-4523.
    • (2012) J Clin Oncol. , vol.30 , Issue.36 , pp. 4515-4523
    • Mrózek, K.1    Marcucci, G.2    Nicolet, D.3
  • 115
    • 73349093723 scopus 로고    scopus 로고
    • The role of cytogenetic abnormalities in acute myeloid leukemia with NPM1 mutations and no FLT3 internal tandem duplication
    • author reply 4602-4603
    • Micol JB, Boissel N, Renneville A, et al. The role of cytogenetic abnormalities in acute myeloid leukemia with NPM1 mutations and no FLT3 internal tandem duplication. Blood. 2009; 114(20):4601-4602, author reply 4602-4603.
    • (2009) Blood , vol.114 , Issue.20 , pp. 4601-4602
    • Micol, J.B.1    Boissel, N.2    Renneville, A.3
  • 116
    • 54349092877 scopus 로고    scopus 로고
    • Monosomal karyotype in acute myeloid leukemia: A better indicator of poor prognosis than a complex karyotype
    • Breems DA, Van Putten WLJ, De Greef GE, et al. Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol. 2008; 26(29):4791-4797.
    • (2008) J Clin Oncol. , vol.26 , Issue.29 , pp. 4791-4797
    • Breems, D.A.1    Van Putten, W.L.J.2    De Greef, G.E.3
  • 117
    • 77957715843 scopus 로고    scopus 로고
    • Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: The Southwest oncology group (SWOG) experience
    • Medeiros BC, Othus M, Fang M, Roulston D, Appelbaum FR. Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience. Blood. 2010;116(13):2224-2228.
    • (2010) Blood , vol.116 , Issue.13 , pp. 2224-2228
    • Medeiros, B.C.1    Othus, M.2    Fang, M.3    Roulston, D.4    Appelbaum, F.R.5
  • 118
    • 84855857727 scopus 로고    scopus 로고
    • Monosomal karyotype in adult acute myeloid leukemia: Prognostic impact and outcome after different treatment strategies
    • Kayser S, Zucknick M, Döhner K, et al; German-Austrian AML Study Group. Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies. Blood. 2012;119(2): 551-558.
    • (2012) Blood , vol.119 , Issue.2 , pp. 551-558
    • Kayser, S.1    Zucknick, M.2    Döhner, K.3
  • 119
    • 84863952219 scopus 로고    scopus 로고
    • Comparative analysis of the value of allogeneic hematopoietic stem-cell transplantation in acute myeloid leukemia with monosomal karyotype versus other cytogenetic risk categories
    • Cornelissen JJ, Breems D, van Putten WL, et al. Comparative analysis of the value of allogeneic hematopoietic stem-cell transplantation in acute myeloid leukemia with monosomal karyotype versus other cytogenetic risk categories. J Clin Oncol. 2012;30(17):2140-2146.
    • (2012) J Clin Oncol. , vol.30 , Issue.17 , pp. 2140-2146
    • Cornelissen, J.J.1    Breems, D.2    Van Putten, W.L.3
  • 120
    • 84958573214 scopus 로고    scopus 로고
    • Hematopoietic cell transplantation outcomes in monosomal karyotype myeloid malignancies
    • Pasquini MC, Zhang MJ, Medeiros BC, et al. Hematopoietic cell transplantation outcomes in monosomal karyotype myeloid malignancies. Biol Blood Marrow Transplant. 2016;22(2): 248-257.
    • (2016) Biol Blood Marrow Transplant. , vol.22 , Issue.2 , pp. 248-257
    • Pasquini, M.C.1    Zhang, M.J.2    Medeiros, B.C.3
  • 121
    • 84964057771 scopus 로고    scopus 로고
    • Prediction of CR following a second course of '713' in patients with newly diagnosed acute myeloid leukemia not in CR after a first course
    • Othus M, Mukherjee S, Sekeres MA, et al. Prediction of CR following a second course of '713' in patients with newly diagnosed acute myeloid leukemia not in CR after a first course. Leukemia. 2016;30(8):1779-1780.
    • (2016) Leukemia , vol.30 , Issue.8 , pp. 1779-1780
    • Othus, M.1    Mukherjee, S.2    Sekeres, M.A.3
  • 122
    • 78650655385 scopus 로고    scopus 로고
    • Characteristics and outcome of patients with acute myeloid leukemia refractory to 1 cycle of high-dose cytarabine-based induction chemotherapy
    • quiz 6153
    • Ravandi F, Cortes J, Faderl S, et al. Characteristics and outcome of patients with acute myeloid leukemia refractory to 1 cycle of high-dose cytarabine-based induction chemotherapy. Blood. 2010;116(26):5818-5823, quiz 6153.
    • (2010) Blood , vol.116 , Issue.26 , pp. 5818-5823
    • Ravandi, F.1    Cortes, J.2    Faderl, S.3
  • 123
    • 84894365265 scopus 로고    scopus 로고
    • Optimization of chemotherapy for younger patients with acute myeloid leukemia: Results of the medical research council AML15 trial
    • Burnett AK, Russell NH, Hills RK, et al. Optimization of chemotherapy for younger patients with acute myeloid leukemia: results of the medical research council AML15 trial. J Clin Oncol. 2013;31(27):3360-3368.
    • (2013) J Clin Oncol. , vol.31 , Issue.27 , pp. 3360-3368
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3
  • 124
    • 79959794787 scopus 로고    scopus 로고
    • Clinical effect of point mutations in myelodysplastic syndromes
    • Bejar R, Stevenson K, Abdel-Wahab O, et al. Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med. 2011;364(26):2496-2506.
    • (2011) N Engl J Med. , vol.364 , Issue.26 , pp. 2496-2506
    • Bejar, R.1    Stevenson, K.2    Abdel-Wahab, O.3
  • 125
    • 84947258738 scopus 로고    scopus 로고
    • Epidemiology and clinical significance of secondary and therapy-related acute myeloid leukemia: A national population-based cohort study
    • Granfeldt Østgård LS, Medeiros BC, Sengeløv H, et al. Epidemiology and clinical significance of secondary and therapy-related acute myeloid leukemia: a national population-based cohort study. J Clin Oncol. 2015;33(31):3641-3649.
    • (2015) J Clin Oncol. , vol.33 , Issue.31 , pp. 3641-3649
    • Granfeldt Østgård, L.S.1    Medeiros, B.C.2    Sengeløv, H.3
  • 126
    • 84866749552 scopus 로고    scopus 로고
    • Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes
    • Bejar R, Stevenson KE, Caughey BA, et al. Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. J Clin Oncol. 2012; 30(27):3376-3382.
    • (2012) J Clin Oncol. , vol.30 , Issue.27 , pp. 3376-3382
    • Bejar, R.1    Stevenson, K.E.2    Caughey, B.A.3
  • 127
    • 84906809218 scopus 로고    scopus 로고
    • Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation
    • Bejar R, Stevenson KE, Caughey B, et al. Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation. J Clin Oncol. 2014;32(25):2691-2698.
    • (2014) J Clin Oncol. , vol.32 , Issue.25 , pp. 2691-2698
    • Bejar, R.1    Stevenson, K.E.2    Caughey, B.3
  • 128
    • 84866621729 scopus 로고    scopus 로고
    • Revised international prognostic scoring system for myelodysplastic syndromes
    • Greenberg PL, Tuechler H, Schanz J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012; 120(12):2454-2465.
    • (2012) Blood , vol.120 , Issue.12 , pp. 2454-2465
    • Greenberg, P.L.1    Tuechler, H.2    Schanz, J.3
  • 129
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al; International Vidaza High-Risk MDS Survival Study Group. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol. 2009;10(3):223-232.
    • (2009) Lancet Oncol. , vol.10 , Issue.3 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 130
    • 78650171819 scopus 로고    scopus 로고
    • Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: A web-based application for prediction of outcomes
    • Krug U, Röllig C, Koschmieder A, et al; German Acute Myeloid Leukaemia Cooperative Group; Study Alliance Leukemia Investigators. Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes. Lancet. 2010;376(9757):2000-2008.
    • (2010) Lancet , vol.376 , Issue.9757 , pp. 2000-2008
    • Krug, U.1    Röllig, C.2    Koschmieder, A.3
  • 131
    • 33644521267 scopus 로고    scopus 로고
    • Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: Predictive prognostic models for outcome
    • Kantarjian H, O'brien S, Cortes J, et al. Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: predictive prognostic models for outcome. Cancer. 2006; 106(5):1090-1098.
    • (2006) Cancer , vol.106 , Issue.5 , pp. 1090-1098
    • Kantarjian, H.1    O'Brien, S.2    Cortes, J.3
  • 132
    • 84937566380 scopus 로고    scopus 로고
    • Geriatric perspective: How to assess fitness for chemotherapy in acute myeloid leukemia
    • Klepin HD. Geriatric perspective: how to assess fitness for chemotherapy in acute myeloid leukemia. Hematology Am Soc Hematol Educ Program. 2014;2014(1):8-13.
    • (2014) Hematology Am Soc Hematol Educ Program , vol.2014 , Issue.1 , pp. 8-13
    • Klepin, H.D.1
  • 133
    • 84880422627 scopus 로고    scopus 로고
    • Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia
    • Klepin HD, Geiger AM, Tooze JA, et al. Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia. Blood. 2013;121(21): 4287-4294.
    • (2013) Blood , vol.121 , Issue.21 , pp. 4287-4294
    • Klepin, H.D.1    Geiger, A.M.2    Tooze, J.A.3
  • 134
    • 84875292808 scopus 로고    scopus 로고
    • Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome
    • Deschler B, Ihorst G, Platzbecker U, et al. Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome. Haematologica. 2013;98(2):208-216.
    • (2013) Haematologica , vol.98 , Issue.2 , pp. 208-216
    • Deschler, B.1    Ihorst, G.2    Platzbecker, U.3
  • 135
    • 33846433493 scopus 로고    scopus 로고
    • The haematopoietic cell transplantation comorbidity index score is predictive of early death and survival in patients over 60 years of age receiving induction therapy for acute myeloid leukaemia
    • Giles FJ, Borthakur G, Ravandi F, et al. The haematopoietic cell transplantation comorbidity index score is predictive of early death and survival in patients over 60 years of age receiving induction therapy for acute myeloid leukaemia. Br J Haematol. 2007;136(4): 624-627.
    • (2007) Br J Haematol. , vol.136 , Issue.4 , pp. 624-627
    • Giles, F.J.1    Borthakur, G.2    Ravandi, F.3
  • 136
    • 84893788771 scopus 로고    scopus 로고
    • Declining rates of treatment-related mortality in patients with newly diagnosed AML given 'intense' induction regimens: A report from SWOG and MD anderson
    • Othus M, Kantarjian H, Petersdorf S, et al. Declining rates of treatment-related mortality in patients with newly diagnosed AML given 'intense' induction regimens: a report from SWOG and MD Anderson. Leukemia. 2014; 28(2):289-292.
    • (2014) Leukemia , vol.28 , Issue.2 , pp. 289-292
    • Othus, M.1    Kantarjian, H.2    Petersdorf, S.3
  • 137
    • 85014898667 scopus 로고    scopus 로고
    • Relative benefit for intensive versus non-intensive induction therapy for patients with newly diagnosed acute myeloid leukemia (AML) using a composite, age-comorbidity-cytogenetic, model [abstract]
    • LB580 11 June Copenhagen, Denmark
    • Sorror M, Storer B, Elsawy M, et al. Relative benefit for intensive versus non-intensive induction therapy for patients with newly diagnosed acute myeloid leukemia (AML) using a composite, age-comorbidity-cytogenetic, model [abstract]. Presented at the 21st Congress of the European Hematology Association. 11 June 2016. Copenhagen, Denmark. Abstract LB580.
    • (2016) 21st Congress of the European Hematology Association
    • Sorror, M.1    Storer, B.2    Elsawy, M.3
  • 138
    • 84955498114 scopus 로고    scopus 로고
    • An update of current treatments for adult acute myeloid leukemia
    • Dombret H, Gardin C. An update of current treatments for adult acute myeloid leukemia. Blood. 2016;127(1):53-61.
    • (2016) Blood , vol.127 , Issue.1 , pp. 53-61
    • Dombret, H.1    Gardin, C.2
  • 139
    • 70349451999 scopus 로고    scopus 로고
    • High-dose daunorubicin in older patients with acute myeloid leukemia [published correction appears in N engl J med. 2010;362(12):1155]
    • Löwenberg B, Ossenkoppele GJ, van Putten W, et al; Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON); German AML Study Group (AMLSG); Swiss Group for Clinical Cancer Research (SAKK) Collaborative Group. High-dose daunorubicin in older patients with acute myeloid leukemia [published correction appears in N Engl J Med. 2010;362(12):1155]. N Engl J Med. 2009;361(13):1235-1248.
    • (2009) N Engl J Med. , vol.361 , Issue.13 , pp. 1235-1248
    • Löwenberg, B.1    Ossenkoppele, G.J.2    Van Putten, W.3
  • 140
    • 70349467775 scopus 로고    scopus 로고
    • Anthracycline dose intensification in acute myeloid leukemia
    • Fernandez HF, Sun Z, Yao X, et al. Anthracycline dose intensification in acute myeloid leukemia. N Engl J Med. 2009;361(13): 1249-1259.
    • (2009) N Engl J Med. , vol.361 , Issue.13 , pp. 1249-1259
    • Fernandez, H.F.1    Sun, Z.2    Yao, X.3
  • 141
    • 80053637528 scopus 로고    scopus 로고
    • A randomized trial comparing standard versus high-dose daunorubicin induction in patients with acute myeloid leukemia
    • Lee JH, Joo YD, Kim H, et al; Cooperative Study Group A for Hematology. A randomized trial comparing standard versus high-dose daunorubicin induction in patients with acute myeloid leukemia. Blood. 2011;118(14): 3832-3841.
    • (2011) Blood , vol.118 , Issue.14 , pp. 3832-3841
    • Lee, J.H.1    Joo, Y.D.2    Kim, H.3
  • 142
    • 84932615484 scopus 로고    scopus 로고
    • A randomized comparison of daunorubicin 90 mg/m2 vs 60 mg/m2 in AML induction: Results from the UK NCRI AML17 trial in 1206 patients
    • Burnett AK, Russell NH, Hills RK, et al; UK NCRI AML Study Group. A randomized comparison of daunorubicin 90 mg/m2 vs 60 mg/m2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients. Blood. 2015;125(25): 3878-3885.
    • (2015) Blood , vol.125 , Issue.25 , pp. 3878-3885
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3
  • 143
    • 84979567382 scopus 로고    scopus 로고
    • Higher daunorubicin exposure benefits FLT3 mutated acute myeloid leukemia
    • Burnett AK, Russell NH, Hills RK; United Kingdom National Cancer Research Institute Acute Myeloid Leukemia Study Group. Higher daunorubicin exposure benefits FLT3 mutated acute myeloid leukemia. Blood. 2016;128(3): 449-452.
    • (2016) Blood , vol.128 , Issue.3 , pp. 449-452
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3
  • 144
    • 77649202987 scopus 로고    scopus 로고
    • Randomized study of intensified anthracycline doses for induction and recombinant interleukin-2 for maintenance in patients with acute myeloid leukemia age 50 to 70 years: Results of the ALFA-9801 study
    • Pautas C, Merabet F, Thomas X, et al. Randomized study of intensified anthracycline doses for induction and recombinant interleukin-2 for maintenance in patients with acute myeloid leukemia age 50 to 70 years: results of the ALFA-9801 study. J Clin Oncol. 2010;28(5): 808-814.
    • (2010) J Clin Oncol. , vol.28 , Issue.5 , pp. 808-814
    • Pautas, C.1    Merabet, F.2    Thomas, X.3
  • 145
    • 79952808421 scopus 로고    scopus 로고
    • Cytarabine dose for acute myeloid leukemia
    • Löwenberg B, Pabst T, Vellenga E, et al; Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON) and Swiss Group for Clinical Cancer Research (SAKK) Collaborative Group. Cytarabine dose for acute myeloid leukemia. N Engl J Med. 2011;364(11):1027-1036.
    • (2011) N Engl J Med. , vol.364 , Issue.11 , pp. 1027-1036
    • Löwenberg, B.1    Pabst, T.2    Vellenga, E.3
  • 146
    • 84897018280 scopus 로고    scopus 로고
    • High-dose cytarabine in induction treatment improves the outcome of adult patients younger than age 46 years with acute myeloid leukemia: Results of the EORTC-GIMEMA AML-12 trial
    • Willemze R, Suciu S, Meloni G, et al. High-dose cytarabine in induction treatment improves the outcome of adult patients younger than age 46 years with acute myeloid leukemia: results of the EORTC-GIMEMA AML-12 trial. J Clin Oncol. 2014;32(3):219-228.
    • (2014) J Clin Oncol. , vol.32 , Issue.3 , pp. 219-228
    • Willemze, R.1    Suciu, S.2    Meloni, G.3
  • 147
    • 84872087060 scopus 로고    scopus 로고
    • Sense and nonsense of high-dose cytarabine for acute myeloid leukemia
    • Löwenberg B. Sense and nonsense of high-dose cytarabine for acute myeloid leukemia. Blood. 2013;121(1):26-28.
    • (2013) Blood , vol.121 , Issue.1 , pp. 26-28
    • Löwenberg, B.1
  • 148
    • 84881305790 scopus 로고    scopus 로고
    • A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
    • Petersdorf SH, Kopecky KJ, Slovak M, et al. A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia. Blood. 2013;121(24):4854-4860.
    • (2013) Blood , vol.121 , Issue.24 , pp. 4854-4860
    • Petersdorf, S.H.1    Kopecky, K.J.2    Slovak, M.3
  • 149
    • 79952099282 scopus 로고    scopus 로고
    • Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: Results of the MRC AML15 trial
    • Burnett AK, Hills RK, Milligan D, et al. Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 trial. J Clin Oncol. 2011;29(4):369-377.
    • (2011) J Clin Oncol. , vol.29 , Issue.4 , pp. 369-377
    • Burnett, A.K.1    Hills, R.K.2    Milligan, D.3
  • 150
    • 84863522871 scopus 로고    scopus 로고
    • Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia
    • Burnett AK, Russell NH, Hills RK, et al. Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia. J Clin Oncol. 2012;30(32):3924-3931.
    • (2012) J Clin Oncol. , vol.30 , Issue.32 , pp. 3924-3931
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3
  • 151
    • 84859911350 scopus 로고    scopus 로고
    • Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised, open-label, phase 3 study
    • Castaigne S, Pautas C, Terré C, et al; Acute Leukemia French Association. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study. Lancet. 2012;379(9825):1508-1516.
    • (2012) Lancet , vol.379 , Issue.9825 , pp. 1508-1516
    • Castaigne, S.1    Pautas, C.2    Terré, C.3
  • 152
    • 84905560676 scopus 로고    scopus 로고
    • Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: A meta-analysis of individual patient data from randomised controlled trials
    • Hills RK, Castaigne S, Appelbaum FR, et al. Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: a meta-analysis of individual patient data from randomised controlled trials. Lancet Oncol. 2014;15(9):986-996.
    • (2014) Lancet Oncol. , vol.15 , Issue.9 , pp. 986-996
    • Hills, R.K.1    Castaigne, S.2    Appelbaum, F.R.3
  • 153
    • 84894352589 scopus 로고    scopus 로고
    • Sequential combination of gemtuzumab ozogamicin and standard chemotherapy in older patients with newly diagnosed acute myeloid leukemia: Results of a randomized phase III trial by the EORTC and GIMEMA consortium (AML-17)
    • Amadori S, Suciu S, Stasi R, et al. Sequential combination of gemtuzumab ozogamicin and standard chemotherapy in older patients with newly diagnosed acute myeloid leukemia: results of a randomized phase III trial by the EORTC and GIMEMA consortium (AML-17). J Clin Oncol. 2013;31(35):4424-4430.
    • (2013) J Clin Oncol. , vol.31 , Issue.35 , pp. 4424-4430
    • Amadori, S.1    Suciu, S.2    Stasi, R.3
  • 154
    • 33748326024 scopus 로고    scopus 로고
    • Ratiometric dosing of anticancer drug combinations: Controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice
    • Mayer LD, Harasym TO, Tardi PG, et al. Ratiometric dosing of anticancer drug combinations: controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice. Mol Cancer Ther. 2006;5(7):1854-1863.
    • (2006) Mol Cancer Ther. , vol.5 , Issue.7 , pp. 1854-1863
    • Mayer, L.D.1    Harasym, T.O.2    Tardi, P.G.3
  • 155
    • 84901412022 scopus 로고    scopus 로고
    • Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML
    • Lancet JE, Cortes JE, Hogge DE, et al. Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML. Blood. 2014;123(21):3239-3246.
    • (2014) Blood , vol.123 , Issue.21 , pp. 3239-3246
    • Lancet, J.E.1    Cortes, J.E.2    Hogge, D.E.3
  • 156
    • 84920870589 scopus 로고    scopus 로고
    • Phase II, multicenter, randomized trial of CPX-351 (cytarabine:daunorubicin) liposome injection versus intensive salvage therapy in adults with first relapse AML
    • Cortes JE, Goldberg SL, Feldman EJ, et al. Phase II, multicenter, randomized trial of CPX-351 (cytarabine:daunorubicin) liposome injection versus intensive salvage therapy in adults with first relapse AML. Cancer. 2015; 121(2):234-242.
    • (2015) Cancer , vol.121 , Issue.2 , pp. 234-242
    • Cortes, J.E.1    Goldberg, S.L.2    Feldman, E.J.3
  • 157
    • 84995449365 scopus 로고    scopus 로고
    • Final results of a phase III randomized trial of CPX-351 versus 713 in older patients with newly diagnosed high risk (secondary) AML [abstract]
    • 7000
    • Lancet JE, Uy GL, Cortes JE, et al. Final results of a phase III randomized trial of CPX-351 versus 713 in older patients with newly diagnosed high risk (secondary) AML [abstract]. J Clin Oncol. 2016;34(suppl). Abstract 7000.
    • (2016) J Clin Oncol. , vol.34
    • Lancet, J.E.1    Uy, G.L.2    Cortes, J.E.3
  • 158
    • 20244361887 scopus 로고    scopus 로고
    • Prognostic index for adult patients with acute myeloid leukemia in first relapse
    • Breems DA, Van Putten WL, Huijgens PC, et al. Prognostic index for adult patients with acute myeloid leukemia in first relapse. J Clin Oncol. 2005;23(9):1969-1978.
    • (2005) J Clin Oncol. , vol.23 , Issue.9 , pp. 1969-1978
    • Breems, D.A.1    Van Putten, W.L.2    Huijgens, P.C.3
  • 159
    • 84864039689 scopus 로고    scopus 로고
    • Cladribine, but not fludarabine, added to daunorubicin and cytarabine during induction prolongs survival of patients with acute myeloid leukemia: A multicenter, randomized phase III study
    • Holowiecki J, Grosicki S, Giebel S, et al. Cladribine, but not fludarabine, added to daunorubicin and cytarabine during induction prolongs survival of patients with acute myeloid leukemia: a multicenter, randomized phase III study. J Clin Oncol. 2012;30(20):2441-2448.
    • (2012) J Clin Oncol. , vol.30 , Issue.20 , pp. 2441-2448
    • Holowiecki, J.1    Grosicki, S.2    Giebel, S.3
  • 160
    • 84989271250 scopus 로고    scopus 로고
    • A comparison of clofarabine with ara-C, each in combination with daunorubicin as induction treatment in older patients with acute myeloid leukaemia [published online ahead of print 30 September 2016]
    • Burnett AK, Russell NH, Hills RK, et al. A comparison of clofarabine with ara-C, each in combination with daunorubicin as induction treatment in older patients with acute myeloid leukaemia [published online ahead of print 30 September 2016]. Leukemia. doi:10.1038/leu.2016.225.
    • Leukemia
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3
  • 161
    • 79960118884 scopus 로고    scopus 로고
    • Cytarabine dose of 36 g/m2 compared with 12 g/m2 within first consolidation in acute myeloid leukemia: Results of patients enrolled onto the prospective randomized AML96 study
    • Schaich M, Röllig C, Soucek S, et al. Cytarabine dose of 36 g/m2 compared with 12 g/m2 within first consolidation in acute myeloid leukemia: results of patients enrolled onto the prospective randomized AML96 study. J Clin Oncol. 2011; 29(19):2696-2702.
    • (2011) J Clin Oncol. , vol.29 , Issue.19 , pp. 2696-2702
    • Schaich, M.1    Röllig, C.2    Soucek, S.3
  • 162
    • 79952133594 scopus 로고    scopus 로고
    • A randomized comparison of 4 courses of standard-dose multiagent chemotherapy versus 3 courses of high-dose cytarabine alone in postremission therapy for acute myeloid leukemia in adults: The JALSG AML201 study
    • Miyawaki S, Ohtake S, Fujisawa S, et al. A randomized comparison of 4 courses of standard-dose multiagent chemotherapy versus 3 courses of high-dose cytarabine alone in postremission therapy for acute myeloid leukemia in adults: the JALSG AML201 Study. Blood. 2011;117(8):2366-2372.
    • (2011) Blood , vol.117 , Issue.8 , pp. 2366-2372
    • Miyawaki, S.1    Ohtake, S.2    Fujisawa, S.3
  • 163
    • 80051877778 scopus 로고    scopus 로고
    • Comparison of high-dose cytarabine and timed-sequential chemotherapy as consolidation for younger adults with AML in first remission: The ALFA-9802 study
    • Thomas X, Elhamri M, Raffoux E, et al. Comparison of high-dose cytarabine and timed-sequential chemotherapy as consolidation for younger adults with AML in first remission: the ALFA-9802 study. Blood. 2011;118(7): 1754-1762.
    • (2011) Blood , vol.118 , Issue.7 , pp. 1754-1762
    • Thomas, X.1    Elhamri, M.2    Raffoux, E.3
  • 164
    • 79958072848 scopus 로고    scopus 로고
    • Impact of post-remission therapy in patients aged 65-70 years with de novo acute myeloid leukemia: A comparison of two concomitant randomized ALFA trials with overlapping age inclusion criteria
    • Itzykson R, Gardin C, Pautas C, et al; Acute Leukemia French Association (ALFA). Impact of post-remission therapy in patients aged 65-70 years with de novo acute myeloid leukemia: a comparison of two concomitant randomized ALFA trials with overlapping age inclusion criteria. Haematologica. 2011;96(6):837-844.
    • (2011) Haematologica , vol.96 , Issue.6 , pp. 837-844
    • Itzykson, R.1    Gardin, C.2    Pautas, C.3
  • 165
    • 82955217795 scopus 로고    scopus 로고
    • Autologous peripheral blood stem cell transplantation for acute myeloid leukemia
    • Vellenga E, van Putten W, Ossenkoppele GJ, et al; Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON); Swiss Group for Clinical Cancer Research Collaborative Group (SAKK). Autologous peripheral blood stem cell transplantation for acute myeloid leukemia. Blood. 2011;118(23):6037-6042.
    • (2011) Blood , vol.118 , Issue.23 , pp. 6037-6042
    • Vellenga, E.1    Van Putten, W.2    Ossenkoppele, G.J.3
  • 166
    • 84856431030 scopus 로고    scopus 로고
    • Prediction of postremission survival in acute myeloid leukaemia: A post-hoc analysis of the AML96 trial
    • Pfirrmann M, Ehninger G, Thiede C, et al; Study Alliance Leukaemia (SAL). Prediction of postremission survival in acute myeloid leukaemia: a post-hoc analysis of the AML96 trial. Lancet Oncol. 2012;13(2):207-214.
    • (2012) Lancet Oncol. , vol.13 , Issue.2 , pp. 207-214
    • Pfirrmann, M.1    Ehninger, G.2    Thiede, C.3
  • 167
    • 84929293374 scopus 로고    scopus 로고
    • Comparative therapeutic value of post-remission approaches in patients with acute myeloid leukemia aged 40-60 years
    • Cornelissen JJ, Versluis J, Passweg JR, et al; HOVON; SAKK Leukemia Groups. Comparative therapeutic value of post-remission approaches in patients with acute myeloid leukemia aged 40-60 years. Leukemia. 2015;29(5):1041-1050.
    • (2015) Leukemia , vol.29 , Issue.5 , pp. 1041-1050
    • Cornelissen, J.J.1    Versluis, J.2    Passweg, J.R.3
  • 168
    • 79959845267 scopus 로고    scopus 로고
    • Individual patient data meta-analysis of randomized trials evaluating IL-2 monotherapy as remission maintenance therapy in acute myeloid leukemia
    • Buyse M, Squifflet P, Lange BJ, et al. Individual patient data meta-analysis of randomized trials evaluating IL-2 monotherapy as remission maintenance therapy in acute myeloid leukemia. Blood. 2011;117(26):7007-7013.
    • (2011) Blood , vol.117 , Issue.26 , pp. 7007-7013
    • Buyse, M.1    Squifflet, P.2    Lange, B.J.3
  • 169
    • 77950992731 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: Results of a multicenter phase 3 study
    • Löwenberg B, Beck J, Graux C, et al; Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON); German Austrian AML Study Group (AMLSG); Swiss Group for Clinical Cancer Research Collaborative Group (SAKK). Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study. Blood. 2010;115(13):2586-2591.
    • (2010) Blood , vol.115 , Issue.13 , pp. 2586-2591
    • Löwenberg, B.1    Beck, J.2    Graux, C.3
  • 170
    • 84930322558 scopus 로고    scopus 로고
    • One million haemopoietic stem-cell transplants: A retrospective observational study
    • Gratwohl A, Pasquini MC, Aljurf M, et al; Worldwide Network for Blood and Marrow Transplantation (WBMT). One million haemopoietic stem-cell transplants: a retrospective observational study. Lancet Haematol. 2015;2(3):e91-e100.
    • (2015) Lancet Haematol. , vol.2 , Issue.3 , pp. e91-e100
    • Gratwohl, A.1    Pasquini, M.C.2    Aljurf, M.3
  • 171
    • 84926420237 scopus 로고    scopus 로고
    • Hematopoietic SCT in Europe 2013: Recent trends in the use of alternative donors showing more haploidentical donors but fewer cord blood transplants
    • Passweg JR, Baldomero H, Bader P, et al; European Society for Blood and Marrow Transplantation (EBMT). Hematopoietic SCT in Europe 2013: recent trends in the use of alternative donors showing more haploidentical donors but fewer cord blood transplants. Bone Marrow Transplant. 2015;50(4):476-482.
    • (2015) Bone Marrow Transplant. , vol.50 , Issue.4 , pp. 476-482
    • Passweg, J.R.1    Baldomero, H.2    Bader, P.3
  • 172
    • 84959109035 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the worldwide network for blood and marrow transplantation group including the global survey
    • Niederwieser D, Baldomero H, Szer J, et al. Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey. Bone Marrow Transplant. 2016;51(6): 778-785.
    • (2016) Bone Marrow Transplant. , vol.51 , Issue.6 , pp. 778-785
    • Niederwieser, D.1    Baldomero, H.2    Szer, J.3
  • 173
    • 79955767844 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation rates and long-term survival in acute myeloid and lymphoblastic leukemia: Real-world population-based data from the swedish acute leukemia registry 1997-2006
    • Juliusson G, Karlsson K, Lazarevic VL, et al; Swedish Acute Leukemia Registry Group, the Swedish Acute Myeloid Leukemia Group, the Swedish Adult Acute Lymphoblastic Leukemia Group. Hematopoietic stem cell transplantation rates and long-term survival in acute myeloid and lymphoblastic leukemia: real-world population-based data from the Swedish Acute Leukemia Registry 1997-2006. Cancer. 2011; 117(18):4238-4246.
    • (2011) Cancer , vol.117 , Issue.18 , pp. 4238-4246
    • Juliusson, G.1    Karlsson, K.2    Lazarevic, V.L.3
  • 174
    • 84867099700 scopus 로고    scopus 로고
    • The European LeukemiaNet AML working party consensus statement on allogeneic HSCT for patients with AML in remission: An integrated-risk adapted approach
    • Cornelissen JJ, Gratwohl A, Schlenk RF, et al. The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach. Nat Rev Clin Oncol. 2012;9(10):579-590.
    • (2012) Nat Rev Clin Oncol. , vol.9 , Issue.10 , pp. 579-590
    • Cornelissen, J.J.1    Gratwohl, A.2    Schlenk, R.F.3
  • 175
    • 84943452957 scopus 로고    scopus 로고
    • Indications for autologous and allogeneic hematopoietic cell transplantation: Guidelines from the American society for blood and marrow transplantation
    • Majhail NS, Farnia SH, Carpenter PA, et al; American Society for Blood and Marrow Transplantation. Indications for autologous and allogeneic hematopoietic cell transplantation: guidelines from the American Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2015;21(11):1863-1869.
    • (2015) Biol Blood Marrow Transplant. , vol.21 , Issue.11 , pp. 1863-1869
    • Majhail, N.S.1    Farnia, S.H.2    Carpenter, P.A.3
  • 176
    • 84938990953 scopus 로고    scopus 로고
    • Indications for allo- and auto-SCT for haematological diseases, solid tumours and immune disorders: Current practice in Europe, 2015
    • Sureda A, Bader P, Cesaro S, et al. Indications for allo- and auto-SCT for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2015. Bone Marrow Transplant. 2015;50(8):1037-1056.
    • (2015) Bone Marrow Transplant. , vol.50 , Issue.8 , pp. 1037-1056
    • Sureda, A.1    Bader, P.2    Cesaro, S.3
  • 177
    • 84955500419 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation for patients with AML in first complete remission
    • Cornelissen JJ, Blaise D. Hematopoietic stem cell transplantation for patients with AML in first complete remission. Blood. 2016;127(1):62-70.
    • (2016) Blood , vol.127 , Issue.1 , pp. 62-70
    • Cornelissen, J.J.1    Blaise, D.2
  • 178
    • 84949092242 scopus 로고    scopus 로고
    • Autologous stem cell transplantation for adult acute leukemia in 2015: Time to rethink? Present status and future prospects
    • Gorin NC, Giebel S, Labopin M, Savani BN, Mohty M, Nagler A. Autologous stem cell transplantation for adult acute leukemia in 2015: time to rethink? Present status and future prospects. Bone Marrow Transplant. 2015; 50(12):1495-1502.
    • (2015) Bone Marrow Transplant. , vol.50 , Issue.12 , pp. 1495-1502
    • Gorin, N.C.1    Giebel, S.2    Labopin, M.3    Savani, B.N.4    Mohty, M.5    Nagler, A.6
  • 179
    • 84936166288 scopus 로고    scopus 로고
    • Reduced intensity conditioning allogeneic hematopoietic cell transplantation for adult acute myeloid leukemia in complete remission - A review from the acute leukemia working party of the EBMT
    • Sengsayadeth S, Savani BN, Blaise D, Malard F, Nagler A, Mohty M. Reduced intensity conditioning allogeneic hematopoietic cell transplantation for adult acute myeloid leukemia in complete remission - a review from the Acute Leukemia Working Party of the EBMT. Haematologica. 2015;100(7):859-869.
    • (2015) Haematologica , vol.100 , Issue.7 , pp. 859-869
    • Sengsayadeth, S.1    Savani, B.N.2    Blaise, D.3    Malard, F.4    Nagler, A.5    Mohty, M.6
  • 180
    • 84940893246 scopus 로고    scopus 로고
    • Pushing the envelope-nonmyeloablative and reduced intensity preparative regimens for allogeneic hematopoietic transplantation
    • Pingali SR, Champlin RE. Pushing the envelope-nonmyeloablative and reduced intensity preparative regimens for allogeneic hematopoietic transplantation. Bone Marrow Transplant. 2015;50(9):1157-1167.
    • (2015) Bone Marrow Transplant. , vol.50 , Issue.9 , pp. 1157-1167
    • Pingali, S.R.1    Champlin, R.E.2
  • 181
    • 84964703686 scopus 로고    scopus 로고
    • Nonmyeloablative allogeneic hematopoietic cell transplantation
    • Storb R, Sandmaier BM. Nonmyeloablative allogeneic hematopoietic cell transplantation. Haematologica. 2016;101(5):521-530.
    • (2016) Haematologica , vol.101 , Issue.5 , pp. 521-530
    • Storb, R.1    Sandmaier, B.M.2
  • 182
    • 84955262893 scopus 로고    scopus 로고
    • Busulfan plus cyclophosphamide versus busulfan plus fludarabine as a preparative regimen for allogeneic haemopoietic stem-cell transplantation in patients with acute myeloid leukaemia: An open-label, multicentre, randomised, phase 3 trial
    • Rambaldi A, Grassi A, Masciulli A, et al. Busulfan plus cyclophosphamide versus busulfan plus fludarabine as a preparative regimen for allogeneic haemopoietic stem-cell transplantation in patients with acute myeloid leukaemia: an open-label, multicentre, randomised, phase 3 trial. Lancet Oncol. 2015; 16(15):1525-1536.
    • (2015) Lancet Oncol. , vol.16 , Issue.15 , pp. 1525-1536
    • Rambaldi, A.1    Grassi, A.2    Masciulli, A.3
  • 183
    • 84879104114 scopus 로고    scopus 로고
    • Comparison of conditioning regimens of various intensities for allogeneic hematopoietic SCT using HLA-identical sibling donors in AML and MDS with, 10% BM blasts: A report from EBMT
    • Martino R, de Wreede L, Fiocco M, et al; Acute Leukemia Working Party the subcommittee for Myelodysplastic Syndromes of the Chronic Malignancies Working Party of the European group for Blood Marrow Transplantation Group (EBMT). Comparison of conditioning regimens of various intensities for allogeneic hematopoietic SCT using HLA-identical sibling donors in AML and MDS with, 10% BM blasts: a report from EBMT. Bone Marrow Transplant. 2013;48(6): 761-770.
    • (2013) Bone Marrow Transplant. , vol.48 , Issue.6 , pp. 761-770
    • Martino, R.1    De Wreede, L.2    Fiocco, M.3
  • 184
    • 84938955303 scopus 로고    scopus 로고
    • Conditioning intensity in middle-aged patients with AML in first CR: No advantage for myeloablative regimens irrespective of the risk group - An observational analysis by the acute leukemia working party of the EBMT
    • Passweg JR, Labopin M, Cornelissen J, et al; Acute Leukemia Working Party of the European Blood and Marrow Transplant Group (EBMT). Conditioning intensity in middle-aged patients with AML in first CR: no advantage for myeloablative regimens irrespective of the risk group - an observational analysis by the Acute Leukemia Working Party of the EBMT. Bone Marrow Transplant. 2015;50(8):1063-1068.
    • (2015) Bone Marrow Transplant. , vol.50 , Issue.8 , pp. 1063-1068
    • Passweg, J.R.1    Labopin, M.2    Cornelissen, J.3
  • 185
    • 84994273699 scopus 로고    scopus 로고
    • Results of a phase III randomized, multi-center study of allogeneic stem cell transplantation after high versus reduced intensity conditioning in patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML): Blood and marrow transplant clinical trials network (BMT CTN) 0901 [abstract]
    • 8 Late Breaking
    • Scott BL, Pasquini MC, Logan B, et al. Results of a phase III randomized, multi-center study of allogeneic stem cell transplantation after high versus reduced intensity conditioning in patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML): Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0901 [abstract]. Blood. 2015;126(23). Late Breaking Abstract 8.
    • (2015) Blood , vol.126 , Issue.23
    • Scott, B.L.1    Pasquini, M.C.2    Logan, B.3
  • 186
    • 84891072099 scopus 로고    scopus 로고
    • Better leukemia-free and overall survival in AML in first remission following cyclophosphamide in combination with busulfan compared with TBI
    • Copelan EA, Hamilton BK, Avalos B, et al. Better leukemia-free and overall survival in AML in first remission following cyclophosphamide in combination with busulfan compared with TBI. Blood. 2013;122(24):3863-3870.
    • (2013) Blood , vol.122 , Issue.24 , pp. 3863-3870
    • Copelan, E.A.1    Hamilton, B.K.2    Avalos, B.3
  • 187
    • 84891601014 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: Comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus cy as conditioning regimen - A report from the acute leukemia working party of the European group for blood and marrow transplantation
    • Nagler A, Rocha V, Labopin M, et al. Allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia in remission: comparison of intravenous busulfan plus cyclophosphamide (Cy) versus total-body irradiation plus Cy as conditioning regimen - a report from the acute leukemia working party of the European Group for Blood and Marrow Transplantation. J Clin Oncol. 2013;31(28):3549-3556.
    • (2013) J Clin Oncol. , vol.31 , Issue.28 , pp. 3549-3556
    • Nagler, A.1    Rocha, V.2    Labopin, M.3
  • 188
    • 84887535514 scopus 로고    scopus 로고
    • Prospective cohort study comparing intravenous busulfan to total body irradiation in hematopoietic cell transplantation
    • Bredeson C, LeRademacher J, Kato K, et al. Prospective cohort study comparing intravenous busulfan to total body irradiation in hematopoietic cell transplantation. Blood. 2013; 122(24):3871-3878.
    • (2013) Blood , vol.122 , Issue.24 , pp. 3871-3878
    • Bredeson, C.1    LeRademacher, J.2    Kato, K.3
  • 189
    • 84976333327 scopus 로고    scopus 로고
    • Up-to-date tools for risk assessment before allogeneic hematopoietic cell transplantation
    • Elsawy M, Sorror ML. Up-to-date tools for risk assessment before allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2016; 51(10):1283-1300.
    • (2016) Bone Marrow Transplant. , vol.51 , Issue.10 , pp. 1283-1300
    • Elsawy, M.1    Sorror, M.L.2
  • 190
    • 84907533471 scopus 로고    scopus 로고
    • Comorbidity-age index: A clinical measure of biologic age before allogeneic hematopoietic cell transplantation
    • Sorror ML, Storb RF, Sandmaier BM, et al. Comorbidity-age index: a clinical measure of biologic age before allogeneic hematopoietic cell transplantation. J Clin Oncol. 2014;32(29): 3249-3256.
    • (2014) J Clin Oncol. , vol.32 , Issue.29 , pp. 3249-3256
    • Sorror, M.L.1    Storb, R.F.2    Sandmaier, B.M.3
  • 191
    • 84905902438 scopus 로고    scopus 로고
    • Validation and refinement of the disease risk index for allogeneic stem cell transplantation
    • Armand P, Kim HT, Logan BR, et al. Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation. Blood. 2014;123(23):3664-3671.
    • (2014) Blood , vol.123 , Issue.23 , pp. 3664-3671
    • Armand, P.1    Kim, H.T.2    Logan, B.R.3
  • 192
    • 0032480589 scopus 로고    scopus 로고
    • Risk assessment for patients with chronic myeloid leukaemia before allogeneic blood or marrow transplantation
    • Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation
    • Gratwohl A, Hermans J, Goldman JM, et al. Risk assessment for patients with chronic myeloid leukaemia before allogeneic blood or marrow transplantation. Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Lancet. 1998; 352(9134):1087-1092.
    • (1998) Lancet , vol.352 , Issue.9134 , pp. 1087-1092
    • Gratwohl, A.1    Hermans, J.2    Goldman, J.M.3
  • 193
    • 84920677167 scopus 로고    scopus 로고
    • Prediction of non-relapse mortality in recipients of reduced intensity conditioning allogeneic stem cell transplantation with AML in first complete remission
    • Versluis J, Labopin M, Niederwieser D, et al. Prediction of non-relapse mortality in recipients of reduced intensity conditioning allogeneic stem cell transplantation with AML in first complete remission. Leukemia. 2015;29(1):51-57.
    • (2015) Leukemia , vol.29 , Issue.1 , pp. 51-57
    • Versluis, J.1    Labopin, M.2    Niederwieser, D.3
  • 194
    • 84947037398 scopus 로고    scopus 로고
    • Patient age, remission status and HCT-CI in a combined score are prognostic for patients with AML undergoing allogeneic hematopoietic cell transplantation in CR1 and CR2
    • Michelis FV, Messner HA, Atenafu EG, et al. Patient age, remission status and HCT-CI in a combined score are prognostic for patients with AML undergoing allogeneic hematopoietic cell transplantation in CR1 and CR2. Bone Marrow Transplant. 2015;50(11):1405-1410.
    • (2015) Bone Marrow Transplant. , vol.50 , Issue.11 , pp. 1405-1410
    • Michelis, F.V.1    Messner, H.A.2    Atenafu, E.G.3
  • 195
    • 79959496711 scopus 로고    scopus 로고
    • Impact of immune modulation with anti-T-cell antibodies on the outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies
    • Soiffer RJ, Lerademacher J, Ho V, et al. Impact of immune modulation with anti-T-cell antibodies on the outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies. Blood. 2011;117(25): 6963-6970.
    • (2011) Blood , vol.117 , Issue.25 , pp. 6963-6970
    • Soiffer, R.J.1    Lerademacher, J.2    Ho, V.3
  • 196
    • 84866554399 scopus 로고    scopus 로고
    • Comparative outcomes of donor graft CD34+ selection and immune suppressive therapy as graft-versus-host disease prophylaxis for patients with acute myeloid leukemia in complete remission undergoing HLA-matched sibling allogeneic hematopoietic cell transplantation
    • Pasquini MC, Devine S, Mendizabal A, et al. Comparative outcomes of donor graft CD34+ selection and immune suppressive therapy as graft-versus-host disease prophylaxis for patients with acute myeloid leukemia in complete remission undergoing HLA-matched sibling allogeneic hematopoietic cell transplantation. J Clin Oncol. 2012;30(26):3194-3201.
    • (2012) J Clin Oncol. , vol.30 , Issue.26 , pp. 3194-3201
    • Pasquini, M.C.1    Devine, S.2    Mendizabal, A.3
  • 197
    • 84936806071 scopus 로고    scopus 로고
    • Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts
    • Bleakley M, Heimfeld S, Loeb KR, et al. Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts. J Clin Invest. 2015;125(7):2677-2689.
    • (2015) J Clin Invest. , vol.125 , Issue.7 , pp. 2677-2689
    • Bleakley, M.1    Heimfeld, S.2    Loeb, K.R.3
  • 198
    • 77951453769 scopus 로고    scopus 로고
    • High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease
    • Luznik L, Bolaños-Meade J, Zahurak M, et al. High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease. Blood. 2010;115(16):3224-3230.
    • (2010) Blood , vol.115 , Issue.16 , pp. 3224-3230
    • Luznik, L.1    Bolanos-Meade, J.2    Zahurak, M.3
  • 199
    • 84890904878 scopus 로고    scopus 로고
    • Proceedings from the national cancer institute's second international workshop on the biology, prevention, and treatment of relapse after hematopoietic stem cell transplantation: Part III. Prevention and treatment of relapse after allogeneic transplantation
    • de Lima M, Porter DL, Battiwalla M, et al. Proceedings from the National Cancer Institute's Second International Workshop on the Biology, Prevention, and Treatment of Relapse After Hematopoietic Stem Cell Transplantation: part III. Prevention and treatment of relapse after allogeneic transplantation. Biol Blood Marrow Transplant. 2014;20(1):4-13.
    • (2014) Biol Blood Marrow Transplant. , vol.20 , Issue.1 , pp. 4-13
    • De Lima, M.1    Porter, D.L.2    Battiwalla, M.3
  • 200
    • 84906100925 scopus 로고    scopus 로고
    • Radiolabeled anti-CD45 antibody with reduced-intensity conditioning and allogeneic transplantation for younger patients with advanced acute myeloid leukemia or myelodysplastic syndrome
    • Mawad R, Gooley TA, Rajendran JG, et al. Radiolabeled anti-CD45 antibody with reduced-intensity conditioning and allogeneic transplantation for younger patients with advanced acute myeloid leukemia or myelodysplastic syndrome. Biol Blood Marrow Transplant. 2014;20(9):1363-1368.
    • (2014) Biol Blood Marrow Transplant. , vol.20 , Issue.9 , pp. 1363-1368
    • Mawad, R.1    Gooley, T.A.2    Rajendran, J.G.3
  • 201
    • 84973345996 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation in FLT3-ITD-positive acute myelogenous leukemia: The role for FLT3 tyrosine kinase inhibitors posttransplantation
    • Schiller GJ, Tuttle P, Desai P. Allogeneic hematopoietic stem cell transplantation in FLT3-ITD-positive acute myelogenous leukemia: the role for FLT3 tyrosine kinase inhibitors posttransplantation. Biol Blood Marrow Transplant. 2016;22(6):982-990.
    • (2016) Biol Blood Marrow Transplant. , vol.22 , Issue.6 , pp. 982-990
    • Schiller, G.J.1    Tuttle, P.2    Desai, P.3
  • 202
    • 84941317871 scopus 로고    scopus 로고
    • Maintenance therapy with decitabine after allogeneic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndrome
    • Pusic I, Choi J, Fiala MA, et al. Maintenance therapy with decitabine after allogeneic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndrome. Biol Blood Marrow Transplant. 2015;21(10):1761-1769.
    • (2015) Biol Blood Marrow Transplant. , vol.21 , Issue.10 , pp. 1761-1769
    • Pusic, I.1    Choi, J.2    Fiala, M.A.3
  • 203
    • 84958682804 scopus 로고    scopus 로고
    • Tolerability and clinical activity of posttransplantation azacitidine in patients allografted for acute myeloid leukemia treated on the RICAZA trial
    • Craddock C, Jilani N, Siddique S, et al. Tolerability and clinical activity of posttransplantation azacitidine in patients allografted for acute myeloid leukemia treated on the RICAZA Trial. Biol Blood Marrow Transplant. 2016;22(2):385-390.
    • (2016) Biol Blood Marrow Transplant. , vol.22 , Issue.2 , pp. 385-390
    • Craddock, C.1    Jilani, N.2    Siddique, S.3
  • 204
    • 84905970560 scopus 로고    scopus 로고
    • Therapeutic applications: Natural killer cells in the clinic
    • Miller JS. Therapeutic applications: natural killer cells in the clinic. Hematology Am Soc Hematol Educ Program. 2013;2013:247-253.
    • (2013) Hematology Am Soc Hematol Educ Program. , vol.2013 , pp. 247-253
    • Miller, J.S.1
  • 205
    • 84902682889 scopus 로고    scopus 로고
    • Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein
    • Bachanova V, Cooley S, Defor TE, et al. Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein. Blood. 2014;123(25):3855-3863.
    • (2014) Blood , vol.123 , Issue.25 , pp. 3855-3863
    • Bachanova, V.1    Cooley, S.2    Defor, T.E.3
  • 206
    • 84875975917 scopus 로고    scopus 로고
    • Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients
    • Chapuis AG, Ragnarsson GB, Nguyen HN, et al. Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients. Sci Transl Med. 2013;5(174): 174ra27.
    • (2013) Sci Transl Med. , vol.5 , Issue.174 , pp. 174ra27
    • Chapuis, A.G.1    Ragnarsson, G.B.2    Nguyen, H.N.3
  • 207
    • 84888226232 scopus 로고    scopus 로고
    • T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia
    • Mardiros A, Dos Santos C, McDonald T, et al. T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia. Blood. 2013; 122(18):3138-3148.
    • (2013) Blood , vol.122 , Issue.18 , pp. 3138-3148
    • Mardiros, A.1    Dos Santos, C.2    McDonald, T.3
  • 208
    • 84938976564 scopus 로고    scopus 로고
    • CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia
    • Kenderian SS, Ruella M, Shestova O, et al. CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia. Leukemia. 2015;29(8): 1637-1647.
    • (2015) Leukemia , vol.29 , Issue.8 , pp. 1637-1647
    • Kenderian, S.S.1    Ruella, M.2    Shestova, O.3
  • 209
    • 84934878821 scopus 로고    scopus 로고
    • Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells
    • Lynn RC, Poussin M, Kalota A, et al. Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells. Blood. 2015;125(22):3466-3476.
    • (2015) Blood , vol.125 , Issue.22 , pp. 3466-3476
    • Lynn, R.C.1    Poussin, M.2    Kalota, A.3
  • 210
    • 84921929872 scopus 로고    scopus 로고
    • How I treat the older patient with acute myeloid leukemia
    • Ossenkoppele G, Löwenberg B. How I treat the older patient with acute myeloid leukemia. Blood. 2015;125(5):767-774.
    • (2015) Blood , vol.125 , Issue.5 , pp. 767-774
    • Ossenkoppele, G.1    Löwenberg, B.2
  • 211
    • 85011426992 scopus 로고    scopus 로고
    • Impact of comorbidities at diagnosis of acute myeloid leukemia on one-year mortality [abstract]
    • 532
    • Sorror ML, Storer BE, Elsawy M, et al. Impact of comorbidities at diagnosis of acute myeloid leukemia on one-year mortality [abstract]. Blood. 2015;126(23). Abstract 532.
    • (2015) Blood , vol.126 , Issue.23
    • Sorror, M.L.1    Storer, B.E.2    Elsawy, M.3
  • 212
    • 33947205565 scopus 로고    scopus 로고
    • A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment
    • Burnett AK, Milligan D, Prentice AG, et al. A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment. Cancer. 2007;109(6):1114-1124.
    • (2007) Cancer , vol.109 , Issue.6 , pp. 1114-1124
    • Burnett, A.K.1    Milligan, D.2    Prentice, A.G.3
  • 213
    • 84864063679 scopus 로고    scopus 로고
    • Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia
    • Kantarjian HM, Thomas XG, Dmoszynska A, et al. Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. J Clin Oncol. 2012;30(21):2670-2677.
    • (2012) J Clin Oncol. , vol.30 , Issue.21 , pp. 2670-2677
    • Kantarjian, H.M.1    Thomas, X.G.2    Dmoszynska, A.3
  • 214
    • 84937804118 scopus 로고    scopus 로고
    • International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts
    • Dombret H, Seymour JF, Butrym A, et al. International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts. Blood. 2015;126(3):291-299.
    • (2015) Blood , vol.126 , Issue.3 , pp. 291-299
    • Dombret, H.1    Seymour, J.F.2    Butrym, A.3
  • 215
    • 85012954906 scopus 로고    scopus 로고
    • Overall survival in older patients with newly diagnosed acute myeloid leukemia (AML) with >30% bone marrow blasts treated with azacitidine by cytogenetic risk status: Results of the AZA-AML-001 study [abstract]
    • 621
    • Döhner H, Seymour JF, Butrym A, et al. Overall survival in older patients with newly diagnosed acute myeloid leukemia (AML) with >30% bone marrow blasts treated with azacitidine by cytogenetic risk status: Results of the AZA-AML-001 study [abstract]. Blood. 2014;124(21). Abstract 621.
    • (2014) Blood , vol.124 , Issue.21
    • Döhner, H.1    Seymour, J.F.2    Butrym, A.3
  • 216
    • 77449149373 scopus 로고    scopus 로고
    • Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
    • Fenaux P, Mufti GJ, Hellström-Lindberg E, et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol. 2010;28(4): 562-569.
    • (2010) J Clin Oncol. , vol.28 , Issue.4 , pp. 562-569
    • Fenaux, P.1    Mufti, G.J.2    Hellström-Lindberg, E.3
  • 217
    • 84883742684 scopus 로고    scopus 로고
    • Epigenetics in clinical practice: The examples of azacitidine and decitabine in myelodysplasia and acute myeloid leukemia
    • Estey EH. Epigenetics in clinical practice: the examples of azacitidine and decitabine in myelodysplasia and acute myeloid leukemia. Leukemia. 2013;27(9):1803-1812.
    • (2013) Leukemia , vol.27 , Issue.9 , pp. 1803-1812
    • Estey, E.H.1
  • 218
    • 84937794580 scopus 로고    scopus 로고
    • How I treat refractory and early relapsed acute myeloid leukemia
    • Thol F, Schlenk RF, Heuser M, Ganser A. How I treat refractory and early relapsed acute myeloid leukemia. Blood. 2015;126(3):319-327.
    • (2015) Blood , vol.126 , Issue.3 , pp. 319-327
    • Thol, F.1    Schlenk, R.F.2    Heuser, M.3    Ganser, A.4
  • 219
    • 79952102924 scopus 로고    scopus 로고
    • Salvage chemotherapy regimens for acute myeloid leukemia: Is one better? Efficacy comparison between CLAG and MEC regimens
    • Price SL, Lancet JE, George TJ, et al. Salvage chemotherapy regimens for acute myeloid leukemia: Is one better? Efficacy comparison between CLAG and MEC regimens. Leuk Res. 2011;35(3):301-304.
    • (2011) Leuk Res. , vol.35 , Issue.3 , pp. 301-304
    • Price, S.L.1    Lancet, J.E.2    George, T.J.3
  • 220
    • 84864050584 scopus 로고    scopus 로고
    • Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: Results from the CLASSIC I trial
    • Faderl S, Wetzler M, Rizzieri D, et al. Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: results from the CLASSIC I Trial. J Clin Oncol. 2012;30(20):2492-2499.
    • (2012) J Clin Oncol. , vol.30 , Issue.20 , pp. 2492-2499
    • Faderl, S.1    Wetzler, M.2    Rizzieri, D.3
  • 221
    • 84905453697 scopus 로고    scopus 로고
    • International randomized phase III study of elacytarabine versus investigator choice in patients with relapsed/refractory acute myeloid leukemia
    • Roboz GJ, Rosenblat T, Arellano M, et al. International randomized phase III study of elacytarabine versus investigator choice in patients with relapsed/refractory acute myeloid leukemia. J Clin Oncol. 2014;32(18): 1919-1926.
    • (2014) J Clin Oncol. , vol.32 , Issue.18 , pp. 1919-1926
    • Roboz, G.J.1    Rosenblat, T.2    Arellano, M.3
  • 222
    • 84940612285 scopus 로고    scopus 로고
    • Vosaroxin plus cytarabine versus placebo plus cytarabine in patients with first relapsed or refractory acute myeloid leukaemia (VALOR): A randomised, controlled, double-blind, multinational, phase 3 study
    • Ravandi F, Ritchie EK, Sayar H, et al. Vosaroxin plus cytarabine versus placebo plus cytarabine in patients with first relapsed or refractory acute myeloid leukaemia (VALOR): a randomised, controlled, double-blind, multinational, phase 3 study. Lancet Oncol. 2015;16(9):1025-1036.
    • (2015) Lancet Oncol. , vol.16 , Issue.9 , pp. 1025-1036
    • Ravandi, F.1    Ritchie, E.K.2    Sayar, H.3
  • 223
    • 84921438631 scopus 로고    scopus 로고
    • Azacitidine for the treatment of relapsed and refractory AML in older patients
    • Itzykson R, Thépot S, Berthon C, et al. Azacitidine for the treatment of relapsed and refractory AML in older patients. Leuk Res. 2015;39(2):124-130.
    • (2015) Leuk Res. , vol.39 , Issue.2 , pp. 124-130
    • Itzykson, R.1    Thépot, S.2    Berthon, C.3
  • 224
    • 84879373375 scopus 로고    scopus 로고
    • 5-azacytidine treatment for relapsed or refractory acute myeloid leukemia after intensive chemotherapy
    • Ivanoff S, Gruson B, Chantepie SP, et al. 5-Azacytidine treatment for relapsed or refractory acute myeloid leukemia after intensive chemotherapy. Am J Hematol. 2013;88(7): 601-605.
    • (2013) Am J Hematol. , vol.88 , Issue.7 , pp. 601-605
    • Ivanoff, S.1    Gruson, B.2    Chantepie, S.P.3
  • 225
    • 84879783893 scopus 로고    scopus 로고
    • Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia
    • Ritchie EK, Feldman EJ, Christos PJ, et al. Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia. Leuk Lymphoma. 2013;54(9):2003-2007.
    • (2013) Leuk Lymphoma , vol.54 , Issue.9 , pp. 2003-2007
    • Ritchie, E.K.1    Feldman, E.J.2    Christos, P.J.3
  • 226
    • 84882601957 scopus 로고    scopus 로고
    • Outcome of older patients with acute myeloid leukemia in first relapse
    • Sarkozy C, Gardin C, Gachard N, et al. Outcome of older patients with acute myeloid leukemia in first relapse. Am J Hematol. 2013;88(9):758-764.
    • (2013) Am J Hematol. , vol.88 , Issue.9 , pp. 758-764
    • Sarkozy, C.1    Gardin, C.2    Gachard, N.3
  • 227
    • 84876087623 scopus 로고    scopus 로고
    • Curability of patients with acute myeloid leukemia who did not undergo transplantation in first remission
    • Burnett AK, Goldstone A, Hills RK, et al. Curability of patients with acute myeloid leukemia who did not undergo transplantation in first remission. J Clin Oncol. 2013;31(10): 1293-1301.
    • (2013) J Clin Oncol. , vol.31 , Issue.10 , pp. 1293-1301
    • Burnett, A.K.1    Goldstone, A.2    Hills, R.K.3
  • 228
    • 77957278020 scopus 로고    scopus 로고
    • Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure
    • Duval M, Klein JP, He W, et al. Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure. J Clin Oncol. 2010;28(23):3730-3738.
    • (2010) J Clin Oncol. , vol.28 , Issue.23 , pp. 3730-3738
    • Duval, M.1    Klein, J.P.2    He, W.3
  • 229
    • 79955795186 scopus 로고    scopus 로고
    • Factors predicting outcome after unrelated donor stem cell transplantation in primary refractory acute myeloid leukaemia
    • Craddock C, Labopin M, Pillai S, et al. Factors predicting outcome after unrelated donor stem cell transplantation in primary refractory acute myeloid leukaemia. Leukemia. 2011;25(5): 808-813.
    • (2011) Leukemia , vol.25 , Issue.5 , pp. 808-813
    • Craddock, C.1    Labopin, M.2    Pillai, S.3
  • 230
    • 84897388751 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation as initial salvage for patients with acute myeloid leukemia refractory to high-dose cytarabine-based induction chemotherapy
    • Jabbour E, Daver N, Champlin R, et al. Allogeneic stem cell transplantation as initial salvage for patients with acute myeloid leukemia refractory to high-dose cytarabine-based induction chemotherapy. Am J Hematol. 2014; 89(4):395-398.
    • (2014) Am J Hematol. , vol.89 , Issue.4 , pp. 395-398
    • Jabbour, E.1    Daver, N.2    Champlin, R.3
  • 231
    • 33746607667 scopus 로고    scopus 로고
    • Long-term survival in refractory acute myeloid leukemia after sequential treatment with chemotherapy and reduced-intensity conditioning for allogeneic stem cell transplantation
    • Schmid C, Schleuning M, Schwerdtfeger R, et al. Long-term survival in refractory acute myeloid leukemia after sequential treatment with chemotherapy and reduced-intensity conditioning for allogeneic stem cell transplantation. Blood. 2006;108(3):1092-1099.
    • (2006) Blood , vol.108 , Issue.3 , pp. 1092-1099
    • Schmid, C.1    Schleuning, M.2    Schwerdtfeger, R.3
  • 232
    • 84940100098 scopus 로고    scopus 로고
    • FLAMSA reduced-intensity conditioning is equally effective in AML patients with primary induction failure as well as in first or second complete remission
    • Holtick U, Shimabukuro-Vornhagen A, Chakupurakal G, et al. FLAMSA reduced-intensity conditioning is equally effective in AML patients with primary induction failure as well as in first or second complete remission. Eur J Haematol. 2016;96(5):475-482.
    • (2016) Eur J Haematol. , vol.96 , Issue.5 , pp. 475-482
    • Holtick, U.1    Shimabukuro-Vornhagen, A.2    Chakupurakal, G.3
  • 233
    • 84922810790 scopus 로고    scopus 로고
    • Fate of patients with newly diagnosed acute myeloid leukemia who fail primary induction therapy
    • Othus M, Appelbaum FR, Petersdorf SH, et al. Fate of patients with newly diagnosed acute myeloid leukemia who fail primary induction therapy. Biol Blood Marrow Transplant. 2015; 21(3):559-564.
    • (2015) Biol Blood Marrow Transplant. , vol.21 , Issue.3 , pp. 559-564
    • Othus, M.1    Appelbaum, F.R.2    Petersdorf, S.H.3
  • 234
    • 84922925469 scopus 로고    scopus 로고
    • Survival of patients with acute myeloid leukemia relapsing after allogeneic hematopoietic cell transplantation: A center for international blood and marrow transplant research study
    • Bejanyan N, Weisdorf DJ, Logan BR, et al. Survival of patients with acute myeloid leukemia relapsing after allogeneic hematopoietic cell transplantation: a center for international blood and marrow transplant research study. Biol Blood Marrow Transplant. 2015;21(3):454-459.
    • (2015) Biol Blood Marrow Transplant. , vol.21 , Issue.3 , pp. 454-459
    • Bejanyan, N.1    Weisdorf, D.J.2    Logan, B.R.3
  • 235
    • 84949099993 scopus 로고    scopus 로고
    • Second allogeneic transplantation for relapse of malignant disease: Retrospective analysis of outcome and predictive factors by the EBMT
    • Ruutu T, de Wreede LC, van Biezen A, et al; European Society for Blood and Marrow Transplantation (EBMT). Second allogeneic transplantation for relapse of malignant disease: retrospective analysis of outcome and predictive factors by the EBMT. Bone Marrow Transplant. 2015;50(12):1542-1550.
    • (2015) Bone Marrow Transplant. , vol.50 , Issue.12 , pp. 1542-1550
    • Ruutu, T.1    De Wreede, L.C.2    Van Biezen, A.3
  • 236
    • 36849048316 scopus 로고    scopus 로고
    • Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: A retrospective risk factors analysis and comparison with other strategies by the EBMT acute leukemia working party
    • Schmid C, Labopin M, Nagler A, et al; EBMT Acute Leukemia Working Party. Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: a retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukemia Working Party. J Clin Oncol. 2007;25(31):4938-4945.
    • (2007) J Clin Oncol. , vol.25 , Issue.31 , pp. 4938-4945
    • Schmid, C.1    Labopin, M.2    Nagler, A.3
  • 237
    • 84884813720 scopus 로고    scopus 로고
    • Chemotherapy followed by modified donor lymphocyte infusion as a treatment for relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion: Superior outcomes compared with chemotherapy alone and an analysis of prognostic factors
    • Yan CH, Wang JZ, Liu DH, et al. Chemotherapy followed by modified donor lymphocyte infusion as a treatment for relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion: superior outcomes compared with chemotherapy alone and an analysis of prognostic factors. Eur J Haematol. 2013;91(4): 304-314.
    • (2013) Eur J Haematol. , vol.91 , Issue.4 , pp. 304-314
    • Yan, C.H.1    Wang, J.Z.2    Liu, D.H.3
  • 238
    • 84977144619 scopus 로고    scopus 로고
    • Clinical activity of azacitidine in patients who relapse after allogeneic stem cell transplantation for acute myeloid leukemia
    • Craddock C, Labopin M, Robin M, et al. Clinical activity of azacitidine in patients who relapse after allogeneic stem cell transplantation for acute myeloid leukemia. Haematologica. 2016; 101(7):879-883.
    • (2016) Haematologica , vol.101 , Issue.7 , pp. 879-883
    • Craddock, C.1    Labopin, M.2    Robin, M.3
  • 239
    • 84924243091 scopus 로고    scopus 로고
    • Treatment of acute myeloid leukemia or myelodysplastic syndrome relapse after allogeneic stem cell transplantation with azacitidine and donor lymphocyte infusions - A retrospective multicenter analysis from the German cooperative transplant study group
    • Schroeder T, Rachlis E, Bug G, et al. Treatment of acute myeloid leukemia or myelodysplastic syndrome relapse after allogeneic stem cell transplantation with azacitidine and donor lymphocyte infusions - a retrospective multicenter analysis from the German Cooperative Transplant Study Group. Biol Blood Marrow Transplant. 2015;21(4):653-660.
    • (2015) Biol Blood Marrow Transplant. , vol.21 , Issue.4 , pp. 653-660
    • Schroeder, T.1    Rachlis, E.2    Bug, G.3
  • 240
    • 84978402706 scopus 로고    scopus 로고
    • Ipilimumab for patients with relapse after allogeneic transplantation
    • Davids MS, Kim HT, Bachireddy P, et al; Leukemia and Lymphoma Society Blood Cancer Research Partnership. Ipilimumab for patients with relapse after allogeneic transplantation. N Engl J Med. 2016;375(2):143-153.
    • (2016) N Engl J Med. , vol.375 , Issue.2 , pp. 143-153
    • Davids, M.S.1    Kim, H.T.2    Bachireddy, P.3
  • 241
    • 84893816646 scopus 로고    scopus 로고
    • The evolving challenge of therapy-related myeloid neoplasms
    • Churpek JE, Larson RA. The evolving challenge of therapy-related myeloid neoplasms. Best Pract Res Clin Haematol. 2013;26(4):309-317.
    • (2013) Best Pract Res Clin Haematol. , vol.26 , Issue.4 , pp. 309-317
    • Churpek, J.E.1    Larson, R.A.2
  • 242
    • 84890357523 scopus 로고    scopus 로고
    • Therapy-related myelodysplasia and acute myeloid leukemia
    • Bhatia S. Therapy-related myelodysplasia and acute myeloid leukemia. Semin Oncol. 2013; 40(6):666-675.
    • (2013) Semin Oncol. , vol.40 , Issue.6 , pp. 666-675
    • Bhatia, S.1
  • 243
    • 84876551509 scopus 로고    scopus 로고
    • Evolving risk of therapy-related acute myeloid leukemia following cancer chemotherapy among adults in the United States, 1975-2008
    • Morton LM, Dores GM, Tucker MA, et al. Evolving risk of therapy-related acute myeloid leukemia following cancer chemotherapy among adults in the United States, 1975-2008. Blood. 2013;121(15):2996-3004.
    • (2013) Blood , vol.121 , Issue.15 , pp. 2996-3004
    • Morton, L.M.1    Dores, G.M.2    Tucker, M.A.3
  • 244
    • 84923114820 scopus 로고    scopus 로고
    • Characterization and prognostic features of secondary acute myeloid leukemia in a population-based setting: A report from the swedish acute leukemia registry
    • Hulegårdh E, Nilsson C, Lazarevic V, et al. Characterization and prognostic features of secondary acute myeloid leukemia in a population-based setting: a report from the Swedish Acute Leukemia Registry. Am J Hematol. 2015;90(3):208-214.
    • (2015) Am J Hematol. , vol.90 , Issue.3 , pp. 208-214
    • Hulegårdh, E.1    Nilsson, C.2    Lazarevic, V.3
  • 245
    • 0035281739 scopus 로고    scopus 로고
    • Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis
    • Christiansen DH, Andersen MK, Pedersen-Bjergaard J. Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis. J Clin Oncol. 2001;19(5):1405-1413.
    • (2001) J Clin Oncol. , vol.19 , Issue.5 , pp. 1405-1413
    • Christiansen, D.H.1    Andersen, M.K.2    Pedersen-Bjergaard, J.3
  • 246
    • 84878446656 scopus 로고    scopus 로고
    • Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia
    • Shih AH, Chung SS, Dolezal EK, et al. Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia. Haematologica. 2013; 98(6):908-912.
    • (2013) Haematologica , vol.98 , Issue.6 , pp. 908-912
    • Shih, A.H.1    Chung, S.S.2    Dolezal, E.K.3
  • 247
    • 84926516821 scopus 로고    scopus 로고
    • High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome
    • Cleven AH, Nardi V, Ok CY, et al. High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome. Mod Pathol. 2015;28(4): 552-563.
    • (2015) Mod Pathol. , vol.28 , Issue.4 , pp. 552-563
    • Cleven, A.H.1    Nardi, V.2    Ok, C.Y.3
  • 248
    • 84924080017 scopus 로고    scopus 로고
    • Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases
    • Ok CY, Patel KP, Garcia-Manero G, et al. Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases. Leuk Res. 2015;39(3):348-354.
    • (2015) Leuk Res. , vol.39 , Issue.3 , pp. 348-354
    • Ok, C.Y.1    Patel, K.P.2    Garcia-Manero, G.3
  • 249
    • 84925518008 scopus 로고    scopus 로고
    • Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
    • Wong TN, Ramsingh G, Young AL, et al. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature. 2015;518(7540):552-555.
    • (2015) Nature , vol.518 , Issue.7540 , pp. 552-555
    • Wong, T.N.1    Ramsingh, G.2    Young, A.L.3
  • 250
    • 84878548536 scopus 로고    scopus 로고
    • Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint
    • Kleiblova P, Shaltiel IA, Benada J, et al. Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint. J Cell Biol. 2013; 201(4):511-521.
    • (2013) J Cell Biol. , vol.201 , Issue.4 , pp. 511-521
    • Kleiblova, P.1    Shaltiel, I.A.2    Benada, J.3
  • 251
    • 84872621246 scopus 로고    scopus 로고
    • Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer
    • Ruark E, Snape K, Humburg P, et al; Breast and Ovarian Cancer Susceptibility Collaboration; Wellcome Trust Case Control Consortium. Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature. 2013;493(7432):406-410.
    • (2013) Nature , vol.493 , Issue.7432 , pp. 406-410
    • Ruark, E.1    Snape, K.2    Humburg, P.3
  • 252
    • 85010637627 scopus 로고    scopus 로고
    • Somatic mosaic mutations in PPM1D and TP53 in the blood of women with ovarian carcinoma
    • Swisher EM, Harrell MI, Norquist BM, et al. Somatic mosaic mutations in PPM1D and TP53 in the blood of women with ovarian carcinoma. JAMA Oncol. 2016;2(3):370-372.
    • (2016) JAMA Oncol. , vol.2 , Issue.3 , pp. 370-372
    • Swisher, E.M.1    Harrell, M.I.2    Norquist, B.M.3
  • 253
    • 84925303588 scopus 로고    scopus 로고
    • Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients
    • Zajkowicz A, Butkiewicz D, Drosik A, Giglok M, Suwiński R, Rusin M. Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients. Br J Cancer. 2015;112(6): 1114-1120.
    • (2015) Br J Cancer , vol.112 , Issue.6 , pp. 1114-1120
    • Zajkowicz, A.1    Butkiewicz, D.2    Drosik, A.3    Giglok, M.4    Suwiński, R.5    Rusin, M.6
  • 254
    • 84962612922 scopus 로고    scopus 로고
    • PPM1D mosaic truncating variants in ovarian cancer cases May be treatment-related somatic mutations
    • Pharoah PD, Song H, Dicks E, et al; Australian Ovarian Cancer Study Group; Ovarian Cancer Association Consortium. PPM1D mosaic truncating variants in ovarian cancer cases may be treatment-related somatic mutations. J Natl Cancer Inst. 2016;108(3):djv347.
    • (2016) J Natl Cancer Inst. , vol.108 , Issue.3 , pp. djv347
    • Pharoah, P.D.1    Song, H.2    Dicks, E.3
  • 255
    • 84864318773 scopus 로고    scopus 로고
    • Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms
    • Schulz E, Valentin A, Ulz P, et al. Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms. J Med Genet. 2012;49(7):422-428.
    • (2012) J Med Genet. , vol.49 , Issue.7 , pp. 422-428
    • Schulz, E.1    Valentin, A.2    Ulz, P.3
  • 256
    • 84954075396 scopus 로고    scopus 로고
    • Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia
    • Churpek J, Marquez R, Neistadt B, et al. Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia. Cancer. 2016;122(2):304-311.
    • (2016) Cancer , vol.122 , Issue.2 , pp. 304-311
    • Churpek, J.1    Marquez, R.2    Neistadt, B.3
  • 257
    • 84864021804 scopus 로고    scopus 로고
    • Cytogenetics, not just previous therapy, determines the course of therapy-related myeloid neoplasms
    • Larson RA. Cytogenetics, not just previous therapy, determines the course of therapy-related myeloid neoplasms. J Clin Oncol. 2012; 30(19):2300-2302.
    • (2012) J Clin Oncol. , vol.30 , Issue.19 , pp. 2300-2302
    • Larson, R.A.1
  • 258
    • 66349097167 scopus 로고    scopus 로고
    • Risk factors for therapy-related myelodysplastic syndrome and acute myeloid leukemia treated with allogeneic stem cell transplantation
    • Kröger N, Brand R, van Biezen A, et al; Myelodysplastic Syndromes Subcommittee of The Chronic Leukaemia Working Party of European Group for Blood and Marrow Transplantation (EBMT). Risk factors for therapy-related myelodysplastic syndrome and acute myeloid leukemia treated with allogeneic stem cell transplantation. Haematologica. 2009; 94(4):542-549.
    • (2009) Haematologica , vol.94 , Issue.4 , pp. 542-549
    • Kröger, N.1    Brand, R.2    Van Biezen, A.3
  • 259
    • 79951825094 scopus 로고    scopus 로고
    • The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML
    • Kayser S, Döhner K, Krauter J, et al; German-Austrian AMLSG. The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML. Blood. 2011;117(7):2137-2145.
    • (2011) Blood , vol.117 , Issue.7 , pp. 2137-2145
    • Kayser, S.1    Döhner, K.2    Krauter, J.3
  • 260
    • 84863994390 scopus 로고    scopus 로고
    • Prognosis and therapy when acute promyelocytic leukemia and other "good risk" acute myeloid leukemias occur as a therapy-related myeloid neoplasm
    • Larson RA, Le Beau MM. Prognosis and therapy when acute promyelocytic leukemia and other "good risk" acute myeloid leukemias occur as a therapy-related myeloid neoplasm. Mediterr J Hematol Infect Dis. 2011;3(1):e2011032.
    • (2011) Mediterr J Hematol Infect Dis. , vol.3 , Issue.1 , pp. e2011032
    • Larson, R.A.1    Le Beau, M.M.2
  • 261
    • 84928253894 scopus 로고    scopus 로고
    • Characteristics and outcome of therapy-related myeloid neoplasms: Report from the Italian network on secondary leukemias
    • Fianchi L, Pagano L, Piciocchi A, et al. Characteristics and outcome of therapy-related myeloid neoplasms: Report from the Italian network on secondary leukemias. Am J Hematol. 2015;90(5):E80-E85.
    • (2015) Am J Hematol. , vol.90 , Issue.5 , pp. E80-E85
    • Fianchi, L.1    Pagano, L.2    Piciocchi, A.3
  • 262
    • 84928013058 scopus 로고    scopus 로고
    • Current challenges in clinical development of "targeted therapies": The case of acute myeloid leukemia
    • Estey E, Levine RL, Löwenberg B. Current challenges in clinical development of "targeted therapies": the case of acute myeloid leukemia. Blood. 2015;125(16):2461-2466.
    • (2015) Blood , vol.125 , Issue.16 , pp. 2461-2466
    • Estey, E.1    Levine, R.L.2    Löwenberg, B.3
  • 263
    • 84880991913 scopus 로고    scopus 로고
    • 'Basket studies' will hold intricate data for cancer drug approvals
    • Willyard C. 'Basket studies' will hold intricate data for cancer drug approvals. Nat Med. 2013; 19(6):655.
    • (2013) Nat Med. , vol.19 , Issue.6 , pp. 655
    • Willyard, C.1
  • 264
    • 84930412755 scopus 로고    scopus 로고
    • A statistical evaluation of dose expansion cohorts in phase I clinical trials
    • Boonstra PS, Shen J, Taylor JM, et al. A statistical evaluation of dose expansion cohorts in phase I clinical trials. J Natl Cancer Inst. 2015; 107(3):dju429.
    • (2015) J Natl Cancer Inst. , vol.107 , Issue.3 , pp. dju429
    • Boonstra, P.S.1    Shen, J.2    Taylor, J.M.3
  • 265
    • 0032794987 scopus 로고    scopus 로고
    • A new statistical method for dose-finding based on efficacy and toxicity in early phase clinical trials
    • Thall PF, Estey EH, Sung HG. A new statistical method for dose-finding based on efficacy and toxicity in early phase clinical trials. Invest New Drugs. 1999;17(2):155-167.
    • (1999) Invest New Drugs , vol.17 , Issue.2 , pp. 155-167
    • Thall, P.F.1    Estey, E.H.2    Sung, H.G.3
  • 266
    • 77957724998 scopus 로고    scopus 로고
    • Shortcomings in the clinical evaluation of new drugs: Acute myeloid leukemia as paradigm
    • Walter RB, Appelbaum FR, Tallman MS, Weiss NS, Larson RA, Estey EH. Shortcomings in the clinical evaluation of new drugs: acute myeloid leukemia as paradigm. Blood. 2010;116(14): 2420-2428.
    • (2010) Blood , vol.116 , Issue.14 , pp. 2420-2428
    • Walter, R.B.1    Appelbaum, F.R.2    Tallman, M.S.3    Weiss, N.S.4    Larson, R.A.5    Estey, E.H.6
  • 267
    • 0037818705 scopus 로고    scopus 로고
    • New designs for phase 2 clinical trials
    • Estey EH, Thall PF. New designs for phase 2 clinical trials. Blood. 2003;102(2):442-448.
    • (2003) Blood , vol.102 , Issue.2 , pp. 442-448
    • Estey, E.H.1    Thall, P.F.2
  • 268
    • 80052420105 scopus 로고    scopus 로고
    • Applicability of a "Pick a winner" trial design to acute myeloid leukemia
    • Hills RK, Burnett AK. Applicability of a "Pick a Winner" trial design to acute myeloid leukemia. Blood. 2011;118(9):2389-2394.
    • (2011) Blood , vol.118 , Issue.9 , pp. 2389-2394
    • Hills, R.K.1    Burnett, A.K.2
  • 269
    • 78650339993 scopus 로고    scopus 로고
    • Outcome-adaptive randomization: Is it useful?
    • Korn EL, Freidlin B. Outcome-adaptive randomization: is it useful? J Clin Oncol. 2011; 29(6):771-776.
    • (2011) J Clin Oncol. , vol.29 , Issue.6 , pp. 771-776
    • Korn, E.L.1    Freidlin, B.2
  • 270
    • 84905829258 scopus 로고    scopus 로고
    • Adaptive dose-finding studies: A review of model-guided phase I clinical trials
    • Iasonos A, O'Quigley J. Adaptive dose-finding studies: a review of model-guided phase I clinical trials. J Clin Oncol. 2014;32(23):2505-2511.
    • (2014) J Clin Oncol. , vol.32 , Issue.23 , pp. 2505-2511
    • Iasonos, A.1    O'Quigley, J.2
  • 271
    • 56049106141 scopus 로고    scopus 로고
    • Patient-specific dose finding based on bivariate outcomes and covariates
    • Thall PF, Nguyen HQ, Estey EH. Patient-specific dose finding based on bivariate outcomes and covariates. Biometrics. 2008;64(4):1126-1136.
    • (2008) Biometrics , vol.64 , Issue.4 , pp. 1126-1136
    • Thall, P.F.1    Nguyen, H.Q.2    Estey, E.H.3
  • 272
    • 84959366777 scopus 로고    scopus 로고
    • New drug approvals in acute myeloid leukemia: What's the best end point?
    • Estey E, Othus M, Lee SJ, Appelbaum FR, Gale RP. New drug approvals in acute myeloid leukemia: what's the best end point? Leukemia. 2016;30(3):521-525.
    • (2016) Leukemia , vol.30 , Issue.3 , pp. 521-525
    • Estey, E.1    Othus, M.2    Lee, S.J.3    Appelbaum, F.R.4    Gale, R.P.5
  • 273
    • 84928021552 scopus 로고    scopus 로고
    • Results of the ECOG E1900 trial in younger adults with AML using an event free survival endpoint are concordant with results based on overall survival: Potential for a surrogate endpoint to facilitate rapid approval of therapies in AML [abstract]
    • 2599
    • Luskin MR, Lee JW, Fernandez HF, et al. Results of the ECOG E1900 trial in younger adults with AML using an event free survival endpoint are concordant with results based on overall survival: Potential for a surrogate endpoint to facilitate rapid approval of therapies in AML [abstract]. Blood. 2014;124(21). Abstract 2599.
    • (2014) Blood , vol.124 , Issue.21
    • Luskin, M.R.1    Lee, J.W.2    Fernandez, H.F.3
  • 274
    • 84977110529 scopus 로고    scopus 로고
    • Relationship between event-free survival and overall survival in acute myeloid leukemia: A report from SWOG, HOVON/SAKK, and MRC/NCRI
    • Othus M, van Putten W, Löwenberg B, et al. Relationship between event-free survival and overall survival in acute myeloid leukemia: a report from SWOG, HOVON/SAKK, and MRC/NCRI. Haematologica. 2016;101(7):e284-e286.
    • (2016) Haematologica , vol.101 , Issue.7 , pp. e284-e286
    • Othus, M.1    Van Putten, W.2    Löwenberg, B.3
  • 275
    • 85014898044 scopus 로고    scopus 로고
    • Event-free survival is a surrogate for overall survival in patients treated for acute myeloid leukemia [abstract]
    • 3744
    • Schlenk RF, Döhner H, Döhner K, et al. Event-free survival is a surrogate for overall survival in patients treated for acute myeloid leukemia [abstract]. Blood. 2015;126(23). Abstract 3744.
    • (2015) Blood , vol.126 , Issue.23
    • Schlenk, R.F.1    Döhner, H.2    Döhner, K.3
  • 276
    • 84873409057 scopus 로고    scopus 로고
    • The addition of gemtuzumab ozogamicin to low-dose ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: Results from the LRF AML14 and NCRI AML16 pick-A-winner comparison
    • Burnett AK, Hills RK, Hunter AE, et al; UK National Cancer Research Institute AML Working Group. The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: results from the LRF AML14 and NCRI AML16 pick-a-winner comparison. Leukemia. 2013;27(1):75-81.
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 75-81
    • Burnett, A.K.1    Hills, R.K.2    Hunter, A.E.3
  • 277
    • 84886859143 scopus 로고    scopus 로고
    • Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival
    • Burnett AK, Russell NH, Hunter AE, et al; UK National Cancer Research Institute AML Working Group. Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival. Blood. 2013;122(8):1384-1394.
    • (2013) Blood , vol.122 , Issue.8 , pp. 1384-1394
    • Burnett, A.K.1    Russell, N.H.2    Hunter, A.E.3
  • 278
    • 58149229323 scopus 로고    scopus 로고
    • Quality of life beyond 6 months after diagnosis in older adults with acute myeloid leukemia
    • Alibhai SM, Leach M, Gupta V, et al. Quality of life beyond 6 months after diagnosis in older adults with acute myeloid leukemia. Crit Rev Oncol Hematol. 2009;69(2):168-174.
    • (2009) Crit Rev Oncol Hematol. , vol.69 , Issue.2 , pp. 168-174
    • Alibhai, S.M.1    Leach, M.2    Gupta, V.3
  • 279
    • 84955474556 scopus 로고    scopus 로고
    • Emerging therapeutic drugs for AML
    • Stein EM, Tallman MS. Emerging therapeutic drugs for AML. Blood. 2016;127(1):71-78.
    • (2016) Blood , vol.127 , Issue.1 , pp. 71-78
    • Stein, E.M.1    Tallman, M.S.2
  • 280
    • 84937414408 scopus 로고    scopus 로고
    • FLT3 tyrosine kinase inhibition as a paradigm for targeted drug development in acute myeloid leukemia
    • Grunwald MR, Levis MJ. FLT3 tyrosine kinase inhibition as a paradigm for targeted drug development in acute myeloid leukemia. Semin Hematol. 2015;52(3):193-199.
    • (2015) Semin Hematol. , vol.52 , Issue.3 , pp. 193-199
    • Grunwald, M.R.1    Levis, M.J.2
  • 281
    • 79953124734 scopus 로고    scopus 로고
    • Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
    • Levis M, Ravandi F, Wang ES, et al. Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse. Blood. 2011; 117(12):3294-3301.
    • (2011) Blood , vol.117 , Issue.12 , pp. 3294-3301
    • Levis, M.1    Ravandi, F.2    Wang, E.S.3
  • 282
    • 85014949568 scopus 로고    scopus 로고
    • A randomised assessment of adding the kinase inhibitor lestaurtinib to 1st-line chemotherapy for FLT3-mutated AML [published online ahead of print 21 November 2016]
    • Knapper S, Russell N, Gilkes A, et al. A randomised assessment of adding the kinase inhibitor lestaurtinib to 1st-line chemotherapy for FLT3-mutated AML [published online ahead of print 21 November 2016]. Blood. doi:10.1182/blood-2016-07-730648.
    • Blood
    • Knapper, S.1    Russell, N.2    Gilkes, A.3
  • 283
    • 84886534519 scopus 로고    scopus 로고
    • Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: Results from a randomized, placebo-controlled trial
    • Serve H, Krug U, Wagner R, et al. Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial. J Clin Oncol. 2013;31(25):3110-3118.
    • (2013) J Clin Oncol. , vol.31 , Issue.25 , pp. 3110-3118
    • Serve, H.1    Krug, U.2    Wagner, R.3
  • 284
    • 84949484439 scopus 로고    scopus 로고
    • Addition of sorafenib versus placebo to standard therapy in patients aged 60 years or younger with newly diagnosed acute myeloid leukaemia (SORAML): A multicentre, phase 2, randomised controlled trial
    • Röllig C, Serve H, Hüttmann A, et al; Study Alliance Leukaemia. Addition of sorafenib versus placebo to standard therapy in patients aged 60 years or younger with newly diagnosed acute myeloid leukaemia (SORAML): a multicentre, phase 2, randomised controlled trial. Lancet Oncol. 2015;16(16):1691-1699.
    • (2015) Lancet Oncol. , vol.16 , Issue.16 , pp. 1691-1699
    • Röllig, C.1    Serve, H.2    Hüttmann, A.3
  • 285
    • 84879698783 scopus 로고    scopus 로고
    • Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
    • Abdel-Wahab O, Levine RL. Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia. Blood. 2013; 121(18):3563-3572.
    • (2013) Blood , vol.121 , Issue.18 , pp. 3563-3572
    • Abdel-Wahab, O.1    Levine, R.L.2
  • 286
    • 84993748460 scopus 로고    scopus 로고
    • Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia
    • Gallipoli P, Giotopoulos G, Huntly BJ. Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia. Ther Adv Hematol. 2015;6(3):103-119.
    • (2015) Ther Adv Hematol. , vol.6 , Issue.3 , pp. 103-119
    • Gallipoli, P.1    Giotopoulos, G.2    Huntly, B.J.3
  • 287
    • 84940600974 scopus 로고    scopus 로고
    • Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: A multicentre, randomised, dose-escalation phase 1 study
    • Issa JP, Roboz G, Rizzieri D, et al. Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study. Lancet Oncol. 2015;16(9):1099-1110.
    • (2015) Lancet Oncol. , vol.16 , Issue.9 , pp. 1099-1110
    • Issa, J.P.1    Roboz, G.2    Rizzieri, D.3
  • 288
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang F, Travins J, DeLaBarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013; 340(6132):622-626.
    • (2013) Science , vol.340 , Issue.6132 , pp. 622-626
    • Wang, F.1    Travins, J.2    DeLaBarre, B.3
  • 289
    • 84954246999 scopus 로고    scopus 로고
    • Safety and efficacy of AG-221, a potent inhibitor of mutant IDH2 that promotes differentiation of myeloid cells in patients with advanced hematologic malignancies: Results of a phase 1/2 trial [abstract]
    • 323
    • Stein EM, DiNardo C, Altman JK, et al. Safety and efficacy of AG-221, a potent inhibitor of mutant IDH2 that promotes differentiation of myeloid cells in patients with advanced hematologic malignancies: results of a phase 1/2 trial [abstract]. Blood. 2015;126(23). Abstract 323.
    • (2015) Blood , vol.126 , Issue.23
    • Stein, E.M.1    DiNardo, C.2    Altman, J.K.3
  • 290
    • 84994353833 scopus 로고    scopus 로고
    • Molecular profiling and relationship with clinical response in patients with IDH1 mutation-positive hematologic malignancies receiving AG-120, a first-in-class potent inhibitor of mutant IDH1, in addition to data from the completed dose escalation portion of the phase 1 study [abstract]
    • 1306
    • DiNardo C, de Botton S, Pollyea DA, et al. Molecular profiling and relationship with clinical response in patients with IDH1 mutation-positive hematologic malignancies receiving AG-120, a first-in-class potent inhibitor of mutant IDH1, in addition to data from the completed dose escalation portion of the phase 1 study [abstract]. Blood. 2015;126(23). Abstract 1306.
    • (2015) Blood , vol.126 , Issue.23
    • DiNardo, C.1    De Botton, S.2    Pollyea, D.A.3
  • 291
    • 84962523963 scopus 로고    scopus 로고
    • Bromodomain inhibitor OTX015 in patients with acute leukaemia: A dose-escalation, phase 1 study
    • Berthon C, Raffoux E, Thomas X, et al. Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study. Lancet Haematol. 2016;3(4):e186-e195.
    • (2016) Lancet Haematol. , vol.3 , Issue.4 , pp. e186-e195
    • Berthon, C.1    Raffoux, E.2    Thomas, X.3
  • 292
    • 84939165694 scopus 로고    scopus 로고
    • Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond
    • Chen CW, Armstrong SA. Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond. Exp Hematol. 2015;43(8): 673-684.
    • (2015) Exp Hematol. , vol.43 , Issue.8 , pp. 673-684
    • Chen, C.W.1    Armstrong, S.A.2
  • 293
    • 84903954701 scopus 로고    scopus 로고
    • Requirement for CDK6 in MLL-rearranged acute myeloid leukemia
    • Placke T, Faber K, Nonami A, et al. Requirement for CDK6 in MLL-rearranged acute myeloid leukemia. Blood. 2014;124(1):13-23.
    • (2014) Blood , vol.124 , Issue.1 , pp. 13-23
    • Placke, T.1    Faber, K.2    Nonami, A.3
  • 295
    • 84897108505 scopus 로고    scopus 로고
    • Leukapheresis and low-dose chemotherapy do not reduce early mortality in acute myeloid leukemia hyperleukocytosis: A systematic review and meta-analysis
    • Oberoi S, Lehrnbecher T, Phillips B, et al. Leukapheresis and low-dose chemotherapy do not reduce early mortality in acute myeloid leukemia hyperleukocytosis: a systematic review and meta-analysis. Leuk Res. 2014;38(4): 460-468.
    • (2014) Leuk Res. , vol.38 , Issue.4 , pp. 460-468
    • Oberoi, S.1    Lehrnbecher, T.2    Phillips, B.3
  • 296
    • 84955120587 scopus 로고    scopus 로고
    • Primary antifungal prophylaxis during curative-intent therapy for acute myeloid leukemia
    • Halpern AB, Lyman GH, Walsh TJ, Kontoyiannis DP, Walter RB. Primary antifungal prophylaxis during curative-intent therapy for acute myeloid leukemia. Blood. 2015;126(26):2790-2797.
    • (2015) Blood , vol.126 , Issue.26 , pp. 2790-2797
    • Halpern, A.B.1    Lyman, G.H.2    Walsh, T.J.3    Kontoyiannis, D.P.4    Walter, R.B.5
  • 297
    • 84867336974 scopus 로고    scopus 로고
    • Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: An open-label, multicentre, randomised study
    • Wandt H, Schaefer-Eckart K, Wendelin K, et al; Study Alliance Leukemia. Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study. Lancet. 2012;380(9850): 1309-1316.
    • (2012) Lancet , vol.380 , Issue.9850 , pp. 1309-1316
    • Wandt, H.1    Schaefer-Eckart, K.2    Wendelin, K.3
  • 298
    • 84877624763 scopus 로고    scopus 로고
    • A no-prophylaxis platelet-transfusion strategy for hematologic cancers
    • Stanworth SJ, Estcourt LJ, Powter G, et al; TOPPS Investigators. A no-prophylaxis platelet-transfusion strategy for hematologic cancers. N Engl J Med. 2013;368(19):1771-1780.
    • (2013) N Engl J Med. , vol.368 , Issue.19 , pp. 1771-1780
    • Stanworth, S.J.1    Estcourt, L.J.2    Powter, G.3
  • 299
    • 84920596795 scopus 로고    scopus 로고
    • Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways
    • Gröschel S, Sanders MA, Hoogenboezem R, et al. Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways. Blood. 2015;125(1):133-139.
    • (2015) Blood , vol.125 , Issue.1 , pp. 133-139
    • Gröschel, S.1    Sanders, M.A.2    Hoogenboezem, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.