메뉴 건너뛰기




Volumn 114, Issue 26, 2009, Pages 5352-5361

AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: Prognostic implication and interaction with other gene alterations

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; CD15 ANTIGEN; CD19 ANTIGEN; CD33 ANTIGEN; CD34 ANTIGEN; CD56 ANTIGEN; CYTARABINE; HLA DR ANTIGEN; IDARUBICIN; LACTATE DEHYDROGENASE; MITOXANTRONE; MIXED LINEAGE LEUKEMIA PROTEIN; NUCLEOPHOSMIN; TRANSCRIPTION FACTOR RUNX1;

EID: 73949090504     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-05-223784     Document Type: Article
Times cited : (292)

References (46)
  • 1
    • 67349135808 scopus 로고    scopus 로고
    • Acute myeloid leukemia: The challenge of capturing disease variety
    • Lowenberg B. Acute myeloid leukemia: the challenge of capturing disease variety. Hematology. 2008:1-11.
    • (2008) Hematology , pp. 1-11
    • Lowenberg, B.1
  • 2
    • 44049086446 scopus 로고    scopus 로고
    • Cooperating gene mutations in acute myeloid leukemia: A review of the literature
    • Renneville A, Roumier C, Biggio V, et al. Cooperating gene mutations in acute myeloid leukemia: a review of the literature. Leukemia. 2008;22(5):915-931.
    • (2008) Leukemia , vol.22 , Issue.5 , pp. 915-931
    • Renneville, A.1    Roumier, C.2    Biggio, V.3
  • 3
    • 33846230449 scopus 로고    scopus 로고
    • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: Are we ready for a prognostically prioritized molecular classification?
    • Mrozek K, Marcucci G, Paschka P, Whitman SP, Bloomfield CD. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood. 2007;109(2):431-448.
    • (2007) Blood , vol.109 , Issue.2 , pp. 431-448
    • Mrozek, K.1    Marcucci, G.2    Paschka, P.3    Whitman, S.P.4    Bloomfield, C.D.5
  • 4
    • 45549092335 scopus 로고    scopus 로고
    • Review: Genetic models of acute myeloid leukaemia
    • McCormack E, Bruserud O, Gjertsen BT. Review: genetic models of acute myeloid leukaemia. Oncogene. 2008;27(27):3765-3779.
    • (2008) Oncogene , vol.27 , Issue.27 , pp. 3765-3779
    • McCormack, E.1    Bruserud, O.2    Gjertsen, B.T.3
  • 5
    • 27244452986 scopus 로고    scopus 로고
    • Genetics of myeloid malignancies: Pathogenetic and clinical implications
    • Frohling S, Scholl C, Gilliland DG, Levine RL. Genetics of myeloid malignancies: pathogenetic and clinical implications. J Clin Oncol. 2005;23(26):6285-6295.
    • (2005) J Clin Oncol , vol.23 , Issue.26 , pp. 6285-6295
    • Frohling, S.1    Scholl, C.2    Gilliland, D.G.3    Levine, R.L.4
  • 6
    • 0036814971 scopus 로고    scopus 로고
    • Molecular genetics of human leukemias: New insights into therapy
    • Gilliland DG. Molecular genetics of human leukemias: new insights into therapy. Semin Hematol. 2002;39[suppl 3]:6-11.
    • (2002) Semin Hematol , vol.39 , Issue.SUPPL. 3 , pp. 6-11
    • Gilliland, D.G.1
  • 7
    • 48749123878 scopus 로고    scopus 로고
    • Prognostic implications of gene mutations in acute myeloid leukemia with normal cytogenetics
    • Gaidzik V, Dohner K. Prognostic implications of gene mutations in acute myeloid leukemia with normal cytogenetics. Semin Oncol. 2008;35(4):346-355.
    • (2008) Semin Oncol , vol.35 , Issue.4 , pp. 346-355
    • Gaidzik, V.1    Dohner, K.2
  • 8
    • 33646557337 scopus 로고    scopus 로고
    • Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    • Thiede C, Koch S, Creutzig E, et al. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood. 2006;107(10):4011-4020.
    • (2006) Blood , vol.107 , Issue.10 , pp. 4011-4020
    • Thiede, C.1    Koch, S.2    Creutzig, E.3
  • 9
    • 42949142189 scopus 로고    scopus 로고
    • Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    • Schlenk RF, Dohner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med. 2008;358(18):1909-1918.
    • (2008) N Engl J Med , vol.358 , Issue.18 , pp. 1909-1918
    • Schlenk, R.F.1    Dohner, K.2    Krauter, J.3
  • 10
    • 36348962321 scopus 로고    scopus 로고
    • RUNX genes in development and cancer: Regulation of viral gene expression and the discovery of RUNX family genes
    • Ito Y. RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes. Adv Cancer Res. 2008;99:33-76.
    • (2008) Adv Cancer Res , vol.99 , pp. 33-76
    • Ito, Y.1
  • 11
    • 2942667930 scopus 로고    scopus 로고
    • Point mutations in the RUNX1/AML1 gene: Another actor in RUNX leukemia
    • Osato M. Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia. Oncogene. 2004;23(24):4284-4296.
    • (2004) Oncogene , vol.23 , Issue.24 , pp. 4284-4296
    • Osato, M.1
  • 12
    • 27244435347 scopus 로고    scopus 로고
    • Runx1/AML1 in normal and abnormal hematopoiesis
    • Yamagata T, Maki K, Mitani K. Runx1/AML1 in normal and abnormal hematopoiesis. Int J Hematol. 2005;82(1):1-8.
    • (2005) Int J Hematol , vol.82 , Issue.1 , pp. 1-8
    • Yamagata, T.1    Maki, K.2    Mitani, K.3
  • 13
    • 0037126635 scopus 로고    scopus 로고
    • Activation of AML1- Mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein
    • Kitabayashi I, Aikawa Y, Nguyen LA, Yokoyama A, Ohki M. Activation of AML1- mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein. EMBO J. 2001;20(24):7184-7196.
    • (2001) EMBO J , vol.20 , Issue.24 , pp. 7184-7196
    • Kitabayashi, I.1    Aikawa, Y.2    Nguyen, L.A.3    Yokoyama, A.4    Ohki, M.5
  • 14
    • 41849097069 scopus 로고    scopus 로고
    • Chromatin regulation by AML1 complex
    • Yoshida H, Kitabayashi I. Chromatin regulation by AML1 complex. Int J Hematol. 2008;87(1):19-24.
    • (2008) Int J Hematol , vol.87 , Issue.1 , pp. 19-24
    • Yoshida, H.1    Kitabayashi, I.2
  • 15
    • 64549100747 scopus 로고    scopus 로고
    • Cell cycle and developmental control of hematopoiesis by Runx1
    • Friedman AD. Cell cycle and developmental control of hematopoiesis by Runx1. J Cell Physiol. 2009;219(3):520-524.
    • (2009) J Cell Physiol , vol.219 , Issue.3 , pp. 520-524
    • Friedman, A.D.1
  • 16
    • 38949105508 scopus 로고    scopus 로고
    • Gatekeeper function of the RUNX1 transcription factor in acute leukemia
    • Niebuhr B, Fischer M, Tager M, Cammenga J, Stocking C. Gatekeeper function of the RUNX1 transcription factor in acute leukemia. Blood Cells Mol Dis. 2008;40(2):211-218.
    • (2008) Blood Cells Mol Dis , vol.40 , Issue.2 , pp. 211-218
    • Niebuhr, B.1    Fischer, M.2    Tager, M.3    Cammenga, J.4    Stocking, C.5
  • 17
    • 0037082499 scopus 로고    scopus 로고
    • In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: Implications for mechanisms of pathogenesis
    • Michaud J, Wu F, Osato M, et al. In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis. Blood. 2002;99(4):1364-1372.
    • (2002) Blood , vol.99 , Issue.4 , pp. 1364-1372
    • Michaud, J.1    Wu, F.2    Osato, M.3
  • 18
    • 0035488475 scopus 로고    scopus 로고
    • Point mutations of the RUNx1/AML1 gene in sporadic and familial myeloid leukemias
    • Osato M, Yanagida M, Shigesada K, Ito Y. Point mutations of the RUNx1/AML1 gene in sporadic and familial myeloid leukemias. Int J Hematol. 2001;74(3):245-251.
    • (2001) Int J Hematol , vol.74 , Issue.3 , pp. 245-251
    • Osato, M.1    Yanagida, M.2    Shigesada, K.3    Ito, Y.4
  • 19
    • 0042522486 scopus 로고    scopus 로고
    • AML1/RUNX1 mutations are infrequent, but related to AML-M0, acquired trisomy 21, and leukemic transformation in pediatric hematologic malignancies
    • Taketani T, Taki T, Takita J, et al. AML1/RUNX1 mutations are infrequent, but related to AML-M0, acquired trisomy 21, and leukemic transformation in pediatric hematologic malignancies. Genes Chromosomes Cancer. 2003;38(1):1-7.
    • (2003) Genes Chromosomes Cancer , vol.38 , Issue.1 , pp. 1-7
    • Taketani, T.1    Taki, T.2    Takita, J.3
  • 20
    • 1542373639 scopus 로고    scopus 로고
    • High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia
    • Harada H, Harada Y, Niimi H, Kyo T, Kimura A, Inaba T. High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia. Blood. 2004;103(6):2316-2324.
    • (2004) Blood , vol.103 , Issue.6 , pp. 2316-2324
    • Harada, H.1    Harada, Y.2    Niimi, H.3    Kyo, T.4    Kimura, A.5    Inaba, T.6
  • 21
    • 34548044732 scopus 로고    scopus 로고
    • Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia
    • Dicker F, Haferlach C, Kern W, Haferlach T, Schnittger S. Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia. Blood. 2007;110(4):1308-1316.
    • (2007) Blood , vol.110 , Issue.4 , pp. 1308-1316
    • Dicker, F.1    Haferlach, C.2    Kern, W.3    Haferlach, T.4    Schnittger, S.5
  • 22
    • 35748939738 scopus 로고    scopus 로고
    • Trisomy 13 correlates with RUNX1 mutation and increased FLT3 expression in AML-M0 patients
    • Silva FP, Lind A, Brouwer-Mandema G, Valk PJ, Giphart-Gassler M. Trisomy 13 correlates with RUNX1 mutation and increased FLT3 expression in AML-M0 patients. Haematologica. 2007;92(8):1123-1126.
    • (2007) Haematologica , vol.92 , Issue.8 , pp. 1123-1126
    • Silva, F.P.1    Lind, A.2    Brouwer-Mandema, G.3    Valk, P.J.4    Giphart-Gassler, M.5
  • 23
    • 0037441589 scopus 로고    scopus 로고
    • M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: A report of 59 cases by the Groupe Francais d'Hematologie Cellulaire (GFHC) and the Groupe Francais de Cytogenetique Hematologique (GFCH)
    • Roumier C, Eclache V, Imbert M, et al. M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: a report of 59 cases by the Groupe Francais d'Hematologie Cellulaire (GFHC) and the Groupe Francais de Cytogenetique Hematologique (GFCH). Blood. 2003;101(4):1277-1283.
    • (2003) Blood , vol.101 , Issue.4 , pp. 1277-1283
    • Roumier, C.1    Eclache, V.2    Imbert, M.3
  • 24
    • 0034667690 scopus 로고    scopus 로고
    • High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
    • Preudhomme C, Warot-Loze D, Roumier C, et al. High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Blood. 2000;96(8):2862-2869.
    • (2000) Blood , vol.96 , Issue.8 , pp. 2862-2869
    • Preudhomme, C.1    Warot-Loze, D.2    Roumier, C.3
  • 25
    • 34848824979 scopus 로고    scopus 로고
    • RUNX1 gene mutation in primary myelodysplastic syndrome: The mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome
    • Chen CY, Lin LI, Tang JL, et al. RUNX1 gene mutation in primary myelodysplastic syndrome: the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome. Br J Haematol. 2007;139(3):405-414.
    • (2007) Br J Haematol , vol.139 , Issue.3 , pp. 405-414
    • Chen, C.Y.1    Lin, L.I.2    Tang, J.L.3
  • 26
    • 0028810735 scopus 로고
    • Correlation of cytogenetic results with immunophenotype, genotype, clinical features, and ras mutation in acute myeloid leukemia: A study of 235 Chinese patients in Taiwan
    • Tien HF, Wang CH, Lin MT, et al. Correlation of cytogenetic results with immunophenotype, genotype, clinical features, and ras mutation in acute myeloid leukemia: a study of 235 Chinese patients in Taiwan. Cancer Genet Cytogenet. 1995;84(1):60-68.
    • (1995) Cancer Genet Cytogenet , vol.84 , Issue.1 , pp. 60-68
    • Tien, H.F.1    Wang, C.H.2    Lin, M.T.3
  • 27
    • 33645501151 scopus 로고    scopus 로고
    • Nucleophosmin mutations in de novo acute myeloid leukemia: The age-dependent incidences and the stability during disease evolution
    • Chou WC, Tang JL, Lin LI, et al. Nucleophosmin mutations in de novo acute myeloid leukemia: the age-dependent incidences and the stability during disease evolution. Cancer Res. 2006;66(6):3310-3316.
    • (2006) Cancer Res , vol.66 , Issue.6 , pp. 3310-3316
    • Chou, W.C.1    Tang, J.L.2    Lin, L.I.3
  • 28
    • 19944427850 scopus 로고    scopus 로고
    • Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
    • Falini B, Mecucci C, Tiacci E, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med. 2005;352(3):254-266.
    • (2005) N Engl J Med , vol.352 , Issue.3 , pp. 254-266
    • Falini, B.1    Mecucci, C.2    Tiacci, E.3
  • 29
    • 20044388101 scopus 로고    scopus 로고
    • Characterization of CEBPA mutations in acute myeloid leukemia: Most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells
    • Lin LI, Chen CY, Lin DT, et al. Characterization of CEBPA mutations in acute myeloid leukemia: most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells. Clin Cancer Res. 2005;11(4):1372-1379.
    • (2005) Clin Cancer Res , vol.11 , Issue.4 , pp. 1372-1379
    • Lin, L.I.1    Chen, C.Y.2    Lin, D.T.3
  • 30
    • 33744496772 scopus 로고    scopus 로고
    • Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome
    • Chen CY, Lin LI, Tang JL, et al. Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome. Leukemia. 2006;20(6):1155-1158.
    • (2006) Leukemia , vol.20 , Issue.6 , pp. 1155-1158
    • Chen, C.Y.1    Lin, L.I.2    Tang, J.L.3
  • 31
    • 0036169298 scopus 로고    scopus 로고
    • Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23
    • Shiah HS, Kuo YY, Tang JL, et al. Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23. Leukemia. 2002;16(2):196-202.
    • (2002) Leukemia , vol.16 , Issue.2 , pp. 196-202
    • Shiah, H.S.1    Kuo, Y.Y.2    Tang, J.L.3
  • 32
    • 43749101634 scopus 로고    scopus 로고
    • Characterization of acute myeloid leukemia with PTPN11 mutation: The mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD
    • Hou HA, Chou WC, Lin LI, et al. Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD. Leukemia. 2008;22(5):1075-1078.
    • (2008) Leukemia , vol.22 , Issue.5 , pp. 1075-1078
    • Hou, H.A.1    Chou, W.C.2    Lin, L.I.3
  • 33
    • 53749101166 scopus 로고    scopus 로고
    • Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: A cancer and leukemia group B study
    • Paschka P, Marcucci G, Ruppert AS, et al. Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol. 2008;26(28):4595-4602.
    • (2008) J Clin Oncol , vol.26 , Issue.28 , pp. 4595-4602
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3
  • 34
    • 65549139174 scopus 로고    scopus 로고
    • Molecular pathways mediating MDS/AML with focus on AML1/RUNX1 point mutations
    • Harada Y, Harada H. Molecular pathways mediating MDS/AML with focus on AML1/RUNX1 point mutations. J Cell Physiol. 2009;220(1):16-20.
    • (2009) J Cell Physiol , vol.220 , Issue.1 , pp. 16-20
    • Harada, Y.1    Harada, H.2
  • 35
    • 77950406426 scopus 로고    scopus 로고
    • RUNX1 mutations can be found in 34% of de novo AML with normal karyotype or single chromosomal imbalances and are associated with good prognosis but turn to unfavourable outcome if further cytogenetic or molecular mutations are acquired
    • abstract
    • Schnittger S, Dicker F, Wendland N, et al. RUNX1 mutations can be found in 34% of de novo AML with normal karyotype or single chromosomal imbalances and are associated with good prognosis but turn to unfavourable outcome if further cytogenetic or molecular mutations are acquired [abstract]. Blood. 2008;112(11):146a.
    • (2008) Blood , vol.112 , Issue.11
    • Schnittger, S.1    Dicker, F.2    Wendland, N.3
  • 36
    • 0033559746 scopus 로고    scopus 로고
    • Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias
    • Osato M, Asou N, Abdalla E, et al. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias. Blood. 1999;93(6):1817-1824.
    • (1999) Blood , vol.93 , Issue.6 , pp. 1817-1824
    • Osato, M.1    Asou, N.2    Abdalla, E.3
  • 38
    • 77950390306 scopus 로고    scopus 로고
    • RUNX1 mutations in acute myeloid leukemia (AML): Correlation with distinct cytogenetic subgroups and clinical outcome. Results of the AML Study Group (AMLSG)
    • abstract 2008
    • Gaidzik VI, Schlenk RF, Wittke K, et al. RUNX1 mutations in acute myeloid leukemia (AML): correlation with distinct cytogenetic subgroups and clinical outcome. Results of the AML Study Group (AMLSG) [abstract]. Blood. 2008 2008;112(11):145a.
    • (2008) Blood , vol.112 , Issue.11
    • Gaidzik, V.I.1    Schlenk, R.F.2    Wittke, K.3
  • 39
    • 0035831044 scopus 로고    scopus 로고
    • Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBF-βeta
    • Tahirov TH, Inoue-Bungo T, Morii H, et al. Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBF-βeta. Cell. 2001;104(5):755-767.
    • (2001) Cell , vol.104 , Issue.5 , pp. 755-767
    • Tahirov, T.H.1    Inoue-Bungo, T.2    Morii, H.3
  • 40
    • 9144270483 scopus 로고    scopus 로고
    • Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype
    • Matsuno N, Osato M, Yamashita N, et al. Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype. Leukemia. 2003;17(12):2492-2499.
    • (2003) Leukemia , vol.17 , Issue.12 , pp. 2492-2499
    • Matsuno, N.1    Osato, M.2    Yamashita, N.3
  • 41
    • 33646475438 scopus 로고    scopus 로고
    • Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations
    • Niimi H, Harada H, Harada Y, et al. Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations. Leukemia. 2006;20(4):635-644.
    • (2006) Leukemia , vol.20 , Issue.4 , pp. 635-644
    • Niimi, H.1    Harada, H.2    Harada, Y.3
  • 42
    • 77950405955 scopus 로고    scopus 로고
    • Accessed March 12, 2009
    • NIH genetic sequence database, GenBank. http://www.ncbi.nlm.nih.gov/ Genbank. Accessed March 12, 2009.
  • 43
    • 0037438508 scopus 로고    scopus 로고
    • Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia
    • Harada H, Harada Y, Tanaka H, Kimura A, Inaba T. Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia. Blood. 2003;101(2):673-680.
    • (2003) Blood , vol.101 , Issue.2 , pp. 673-680
    • Harada, H.1    Harada, Y.2    Tanaka, H.3    Kimura, A.4    Inaba, T.5
  • 44
    • 58149378467 scopus 로고    scopus 로고
    • Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy
    • Owen CJ, Toze CL, Koochin A, et al. Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy. Blood. 2008;112(12):4639-4645.
    • (2008) Blood , vol.112 , Issue.12 , pp. 4639-4645
    • Owen, C.J.1    Toze, C.L.2    Koochin, A.3
  • 45
    • 67049162141 scopus 로고    scopus 로고
    • High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder
    • Preudhomme C, Renneville A, Bourdon V, et al. High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder. Blood. 2009;113(22):5583-5587.
    • (2009) Blood , vol.113 , Issue.22 , pp. 5583-5587
    • Preudhomme, C.1    Renneville, A.2    Bourdon, V.3
  • 46
    • 38549140634 scopus 로고    scopus 로고
    • A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies
    • Kirito K, Sakoe K, Shinoda D, Takiyama Y, Kaushansky K, Komatsu N. A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies. Haematologica. 2008;93(1):155-156.
    • (2008) Haematologica , vol.93 , Issue.1 , pp. 155-156
    • Kirito, K.1    Sakoe, K.2    Shinoda, D.3    Takiyama, Y.4    Kaushansky, K.5    Komatsu, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.