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Volumn 28, Issue 1, 2014, Pages 129-137

Monitoring of residual disease by next-generation deep-sequencing of RUNX1 mutations can identify acute myeloid leukemia patients with resistant disease

Author keywords

mutation analysis; next generation sequencing; RUNX1

Indexed keywords

TRANSCRIPTION FACTOR RUNX1;

EID: 84891855434     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.239     Document Type: Article
Times cited : (85)

References (42)
  • 2
    • 77955715121 scopus 로고    scopus 로고
    • Mutation analysis for RUNX1, MLL-PTD, FLT3-ITD, NPM1 and NRAS in 269 patients with MDS or secondary AML
    • Dicker F, Haferlach C, Sundermann J, Wendland N, Weiss T, Kern W et al. Mutation analysis for RUNX1, MLL-PTD, FLT3-ITD, NPM1 and NRAS in 269 patients with MDS or secondary AML. Leukemia 2010; 24: 1528-1532.
    • (2010) Leukemia , vol.24 , pp. 1528-1532
    • Dicker, F.1    Haferlach, C.2    Sundermann, J.3    Wendland, N.4    Weiss, T.5    Kern, W.6
  • 3
    • 84867808559 scopus 로고    scopus 로고
    • Monitoring of minimal residual disease using next-generation deep-sequencing in 460 acute myeloid leukemia cases identifies RUNX1 mutated patients with resistant disease
    • Kohlmann A, Grossmann V, Harbich S, Dicker F, Alpermann T, Nadarajah N et al. Monitoring of minimal residual disease using next-generation deep-sequencing in 460 acute myeloid leukemia cases identifies RUNX1 mutated patients with resistant disease. Blood 2011; 118: 747a.
    • (2011) Blood , vol.118
    • Kohlmann, A.1    Grossmann, V.2    Harbich, S.3    Dicker, F.4    Alpermann, T.5    Nadarajah, N.6
  • 4
    • 79952134550 scopus 로고    scopus 로고
    • RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis
    • Schnittger S, Dicker F, Kern W, Wendland N, Sundermann J, Alpermann T et al. RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis. Blood 2011; 117: 2348-2357.
    • (2011) Blood , vol.117 , pp. 2348-2357
    • Schnittger, S.1    Dicker, F.2    Kern, W.3    Wendland, N.4    Sundermann, J.5    Alpermann, T.6
  • 5
    • 79954448043 scopus 로고    scopus 로고
    • RUNX1 mutations in acute myeloid leukemia: Results from a comprehensive genetic and clinical analysis from the AML study group
    • Gaidzik VI, Bullinger L, Schlenk RF, Zimmermann AS, Rock J, Paschka P et al. RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group. J Clin Oncol 2011; 29: 1364-1372.
    • (2011) J Clin Oncol , vol.29 , pp. 1364-1372
    • Gaidzik, V.I.1    Bullinger, L.2    Schlenk, R.F.3    Zimmermann, A.S.4    Rock, J.5    Paschka, P.6
  • 6
    • 77958468721 scopus 로고    scopus 로고
    • Assessment of minimal residual disease in acute myeloid leukemia
    • Grimwade D, Vyas P, Freeman S. Assessment of minimal residual disease in acute myeloid leukemia. Curr Opin Oncol 2010; 22: 656-663.
    • (2010) Curr Opin Oncol , vol.22 , pp. 656-663
    • Grimwade, D.1    Vyas, P.2    Freeman, S.3
  • 7
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Dohner H, Estey EH, Amadori S, Appelbaum FR, Buchner T, Burnett AK et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010; 115: 453-474.
    • (2010) Blood , vol.115 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3    Appelbaum, F.R.4    Buchner, T.5    Burnett, A.K.6
  • 8
    • 84855838173 scopus 로고    scopus 로고
    • Prognostic and therapeutic implications of minimal residual disease detection in acute myeloid leukemia
    • Buccisano F, Maurillo L, Del Principe MI, Del PG, Sconocchia G, Lo-Coco F et al. Prognostic and therapeutic implications of minimal residual disease detection in acute myeloid leukemia. Blood 2012; 119: 332-341.
    • (2012) Blood , vol.119 , pp. 332-341
    • Buccisano, F.1    Maurillo, L.2    Del Principe, M.I.3    Del Sconocchia, P.G.G.4    Lo-Coco, F.5
  • 9
    • 75649091203 scopus 로고    scopus 로고
    • Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias
    • Ommen HB, Schnittger S, Jovanovic JV, Ommen IB, Hasle H, Ostergaard M et al. Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias. Blood 2010; 115: 198-205.
    • (2010) Blood , vol.115 , pp. 198-205
    • Ommen, H.B.1    Schnittger, S.2    Jovanovic, J.V.3    Ommen, I.B.4    Hasle, H.5    Ostergaard, M.6
  • 10
    • 70349579540 scopus 로고    scopus 로고
    • Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML
    • Schnittger S, Kern W, Tschulik C, Weiss T, Dicker F, Falini B et al. Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML. Blood 2009; 114: 2220-2231.
    • (2009) Blood , vol.114 , pp. 2220-2231
    • Schnittger, S.1    Kern, W.2    Tschulik, C.3    Weiss, T.4    Dicker, F.5    Falini, B.6
  • 11
    • 73949090504 scopus 로고    scopus 로고
    • AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: Prognostic implication and interaction with other gene alterations
    • Tang JL, Hou HA, Chen CY, Liu CY, Chou WC, Tseng MH et al. AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. Blood 2009; 114: 5352-5361.
    • (2009) Blood , vol.114 , pp. 5352-5361
    • Tang, J.L.1    Hou, H.A.2    Chen, C.Y.3    Liu, C.Y.4    Chou, W.C.5    Tseng, M.H.6
  • 13
    • 49349140725 scopus 로고    scopus 로고
    • Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype
    • Haferlach C, Dicker F, Herholz H, Schnittger S, Kern W, Haferlach T. Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype. Leukemia 2008; 22: 1539-1541.
    • (2008) Leukemia , vol.22 , pp. 1539-1541
    • Haferlach, C.1    Dicker, F.2    Herholz, H.3    Schnittger, S.4    Kern, W.5    Haferlach, T.6
  • 14
    • 84857734093 scopus 로고    scopus 로고
    • TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome
    • Rucker FG, Schlenk RF, Bullinger L, Kayser S, Teleanu V, Kett H et al. TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood 2012; 119: 2114-2121.
    • (2012) Blood , vol.119 , pp. 2114-2121
    • Rucker, F.G.1    Schlenk, R.F.2    Bullinger, L.3    Kayser, S.4    Teleanu, V.5    Kett, H.6
  • 16
    • 79954428737 scopus 로고    scopus 로고
    • TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Metzeler KH, Maharry K, Radmacher MD, Mrozek K, Margeson D, Becker H et al. TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2011; 29: 1373-1381.
    • (2011) J Clin Oncol , vol.29 , pp. 1373-1381
    • Metzeler, K.H.1    Maharry, K.2    Radmacher, M.D.3    Mrozek, K.4    Margeson, D.5    Becker, H.6
  • 18
    • 84255176496 scopus 로고    scopus 로고
    • ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category
    • Metzeler KH, Becker H, Maharry K, Radmacher MD, Kohlschmidt J, Mrozek K et al. ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category. Blood 2011; 118: 6920-6929.
    • (2011) Blood , vol.118 , pp. 6920-6929
    • Metzeler, K.H.1    Becker, H.2    Maharry, K.3    Radmacher, M.D.4    Kohlschmidt, J.5    Mrozek, K.6
  • 19
    • 84873568769 scopus 로고    scopus 로고
    • ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome
    • Schnittger S, Eder C, Jeromin S, Alpermann T, Fasan A, Grossmann V et al. ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome. Leukemia 2013; 27: 82-91.
    • (2013) Leukemia , vol.27 , pp. 82-91
    • Schnittger, S.1    Eder, C.2    Jeromin, S.3    Alpermann, T.4    Fasan, A.5    Grossmann, V.6
  • 20
    • 84874735262 scopus 로고    scopus 로고
    • Next-generation sequencing-feasibility and practicality in haematology
    • Kohlmann A, Grossmann V, Nadarajah N, Haferlach T. Next-generation sequencing-feasibility and practicality in haematology. Br J Haematol 2013; 160: 736-753.
    • (2013) Br J Haematol , vol.160 , pp. 736-753
    • Kohlmann, A.1    Grossmann, V.2    Nadarajah, N.3    Haferlach, T.4
  • 21
  • 22
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • The Cancer Genome Atlas Research Network.
    • The Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013; 368: 2059-2074.
    • (2013) N Engl J Med , vol.368 , pp. 2059-2074
  • 25
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet 2011; 43: 309-315.
    • (2011) Nat Genet , vol.43 , pp. 309-315
    • Yan, X.J.1    Xu, J.2    Zh, G.3    Pan, C.M.4    Lu, G.5    Shen, Y.6
  • 26
    • 83055161507 scopus 로고    scopus 로고
    • Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype
    • Grossmann V, Tiacci E, Holmes AB, Kohlmann A, Martelli MP, Kern W et al. Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood 2011; 118: 6153-6163.
    • (2011) Blood , vol.118 , pp. 6153-6163
    • Grossmann, V.1    Tiacci, E.2    Holmes, A.B.3    Kohlmann, A.4    Martelli, M.P.5    Kern, W.6
  • 28
    • 84856390048 scopus 로고    scopus 로고
    • Integration of next-generation sequencing into clinical practice: Are we there yet
    • Kohlmann A, Grossmann V, Haferlach T. Integration of next-generation sequencing into clinical practice: are we there yet Semin Oncol 2012; 39: 26-36.
    • (2012) Semin Oncol , vol.39 , pp. 26-36
    • Kohlmann, A.1    Grossmann, V.2    Haferlach, T.3
  • 29
    • 84865720625 scopus 로고    scopus 로고
    • RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures
    • Mendler JH, Maharry K, Radmacher MD, Mrozek K, Becker H, Metzeler KH et al. RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures. J Clin Oncol 2012; 30: 3109-3118.
    • (2012) J Clin Oncol , vol.30 , pp. 3109-3118
    • Mendler, J.H.1    Maharry, K.2    Radmacher, M.D.3    Mrozek, K.4    Becker, H.5    Metzeler, K.H.6
  • 30
    • 77956237515 scopus 로고    scopus 로고
    • Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1
    • Kohlmann A, Grossmann V, Klein HU, Schindela S, Weiss T, Kazak B et al. Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1. J Clin Oncol 2010; 28: 3858-3865.
    • (2010) J Clin Oncol , vol.28 , pp. 3858-3865
    • Kohlmann, A.1    Grossmann, V.2    Klein, H.U.3    Schindela, S.4    Weiss, T.5    Kazak, B.6
  • 31
    • 83555166249 scopus 로고    scopus 로고
    • The Interlaboratory RObustness of Next-generation sequencing (IRON) study: A deep sequencing investigation of TET2 CBL and KRAS mutations by an international consortium involving 10 laboratories
    • Kohlmann A, Klein HU, Weissmann S, Bresolin S, Chaplin T, Cuppens H et al. The Interlaboratory RObustness of Next-generation sequencing (IRON) study: a deep sequencing investigation of TET2, CBL and KRAS mutations by an international consortium involving 10 laboratories. Leukemia 2011; 25: 1840-1848.
    • (2011) Leukemia , vol.25 , pp. 1840-1848
    • Kohlmann, A.1    Klein, H.U.2    Weissmann, S.3    Bresolin, S.4    Chaplin, T.5    Cuppens, H.6
  • 32
    • 84860675045 scopus 로고    scopus 로고
    • Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations
    • Thol F, Kolking B, Damm F, Reinhardt K, Klusmann JH, Reinhardt D et al. Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations. Genes Chromosomes Cancer 2012; 51: 689-695.
    • (2012) Genes Chromosomes Cancer , vol.51 , pp. 689-695
    • Thol, F.1    Kolking, B.2    Damm, F.3    Reinhardt, K.4    Klusmann, J.H.5    Reinhardt, D.6
  • 35
    • 84879307454 scopus 로고    scopus 로고
    • Robustness of amplicon deep sequencing underlines its utility in clinical applications
    • Grossmann V, Roller A, Klein HU, Weissmann S, Kern W, Haferlach C et al. Robustness of amplicon deep sequencing underlines its utility in clinical applications. J Mol Diagn 2013; 15: 473-484.
    • (2013) J Mol Diagn , vol.15 , pp. 473-484
    • Grossmann, V.1    Roller, A.2    Klein, H.U.3    Weissmann, S.4    Kern, W.5    Haferlach, C.6
  • 37
    • 77955151784 scopus 로고    scopus 로고
    • MutationTaster evaluates disease-causing potential of sequence alterations
    • Schwarz JM, Rodelsperger C, Schuelke M, Seelow D. MutationTaster evaluates disease-causing potential of sequence alterations. Nat Methods 2010; 7: 575-576.
    • (2010) Nat Methods , vol.7 , pp. 575-576
    • Schwarz, J.M.1    Rodelsperger, C.2    Schuelke, M.3    Seelow, D.4
  • 39
    • 68149165614 scopus 로고    scopus 로고
    • Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
    • Kumar P, Henikoff S, Ng PC. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc 2009; 4: 1073-1081.
    • (2009) Nat Protoc , vol.4 , pp. 1073-1081
    • Kumar, P.1    Henikoff, S.2    Ng, P.C.3
  • 40
    • 83255185441 scopus 로고    scopus 로고
    • RUNX1 mutations in clonal myeloid disorders: From conventional cytogenetics to next generation sequencing, a story 40 years in the making
    • Mangan JK, Speck NA. RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making. Crit Rev Oncog 2011; 16: 77-91.
    • (2011) Crit Rev Oncog , vol.16 , pp. 77-91
    • Mangan, J.K.1    Speck, N.A.2
  • 41
    • 84867806184 scopus 로고    scopus 로고
    • A novel hierarchical prognostic model of AML solely based on molecular mutations
    • Grossmann V, Schnittger S, Kohlmann A, Eder C, Roller A, Dicker F et al. A novel hierarchical prognostic model of AML solely based on molecular mutations. Blood 2012; 120: 2963-2972.
    • (2012) Blood , vol.120 , pp. 2963-2972
    • Grossmann, V.1    Schnittger, S.2    Kohlmann, A.3    Eder, C.4    Roller, A.5    Dicker, F.6
  • 42
    • 40749159081 scopus 로고    scopus 로고
    • Incorporating hematopoietic cell transplantation (HCT) into the management of adults aged under 60 years with acute myeloid leukemia (AML)
    • DOI 10.1016/j.beha.2007.11.013, PII S1521692607001028
    • Appelbaum FR. Incorporating hematopoietic cell transplantation (HCT) into the management of adults aged under 60 years with acute myeloid leukemia (AML). Best Pract Res Clin Haematol 2008; 21: 85-92. (Pubitemid 351377515)
    • (2008) Best Practice and Research: Clinical Haematology , vol.21 , Issue.1 , pp. 85-92
    • Appelbaum, F.R.1


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