-
1
-
-
84894245627
-
HALT Pan- Leukemia gene panel consortium. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
-
Shlush LI, Zandi S, Mitchell A, et al; HALT Pan- Leukemia Gene Panel Consortium. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014;506(7488): 328-333.
-
(2014)
Nature
, vol.506
, Issue.7488
, pp. 328-333
-
-
Shlush, L.I.1
Zandi, S.2
Mitchell, A.3
-
2
-
-
79952086942
-
Therapeutic advances in acute myeloid leukemia
-
Burnett A, Wetzler M, Lowenberg B. Therapeutic advances in acute myeloid leukemia. J Clin Oncol. 2011;29(5):487-494.
-
(2011)
J Clin Oncol
, vol.29
, Issue.5
, pp. 487-494
-
-
Burnett, A.1
Wetzler, M.2
Lowenberg, B.3
-
3
-
-
17544388046
-
Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype
-
Bloomfield CD, Lawrence D, Byrd JC, et al. Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype. Cancer Res. 1998;58(18):4173-4179.
-
(1998)
Cancer Res
, vol.58
, Issue.18
, pp. 4173-4179
-
-
Bloomfield, C.D.1
Lawrence, D.2
Byrd, J.C.3
-
4
-
-
84889632633
-
Important milestones in acute leukemia in 2013
-
Rowe JM. Important milestones in acute leukemia in 2013. Best Pract Res Clin Haematol. 2013; 26(3):241-244.
-
(2013)
Best Pract Res Clin Haematol
, vol.26
, Issue.3
, pp. 241-244
-
-
Rowe, J.M.1
-
5
-
-
33748747555
-
The clinical spectrum of adult acute myeloid leukaemia associated with core binding factor translocations
-
Appelbaum FR, Kopecky KJ, Tallman MS, et al. The clinical spectrum of adult acute myeloid leukaemia associated with core binding factor translocations. Br J Haematol. 2006;135(2): 165-173.
-
(2006)
Br, J Haematol
, vol.135
, Issue.2
, pp. 165-173
-
-
Appelbaum, F.R.1
Kopecky, K.J.2
Tallman, M.S.3
-
6
-
-
84864063679
-
Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia
-
Kantarjian HM, Thomas XG, Dmoszynska A, et al. Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. J Clin Oncol. 2012;30(21):2670-2677.
-
(2012)
J Clin Oncol
, vol.30
, Issue.21
, pp. 2670-2677
-
-
Kantarjian, H.M.1
Thomas, X.G.2
Dmoszynska, A.3
-
7
-
-
84937804118
-
International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with.30% blasts
-
Dombret H, Seymour JF, Butrym A, et al. International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with .30% blasts. Blood. 2015;126(3):291-299.
-
(2015)
Blood
, vol.126
, Issue.3
, pp. 291-299
-
-
Dombret, H.1
Seymour, J.F.2
Butrym, A.3
-
8
-
-
84928013058
-
Current challenges in clinical development of "targeted therapies": The case of acute myeloid leukemia
-
Estey E, Levine RL, Lowenberg B. Current challenges in clinical development of "targeted therapies": The case of acute myeloid leukemia. Blood. 2015;125(16):2461-2466.
-
(2015)
Blood
, vol.125
, Issue.16
, pp. 2461-2466
-
-
Estey, E.1
Levine, R.L.2
Lowenberg, B.3
-
9
-
-
70349467775
-
Anthracycline dose intensification in acute myeloid leukemia
-
Fernandez HF, Sun Z, Yao X, et al. Anthracycline dose intensification in acute myeloid leukemia. N Engl J Med. 2009;361(13):1249-1259.
-
(2009)
N Engl J Med
, vol.361
, Issue.13
, pp. 1249-1259
-
-
Fernandez, H.F.1
Sun, Z.2
Yao, X.3
-
10
-
-
84864039689
-
Cladribine, but not fludarabine, added to daunorubicin and cytarabine during induction prolongs survival of patients with acute myeloid leukemia: A multicenter, randomized phase III study
-
Holowiecki J, Grosicki S, Giebel S, et al. Cladribine, but not fludarabine, added to daunorubicin and cytarabine during induction prolongs survival of patients with acute myeloid leukemia: A multicenter, randomized phase III study. J Clin Oncol. 2012;30(20):2441-2448.
-
(2012)
J Clin Oncol
, vol.30
, Issue.20
, pp. 2441-2448
-
-
Holowiecki, J.1
Grosicki, S.2
Giebel, S.3
-
11
-
-
33748326024
-
Ratiometric dosing of anticancer drug combinations: Controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice
-
Mayer LD, Harasym TO, Tardi PG, et al. Ratiometric dosing of anticancer drug combinations: controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice. Mol Cancer Ther. 2006;5(7):1854-1863.
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.7
, pp. 1854-1863
-
-
Mayer, L.D.1
Harasym, T.O.2
Tardi, P.G.3
-
12
-
-
84901412022
-
Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML
-
Lancet JE, Cortes JE, Hogge DE, et al. Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML. Blood. 2014;123(21):3239-3246.
-
(2014)
Blood
, vol.123
, Issue.21
, pp. 3239-3246
-
-
Lancet, J.E.1
Cortes, J.E.2
Hogge, D.E.3
-
13
-
-
84920870589
-
Phase II, multicenter, randomized trial of CPX-351 (cytarabine:daunorubicin) liposome injection versus intensive salvage therapy in adults with first relapse AML
-
Cortes JE, Goldberg SL, Feldman EJ, et al. Phase II, multicenter, randomized trial of CPX-351 (cytarabine:daunorubicin) liposome injection versus intensive salvage therapy in adults with first relapse AML. Cancer. 2015;121(2):234-242.
-
(2015)
Cancer
, vol.121
, Issue.2
, pp. 234-242
-
-
Cortes, J.E.1
Goldberg, S.L.2
Feldman, E.J.3
-
14
-
-
20244361887
-
Prognostic index for adult patients with acute myeloid leukemia in first relapse
-
Breems DA, Van Putten WL, Huijgens PC, et al. Prognostic index for adult patients with acute myeloid leukemia in first relapse. J Clin Oncol. 2005;23(9):1969-1978.
-
(2005)
J Clin Oncol
, vol.23
, Issue.9
, pp. 1969-1978
-
-
Breems, D.A.1
Van Putten, W.L.2
Huijgens, P.C.3
-
15
-
-
70349451999
-
Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON); German AML Study Group (AMLSG); Swiss Group for Clinical Cancer Research (SAKK) Collaborative Group. Highdose daunorubicin in older patients with acute myeloid leukemia
-
Lowenberg B, Ossenkoppele GJ, van Putten W, et al; Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON); German AML Study Group (AMLSG); Swiss Group for Clinical Cancer Research (SAKK) Collaborative Group. Highdose daunorubicin in older patients with acute myeloid leukemia. N Engl J Med. 2009;361(13): 1235-1248.
-
(2009)
N Engl J Med
, vol.361
, Issue.13
, pp. 1235-1248
-
-
Lowenberg, B.1
Ossenkoppele, G.J.2
Van Putten, W.3
-
16
-
-
84940612285
-
Vosaroxin plus cytarabine versus placebo plus cytarabine in patients with first relapsed or refractory acute myeloid leukaemia (VALOR): A randomised, controlled, double-blind, multinational, phase 3 study
-
Ravandi F, Ritchie EK, Sayar H, et al. Vosaroxin plus cytarabine versus placebo plus cytarabine in patients with first relapsed or refractory acute myeloid leukaemia (VALOR): A randomised, controlled, double-blind, multinational, phase 3 study. Lancet Oncol. 2015;16(9):1025-1036.
-
(2015)
Lancet Oncol
, vol.16
, Issue.9
, pp. 1025-1036
-
-
Ravandi, F.1
Ritchie, E.K.2
Sayar, H.3
-
17
-
-
84929170526
-
Vosaroxin and vosaroxin plus low-dose Ara-C (LDAC) vs low-dose Ara-C alone in older patients with acute myeloid leukemia
-
Dennis M, Russell N, Hills RK, et al. Vosaroxin and vosaroxin plus low-dose Ara-C (LDAC) vs low-dose Ara-C alone in older patients with acute myeloid leukemia. Blood. 2015;125(19): 2923-2932.
-
(2015)
Blood
, vol.125
, Issue.19
, pp. 2923-2932
-
-
Dennis, M.1
Russell, N.2
Hills, R.K.3
-
18
-
-
84924020604
-
REVEAL-1, a phase 2 dose regimen optimization study of vosaroxin in older poor-risk patients with previously untreated acute myeloid leukaemia
-
Stuart RK, Cripe LD, Maris MB, et al. REVEAL-1, a phase 2 dose regimen optimization study of vosaroxin in older poor-risk patients with previously untreated acute myeloid leukaemia. Br J Haematol. 2015;168(6):796-805.
-
(2015)
Br J Haematol
, vol.168
, Issue.6
, pp. 796-805
-
-
Stuart, R.K.1
Cripe, L.D.2
Maris, M.B.3
-
19
-
-
84955451893
-
Late responses and overall survival (OS) from long term follow up of a randomized phase II study of SGI-110 (guadecitabine) 5-day regimen in elderly AML who are not eligible for intensive chemotherapy [abstract]
-
June, Vienna, Austria. Abstract P571
-
Kropf P, Jabbour E, Yee K, et al. Late responses and overall survival (OS) from long term follow up of a randomized phase II study of SGI-110 (guadecitabine) 5-day regimen in elderly AML who are not eligible for intensive chemotherapy [abstract]. 20th Congress of the European Hematology Association; June 11-14, 2015; Vienna, Austria. Abstract P571.
-
(2015)
20th Congress of the European Hematology Association
, pp. 11-14
-
-
Kropf, P.1
Jabbour, E.2
Yee, K.3
-
20
-
-
78049456138
-
Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemia
-
Rosenblat TL, McDevitt MR, Mulford DA, et al. Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemia. Clin Cancer Res. 2010;16(21):5303-5311.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.21
, pp. 5303-5311
-
-
Rosenblat, T.L.1
McDevitt, M.R.2
Mulford, D.A.3
-
21
-
-
84872072793
-
Randomized phase IIb study of low-dose cytarabine and lintuzumab versus low-dose cytarabine and placebo in older adults with untreated acute myeloid leukemia
-
Sekeres MA, Lancet JE, Wood BL, et al. Randomized phase IIb study of low-dose cytarabine and lintuzumab versus low-dose cytarabine and placebo in older adults with untreated acute myeloid leukemia. Haematologica. 2013;98(1):119-128.
-
(2013)
Haematologica
, vol.98
, Issue.1
, pp. 119-128
-
-
Sekeres, M.A.1
Lancet, J.E.2
Wood, B.L.3
-
22
-
-
23044471884
-
Phase III randomized multicenter study of a humanized anti-CD33 monoclonal antibody, lintuzumab, in combination with chemotherapy, versus chemotherapy alone in patients with refractory or first-relapsed acute myeloid leukemia
-
Feldman EJ, Brandwein J, Stone R, et al. Phase III randomized multicenter study of a humanized anti-CD33 monoclonal antibody, lintuzumab, in combination with chemotherapy, versus chemotherapy alone in patients with refractory or first-relapsed acute myeloid leukemia. J Clin Oncol. 2005;23(18):4110-4116.
-
(2005)
J Clin Oncol
, vol.23
, Issue.18
, pp. 4110-4116
-
-
Feldman, E.J.1
Brandwein, J.2
Stone, R.3
-
23
-
-
84881305790
-
A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
-
Petersdorf SH, Kopecky KJ, Slovak M, et al. A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia. Blood. 2013;121(24):4854-4860.
-
(2013)
Blood
, vol.121
, Issue.24
, pp. 4854-4860
-
-
Petersdorf, S.H.1
Kopecky, K.J.2
Slovak, M.3
-
24
-
-
84863522871
-
Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia
-
Burnett AK, Russell NH, Hills RK, et al. Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia. J Clin Oncol. 2012; 30(32):3924-3931.
-
(2012)
J Clin Oncol
, vol.30
, Issue.32
, pp. 3924-3931
-
-
Burnett, A.K.1
Russell, N.H.2
Hills, R.K.3
-
25
-
-
84859911350
-
Acute Leukemia French Association. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised, open-label, phase 3 study
-
Castaigne S, Pautas C, Terŕe C, et al; Acute Leukemia French Association. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised, open-label, phase 3 study. Lancet. 2012;379(9825):1508-1516.
-
(2012)
Lancet
, vol.379
, Issue.9825
, pp. 1508-1516
-
-
Castaigne, S.1
Pautas, C.2
Terŕe, C.3
-
26
-
-
84929951136
-
Interim Analysis of a Phase 1 Trial of SGN-CD33A in Patients with CD33-Positive Acute Myeloid Leukemia (AML) [abstract]
-
Abstract 623
-
Stein EM, Stein A, Walter RB, et al. Interim Analysis of a Phase 1 Trial of SGN-CD33A in Patients with CD33-Positive Acute Myeloid Leukemia (AML) [abstract]. Blood. 2014;124(21). Abstract 623.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Stein, E.M.1
Stein, A.2
Walter, R.B.3
-
27
-
-
84907300532
-
Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy
-
Dohner H, Lubbert M, Fiedler W, et al. Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy. Blood. 2014;124(9): 1426-1433.
-
(2014)
Blood
, vol.124
, Issue.9
, pp. 1426-1433
-
-
Dohner, H.1
Lubbert, M.2
Fiedler, W.3
-
28
-
-
0035885955
-
The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
-
Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98(6):1752-1759.
-
(2001)
Blood
, vol.98
, Issue.6
, pp. 1752-1759
-
-
Kottaridis, P.D.1
Gale, R.E.2
Frew, M.E.3
-
29
-
-
0037114829
-
AML Study Group Ulm. Acute myeloid leukemia. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm
-
Fr ohling S, Schlenk RF, Breitruck J, et al; AML Study Group Ulm. Acute myeloid leukemia. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm. Blood. 2002;100(13):4372-4380.
-
(2002)
Blood
, vol.100
, Issue.13
, pp. 4372-4380
-
-
Fr, O.S.1
Schlenk, R.F.2
Breitruck, J.3
-
30
-
-
84865865542
-
Phase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemia
-
Stone RM, Fischer T, Paquette R, et al. Phase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemia. Leukemia. 2012;26(9):2061-2068.
-
(2012)
Leukemia
, vol.26
, Issue.9
, pp. 2061-2068
-
-
Stone, R.M.1
Fischer, T.2
Paquette, R.3
-
31
-
-
84872614662
-
CALGB 10603 (RATIFY): A randomized phase III study of induction (daunorubicin/cytarabine) and consolidation (high-dose cytarabine) chemotherapy combined with midostaurin or placebo in treatment-naive patients with FLT3 mutated AML [abstract]
-
Abstract TPS199
-
Stone RM, Dohner H, Ehninger M, et al. CALGB 10603 (RATIFY): A randomized phase III study of induction (daunorubicin/cytarabine) and consolidation (high-dose cytarabine) chemotherapy combined with midostaurin or placebo in treatment-naive patients with FLT3 mutated AML [abstract]. J Clin Oncol. 2011;29. Abstract TPS199.
-
(2011)
J Clin Oncol
, vol.29
-
-
Stone, R.M.1
Dohner, H.2
Ehninger, M.3
-
32
-
-
70449475105
-
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
-
Zarrinkar PP, Gunawardane RN, Cramer MD, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood. 2009;114(14): 2984-2992.
-
(2009)
Blood
, vol.114
, Issue.14
, pp. 2984-2992
-
-
Zarrinkar, P.P.1
Gunawardane, R.N.2
Cramer, M.D.3
-
33
-
-
84890029517
-
Phase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status
-
Cortes JE, Kantarjian H, Foran JM, et al. Phase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status. J Clin Oncol. 2013;31(29):3681-3687.
-
(2013)
J Clin Oncol
, vol.31
, Issue.29
, pp. 3681-3687
-
-
Cortes, J.E.1
Kantarjian, H.2
Foran, J.M.3
-
34
-
-
84875635430
-
Final results of a phase 2 Open-Label, monotherapy efficacy and safety study of quizartinib (ac220) in patients with FLT3-ITD Positive or Negative Relapsed/Refractory Acute Myeloid Leukemia After Second-Line Chemotherapy or Hematopoietic Stem Cell Transplantation [abstract]
-
Abstract 673
-
Levis MJ, Perl AE, Dombret H, et al. Final Results of a Phase 2 Open-Label, Monotherapy Efficacy and Safety Study of Quizartinib (AC220) in Patients with FLT3-ITD Positive or Negative Relapsed/Refractory Acute Myeloid Leukemia After Second-Line Chemotherapy or Hematopoietic Stem Cell Transplantation [abstract]. Blood. 2012;120(21). Abstract 673.
-
(2012)
Blood
, vol.120
, Issue.21
-
-
Levis, M.J.1
Perl, A.E.2
Dombret, H.3
-
35
-
-
84875592100
-
Final results of a phase 2 Open-Label, monotherapy efficacy and safety study of quizartinib (AC220) in Patients $ 60 Years of Age with FLT3 ITD Positive or negative relapsed/Refractory acute myeloid leukemia [abstract]
-
Abstract 48
-
Cortes JE, Perl AE, Dombret H, et al. Final Results of a Phase 2 Open-Label, Monotherapy Efficacy and Safety Study of Quizartinib (AC220) in Patients $ 60 Years of Age with FLT3 ITD Positive or Negative Relapsed/Refractory Acute Myeloid Leukemia [abstract]. Blood. 2012;120 (21). Abstract 48.
-
(2012)
Blood
, vol.120
, Issue.21
-
-
Cortes, J.E.1
Perl, A.E.2
Dombret, H.3
-
36
-
-
84989920288
-
Final results of a randomized phase 2 study showing the clinical benefit of quizartinib (AC220) in patients with FLT3-ITD positive relapsed or refractory acute myeloid leukemia [abstract]
-
Abstract 7100
-
Schiller GJ, Tallman MS, Goldberg SL, et al. Final results of a randomized phase 2 study showing the clinical benefit of quizartinib (AC220) in patients with FLT3-ITD positive relapsed or refractory acute myeloid leukemia [abstract]. J Clin Oncol. 2014;32(5s). Abstract 7100.
-
(2014)
J Clin Oncol
, vol.32
, Issue.5 S
-
-
Schiller, G.J.1
Tallman, M.S.2
Goldberg, S.L.3
-
37
-
-
84903768441
-
Treatment with FLT3 inhibitor in patients with FLT3-mutated acute myeloid leukemia is associated with development of secondary FLT3- Tyrosine kinase domain mutations
-
Alvarado Y, Kantarjian HM, Luthra R, et al. Treatment with FLT3 inhibitor in patients with FLT3-mutated acute myeloid leukemia is associated with development of secondary FLT3- Tyrosine kinase domain mutations. Cancer. 2014; 120(14):2142-2149.
-
(2014)
Cancer
, vol.120
, Issue.14
, pp. 2142-2149
-
-
Alvarado, Y.1
Kantarjian, H.M.2
Luthra, R.3
-
38
-
-
84878916655
-
The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD1 AML but retains in vitro sensitivity to PKC412 and Sunitinib
-
Albers C, Leischner H, Verbeek M, et al. The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD1 AML but retains in vitro sensitivity to PKC412 and Sunitinib. Leukemia. 2013;27(6):1416-1418.
-
(2013)
Leukemia
, vol.27
, Issue.6
, pp. 1416-1418
-
-
Albers, C.1
Leischner, H.2
Verbeek, M.3
-
39
-
-
84925604797
-
Results of a Phase II Study of Crenolanib in Relapsed/Refractory Acute Myeloid Leukemia Patients (Pts) with Activating FLT3 Mutations [abstract]
-
Abstract 389
-
Randhawa JK, Kantarjian HM, Borthakur G, et al. Results of a Phase II Study of Crenolanib in Relapsed/Refractory Acute Myeloid Leukemia Patients (Pts) with Activating FLT3 Mutations [abstract]. Blood. 2014;124(21). Abstract 389.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Randhawa, J.K.1
Kantarjian, H.M.2
Borthakur, G.3
-
40
-
-
84947937683
-
Results of a first-in-human, phase I/II trial of ASP2215, a selective, potent inhibitor of FLT3/Axl in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) [abstract]
-
Abstract 7003
-
Levis MJ, Perl AE, Altman JK, et al. Results of a first-in-human, phase I/II trial of ASP2215, a selective, potent inhibitor of FLT3/Axl in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) [abstract]. J Clin Oncol. 2015;33. Abstract 7003.
-
(2015)
J Clin Oncol
, vol.33
-
-
Levis, M.J.1
Perl, A.E.2
Altman, J.K.3
-
41
-
-
79960534917
-
The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
-
Green CL, Evans CM, Zhao L, et al. The prognostic significance of IDH2 mutations in AML depends on the location of the mutation. Blood. 2011;118(2):409-412.
-
(2011)
Blood
, vol.118
, Issue.2
, pp. 409-412
-
-
Green, C.L.1
Evans, C.M.2
Zhao, L.3
-
42
-
-
77955907891
-
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
-
Paschka P, Schlenk RF, Gaidzik VI, et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol. 2010;28(22):3636-3643.
-
(2010)
J Clin Oncol
, vol.28
, Issue.22
, pp. 3636-3643
-
-
Paschka, P.1
Schlenk, R.F.2
Gaidzik, V.I.3
-
43
-
-
77952536841
-
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
-
Marcucci G, Maharry K, Wu YZ, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study. J Clin Oncol. 2010;28(14): 2348-2355.
-
(2010)
J Clin Oncol
, vol.28
, Issue.14
, pp. 2348-2355
-
-
Marcucci, G.1
Maharry, K.2
Wu, Y.Z.3
-
44
-
-
80054035931
-
IDH1 and IDH2 mutations in pediatric acute leukemia
-
Andersson AK, Miller DW, Lynch JA, et al. IDH1 and IDH2 mutations in pediatric acute leukemia. Leukemia. 2011;25(10):1570-1577.
-
(2011)
Leukemia
, vol.25
, Issue.10
, pp. 1570-1577
-
-
Andersson, A.K.1
Miller, D.W.2
Lynch, J.A.3
-
45
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward PS, Patel J, Wise DR, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010;17(3): 225-234.
-
(2010)
Cancer Cell
, vol.17
, Issue.3
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
-
46
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010;18(6):553-567.
-
(2010)
Cancer, Cell
, vol.18
, Issue.6
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
-
47
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
Lu C, Ward PS, Kapoor GS, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 2012; 483(7390):474-478.
-
(2012)
Nature
, vol.483
, Issue.7390
, pp. 474-478
-
-
Lu, C.1
Ward, P.S.2
Kapoor, G.S.3
-
48
-
-
84955457435
-
-
DiNardo C, Stein EM, Altman JK, et al. AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant enzyme, induced durable responses in a phase 1 study of IDH2 mutationpositive advanced hematologic malignancies. 2015.
-
(2015)
AG-221, An Oral, Selective, First-in-class, Potent Inhibitor of the IDH2 Mutant Enzyme, Induced Durable Responses in a Phase 1 Study of IDH2 Mutationpositive Advanced Hematologic Malignancies
-
-
DiNardo, C.1
Stein, E.M.2
Altman, J.K.3
-
49
-
-
0141816710
-
AML with 11q23/MLL abnormalities as defined by the WHO classification: Incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases
-
Schoch C, Schnittger S, Klaus M, Kern W, Hiddemann W, Haferlach T. AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases. Blood. 2003;102(7):2395-2402.
-
(2003)
Blood
, vol.102
, Issue.7
, pp. 2395-2402
-
-
Schoch, C.1
Schnittger, S.2
Klaus, M.3
Kern, W.4
Hiddemann, W.5
Haferlach, T.6
-
50
-
-
79960044951
-
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
-
Bernt KM, Zhu N, Sinha AU, et al. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell. 2011;20(1):66-78.
-
(2011)
Cancer Cell
, vol.20
, Issue.1
, pp. 66-78
-
-
Bernt, K.M.1
Zhu, N.2
Sinha, A.U.3
-
51
-
-
84878383491
-
Leukemic transformation by the MLL-AF6 fusion oncogene. Requires the H3K79 methyltransferase Dot1l
-
Deshpande AJ, Chen L, Fazio M, et al. Leukemic transformation by the MLL-AF6 fusion oncogene. requires the H3K79 methyltransferase Dot1l. Blood. 2013;121(13):2533-2541.
-
(2013)
Blood
, vol.121
, Issue.13
, pp. 2533-2541
-
-
Deshpande, A.J.1
Chen, L.2
Fazio, M.3
-
52
-
-
84876143288
-
Abrogation of MLL-AF10 and CALM-AF10- mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l
-
Chen L, Deshpande AJ, Banka D, et al. Abrogation of MLL-AF10 and CALM-AF10- mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013;27(4):813-822.
-
(2013)
Leukemia
, vol.27
, Issue.4
, pp. 813-822
-
-
Chen, L.1
Deshpande, A.J.2
Banka, D.3
-
53
-
-
84926628784
-
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLLrearranged leukemia
-
Chen CW, Koche RP, Sinha AU, et al. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLLrearranged leukemia. Nat Med. 2015;21(4):335-343.
-
(2015)
Nat Med
, vol.21
, Issue.4
, pp. 335-343
-
-
Chen, C.W.1
Koche, R.P.2
Sinha, A.U.3
-
54
-
-
84929100337
-
MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition
-
Kuhn MW, Hadler MJ, Daigle SR, et al. MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition. Haematologica. 2015;100(5):e190-e193.
-
(2015)
Haematologica
, vol.100
, Issue.5
, pp. e190-e193
-
-
Kuhn, M.W.1
Hadler, M.J.2
Daigle, S.R.3
-
55
-
-
79960058024
-
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
-
Daigle SR, Olhava EJ, Therkelsen CA, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011;20(1):53-65.
-
(2011)
Cancer Cell
, vol.20
, Issue.1
, pp. 53-65
-
-
Daigle, S.R.1
Olhava, E.J.2
Therkelsen, C.A.3
-
56
-
-
84886864184
-
Potent inhibition of DOT1L as treatment of MLLfusion leukemia
-
Daigle SR, Olhava EJ, Therkelsen CA, et al. Potent inhibition of DOT1L as treatment of MLLfusion leukemia. Blood. 2013;122(6):1017-1025.
-
(2013)
Blood
, vol.122
, Issue.6
, pp. 1017-1025
-
-
Daigle, S.R.1
Olhava, E.J.2
Therkelsen, C.A.3
-
57
-
-
84923222497
-
The DOT1L Inhibitor EPZ-5676: Safety and Activity in Relapsed/Refractory Patients with MLLRearranged Leukemia [abstract]
-
Abstract 387
-
Stein EM, Garcia-Manero G, Rizzieri DA, et al. The DOT1L Inhibitor EPZ-5676: Safety and Activity in Relapsed/Refractory Patients with MLLRearranged Leukemia [abstract]. Blood. 2014;124 (21). Abstract 387.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Stein, E.M.1
Garcia-Manero, G.2
Rizzieri, D.A.3
-
58
-
-
84928333417
-
A Phase 2 Study of ABT-199 (GDC-0199) in Patients with Acute Myelogenous Leukemia (AML) [abstract]
-
Abstract 118
-
Konopleva M, Pollyea DA, Potluri J, et al. A Phase 2 Study of ABT-199 (GDC-0199) in Patients with Acute Myelogenous Leukemia (AML) [abstract]. Blood. 2014;124(21). Abstract 118.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Konopleva, M.1
Pollyea, D.A.2
Potluri, J.3
-
59
-
-
84922652321
-
Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
-
Chan SM, Thomas D, Corces-Zimmerman MR, et al. Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. Nat Med. 2015;21(2):178-184.
-
(2015)
Nat Med.
, vol.21
, Issue.2
, pp. 178-184
-
-
Chan, S.M.1
Thomas, D.2
Corces-Zimmerman, M.R.3
-
60
-
-
80055000824
-
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
-
Zuber J, Shi J, Wang E, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011;478(7370):524-528.
-
(2011)
Nature
, vol.478
, Issue.7370
, pp. 524-528
-
-
Zuber, J.1
Shi, J.2
Wang, E.3
-
61
-
-
80052595172
-
Short hairpin RNA screen reveals bromodomain proteins as novel targets in acute myeloid leukemia
-
Blobel GA, Kalota A, Sanchez PV, Carroll M. Short hairpin RNA screen reveals bromodomain proteins as novel targets in acute myeloid leukemia. Cancer Cell. 2011; 20(3):287-288.
-
(2011)
Cancer Cell
, vol.20
, Issue.3
, pp. 287-288
-
-
Blobel, G.A.1
Kalota, A.2
Sanchez, P.V.3
Carroll, M.4
-
62
-
-
80054984945
-
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
-
Dawson MA, Prinjha RK, Dittmann A, et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011;478(7370): 529-533.
-
(2011)
Nature
, vol.478
, Issue.7370
, pp. 529-533
-
-
Dawson, M.A.1
Prinjha, R.K.2
Dittmann, A.3
-
63
-
-
84966527823
-
A Phase 1 Study of the BET-Bromodomain Inhibitor OTX015 in Patients with Advanced Acute Leukemia [abstract]
-
Abstract 117
-
Dombret H, Preudhomme C, Berthon C, et al. A Phase 1 Study of the BET-Bromodomain Inhibitor OTX015 in Patients with Advanced Acute Leukemia [abstract]. Blood. 2014;124(21). Abstract 117.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Dombret, H.1
Preudhomme, C.2
Berthon, C.3
-
64
-
-
84869458541
-
Boulevard of broken dreams: Drug approval for older adults with acute myeloid leukemia
-
Sekeres MA, Steensma DP. Boulevard of broken dreams: drug approval for older adults with acute myeloid leukemia. J Clin Oncol. 2012;30(33): 4061-4063.
-
(2012)
J Clin Oncol
, vol.30
, Issue.33
, pp. 4061-4063
-
-
Sekeres, M.A.1
Steensma, D.P.2
|