The prognostic value of multilineage dysplasia in de novo acute myeloid leukemia patients with intermediate-risk cytogenetics is dependent on NPM1 mutational status

Blood

Volumn 116, Issue 26, 2010, Pages 6147-6148

  Díaz Beyá, Marina ^a   Rozman, María ^a   Pratcorona, Marta ^a   Torrebadell, Montserrat ^a   Camós, Mireia ^a   Aguilar, Josep LL ^a   Esteve, Jordi ^a  

^a HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; NUCLEOPHOSMIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; CANCER CHEMOTHERAPY; CANCER PATIENT; CELL INFILTRATION; COHORT ANALYSIS; CONFIDENCE INTERVAL; CYTOGENETICS; DYSPLASIA; EPIGENETICS; FEMALE; GENE DUPLICATION; GENE MUTATION; GENETIC MARKER; HUMAN; KARYOTYPE; LETTER; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR; SURVIVAL; TREATMENT OUTCOME;

EID: 78650676071     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-09-307314     Document Type: Letter

References (6)

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2. Arber DA, Stein AS, Carter NH, Ikle D, Forman SJ, Slovak ML. Prognostic impact of acute myeloid leukemia classification. Importance of detection of recurring cytogenetic abnormalities and multilineage dysplasia on survival. Am J Clin Pathol. 2003;119(5):672-680.
3. Wandt H, Schakel U, Kroschinsky F, et al. MLD according to the WHO classification in AML has no correlation with age and no independent prognostic relevance as analyzed in 1766 patients. Blood. 2008;111(4):1855-1861.
4. Weinberg OK, Seetharam M, Ren L, et al. Clinical characterization of acute myeloid leukemia with myelodysplasia-related changes as defined by the 2008 WHO classification system. Blood. 2009;113(9):1906-1908.
5. Falini B, Macijewski K, Weiss T, et al. Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1). Blood. 2010;115(18):3776-3785.
6. Arber DA, Brunning RD, Orazi A, et al. Acute myeloid leukemia with myelodysplasic-related changes. In: Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. Lyon, France: International Agency for Research on Cancer (IARC); 2008:124-126.