메뉴 건너뛰기




Volumn 7, Issue , 2017, Pages

Immature mice are more susceptible than adult mice to acetaminophen-induced acute liver injury

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; CYP3A11 PROTEIN, MOUSE; CYTOCHROME P-450 2E1, MOUSE; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; GLUTATHIONE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MEMBRANE PROTEIN; PARACETAMOL; RALBP1 PROTEIN, MOUSE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, MOUSE;

EID: 85012960871     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep42736     Document Type: Article
Times cited : (17)

References (45)
  • 1
    • 84940580142 scopus 로고    scopus 로고
    • Translational biomarkers of acetaminophen-induced acute liver injury
    • Beger, R. D. et al. Translational biomarkers of acetaminophen-induced acute liver injury. Arch. Toxicol. 89, 1497-1522 (2015).
    • (2015) Arch. Toxicol. , vol.89 , pp. 1497-1522
    • Beger, R.D.1
  • 2
    • 84855892790 scopus 로고    scopus 로고
    • Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity
    • Jaeschke, H., McGill, M. R. & Ramachandran, A. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab. Rev. 44, 88-106 (2012).
    • (2012) Drug Metab. Rev. , vol.44 , pp. 88-106
    • Jaeschke, H.1    McGill, M.R.2    Ramachandran, A.3
  • 3
    • 84949524307 scopus 로고    scopus 로고
    • Experimental models of hepatotoxicity related to acute liver failure
    • Maes, M., Vinken, M. & Jaeschke, H. Experimental models of hepatotoxicity related to acute liver failure. Toxicol. Appl. Pharmacol. 290, 86-97 (2016).
    • (2016) Toxicol. Appl. Pharmacol. , vol.290 , pp. 86-97
    • Maes, M.1    Vinken, M.2    Jaeschke, H.3
  • 4
    • 0031949068 scopus 로고    scopus 로고
    • Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6
    • Chen, W. et al. Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6. Chem. Res. Toxicol. 11, 295-301 (1998).
    • (1998) Chem. Res. Toxicol. , vol.11 , pp. 295-301
    • Chen, W.1
  • 5
    • 84941807061 scopus 로고    scopus 로고
    • Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures
    • Hartman, J. H. et al. Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures. Biochem. Pharmacol. 97, 341-349 (2015).
    • (2015) Biochem. Pharmacol. , vol.97 , pp. 341-349
    • Hartman, J.H.1
  • 6
    • 0031765730 scopus 로고    scopus 로고
    • Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice
    • Zaher, H. et al. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. Toxicol. Appl. Pharmacol. 152, 193-199 (1998).
    • (1998) Toxicol. Appl. Pharmacol. , vol.152 , pp. 193-199
    • Zaher, H.1
  • 7
    • 0005590750 scopus 로고    scopus 로고
    • Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation
    • Manyike, P. T., Kharasch, E. D., Kalhorn, T. F. & Slattery, J. T. Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. Clin. Pharmacol. Ther. 67, 275-282 (2000).
    • (2000) Clin. Pharmacol. Ther. , vol.67 , pp. 275-282
    • Manyike, P.T.1    Kharasch, E.D.2    Kalhorn, T.F.3    Slattery, J.T.4
  • 8
    • 10044229222 scopus 로고    scopus 로고
    • Enhanced acetaminophen toxicity by activation of the pregnane X receptor
    • Guo, G. L. et al. Enhanced acetaminophen toxicity by activation of the pregnane X receptor. Toxicol. Sci. 82,374-380 (2004).
    • (2004) Toxicol. Sci. , vol.82 , pp. 374-380
    • Guo, G.L.1
  • 9
    • 61649089975 scopus 로고    scopus 로고
    • Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
    • Laine, J. E., Auriola, S., Pasanen, M. & Juvonen, R. O. Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica. 39, 11-21 (2009).
    • (2009) Xenobiotica. , vol.39 , pp. 11-21
    • Laine, J.E.1    Auriola, S.2    Pasanen, M.3    Juvonen, R.O.4
  • 10
    • 0027253615 scopus 로고
    • Oxidation of acetaminophen to N-acetyl-paminobenzoquinone imine by human CYP3A4
    • Thummel, K. E., Lee, C. A., Kunze, K. L., Nelson, S. D. & Slattery, J. T. Oxidation of acetaminophen to N-acetyl-paminobenzoquinone imine by human CYP3A4. Biochem. Pharmacol. 45, 1563-1569 (1993).
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 1563-1569
    • Thummel, K.E.1    Lee, C.A.2    Kunze, K.L.3    Nelson, S.D.4    Slattery, J.T.5
  • 11
    • 33745758229 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity
    • Gunawan, B. K. et al. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology 131, 165-178 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 165-178
    • Gunawan, B.K.1
  • 12
    • 33847750361 scopus 로고    scopus 로고
    • Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury
    • Latchoumycandane, C., Goh, C. W., Ong, M. M. & Boelsterli, U. A. Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury. Hepatology 45, 412-421 (2007).
    • (2007) Hepatology , vol.45 , pp. 412-421
    • Latchoumycandane, C.1    Goh, C.W.2    Ong, M.M.3    Boelsterli, U.A.4
  • 13
    • 33749617086 scopus 로고    scopus 로고
    • Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury
    • Bajt, M. L., Cover, C., Lemasters, J. J. & Jaeschke, H. Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol. Sci. 94, 217-225 (2006).
    • (2006) Toxicol. Sci. , vol.94 , pp. 217-225
    • Bajt, M.L.1    Cover, C.2    Lemasters, J.J.3    Jaeschke, H.4
  • 14
    • 80051704387 scopus 로고    scopus 로고
    • Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity
    • Bajt, M. L. et al. Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity. Toxicol. Sci. 122, 598-605 (2011).
    • (2011) Toxicol. Sci. , vol.122 , pp. 598-605
    • Bajt, M.L.1
  • 15
    • 84970916712 scopus 로고    scopus 로고
    • Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury
    • Deutsch, M. et al. Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. Cell Death Dis. 6, e1759 (2015).
    • (2015) Cell Death Dis. , vol.6 , pp. e1759
    • Deutsch, M.1
  • 16
    • 84946778740 scopus 로고    scopus 로고
    • Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis
    • Dara, L. et al. Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology 62, 1847-1857 (2015).
    • (2015) Hepatology , vol.62 , pp. 1847-1857
    • Dara, L.1
  • 17
    • 84893653487 scopus 로고    scopus 로고
    • Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice
    • Zhang, Y. F. et al. Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice. Toxicol. Lett. 225, 445-453 (2014).
    • (2014) Toxicol. Lett. , vol.225 , pp. 445-453
    • Zhang, Y.F.1
  • 18
    • 84888296794 scopus 로고    scopus 로고
    • Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice
    • Ramachandran, A. et al. Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology. 58, 2099-2108 (2013).
    • (2013) Hepatology. , vol.58 , pp. 2099-2108
    • Ramachandran, A.1
  • 19
    • 84897026317 scopus 로고    scopus 로고
    • Paracetamol: A focus for the general pediatrician
    • Marzuillo, P., Guarino, S. & Barbi, E. Paracetamol: a focus for the general pediatrician. Eur. J. Pediatr. 173, 415-425 (2014).
    • (2014) Eur. J. Pediatr. , vol.173 , pp. 415-425
    • Marzuillo, P.1    Guarino, S.2    Barbi, E.3
  • 20
    • 80053024755 scopus 로고    scopus 로고
    • Assessment of the clinical use of intravenous and oral N-acetylcysteine in the treatment of acute acetaminophen poisoning in children: A retrospective review
    • Blackford, M. G., Felter, T., Gothard, M. D. & Reed, M. D. Assessment of the clinical use of intravenous and oral N-acetylcysteine in the treatment of acute acetaminophen poisoning in children: a retrospective review. Clin. Ther. 33, 1322-1330 (2011).
    • (2011) Clin. Ther. , vol.33 , pp. 1322-1330
    • Blackford, M.G.1    Felter, T.2    Gothard, M.D.3    Reed, M.D.4
  • 21
    • 84874618565 scopus 로고    scopus 로고
    • Chronic acetaminophen exposure in pediatric acute liver failure
    • Leonis, M. A. et al. Chronic acetaminophen exposure in pediatric acute liver failure. Pediatrics 131, e740-746 (2013).
    • (2013) Pediatrics , vol.131 , pp. e740-e746
    • Leonis, M.A.1
  • 23
    • 33646946176 scopus 로고    scopus 로고
    • Acute liver failure in children: The first. 348 patients in the pediatric acute liver failure study group
    • Squires, R. H. Jr. et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J. Pediatr. 148, 652-658 (2006).
    • (2006) J. Pediatr. , vol.148 , pp. 652-658
    • Squires, R.H.1
  • 24
    • 79551568441 scopus 로고    scopus 로고
    • Fulminant hepatitis after 10 days of acetaminophen treatment at recommended dosage in an infant
    • Savino, F. et al. Fulminant hepatitis after 10 days of acetaminophen treatment at recommended dosage in an infant. Pediatrics 127, e494-497 (2011).
    • (2011) Pediatrics , vol.127 , pp. e494-e497
    • Savino, F.1
  • 25
    • 84899023191 scopus 로고    scopus 로고
    • The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats
    • Mach. J. et al. The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats. J. Gerontol. A Biol. Sci. Med. Sci. 69, 387-397 (2014).
    • (2014) J. Gerontol. A Biol. Sci. Med. Sci. , vol.69 , pp. 387-397
    • Mach, J.1
  • 26
    • 46649084880 scopus 로고    scopus 로고
    • Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminopheninduced liver injury
    • Hanawa, N. et al. Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminopheninduced liver injury. J. Biol. Chem. 283, 13565-13577 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 13565-13577
    • Hanawa, N.1
  • 27
    • 85028256263 scopus 로고    scopus 로고
    • The end of RIPK1-RIPK3-MLKL-mediated necroptosis in acetaminophen-induced hepatotoxicity
    • Yang, X., Chao, X., Wang, Z. T. & Ding, W. X. The end of RIPK1-RIPK3-MLKL-mediated necroptosis in acetaminophen-induced hepatotoxicity Hepatology 64, 311-312 (2016).
    • (2016) Hepatology , vol.64 , pp. 311-312
    • Yang, X.1    Chao, X.2    Wang, Z.T.3    Ding, W.X.4
  • 28
    • 84952361801 scopus 로고    scopus 로고
    • Receptor interacting protein kinase 1 (RIPK1) in hepatocytes does not mediate murine acetaminophen toxicity
    • Schneider, A. T., Gautheron, J., Tacke, F., Vucur, M. & Luedde, T. Receptor interacting protein kinase 1 (RIPK1) in hepatocytes does not mediate murine acetaminophen toxicity. Hepatology 64, 306-308 (2016).
    • (2016) Hepatology , vol.64 , pp. 306-308
    • Schneider, A.T.1    Gautheron, J.2    Tacke, F.3    Vucur, M.4    Luedde, T.5
  • 29
    • 84929455988 scopus 로고    scopus 로고
    • Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity
    • Coen, M. Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity. Drug Metab. Rev. 47, 29-44 (2015).
    • (2015) Drug Metab. Rev. , vol.47 , pp. 29-44
    • Coen, M.1
  • 30
    • 7544222053 scopus 로고    scopus 로고
    • Acetaminophen-induced hepatotoxicity: Role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition
    • Hinson, J. A., Reid, A. B., McCullough, S. S. & James, L. P. Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition. Drug Metab. Rev. 36, 805-822 (2004).
    • (2004) Drug Metab. Rev. , vol.36 , pp. 805-822
    • Hinson, J.A.1    Reid, A.B.2    McCullough, S.S.3    James, L.P.4
  • 31
    • 84883295568 scopus 로고    scopus 로고
    • Metabolism and disposition of acetaminophen: Recent advances in relation to hepatotoxicity and diagnosis
    • McGill, M. R. & Jaeschke, H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm. Res. 30, 2174-2187 (2013).
    • (2013) Pharm. Res. , vol.30 , pp. 2174-2187
    • McGill, M.R.1    Jaeschke, H.2
  • 32
    • 1542376929 scopus 로고    scopus 로고
    • Glutathione metabolism and its implications for health
    • Wu, G., Fang, Y. Z., Yang, S., Lupton, J. R. & Turner, N. D. Glutathione metabolism and its implications for health. J. Nutr. 134, 489-492 (2004).
    • (2004) J. Nutr. , vol.134 , pp. 489-492
    • Wu, G.1    Fang, Y.Z.2    Yang, S.3    Lupton, J.R.4    Turner, N.D.5
  • 33
    • 70350202531 scopus 로고    scopus 로고
    • Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity
    • Abdelmegeed, M. A., Moon, K. H., Chen, C., Gonzalez, F. J. & Song, B. J. Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity. Biochem. Pharmacol. 79, 57-66 (2010).
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 57-66
    • Abdelmegeed, M.A.1    Moon, K.H.2    Chen, C.3    Gonzalez, F.J.4    Song, B.J.5
  • 34
    • 0031047586 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: Hepatoprotective effects
    • Kim, N. D., Kwak, M. K. & Kim, S. G. Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: hepatoprotective effects. Biochem. Pharmacol. 53, 261-269 (1997).
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 261-269
    • Kim, N.D.1    Kwak, M.K.2    Kim, S.G.3
  • 35
    • 0031172563 scopus 로고    scopus 로고
    • Effects of phenethyl isothiocyanate on acetaminophen metabolism and hepatotoxicity in mice
    • Li, Y. et al. Effects of phenethyl isothiocyanate on acetaminophen metabolism and hepatotoxicity in mice. Toxicol. Appl. Pharmacol. 144, 306-314 (1997).
    • (1997) Toxicol. Appl. Pharmacol. , vol.144 , pp. 306-314
    • Li, Y.1
  • 36
    • 0030030355 scopus 로고    scopus 로고
    • Protective effects of garlic and related organosulfur compounds on acetaminophen-induced hepatotoxicity in mice
    • Wang, E. J. et al. Protective effects of garlic and related organosulfur compounds on acetaminophen-induced hepatotoxicity in mice. Toxicol. Appl. Pharmacol. 136, 146-154 (1996).
    • (1996) Toxicol. Appl. Pharmacol. , vol.136 , pp. 146-154
    • Wang, E.J.1
  • 37
    • 0032525015 scopus 로고    scopus 로고
    • Alcohol-mediated increases in acetaminophen hepatotoxicity: Role of CYP2E and CYP3A
    • Sinclair, J. et al. Alcohol-mediated increases in acetaminophen hepatotoxicity: role of CYP2E and CYP3A. Biochem. Pharmacol. 55, 1557-1565 (1998).
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 1557-1565
    • Sinclair, J.1
  • 38
    • 0034047262 scopus 로고    scopus 로고
    • Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults
    • Thummel, K. E. et al. Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults. Clin. Pharmacol. Ther. 67, 591-599 (2000).
    • (2000) Clin. Pharmacol. Ther. , vol.67 , pp. 591-599
    • Thummel, K.E.1
  • 39
    • 34250785095 scopus 로고    scopus 로고
    • Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: Comparison of wildtype and Cyp2e1(-/-) mice
    • Wolf, K. K. et al. Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wildtype and Cyp2e1(-/-) mice. Drug Metab. Dispos. 35, 1223-1231 (2007).
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 1223-1231
    • Wolf, K.K.1
  • 40
    • 84908340821 scopus 로고    scopus 로고
    • Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase
    • Du, K., Williams, C. D., McGill, M. R. & Jaeschke, H. Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase. Toxicol. Appl. Pharmacol. 281, 58-66 (2014).
    • (2014) Toxicol. Appl. Pharmacol. , vol.281 , pp. 58-66
    • Du, K.1    Williams, C.D.2    McGill, M.R.3    Jaeschke, H.4
  • 41
    • 0022272493 scopus 로고
    • Determination of glutathione and glutathione disulfide in biological samples
    • Anderson, M. E. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113, 548-555 (1985).
    • (1985) Methods Enzymol. , vol.113 , pp. 548-555
    • Anderson, M.E.1
  • 42
    • 84859808073 scopus 로고    scopus 로고
    • Exon skipping quantification by real-time PCR
    • Ferlini, A. & Rimessi, P. Exon skipping quantification by real-time PCR. Methods Mol. Biol. 867, 189-199 (2012).
    • (2012) Methods Mol. Biol. , vol.867 , pp. 189-199
    • Ferlini, A.1    Rimessi, P.2
  • 43
    • 34247217272 scopus 로고    scopus 로고
    • Real-time quantitative PCR as an alternative to Southern blot or fluorescence in situ hybridization for detection of gene copy number changes
    • Hoebeeck, J., Speleman, F. & Vandesompele, J. Real-time quantitative PCR as an alternative to Southern blot or fluorescence in situ hybridization for detection of gene copy number changes. Methods Mol. Biol. 353, 205-226 (2007).
    • (2007) Methods Mol. Biol. , vol.353 , pp. 205-226
    • Hoebeeck, J.1    Speleman, F.2    Vandesompele, J.3
  • 44
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
    • Paglia, D. E. & Valentine, W. N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70, 158-169 (1967).
    • (1967) J. Lab. Clin. Med. , vol.70 , pp. 158-169
    • Paglia, D.E.1    Valentine, W.N.2
  • 45
    • 0019741605 scopus 로고
    • Assays for differentiation of glutathione S-transferases
    • Habig, W. H. & Jakoby, W. B. Assays for differentiation of glutathione S-transferases. Methods Enzymol. 77, 398-405 (1981).
    • (1981) Methods Enzymol. , vol.77 , pp. 398-405
    • Habig, W.H.1    Jakoby, W.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.