Receptor interacting protein kinase 1 (RIPK1) in hepatocytes does not mediate murine acetaminophen toxicity

Hepatology

Volumn 64, Issue 1, 2016, Pages 306-308

  Schneider, Anne T ^a   Gautheron, Jérémie ^a   Tacke, Frank ^a   Vucur, Mihael ^a   Luedde, Tom ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; LIVER EXTRACT; PARACETAMOL; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN KINASE 1; UNCLASSIFIED DRUG; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE;

ACUTE TOXICITY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; GENE EXPRESSION; GENE LOSS; LETTER; LIVER CELL; LIVER CELL CULTURE; LIVER TOXICITY; MACROPHAGE; MONOCYTE; NECROPTOSIS; NONHUMAN; PRIMARY CELL CULTURE; PRIORITY JOURNAL; PROTEIN PROCESSING; T LYMPHOCYTE; WESTERN BLOTTING; ANIMAL; HUMAN; MOUSE;

ACETAMINOPHEN; ANIMALS; HEPATOCYTES; HUMANS; MICE; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES;

EID: 84952361801     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.28225     Document Type: Letter

References (5)

1. Luedde T, Kaplowitz N, Schwabe RF. Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology 2014;147:765-783.e4.
2. Dara L, Johnson H, Suda J, Win S, Gaarde W, Han D, Kaplowitz N. Receptor Interacting protein kinase-1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology 2015;62:1847-1857.
3. Taylor MF, Paulauskis JD, Weller DD, Kobzik L. Comparison of efficacy of antisense oligomers directed toward TNF-alpha in helper T and macrophage cell lines. Cytokine 1997;9:672-681.
4. Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, et al. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A 2014;111:7391-7396.
5. Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, et al. Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure. FEBS Open Bio 2014;4:777-787.