Fulminant hepatitis after 10 days of acetaminophen treatment at recommended dosage in an infant

Pediatrics

Volumn 127, Issue 2, 2011, Pages

  Savino, Francesco ^a   Lupica, Maria Maddalena ^a   Tarasco, Valentina ^a   Locatelli, Emanuela ^a   Garazzino, Silvia ^a   Tovo, Pier Angelo ^a  

^a REGINA MARGHERITA CHILDREN S HOSPITAL   (Italy)

Author keywords

Acetaminophen; Hepatic failure; Infant; Toxicity

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; PARACETAMOL;

ACUTE LIVER FAILURE; ARTICLE; BRAIN DISEASE; CASE REPORT; DRUG BLOOD LEVEL; FEVER; HUMAN; INFANT; LABORATORY TEST; MALE; PRIORITY JOURNAL; THORAX RADIOGRAPHY;

ACETAMINOPHEN; DRUG ADMINISTRATION SCHEDULE; HEPATITIS; HUMANS; INFANT; LIVER FAILURE, ACUTE; MALE; TIME FACTORS; TREATMENT OUTCOME;

EID: 79551568441     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2010-1965     Document Type: Article

References (28)

1. American Academy of Pediatrics, Committee on Drugs. Acetaminophen toxicity in children. Pediatrics. 2001;108(4):1020-1024
2. Proudfoot AT, Wright N. Acute paracetamol poisoning. BMJ. 1970;3(5722):557-558
3. Muñiz AE, Rose SR 2nd, Liner SR, Foster RL. Unsuspected acetaminophen toxicity in a 58-day-old infant. Pediatr Emerg Care. 2004;20(12):824-828
4. Kozer E, Greenberg R, Zimmerman DR, Berkovitch M. Repeated supratherapeutic doses of paracetamol in children: a literature review and suggested clinical approach. Acta Paediatr. 2006;95(10):1165-1171 (Pubitemid 44423177)
5. Dart RC, Bailey E. Does therapeutic use of acetaminophen cause acute liver failure? Pharmacotherapy. 2007;27(9):1219-1230
6. Lesko SM, Mitchell AA. The safety of acetaminophen and ibuprofen among children younger than two years old. Pediatrics. 1999;104(4). Available at: www.pediatrics. org/cgi/content/full/104/4/e39
7. Alander SW, Dowd MD, Bratton SL, et al. Pediatric acetaminophen overdose: risk factors associated with hepatocellular injury. Arch Pediatr Adolesc Med. 2000;154(4):346-350
8. Frank OR, Coulthard KP. Paracetamol for fever in children. Aust Fam Physician. 1988;17(9):771
9. van Lingen RA, Deinum HT, Quak CME. Multiple-dose pharmacokinetics of rectally administered acetaminophen in term infants. Clin Pharmacol Ther. 1999;66(5):509-515
10. US Food and Drug Administration. June 29 -30, 2009: joint meeting of the Drug Safety and Risk Management Advisory Committee with the Anesthetic and Life Support Drugs Advisory Committee and the Nonprescription Drugs Advisory Committee - meeting announcement. Available at: www. fda.gov/advisorycommittees/ calendar/ ucm143083.htm. Accessed December 16, 2010
11. Nahata MC, Powell DA, Durrell DE, Miller MA. Acetaminophen accumulation in pediatric patients after repeated therapeutic doses. Eur J Clin Pharmacol. 1984;27(1):57-59
12. Heubi JE, Barbacci MB, Zimmerman HJ. Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children. J Pediatr. 1998;132(1):22-27
13. Mitchell JR, Thorgeirsson SS, Potter WZ, Jollow DJ, Keiser H. Acetaminophen induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clin Pharmacol Ther. 1974;16(4):676-684
14. Davis M, Simmons CJ, Harrison NG, Williams R. Paracetamol overdose in man: relationship between pattern of urinary metabolites and severity of liver damage. Q J Med. 1976;45(178):181-191
15. Clements JA, Critchley JA, Prescott LG. The role of sulphate conjugation in the metabolism and disposition of oral and intravenous paracetamol in man. Br J Clin Pharmacol. 1984;18(4):481-485
16. Hendrix-Treacy S, Wallace SM, Hindmarsh KW, Wyant GM, Danilkewich A. The effect of acetaminophen administration on its disposition and body stores of sulphate. Eur J Clin Pharmacol. 1986;30(3):273-278
17. Chen W, Koenigs LL, Thompson SJ, et al. Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6. Chem Res Toxicol. 1998;11(4):295-301
18. Tang W. Drug metabolite profiling and elucidation of drug-induced hepatotoxicity. Expert Opin Drug Metab Toxicol. 2007;3(3):407-420
19. Liu ZX, Kaplowitz N. Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol. 2006;2(4):493-503
20. de Wildt SN, Kearns GL, Leeder JS, van den Anker JN. Glucuronidation in humans: pharmacogenetic and developmental aspects. Clin Pharmacokinet. 1999;36(6):439-452
21. Critchley JA, Nimmo GR, Gregson CA, Wool-house NM, Prescott LF. Inter-subject and ethnic differences in paracetamol metabolism. Br J Clin Pharmacol. 1986;22(6):649-657
22. Ueshima Y, Tsutsumi M, Takase S, Matsuda Y, Kawahara H. Acetaminophen metabolism in patients with different cytochromeP450 2E1 genotypes. Alcohol Clin Exp Res. 1996;20(1 suppl):25A-28A
23. Spielberg SP. Acetaminophen toxicity in lymphocytes heterozygous for glutathione synthetase deficiency. Can J Physiol Pharmacol. 1985;63(5):468-471
24. Rumack BH. Acetaminophen overdose? A quick answer. J Pediatr. 1999;135(3):269-270
25. Rumack BH, Peterson RC, Koch GG, Amara IA. Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med. 1981;141(3 spec No.):380-385
26. Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose: analysis of the national multicenter study (1976-1985). N Engl J Med. 1988;319(24):1557-1562
27. Keays R, Harrison PM, Wendon JA, et al. Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ. 1991;303(6809):1026-1029
28. Prescott LF, Illingworth RN, Critchley JA, Stewart MJ, Adam RD, Proudfoot AT. Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning. Br Med J. 1979;2(6198):1097-1100