Alcohol-mediated increases in acetaminophen hepatotoxicity: Role of CYP2E and CYP3A

Biochemical Pharmacology

Volumn 55, Issue 10, 1998, Pages 1557-1565

  Sinclair, J ^a   Jeffery, E ^a   Wrighton, S ^a   Kostrubsky, V ^a   Szakacs, J ^a   Wood, S ^a   Sinclair, P ^a  

^a VA MEDICAL CENTER   (United States)

Author keywords

Acetaminophen; Alcohol; CYP2E; CYP3A; Hepatotoxicity

Indexed keywords

ALCOHOL; CYP2E; CYTOCHROME P450; CYTOCHROME P450 3A; CYTOCHROME P450 INHIBITOR; DRUG METABOLITE; ISOPENTYL ALCOHOL; PARACETAMOL; TROLEANDOMYCIN; UNCLASSIFIED DRUG;

DRUG ACTIVATION; DRUG ACTIVITY; DRUG BINDING; DRUG EXPOSURE; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG METABOLISM; DRUG SPECIFICITY; DRUG TRANSFORMATION; ENZYME INDUCTION; LIVER TOXICITY; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW;

EID: 0032525015     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00656-4     Document Type: Note

References (98)