Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity

Biochemical Pharmacology

Volumn 79, Issue 1, 2010, Pages 57-66

  Abdelmegeed, Mohamed A ^a   Moon, Kwan Hoon ^a   Chen, Chi ^b   Gonzalez, Frank J ^b   Song, Byoung Joon ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Acetaminophen; CYP2E1; Liver toxicity; Nitrotyrosine; Superoxide dismutase; Ubiquitin

Indexed keywords

3 NITROTYROSINE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME P450 2E1; MALONALDEHYDE; NITRIC OXIDE SYNTHASE; PARACETAMOL; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG TRANSFORMATION; ENZYME ACTIVATION; FEMALE; HALF LIFE TIME; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIVER NECROSIS; LIVER TOXICITY; MALE; MOUSE; NITRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TIME; UBIQUITINATION; WILD TYPE;

ACETAMINOPHEN; ANIMALS; CYTOCHROME P-450 CYP2E1; FEMALE; MALE; MICE; MICE, KNOCKOUT; NITRATES; PROTEINS; UBIQUITIN;

EID: 70350202531     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.07.016     Document Type: Article

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