Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype

PLoS Pathogens

Volumn 13, Issue 1, 2017, Pages

  Kong, Fanping ^a,b   Saldarriaga, Omar A ^b   Spratt, Heidi ^a,b   Osorio, E Yaneth ^b   Travi, Bruno L ^b   Luxon, Bruce A ^a,b   Melby, Peter C ^b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE 1; CD68 ANTIGEN; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; ENDOTOXIN; EOTAXIN; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 2; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTOME; CYTOKINE; NITRIC OXIDE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOBLOTTING; INFLAMMATION; MACROPHAGE; MACROPHAGE ACTIVATION; MACROPHAGE CULTURE; MOLECULAR LIBRARY; NONHUMAN; PARASITE GROWTH; PARASITE LOAD; PARASITE PHENOMENA AND FUNCTIONS; PHENOTYPE; POLARIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; RNA SEQUENCE; SIGNAL TRANSDUCTION; SPLEEN CELL; SPLEEN DISEASE; SYRIAN HAMSTER; UPREGULATION; VISCERAL LEISHMANIASIS; ANIMAL; DISEASE MODEL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETICS; HAMSTER; HUMAN; IMMUNOLOGY; LEISHMANIA DONOVANI; MESOCRICETUS; METABOLISM; PARASITOLOGY; SEQUENCE ANALYSIS; SPLEEN;

ANIMALS; CRICETINAE; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE LIBRARY; HUMANS; INFLAMMATION; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MACROPHAGE ACTIVATION; MACROPHAGES; MESOCRICETUS; NITRIC OXIDE; PHENOTYPE; SEQUENCE ANALYSIS, RNA; SPLEEN; TRANSCRIPTOME; UP-REGULATION;

EID: 85010987091     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006165     Document Type: Article

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