Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes

BMC Immunology

Volumn 14, Issue 1, 2013, Pages

  Dalrymple, Heidi ^a   Barna, Barbara P ^a   Malur, Anagha ^a   Malur, Achut G ^a   Kavuru, Mani S ^a   Thomassen, Mary J ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Activin A; Alveolar macrophages; Interferon gamma

Indexed keywords

ACTIVIN A; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RANTES;

ARTICLE; GENE SILENCING; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; LENTIVIRINAE; LUNG ALVEOLUS MACROPHAGE; LUNG ALVEOLUS PROTEINOSIS; LUNG LAVAGE; PHENOTYPE; WILD TYPE;

ACTIVINS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELLS, CULTURED; CHEMOKINE CCL5; GENE EXPRESSION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; INTERLEUKIN-6; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE TYPE II; PPAR GAMMA; PULMONARY ALVEOLAR PROTEINOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84883870654     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-14-41     Document Type: Article

References (45)

1. Vale W, Rivier J, Vaughan J, McClintock R, Corrigan A, Woo W, et al. Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature 1986, 321:776-779. 10.1038/321776a0, 3012369.
2. Ling N, Ying SY, Ueno N, Shimasaki S, Esch F, Hotta M, et al. Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin. Nature 1986, 321:779-782. 10.1038/321779a0, 3086749.
3. Matzuk MM, Kumar TR, Vassalli A, Bickenbach JR, Roop DR, Jaenisch R, et al. Functional analysis of activins during mammalian development. Nature 1995, 374:354-356. 10.1038/374354a0, 7885473.
4. De Kretser DM, O'Hehir RE, Hardy CL, Hedger MP. The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair. Mol Cell Endocrinol 2012, 359:101-106. 10.1016/j.mce.2011.10.009, 22037168.
5. Shao L, Frigon NL, Sehy DW, Yu AL, Lofgren J, Schwall R, et al. Regulation of production of activin A in human marrow stromal cells and monocytes. Exp Hematol 1992, 20:1235-1242.
6. Abe M, Shintani Y, Eto Y, Harada K, Kosaka M, Matsumoto T. Potent induction of activin A secretion from monocytes and bone marrow stromal fibroblasts by cognate interaction with activated T cells. J Leukoc Biol 2002, 72:347-352.
7. Lacey DC, Achuthan A, Fleetwood AJ, Dinh H, Roiniotis J, Scholz GM, et al. Defining GM-CSF-and macrophage-CSF-dependent macrophage responses by in vitro models. J Immunol 2012, 188:5752-5765. 10.4049/jimmunol.1103426, 22547697.
8. Ohguchi M, Yamato K, Ishihara Y, Koide M, Ueda N, Okahashi N, et al. Activin A regulates the production of mature interleukin-1beta and interleukin-1 receptor antagonist in human monocytic cells. J Interferon Cytokine Res 1998, 18:491-498. 10.1089/jir.1998.18.491, 9712365.
9. Karagiannidis C, Hense G, Martin C, Epstein M, Ruckert B, Mantel PY, et al. Activin A is an acute allergen-responsive cytokine and provides a link to TGF-beta-mediated airway remodeling in asthma. J Allergy Clin Immunol 2006, 117:111-118. 10.1016/j.jaci.2005.09.017, 16387593.
10. Trapnell BC, Whitsett JA. GM-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense. Annu Rev Physiol 2002, 64:775-802. 10.1146/annurev.physiol.64.090601.113847, 11826288.
11. Dranoff G, Crawford AD, Sadelain M, Ream B, Rashid A, Bronson RT, et al. Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science 1994, 264:713-716. 10.1126/science.8171324, 8171324.
12. Dranoff G, Mulligan RC. Activities of granulocyte-macrophage colony-stimulating factor revealed by gene transfer and gene knockout studies. Stem Cells 1994, 12(Suppl 1):173-182.
13. Kitamura T, Tanaka N, Watanabe J, Uchida K, Kanegasaki S, Yamada Y, et al. Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor. J Exp Med 1999, 190:875-880. 10.1084/jem.190.6.875, 2195627, 10499925.
14. Trapnell BC, Whitsett JA, Nakata K. Pulmonary alveolar proteinosis. N Engl J Med 2003, 349:2527-2539. 10.1056/NEJMra023226, 14695413.
15. Reed JA, Ikegami M, Cianciolo ER, Lu W, Cho PS, Hull W, et al. Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice. Am J Physiol 1999, 276:L556-L563.
16. Bonfield TL, Barna BP, John N, Malur A, Culver DA, Kavuru MS, et al. Suppression of activin A in autoimmune lung disease associated with anti-GM-CSF. J Autoimmun 2006, 26:37-41. 10.1016/j.jaut.2005.10.004, 16337108.
17. Bonfield TL, Raychaudhuri B, Malur A, Abraham S, Trapnell BC, Kavuru MS, et al. PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factor. Am J Physiol Lung Cell Mol Physiol 2003, 285:L1132-L1136.
18. Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC, Perissi V, et al. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-[gamma]. Nature 2005, 437:759-763. 10.1038/nature03988, 1464798, 16127449.
19. Glass CK, Saijo K. Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells. Nat Rev Immunol 2010, 10:365-376. 10.1038/nri2748, 20414208.
20. Thomassen MJ, Barna BP, Malur A, Bonfield TL, Farver CF, Malur A, et al. ABCG1 is deficient in alveolar macrophages of GM-CSF knock-out mice and patients with pulmonary alveolar proteinsosis. J Lipid Res 2007, 48:2762-2768. 10.1194/jlr.P700022-JLR200, 17848583.
21. Mather JP. Follistatins and alpha 2-macroglobulin are soluble binding proteins for inhibin and activin. Horm Res 1996, 45:207-210. 10.1159/000184789, 8964585.
22. Shibata Y, Berclaz YP, Chroneos ZC, Yoshida M, Whitsett JA, Trapnell BC. GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity 2001, 15:557-567. 10.1016/S1074-7613(01)00218-7, 11672538.
23. Su YC, Rolph MS, Hansbro NG, Mackay CR, Sewell WA. Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation. J Immunol 2008, 180:2600-2607.
24. Weigert J, Neumeier M, Wanninger J, Schober F, Sporrer D, Weber M, et al. Adiponectin upregulates monocytic activin A but systemic levels are not altered in obesity or type 2 diabetes. Cytokine 2009, 45:86-91. 10.1016/j.cyto.2008.10.017, 19128983.
25. Malur A, Mccoy AJ, Arce S, Barna BP, Kavuru MS, Malur AG, et al. Deletion of PPARγ in alveolar macrophages is associated with a Th-1 pulmonary inflammatory response. J Immunol 2009, 182:5816-5822. 10.4049/jimmunol.0803504, 19380830.
26. Bonfield TL, Thomassen MJ, Farver CF, Abraham S, Koloze MT, Zhang X, et al. Peroxisome proliferator-activated receptor-{gamma} regulates the expression of alveolar macrophage macrophage colony-stimulating factor. J Immunol 2008, 181:235-242. 2819287, 18566389.
27. Sierra-Filardi E, Puig-Kroger A, Blanco FJ, Nieto C, Bragado R, Palomero MI, et al. Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood 2011, 117:5092-5101. 10.1182/blood-2010-09-306993, 21389328.
28. Thomassen MJ, Raychaudhuri B, Bonfield TL, Malur A, Abraham S, Barna BP, et al. Elevated IL-10 inhibits GM-CSF synthesis in pulmonary alveolar proteinosis. Autoimmunity 2003, 36:285-290. 10.1080/0891693031000152688, 14567558.
29. Thomassen MJ, Yi T, Raychaudhuri B, Malur A, Kavuru MS. Pulmonary alveolar proteinosis is a disease of decreased availability of GM-CSF rather than an intrinsic cellular defect. Clin Immunol 2000, 95:85-92. 10.1006/clim.2000.4859, 10779401.
30. Bonfield TL, Russell D, Burgess S, Malur A, Kavuru MS, Thomassen MJ. Autoantibodies against granulocyte macrophage colony-stimulating factor are diagnostic for pulmonary alveolar proteinosis. Am J Respir Cell Mol Biol 2002, 27:481-486. 10.1165/rcmb.2002-0023OC, 12356582.
31. Bonfield TL, Farver CF, Barna BP, Malur A, Abraham S, Raychaudhuri B, et al. Peroxisome proliferator-activated receptor-gamma is deficient in alveolar macrophages from patients with alveolar proteinosis. Am J Respir Cell Mol Biol 2003, 29:677-682. 10.1165/rcmb.2003-0148OC, 12805087.
32. Bonfield TL, John N, Malur A, Barna BP, Culver DA, Kavuru MS, et al. Elevated monocyte chemotactic proteins 1, 2, and 3 in pulmonary alveolar proteinosis are associated with chemokine receptor suppression. Clin Immunol 2005, 114:79-85. 10.1016/j.clim.2004.09.004, 15596412.
33. Bonfield TL, Swaisgood CM, Barna BP, Kavuru MS, Thomassen MJ. Elevated gelatinous activity in pulmonary alveolar proteinosis: role of macrophage-colony stimulating factor. J Leukoc Biol 2006, 79:133-139.
34. Ricote M, Huang JT, Welch JS, Glass CK. The peroxisome proliferator-activated receptor-γ (PPARγ) as a regulator of monocyte/macrophage function. J Leukoc Biol 1999, 66:733-739.
35. Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008, 8:958-969. 10.1038/nri2448, 2724991, 19029990.
36. Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity 2010, 32:593-604. 10.1016/j.immuni.2010.05.007, 20510870.
37. Liu G, Yang H. Modulation of macrophage activation and programming in immunity. J Cell Physiol 2013, 228:502-512. 10.1002/jcp.24157, 22777800.
38. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003, 3:23-35. 10.1038/nri978, 12511873.
39. Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 2012, 122:787-795. 10.1172/JCI59643, 3287223, 22378047.
40. Fleetwood AJ, Lawrence T, Hamilton JA, Cook AD. Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation. J Immunol 2007, 178:5245-5252.
41. Chawla A. Control of macrophage activation and function by PPARs. Circ Res 2010, 106:1559-1569. 10.1161/CIRCRESAHA.110.216523, 2897247, 20508200.
42. Weidenbusch M, Anders HJ. Tissue microenvironments define and get reinforced by macrophage phenotypes in homeostasis or during inflammation, repair and fibrosis. J Innate Immun 2012, 4:463-477. 10.1159/000336717, 22507825.
43. Malur A, Baker AD, McCoy AJ, Wells G, Barna BP, Kavuru MS, et al. Restoration of PPARgamma reverses lipid accumulation in alveolar macrophages of GM-CSF knockout mice. Am J Physiol Lung Cell Mol Physiol 2011, 300:L73-L80. 10.1152/ajplung.00128.2010, 21036914.
44. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262, 11846609.
45. Malur AG, Chattopadhyay S, Maitra RK, Banerjee AK. Inhibition of STAT 1 phosphorylation by human parainfluenza virus type 3 C protein. J Virol 2005, 79:7877-7882. 10.1128/JVI.79.12.7877-7882.2005, 1143680, 15919942.