Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes

BMC Immunology

Volumn 15, Issue 1, 2014, Pages

  Espitia, Claudia M ^a   Saldarriaga, Omar A ^b   Travi, Bruno L ^b   Osorio, E Yaneth ^b   Hernandez, Alvaro ^c   Band, Mark ^c   Patel, Mandakini J ^a   Medina, Audrie A ^b   Cappello, Michael ^d   Pekosz, Andrew ^e   Melby, Peter C ^b  

^a CTRC Institute for Drug Development   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Hamster; Interferon gamma; Interleukin 4; Leishmania donovani; Microarray; Transcriptional profiling; Visceral leishmaniasis

Indexed keywords

COMPLEMENTARY DNA; CXCL9 CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INDOLEAMINE 2,3 DIOXYGENASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; STAT6 PROTEIN; SYNAPTOTAGMIN I; TRYPTOPHAN 2,3 DIOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; CYTOKINE RESPONSIVE ELEMENT; DNA LIBRARY; DNA SEQUENCE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE ONTOLOGY; IMMUNE RESPONSE; IMMUNE RESPONSE GENE; LEISHMANIA DONOVANI; MACROPHAGE ACTIVATION; MICROARRAY ANALYSIS; NONHUMAN; PARASITE LOAD; PATHOGENESIS; PERITONEUM MACROPHAGE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPLEEN; SPLEEN SIZE; SYRIAN HAMSTER; T LYMPHOCYTE SUBPOPULATION; UPREGULATION; VISCERAL LEISHMANIASIS; ANIMAL; CLUSTER ANALYSIS; DISEASE COURSE; DNA MICROARRAY; EXPRESSED SEQUENCE TAG; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; HUMAN; IMMUNOLOGY; MESOCRICETUS; METABOLISM; MOLECULAR GENETICS; PARASITOLOGY; PATHOLOGY; PRINCIPAL COMPONENT ANALYSIS;

ANIMALS; CLUSTER ANALYSIS; CRICETINAE; CYTOKINES; DISEASE PROGRESSION; DNA, COMPLEMENTARY; EXPRESSED SEQUENCE TAGS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE ONTOLOGY; HUMANS; INTERFERON-GAMMA; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MESOCRICETUS; MOLECULAR SEQUENCE ANNOTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPLEEN; UP-REGULATION;

EID: 84923934112     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/s12865-014-0038-z     Document Type: Article

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