Co-existence of classical and alternative activation programs in macrophages responding to Toxoplasma gondii

International Journal for Parasitology

Volumn 44, Issue 2, 2014, Pages 161-164

  Patil, Veerupaxagouda ^a   Zhao, Yanlin ^a   Shah, Suhagi ^a   Fox, Barbara A ^b   Rommereim, Leah M ^b   Bzik, David J ^b   Yap, George S ^a  

^a Rutgers The State University of New Jersey   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Alternative activation; Classical activation; Macrophage; Toxoplasma gondii; Virulence factor

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; PROTEIN ROP16; STAT6 PROTEIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

COEXISTENCE; EXPERIMENTAL STUDY; GENE EXPRESSION; HOMEOSTASIS; PARASITE; PATHOGEN; VIRULENCE;

ALTERNATIVE MACROPHAGE ACTIVATION; ANIMAL CELL; ARTICLE; CLASSICAL MACROPHAGE ACTIVATION; CONTROLLED STUDY; CYTOKINE RESPONSE; FEMALE; HOST CELL; HOST PARASITE INTERACTION; IMMUNE RESPONSE; IN VITRO STUDY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PARASITE VIRULENCE; PHENOTYPE; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TOXOPLASMA GONDII;

TOXOPLASMA GONDII;

ALTERNATIVE ACTIVATION; CLASSICAL ACTIVATION; MACROPHAGE; TOXOPLASMA GONDII; VIRULENCE FACTOR;

ANIMALS; CELLS, CULTURED; CYTOKINES; GENE EXPRESSION REGULATION; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; PROTOZOAN PROTEINS; TOXOPLASMA;

EID: 84892502384     PISSN: 00207519     EISSN: 18790135     Source Type: Journal    
DOI: 10.1016/j.ijpara.2013.08.003     Document Type: Article

References (14)

1. Arnold L., Henry A., Poron F., Baba-Amer Y., van Rooijen N., Plonquet A., Gherardi R.K., Chazaud B. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J. Exp. Med. 2007, 204:1057-1069.
2. Butcher B.A., Fox B.A., Rommereim L.M., Kim S.G., Maurer K.J., Yarovinsky F., Herbert D.R., Bzik D.J., Denkers E.Y. Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control. PLoS Pathog. 2011, 7:e1002236.
3. El Kasmi K.C., Qualls J.E., Pesce J.T., Smith A.M., Thompson R.W., Henao-Tamayo M., Basaraba R.J., Konig T., Schleicher U., Koo M.S., Kaplan G., Fitzgerald K.A., Tuomanen E.I., Orme I.M., Kanneganti T.D., Bogdan C., Wynn T.A., Murray P.J. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat. Immunol. 2008, 9:1399-1406.
4. Fox B.A., Bzik D.J. De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii. Nature 2002, 415:926-929.
5. Gordon S. Alternative activation of macrophages. Nat. Rev. Immunol. 2003, 3:23-35.
6. Jenkins S.J., Ruckerl D., Cook P.C., Jones L.H., Finkelman F.D., van Rooijen N., MacDonald A.S., Allen J.E. Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 2011, 332:1284-1288.
7. Jensen K.D., Wang Y., Wojno E.D., Shastri A.J., Hu K., Cornel L., Boedec E., Ong Y.C., Chien Y.H., Hunter C.A., Boothroyd J.C., Saeij J.P. Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation. Cell. Host Microbe 2011, 9:472-483.
8. Ling Y.M., Shaw M.H., Ayala C., Coppens I., Taylor G.A., Ferguson D.J., Yap G.S. Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J. Exp. Med. 2006, 203:2063-2071.
9. Murray P.J., Wynn T.A. Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 2011, 11:723-737.
10. Nahrendorf M., Swirski F.K., Aikawa E., Stangenberg L., Wurdinger T., Figueiredo J.L., Libby P., Weissleder R., Pittet M.J. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J. Exp. Med. 2007, 204:3037-3047.
11. Nance J.P., Vannella K.M., Worth D., David C., Carter D., Noor S., Hubeau C., Fitz L., Lane T.E., Wynn T.A., Wilson E.H. Chitinase dependent control of protozoan cyst burden in the brain. PLoS Pathog. 2012, 8:e1002990.
12. Saeij J.P., Coller S., Boyle J.P., Jerome M.E., White M.W., Boothroyd J.C. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature 2007, 445:324-327.
13. Stables M.J., Shah S., Camon E.B., Lovering R.C., Newson J., Bystrom J., Farrow S., Gilroy D.W. Transcriptomic analyses of murine resolution-phase macrophages. Blood 2011, 118:e192-e208.
14. Yap G.S., Shaw M.H., Ling Y., Sher A. Genetic analysis of host resistance to intracellular pathogens: lessons from studies of Toxoplasma gondii infection. Microbes Infect. 2006, 8:1174-1178.