Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1862, Issue 11, 2017, Pages 1439-1450

  Scott, Alison J ^a   Oyler, Benjamin L ^b   Goodlett, David R ^c   Ernst, Robert K ^a  

^a UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

^b UNIVERSITY OF MARYLAND CENTER FOR ENVIRONMENTAL SCIENCE   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Lipid A modifying enzymes; Lipid A structure; Marine bacteria; TLR4 agonists; TLR4 antagonists; TLR4 immunomodulation

Indexed keywords

ENZYME; LIPID A; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 4 AGONIST; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; BACTERIAL PROTEIN;

CELL DIFFERENTIATION; COMPLEX FORMATION; CRYSTAL STRUCTURE; CYANOBACTERIUM; ENZYME MODIFICATION; ENZYME STRUCTURE; ESCHERICHIA COLI; EXTRACELLULAR MATRIX; HALOPHILE; HUMAN; HYDROXYLATION; INNER MEMBRANE; LIPID ANALYSIS; LIPOGENESIS; MACROPHAGE; MARINE BACTERIUM; MARINE ENVIRONMENT; MOLECULAR RECOGNITION; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PSYCHROPHILE; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; THERMOPHILE; ANIMAL; BACTERIUM; BIOSYNTHESIS; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PROTEIN CONFORMATION;

ANIMALS; BACTERIA; BACTERIAL PROTEINS; DRUG DESIGN; ENZYMES; HUMANS; LIPID A; LIPOGENESIS; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 4;

EID: 85010192988     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2017.01.004     Document Type: Review

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