Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(R-3-hydroxymyristoyl)-N- acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs

Journal of Biological Chemistry

Volumn 275, Issue 15, 2000, Pages 11002-11009

  Jackman, Jane E ^a   Fierke, Carol A ^a,b   Tumey, L Nathan ^a   Pirrung, Michael ^a   Uchiyama, Taketo ^c   Tahir, S Hasan ^c   Hindsgaul, Ole ^c   Raetz, Christian R H ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DEACETYLIN; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; LIPOGENESIS; NONHUMAN; PRIORITY JOURNAL;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; BINDING SITES; CLONING, MOLECULAR; ESCHERICHIA COLI; GRAM-NEGATIVE AEROBIC RODS AND COCCI; HYDROXAMIC ACIDS; KINETICS; LIPID A; OXAZOLES; ZINC;

AQUIFEX AEOLICUS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0034646694     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.15.11002     Document Type: Article

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