Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains: LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3″-hydroxyl group

Journal of Biological Chemistry

Volumn 279, Issue 24, 2004, Pages 25411-25419

  Sweet, Charles R ^a,d   Williams, Allison H ^a   Karbarz, Mark J ^a   Werts, Catherine ^b   Kalb, Suzanne R ^c   Cotter, Robert J ^c   Raetz, Christian R H ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b INSTITUT PASTEUR   (France)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DERIVATIVES; ENZYMES; ESCHERICHIA COLI; LIPIDS; SYNTHESIS (CHEMICAL);

ENZYMATIC SYNTHESIS; SUBSTRATE SELECTIVITY;

BIOCHEMISTRY;

2,3 DIAMINO 2,3 DIDEOXY DEXTRO GLUCOPYRANOSE; 3 HYDROXYACYL ACYL CARRIER PROTEIN; 3 HYDROXYLAUROYL ACYL CARRIER PROTEIN; ACYL CARRIER PROTEIN; ACYLTRANSFERASE; AMIDE; AMINE; BACTERIAL PROTEIN; GLUCOSAMINE; GLYCOPYRANOSIDE; HISTIDINE; HYDROXYL GROUP; LIPID A; PROTEIN GNNA; PROTEIN GNNB; PROTEIN LPXA; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE 2 ACETAMIDO 3 AMINO 2,3 DIDEOXY DEXTRO GLUCOPYRANOSE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

ACIDITHIOBACILLUS FERROOXIDANS; ACYLATION; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; LEPTOSPIRA INTERROGANS; LIPOGENESIS; MESORHIZOBIUM LOTI; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RHIZOBIUM;

ACIDITHIOBACILLUS; ACYLTRANSFERASES; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CLONING, MOLECULAR; LEPTOSPIRA INTERROGANS; LIPID A; MOLECULAR SEQUENCE DATA; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; URIDINE DIPHOSPHATE N-ACETYLGLUCOSAMINE;

ACIDITHIOBACILLUS; ACIDITHIOBACILLUS FERROOXIDANS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; LEPTOSPIRA; LEPTOSPIRA INTERROGANS; MESORHIZOBIUM; MESORHIZOBIUM LOTI; NEGIBACTERIA; POSIBACTERIA; RHIZOBIUM; THIOBACILLUS;

EID: 2942595771     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400597200     Document Type: Article

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