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Volumn 3, Issue , 2017, Pages

Chronic lymphocytic leukaemia

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CHLORAMBUCIL; DUVELISIB; IBRUTINIB; IDELALISIB; IMMUNOGLOBULIN HEAVY CHAIN; MICRORNA; OFATUMUMAB; PROTEIN BCL 2; VENETOCLAX;

EID: 85009999724     PISSN: None     EISSN: 2056676X     Source Type: Journal    
DOI: 10.1038/nrdp.2016.96     Document Type: Article
Times cited : (342)

References (213)
  • 1
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin, T. J., Davis, Z., Gardiner, A., Oscier, D. G. & Stevenson, F. K. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94, 1848-1854 (1999).
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 2
    • 0033567968 scopus 로고    scopus 로고
    • Ig v gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle, R. N. et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94, 1840-1847 (1999).
    • (1999) Blood , vol.94 , pp. 1840-1847
    • Damle, R.N.1
  • 3
    • 0037085801 scopus 로고    scopus 로고
    • Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia
    • Tobin, G. et al. Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood 99, 2262-2264 (2002).
    • (2002) Blood , vol.99 , pp. 2262-2264
    • Tobin, G.1
  • 4
    • 46749099871 scopus 로고    scopus 로고
    • Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection
    • Ghia, E. M. et al. Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection. Blood 111, 5101-5108 (2008).
    • (2008) Blood , vol.111 , pp. 5101-5108
    • Ghia, E.M.1
  • 5
    • 0000634555 scopus 로고
    • Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia
    • Kipps, T. J. et al. Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 86, 5913-5917 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 5913-5917
    • Kipps, T.J.1
  • 6
    • 0032532668 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J. Clin. Invest. 102, 1515-1525 (1998).
    • (1998) J. Clin. Invest , vol.102 , pp. 1515-1525
  • 7
    • 84861033763 scopus 로고    scopus 로고
    • Stereotyped B-cell receptors in one-Third of chronic lymphocytic leukemia: A molecular classification with implications for targeted therapies
    • Agathangelidis, A. et al. Stereotyped B-cell receptors in one-Third of chronic lymphocytic leukemia: A molecular classification with implications for targeted therapies. Blood 119, 4467-4475 (2012).
    • (2012) Blood , vol.119 , pp. 4467-4475
    • Agathangelidis, A.1
  • 8
    • 4944244255 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins
    • Widhopf, G. F. 2nd et al. Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood 104, 2499-2504 (2004).
    • (2004) Blood , vol.104 , pp. 2499-2504
    • Widhopf, I.I.G.F.1
  • 9
    • 84901354501 scopus 로고    scopus 로고
    • Cell of origin associated classification of B-cell malignancies by gene signatures of the normal B-cell hierarchy
    • Johnsen, H. E. et al. Cell of origin associated classification of B-cell malignancies by gene signatures of the normal B-cell hierarchy. Leuk. Lymphoma 55, 1251-1260 (2014).
    • (2014) Leuk. Lymphoma , vol.55 , pp. 1251-1260
    • Johnsen, H.E.1
  • 10
    • 84923699047 scopus 로고    scopus 로고
    • Germinal centres and B cell lymphomagenesis
    • Basso, K. & Dalla-Favera, R. Germinal centres and B cell lymphomagenesis. Nat. Rev. Immunol. 15, 172-184 (2015).
    • (2015) Nat. Rev. Immunol , vol.15 , pp. 172-184
    • Basso, K.1    Dalla-Favera, R.2
  • 11
    • 84863707351 scopus 로고    scopus 로고
    • Cancer treatment and survivorship statistics
    • Siegel, R. et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J. Clin. 62, 220-241 (2012).
    • (2012) CA Cancer J. Clin 2012 , vol.62 , pp. 220-241
    • Siegel, R.1
  • 12
    • 84919458316 scopus 로고    scopus 로고
    • The impact of race, ethnicity, age and sex on clinical outcome in chronic lymphocytic leukemia: A comprehensive Surveillance, Epidemiology, and End Results analysis in the modern era
    • Nabhan, C. et al. The impact of race, ethnicity, age and sex on clinical outcome in chronic lymphocytic leukemia: A comprehensive Surveillance, Epidemiology, and End Results analysis in the modern era. Leuk. Lymphoma 55, 2778-2784 (2014).
    • (2014) Leuk. Lymphoma , vol.55 , pp. 2778-2784
    • Nabhan, C.1
  • 13
    • 84925146155 scopus 로고    scopus 로고
    • Racial differences in three major NHL subtypes: Descriptive epidemiology
    • Li, Y., Wang, Y., Wang, Z., Yi, D. & Ma, S. Racial differences in three major NHL subtypes: descriptive epidemiology. Cancer Epidemiol. 39, 8-13 (2015).
    • (2015) Cancer Epidemiol , vol.39 , pp. 8-13
    • Li, Y.1    Wang, Y.2    Wang, Z.3    Yi, D.4    Ma, S.5
  • 14
    • 84929134565 scopus 로고    scopus 로고
    • Survival for patients with chronic leukemias in the US and Britain: Age-related disparities and changes in the early 21st century
    • Pulte, D., Redaniel, M. T., Bird, J. & Jeffreys, M. Survival for patients with chronic leukemias in the US and Britain: Age-related disparities and changes in the early 21st century. Eur. J. Haematol. 94, 540-545 (2015).
    • (2015) Eur. J. Haematol , vol.94 , pp. 540-545
    • Pulte, D.1    Redaniel, M.T.2    Bird, J.3    Jeffreys, M.4
  • 15
    • 84949033631 scopus 로고    scopus 로고
    • Familial predisposition and genetic risk factors for lymphoma
    • Cerhan, J. R. & Slager, S. L. Familial predisposition and genetic risk factors for lymphoma. Blood 126, 2265-2273 (2015).
    • (2015) Blood , vol.126 , pp. 2265-2273
    • Cerhan, J.R.1    Slager, S.L.2
  • 16
    • 0034644185 scopus 로고    scopus 로고
    • Environmental and heritable factors in the causation of cancer-Analyses of cohorts of twins from Sweden, Denmark, and Finland
    • Lichtenstein, P. et al. Environmental and heritable factors in the causation of cancer-Analyses of cohorts of twins from Sweden, Denmark, and Finland. N. Engl. J. Med. 343, 78-85 (2000).
    • (2000) N. Engl. J. Med , vol.343 , pp. 78-85
    • Lichtenstein, P.1
  • 17
    • 52949139429 scopus 로고    scopus 로고
    • A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
    • Di Bernardo, M. C. et al. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nat. Genet. 40, 1204-1210 (2008).
    • (2008) Nat. Genet , vol.40 , pp. 1204-1210
    • Di Bernardo, M.C.1
  • 18
    • 79951498059 scopus 로고    scopus 로고
    • Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL
    • Slager, S. L. et al. Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL. Blood 117, 1911-1916 (2011).
    • (2011) Blood , vol.117 , pp. 1911-1916
    • Slager, S.L.1
  • 19
    • 75749138023 scopus 로고    scopus 로고
    • Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk
    • Crowther-Swanepoel, D. et al. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. Nat. Genet. 42, 132-136 (2010).
    • (2010) Nat. Genet , vol.42 , pp. 132-136
    • Crowther-Swanepoel, D.1
  • 20
    • 84881023533 scopus 로고    scopus 로고
    • Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
    • Berndt, S. I. et al. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Nat. Genet. 45, 868-876 (2013).
    • (2013) Nat. Genet , vol.45 , pp. 868-876
    • Berndt, S.I.1
  • 21
    • 84891371778 scopus 로고    scopus 로고
    • A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
    • Speedy, H. E. et al. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Nat. Genet. 46, 56-60 (2014).
    • (2014) Nat. Genet , vol.46 , pp. 56-60
    • Speedy, H.E.1
  • 22
    • 84960517435 scopus 로고    scopus 로고
    • Meta-Analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
    • Berndt, S. I. et al. Meta-Analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Nat. Commun. 7, 10933 (2016).
    • (2016) Nat. Commun , vol.7 , pp. 10933
    • Berndt, S.I.1
  • 23
    • 84888211403 scopus 로고    scopus 로고
    • A role for IRF4 in the development of CLL
    • Shukla, V., Ma, S., Hardy, R. R., Joshi, S. S. & Lu, R. A role for IRF4 in the development of CLL. Blood 122, 2848-2855 (2013).
    • (2013) Blood , vol.122 , pp. 2848-2855
    • Shukla, V.1    Ma, S.2    Hardy, R.R.3    Joshi, S.S.4    Lu, R.5
  • 24
    • 85016091426 scopus 로고    scopus 로고
    • Interferon regulatory factor 4 attenuates notch signaling to suppress the development of chronic lymphocytic leukemia
    • Shukla, V., Shukla, A., Joshi, S. S. & Lu, R. Interferon regulatory factor 4 attenuates notch signaling to suppress the development of chronic lymphocytic leukemia. Oncotarget 7, 41081-41094 (2016).
    • (2016) Oncotarget , vol.7 , pp. 41081-41094
    • Shukla, V.1    Shukla, A.2    Joshi, S.S.3    Lu, R.4
  • 25
    • 84862006553 scopus 로고    scopus 로고
    • Dysregulation of TNFalpha-induced necroptotic signaling in chronic lymphocytic leukemia: Suppression of CYLD gene by LEF1
    • Liu, P. et al. Dysregulation of TNFalpha-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1. Leukemia 26, 1293-1300 (2012).
    • (2012) Leukemia , vol.26 , pp. 1293-1300
    • Liu, P.1
  • 26
    • 27244434788 scopus 로고    scopus 로고
    • A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    • Calin, G. A. et al. A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N. Engl. J. Med. 353, 1793-1801 (2005).
    • (2005) N. Engl. J. Med , vol.353 , pp. 1793-1801
    • Calin, G.A.1
  • 27
    • 84920689479 scopus 로고    scopus 로고
    • Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia
    • Veronese, A. et al. Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia. Leukemia 29, 86-95 (2015).
    • (2015) Leukemia , vol.29 , pp. 86-95
    • Veronese, A.1
  • 28
    • 25444520537 scopus 로고    scopus 로고
    • MiR-15 and miR-16 induce apoptosis by targeting BCL2
    • Cimmino, A. et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl Acad. Sci. USA 102, 13944-13949 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 13944-13949
    • Cimmino, A.1
  • 29
    • 14944352799 scopus 로고    scopus 로고
    • ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia
    • Chen, L. et al. ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood 105, 2036-2041 (2005).
    • (2005) Blood , vol.105 , pp. 2036-2041
    • Chen, L.1
  • 30
    • 34250013672 scopus 로고    scopus 로고
    • Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice
    • Raveche, E. S. et al. Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood 109, 5079-5086 (2007).
    • (2007) Blood , vol.109 , pp. 5079-5086
    • Raveche, E.S.1
  • 31
    • 84977127263 scopus 로고    scopus 로고
    • Genetic variation associated with longer telomere length increases risk of chronic lymphocytic leukemia
    • Ojha, J. et al. Genetic variation associated with longer telomere length increases risk of chronic lymphocytic leukemia. Cancer Epidemiol. Biomarkers Prev. 25, 1043-1049 (2016).
    • (2016) Cancer Epidemiol. Biomarkers Prev , vol.25 , pp. 1043-1049
    • Ojha, J.1
  • 32
    • 84976510388 scopus 로고    scopus 로고
    • A high rate of telomeric sister chromatid exchange occurs in chronic lymphocytic leukaemia B-cells
    • Medves, S. et al. A high rate of telomeric sister chromatid exchange occurs in chronic lymphocytic leukaemia B-cells. Br. J. Haematol. 174, 57-70 (2016).
    • (2016) Br. J. Haematol , vol.174 , pp. 57-70
    • Medves, S.1
  • 33
    • 84891366353 scopus 로고    scopus 로고
    • The impact of Agent Orange exposure on presentation and prognosis of patients with chronic lymphocytic leukemia
    • Baumann Kreuziger, L. M., Tarchand, G. & Morrison, V. A. The impact of Agent Orange exposure on presentation and prognosis of patients with chronic lymphocytic leukemia. Leuk. Lymphoma 55, 63-66 (2014).
    • (2014) Leuk. Lymphoma , vol.55 , pp. 63-66
    • Baumann Kreuziger, L.M.1    Tarchand, G.2    Morrison, V.A.3
  • 34
    • 84945459399 scopus 로고    scopus 로고
    • Insecticide exposure and farm history in relation to risk of lymphomas and leukemias in the Womens Health Initiative observational study cohort
    • Schinasi, L. H. et al. Insecticide exposure and farm history in relation to risk of lymphomas and leukemias in the Womens Health Initiative observational study cohort. Ann. Epidemiol. 25, 803-810 (2015).
    • (2015) Ann. Epidemiol , vol.25 , pp. 803-810
    • Schinasi, L.H.1
  • 35
    • 84874885450 scopus 로고    scopus 로고
    • The incidence of leukemia, lymphoma and multiple myeloma among atomic bomb survivors 1950-2001
    • Hsu, W. L. et al. The incidence of leukemia, lymphoma and multiple myeloma among atomic bomb survivors: 1950-2001. Radiat. Res. 179, 361-382 (2013).
    • (2013) Radiat. Res , vol.179 , pp. 361-382
    • Hsu, W.L.1
  • 36
    • 84959140935 scopus 로고    scopus 로고
    • Ionizing radiation exposures in treatments of solid neoplasms are not associated with subsequent increased risks of chronic lymphocytic leukemia
    • Radivoyevitch, T., Sachs, R. K., Gale, R. P., Smith, M. R. & Hill, B. T. Ionizing radiation exposures in treatments of solid neoplasms are not associated with subsequent increased risks of chronic lymphocytic leukemia. Leuk. Res. 43, 9-12 (2016).
    • (2016) Leuk. Res , vol.43 , pp. 9-12
    • Radivoyevitch, T.1    Sachs, R.K.2    Gale, R.P.3    Smith, M.R.4    Hill, B.T.5
  • 37
    • 84944892380 scopus 로고    scopus 로고
    • No evidence of transmission of chronic lymphocytic leukemia through blood transfusion
    • Hjalgrim, H. et al. No evidence of transmission of chronic lymphocytic leukemia through blood transfusion. Blood 126, 2059-2061 (2015).
    • (2015) Blood , vol.126 , pp. 2059-2061
    • Hjalgrim, H.1
  • 38
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Dohner, H. et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N. Engl. J. Med. 343, 1910-1916 (2000).
    • (2000) N. Engl. J. Med , vol.343 , pp. 1910-1916
    • Dohner, H.1
  • 39
    • 73649116987 scopus 로고    scopus 로고
    • The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia
    • Klein, U. et al. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 17, 28-40 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 28-40
    • Klein, U.1
  • 41
    • 84957717732 scopus 로고    scopus 로고
    • The Dohner fluorescence in situ hybridization prognostic classification of chronic lymphocytic leukaemia (CLL): The CLL Research Consortium experience
    • Van Dyke, D. L. et al. The Dohner fluorescence in situ hybridization prognostic classification of chronic lymphocytic leukaemia (CLL): The CLL Research Consortium experience. Br. J. Haematol. 173, 105-113 (2016).
    • (2016) Br. J. Haematol , vol.173 , pp. 105-113
    • Van Dyke, D.L.1
  • 42
    • 79960353160 scopus 로고    scopus 로고
    • Analysis of the chronic lymphocytic leukemia coding genome: Role of notch1 mutational activation
    • Fabbri, G. et al. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J. Exp. Med. 208, 1389-1401 (2011).
    • (2011) J. Exp. Med , vol.208 , pp. 1389-1401
    • Fabbri, G.1
  • 43
    • 74449093973 scopus 로고    scopus 로고
    • A comprehensive catalogue of somatic mutations from a human cancer genome
    • Pleasance, E. D. et al. A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 463, 191-196 (2010).
    • (2010) Nature , vol.463 , pp. 191-196
    • Pleasance, E.D.1
  • 44
    • 79960036578 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • Puente, X. S. et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475, 101-105 (2011).
    • (2011) Nature , vol.475 , pp. 101-105
    • Puente, X.S.1
  • 45
    • 84855370035 scopus 로고    scopus 로고
    • SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
    • Wang, L. et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N. Engl. J. Med. 365, 2497-2506 (2011).
    • (2011) N. Engl. J. Med , vol.365 , pp. 2497-2506
    • Wang, L.1
  • 46
    • 84906908742 scopus 로고    scopus 로고
    • Acquired initiating mutations in early hematopoietic cells of CLL patients
    • Damm, F. et al. Acquired initiating mutations in early hematopoietic cells of CLL patients. Cancer Discov. 4, 1088-1101 (2014).
    • (2014) Cancer Discov , vol.4 , pp. 1088-1101
    • Damm, F.1
  • 47
    • 84905990862 scopus 로고    scopus 로고
    • Somatic mutation as a mechanism of Wnt/beta-catenin pathway activation in CLL
    • Wang, L. et al. Somatic mutation as a mechanism of Wnt/beta-catenin pathway activation in CLL. Blood 124, 1089-1098 (2014).
    • (2014) Blood , vol.124 , pp. 1089-1098
    • Wang, L.1
  • 48
    • 84893699492 scopus 로고    scopus 로고
    • Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia
    • Ferreira, P. G. et al. Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia. Genome Res. 24, 212-226 (2014).
    • (2014) Genome Res , vol.24 , pp. 212-226
    • Ferreira, P.G.1
  • 49
    • 84555171449 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
    • Quesada, V. et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat. Genet. 44, 47-52 (2012).
    • (2012) Nat. Genet , vol.44 , pp. 47-52
    • Quesada, V.1
  • 50
    • 84929291816 scopus 로고    scopus 로고
    • The impact of SF3B1 mutations in CLL on the DNA-damage response
    • Te Raa, G. D. et al. The impact of SF3B1 mutations in CLL on the DNA-damage response. Leukemia 29, 1133-1142 (2015).
    • (2015) Leukemia , vol.29 , pp. 1133-1142
    • Te Raa, G.D.1
  • 51
    • 84945302209 scopus 로고    scopus 로고
    • Mutations driving CLL and their evolution in progression and relapse
    • Landau, D. A. et al. Mutations driving CLL and their evolution in progression and relapse. Nature 526, 525-530 (2015).
    • (2015) Nature , vol.526 , pp. 525-530
    • Landau, D.A.1
  • 52
    • 84945248976 scopus 로고    scopus 로고
    • Non-coding recurrent mutations in chronic lymphocytic leukaemia
    • Puente, X. S. et al. Non-coding recurrent mutations in chronic lymphocytic leukaemia. Nature 526, 519-524 (2015).
    • (2015) Nature , vol.526 , pp. 519-524
    • Puente, X.S.1
  • 53
    • 84960461460 scopus 로고    scopus 로고
    • Whole-exome sequencing in relapsing chronic lymphocytic leukemia: Clinical impact of recurrent RPS15 mutations
    • Ljungstrom, V. et al. Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations. Blood 127, 1007-1016 (2016).
    • (2016) Blood , vol.127 , pp. 1007-1016
    • Ljungstrom, V.1
  • 54
    • 84255170476 scopus 로고    scopus 로고
    • The Pax-5 gene: A pluripotent regulator of B-cell differentiation and cancer disease
    • OBrien, P., Morin, P. Jr, Ouellette, R. J. & Robichaud, G. A. The Pax-5 gene: A pluripotent regulator of B-cell differentiation and cancer disease. Cancer Res. 71, 7345-7350 (2011).
    • (2011) Cancer Res , vol.71 , pp. 7345-7350
    • Obrien, P.1    Morin, P.2    Ouellette, R.J.3    Robichaud, G.A.4
  • 55
    • 84877635463 scopus 로고    scopus 로고
    • NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome
    • Villamor, N. et al. NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome. Leukemia 27, 1100-1106 (2013).
    • (2013) Leukemia , vol.27 , pp. 1100-1106
    • Villamor, N.1
  • 56
    • 84945961824 scopus 로고    scopus 로고
    • Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL
    • Guieze, R. et al. Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL. Blood 126, 2110-2117 (2015).
    • (2015) Blood , vol.126 , pp. 2110-2117
    • Guieze, R.1
  • 57
    • 84991237207 scopus 로고    scopus 로고
    • Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia
    • Wang, J. et al. Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia. eLife 3, e02869 (2014).
    • (2014) ELife , vol.3 , pp. e02869
    • Wang, J.1
  • 58
    • 84970003155 scopus 로고    scopus 로고
    • Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition
    • Burger, J. A. et al. Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition. Nat. Commun. 7, 11589 (2016).
    • (2016) Nat. Commun , vol.7 , pp. 11589
    • Burger, J.A.1
  • 59
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin, G. A. et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 99, 15524-15529 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1
  • 60
    • 78650861867 scopus 로고    scopus 로고
    • Association of a microrna/tp53 feedback circuitry with pathogenesis and outcome of b-cell chronic lymphocytic leukemia
    • Fabbri, M. et al. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA 305, 59-67 (2011).
    • (2011) JAMA , vol.305 , pp. 59-67
    • Fabbri, M.1
  • 61
    • 84880293043 scopus 로고    scopus 로고
    • MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia
    • Mraz, M. & Kipps, T. J. MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia. Leuk. Lymphoma 54, 1836-1839 (2013).
    • (2013) Leuk. Lymphoma , vol.54 , pp. 1836-1839
    • Mraz, M.1    Kipps, T.J.2
  • 62
    • 84923197477 scopus 로고    scopus 로고
    • TCL1 targeting miR-3676 is codeleted with tumor protein p53 in chronic lymphocytic leukemia
    • Balatti, V. et al. TCL1 targeting miR-3676 is codeleted with tumor protein p53 in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 112, 2169-2174 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 2169-2174
    • Balatti, V.1
  • 63
    • 0037076279 scopus 로고    scopus 로고
    • Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
    • Bichi, R. et al. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc. Natl Acad. Sci. USA 99, 6955-6960 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 6955-6960
    • Bichi, R.1
  • 64
    • 33646471662 scopus 로고    scopus 로고
    • Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eu-miR155 transgenic mice
    • Costinean, S. et al. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eu-miR155 transgenic mice. Proc. Natl Acad. Sci. USA 103, 7024-7029 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 7024-7029
    • Costinean, S.1
  • 65
    • 84904887947 scopus 로고    scopus 로고
    • MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia
    • Cui, B. et al. MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. Blood 124, 546-554 (2014).
    • (2014) Blood , vol.124 , pp. 546-554
    • Cui, B.1
  • 66
    • 84873570131 scopus 로고    scopus 로고
    • 450K-Array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments
    • Cahill, N. et al. 450K-Array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments. Leukemia 27, 150-158 (2013).
    • (2013) Leukemia , vol.27 , pp. 150-158
    • Cahill, N.1
  • 67
    • 0026786945 scopus 로고
    • Genomic hypomethylation in human chronic lymphocytic leukemia
    • Wahlfors, J. et al. Genomic hypomethylation in human chronic lymphocytic leukemia. Blood 80, 2074-2080 (1992).
    • (1992) Blood , vol.80 , pp. 2074-2080
    • Wahlfors, J.1
  • 68
    • 84882884517 scopus 로고    scopus 로고
    • Charting a dynamic DNA methylation landscape of the human genome
    • Ziller, M. J. et al. Charting a dynamic DNA methylation landscape of the human genome. Nature 500, 477-481 (2013).
    • (2013) Nature , vol.500 , pp. 477-481
    • Ziller, M.J.1
  • 69
    • 84868198427 scopus 로고    scopus 로고
    • Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
    • Kulis, M. et al. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat. Genet. 44, 1236-1242 (2012).
    • (2012) Nat. Genet , vol.44 , pp. 1236-1242
    • Kulis, M.1
  • 70
    • 84919469035 scopus 로고    scopus 로고
    • Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia
    • Landau, D. A. et al. Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia. Cancer Cell 26, 813-825 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 813-825
    • Landau, D.A.1
  • 71
    • 84895783051 scopus 로고    scopus 로고
    • Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia
    • Oakes, C. C. et al. Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia. Cancer Discov. 4, 348-361 (2014).
    • (2014) Cancer Discov , vol.4 , pp. 348-361
    • Oakes, C.C.1
  • 72
    • 84861922114 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia
    • Pei, L. et al. Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia. Epigenetics 7, 567-578 (2012).
    • (2012) Epigenetics , vol.7 , pp. 567-578
    • Pei, L.1
  • 73
    • 84924540077 scopus 로고    scopus 로고
    • A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact
    • Queiros, A. C. et al. A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact. Leukemia 29, 598-605 (2015).
    • (2015) Leukemia , vol.29 , pp. 598-605
    • Queiros, A.C.1
  • 74
    • 84973167177 scopus 로고    scopus 로고
    • Prognostic impact of epigenetic classification in chronic lymphocytic leukemia: The case of subset #2
    • Bhoi, S. et al. Prognostic impact of epigenetic classification in chronic lymphocytic leukemia: The case of subset #2. Epigenetics 11, 449-455 (2016).
    • (2016) Epigenetics , vol.11 , pp. 449-455
    • Bhoi, S.1
  • 75
    • 84959519942 scopus 로고    scopus 로고
    • DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia
    • Oakes, C. C. et al. DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia. Nat. Genet. 48, 253-264 (2016).
    • (2016) Nat. Genet , vol.48 , pp. 253-264
    • Oakes, C.C.1
  • 76
    • 0342711256 scopus 로고    scopus 로고
    • In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
    • Lam, K. P., Kuhn, R. & Rajewsky, K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90, 1073-1083 (1997).
    • (1997) Cell , vol.90 , pp. 1073-1083
    • Lam, K.P.1    Kuhn, R.2    Rajewsky, K.3
  • 77
    • 78751549662 scopus 로고    scopus 로고
    • The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
    • Herishanu, Y. et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood 117, 563-574 (2011).
    • (2011) Blood , vol.117 , pp. 563-574
    • Herishanu, Y.1
  • 78
    • 34248354409 scopus 로고    scopus 로고
    • Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status
    • Mockridge, C. I. et al. Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status. Blood 109, 4424-4431 (2007).
    • (2007) Blood , vol.109 , pp. 4424-4431
    • Mockridge, C.I.1
  • 79
    • 84866152172 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia is driven by antigen-independent cell-Autonomous signalling
    • Duhren-von Minden, M. et al. Chronic lymphocytic leukaemia is driven by antigen-independent cell-Autonomous signalling. Nature 489, 309-312 (2012).
    • (2012) Nature , vol.489 , pp. 309-312
    • Duhren-Von Minden, M.1
  • 80
    • 84918536030 scopus 로고    scopus 로고
    • New strategies in chronic lymphocytic leukemia: Shifting treatment paradigms
    • Awan, F. T. & Byrd, J. C. New strategies in chronic lymphocytic leukemia: shifting treatment paradigms. Clin. Cancer Res. 20, 5869-5874 (2014).
    • (2014) Clin. Cancer Res , vol.20 , pp. 5869-5874
    • Awan, F.T.1    Byrd, J.C.2
  • 81
    • 77955916272 scopus 로고    scopus 로고
    • Molecular underpinning of B-cell anergy
    • Yarkoni, Y., Getahun, A. & Cambier, J. C. Molecular underpinning of B-cell anergy. Immunol. Rev. 237, 249-263 (2010).
    • (2010) Immunol. Rev , vol.237 , pp. 249-263
    • Yarkoni, Y.1    Getahun, A.2    Cambier, J.C.3
  • 82
    • 84969247704 scopus 로고    scopus 로고
    • Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells
    • Getahun, A., Beavers, N. A., Larson, S. R., Shlomchik, M. J. & Cambier, J. C. Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J. Exp. Med. 213, 751-769 (2016).
    • (2016) J. Exp. Med , vol.213 , pp. 751-769
    • Getahun, A.1    Beavers, N.A.2    Larson, S.R.3    Shlomchik, M.J.4    Cambier, J.C.5
  • 83
    • 81955161811 scopus 로고    scopus 로고
    • Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy
    • ONeill, S. K. et al. Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity 35, 746-756 (2011).
    • (2011) Immunity , vol.35 , pp. 746-756
    • Oneill, S.K.1
  • 84
    • 84903642390 scopus 로고    scopus 로고
    • The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: Proliferation or anergy
    • Packham, G. et al. The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy. Haematologica 99, 1138-1148 (2014).
    • (2014) Haematologica , vol.99 , pp. 1138-1148
    • Packham, G.1
  • 85
    • 34547193611 scopus 로고    scopus 로고
    • B-cell anergy: From transgenic models to naturally occurring anergic B cells?
    • Cambier, J. C., Gauld, S. B., Merrell, K. T. & Vilen, B. J. B-cell anergy: from transgenic models to naturally occurring anergic B cells? Nat. Rev. Immunol. 7, 633-643 (2007).
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 633-643
    • Cambier, J.C.1    Gauld, S.B.2    Merrell, K.T.3    Vilen, B.J.4
  • 86
    • 84858636448 scopus 로고    scopus 로고
    • The clinically active btk inhibitor pci-32765 targets b-cell receptor-And chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
    • de Rooij, M. F. et al. The clinically active BTK inhibitor PCI-32765 targets B-cell receptor-And chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. Blood 119, 2590-2594 (2012).
    • (2012) Blood , vol.119 , pp. 2590-2594
    • De Rooij, M.F.1
  • 87
    • 69249120197 scopus 로고    scopus 로고
    • Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease
    • Vlad, A. et al. Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease. Cancer Res. 69, 6387-6395 (2009).
    • (2009) Cancer Res , vol.69 , pp. 6387-6395
    • Vlad, A.1
  • 88
    • 70349237504 scopus 로고    scopus 로고
    • B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406
    • Quiroga, M. P. et al. B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood 114, 1029-1037 (2009).
    • (2009) Blood , vol.114 , pp. 1029-1037
    • Quiroga, M.P.1
  • 89
    • 77955352121 scopus 로고    scopus 로고
    • Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis
    • OHayre, M. et al. Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis. PLoS ONE 5, e11716 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e11716
    • Ohayre, M.1
  • 90
    • 33846258010 scopus 로고    scopus 로고
    • BAFF and April support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway
    • Endo, T. et al. BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood 109, 703-710 (2007).
    • (2007) Blood , vol.109 , pp. 703-710
    • Endo, T.1
  • 91
    • 84976274450 scopus 로고    scopus 로고
    • IL-4 enhances expression and function of surface IgM in CLL cells
    • Aguilar-Hernandez, M. M. et al. IL-4 enhances expression and function of surface IgM in CLL cells. Blood 127, 3015-3025 (2016).
    • (2016) Blood , vol.127 , pp. 3015-3025
    • Aguilar-Hernandez, M.M.1
  • 92
    • 1542267803 scopus 로고    scopus 로고
    • Activation of the Wnt signaling pathway in chronic lymphocytic leukemia
    • Lu, D. et al. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 101, 3118-3123 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 3118-3123
    • Lu, D.1
  • 93
    • 84956954700 scopus 로고    scopus 로고
    • Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation
    • Yu, J. et al. Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation. J. Clin. Invest. 126, 585-598 (2016).
    • (2016) J. Clin. Invest , vol.126 , pp. 585-598
    • Yu, J.1
  • 94
    • 85014946822 scopus 로고    scopus 로고
    • High-level ROR1 associates with accelerated disease-progression in chronic lymphocytic leukemia
    • Cui, B. et al. High-level ROR1 associates with accelerated disease-progression in chronic lymphocytic leukemia. Blood 128, 2931-2940 (2016).
    • (2016) Blood , vol.128 , pp. 2931-2940
    • Cui, B.1
  • 95
    • 84860001611 scopus 로고    scopus 로고
    • Interactions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells: Any role for Notch, Wnt and Hh signaling pathways?
    • Seke Etet, P. F., Vecchio, L. & Nwabo Kamdje, A. H. Interactions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells: Any role for Notch, Wnt and Hh signaling pathways? Cell Signal. 24, 1433-1443 (2012).
    • (2012) Cell Signal , vol.24 , pp. 1433-1443
    • Seke Etet, P.F.1    Vecchio, L.2    Nwabo Kamdje, A.H.3
  • 96
    • 84856303562 scopus 로고    scopus 로고
    • Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL
    • Decker, S. et al. Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL. Blood 119, 997-1007 (2012).
    • (2012) Blood , vol.119 , pp. 997-1007
    • Decker, S.1
  • 97
    • 84937911110 scopus 로고    scopus 로고
    • Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL
    • De Falco, F. et al. Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL. Oncotarget 6, 16559-16572 (2015).
    • (2015) Oncotarget , vol.6 , pp. 16559-16572
    • De Falco, F.1
  • 98
    • 84891519509 scopus 로고    scopus 로고
    • Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function
    • Coelho, V. et al. Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function. Blood 122, 2664-2672 (2013).
    • (2013) Blood , vol.122 , pp. 2664-2672
    • Coelho, V.1
  • 99
    • 0033485625 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells
    • Burger, J. A., Burger, M. & Kipps, T. J. Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood 94, 3658-3667 (1999).
    • (1999) Blood , vol.94 , pp. 3658-3667
    • Burger, J.A.1    Burger, M.2    Kipps, T.J.3
  • 100
    • 0034667624 scopus 로고    scopus 로고
    • Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1
    • Burger, J. A. et al. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood 96, 2655-2663 (2000).
    • (2000) Blood , vol.96 , pp. 2655-2663
    • Burger, J.A.1
  • 101
    • 82855177892 scopus 로고    scopus 로고
    • Intraclonal complexity in chronic lymphocytic leukemia: Fractions enriched in recently born/divided and older/quiescent cells
    • Calissano, C. et al. Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells. Mol. Med. 17, 1374-1382 (2011).
    • (2011) Mol. Med , vol.17 , pp. 1374-1382
    • Calissano, C.1
  • 102
    • 84924569820 scopus 로고    scopus 로고
    • Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kdelta inhibition
    • Pepper, C. et al. Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kdelta inhibition. Leukemia 29, 744-747 (2015).
    • (2015) Leukemia , vol.29 , pp. 744-747
    • Pepper, C.1
  • 103
    • 84964378606 scopus 로고    scopus 로고
    • Disruption of in vivo chronic lymphocytic leukemia tumor-microenvironment interactions by ibrutinib-findings from an investigator-initiated phase II study
    • Niemann, C. U. et al. Disruption of in vivo chronic lymphocytic leukemia tumor-microenvironment interactions by ibrutinib-findings from an investigator-initiated phase II study. Clin. Cancer Res. 22, 1572-1582 (2016).
    • (2016) Clin. Cancer Res , vol.22 , pp. 1572-1582
    • Niemann, C.U.1
  • 104
    • 33746377279 scopus 로고    scopus 로고
    • Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation
    • Izcue, A., Coombes, J. L. & Powrie, F. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol. Rev. 212, 256-271 (2006).
    • (2006) Immunol. Rev , vol.212 , pp. 256-271
    • Izcue, A.1    Coombes, J.L.2    Powrie, F.3
  • 105
    • 84873567628 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function
    • DiLillo, D. J. et al. Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function. Leukemia 27, 170-182 (2013).
    • (2013) Leukemia , vol.27 , pp. 170-182
    • DiLillo, D.J.1
  • 106
    • 84865165316 scopus 로고    scopus 로고
    • Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: Establishing a reversible immune evasion mechanism in human cancer
    • Ramsay, A. G., Clear, A. J., Fatah, R. & Gribben, J. G. Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. Blood 120, 1412-1421 (2012).
    • (2012) Blood , vol.120 , pp. 1412-1421
    • Ramsay, A.G.1    Clear, A.J.2    Fatah, R.3    Gribben, J.G.4
  • 107
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the international workshop on chronic lymphocytic leukemia updating the national cancer institute-working group 1996 guidelines
    • Hallek, M. et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 111, 5446-5456 (2008).
    • (2008) Blood , vol.111 , pp. 5446-5456
    • Hallek, M.1
  • 109
    • 84855265260 scopus 로고    scopus 로고
    • Diagnostic usefulness and prognostic impact of CD200 expression in lymphoid malignancies and plasma cell myeloma
    • Alapat, D. et al. Diagnostic usefulness and prognostic impact of CD200 expression in lymphoid malignancies and plasma cell myeloma. Am. J. Clin. Pathol. 137, 93-100 (2012).
    • (2012) Am. J. Clin. Pathol , vol.137 , pp. 93-100
    • Alapat, D.1
  • 110
    • 42949121156 scopus 로고    scopus 로고
    • Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a
    • Fukuda, T. et al. Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc. Natl Acad. Sci. USA 105, 3047-3052 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 3047-3052
    • Fukuda, T.1
  • 111
    • 84879369188 scopus 로고    scopus 로고
    • B-And T-cell prolymphocytic leukemia: Antibody approaches
    • Dearden, C. B-And T-cell prolymphocytic leukemia: Antibody approaches. Hematol. Am. Soc. Hematol. Educ. Program 2012, 645-651 (2012).
    • (2012) Hematol. Am. Soc. Hematol. Educ. Program , vol.2012 , pp. 645-651
    • Dearden, C.1
  • 112
    • 0020876201 scopus 로고
    • Bone marrow biopsy in chronic lymphocytic leukaemia: A study of 208 cases
    • Montserrat, E. & Rozman, C. Bone marrow biopsy in chronic lymphocytic leukaemia: A study of 208 cases. Haematologia (Budap.) 16, 73-79 (1983).
    • (1983) Haematologia (Budap.) , vol.16 , pp. 73-79
    • Montserrat, E.1    Rozman, C.2
  • 113
    • 0033696315 scopus 로고    scopus 로고
    • Small lymphocytic lymphoma with perifollicular, marginal zone, or interfollicular distribution
    • Gupta, D., Lim, M. S., Medeiros, L. J. & Elenitoba-Johnson, K. S. Small lymphocytic lymphoma with perifollicular, marginal zone, or interfollicular distribution. Mod. Pathol. 13, 1161-1166 (2000).
    • (2000) Mod. Pathol , vol.13 , pp. 1161-1166
    • Gupta, D.1    Lim, M.S.2    Medeiros, L.J.3    Elenitoba-Johnson, K.S.4
  • 114
    • 0016740933 scopus 로고
    • Clinical staging of chronic lymphocytic leukemia
    • Rai, K. R. et al. Clinical staging of chronic lymphocytic leukemia. Blood 46, 219-234 (1975).
    • (1975) Blood , vol.46 , pp. 219-234
    • Rai, K.R.1
  • 115
    • 0017751562 scopus 로고
    • A clinical staging system for chronic lymphocytic leukemia: Prognostic significance
    • Binet, J. L. et al. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer 40, 855-864 (1977).
    • (1977) Cancer , vol.40 , pp. 855-864
    • Binet, J.L.1
  • 116
    • 84874428346 scopus 로고    scopus 로고
    • Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
    • Rossi, D. et al. Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood 121, 1403-1412 (2013).
    • (2013) Blood , vol.121 , pp. 1403-1412
    • Rossi, D.1
  • 117
    • 84903971364 scopus 로고    scopus 로고
    • Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia
    • Pflug, N. et al. Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia. Blood 124, 49-62 (2014).
    • (2014) Blood , vol.124 , pp. 49-62
    • Pflug, N.1
  • 118
    • 84966746552 scopus 로고    scopus 로고
    • International CLL-IPI working group. An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): A meta-Analysis of individual patient data
    • International CLL-IPI working group. An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): A meta-Analysis of individual patient data. Lancet Oncol. 17, 779-790 (2016).
    • (2016) Lancet Oncol , vol.17 , pp. 779-790
  • 119
    • 34249733155 scopus 로고    scopus 로고
    • Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia
    • Wierda, W. G. et al. Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia. Blood 109, 4679-4685 (2007).
    • (2007) Blood , vol.109 , pp. 4679-4685
    • Wierda, W.G.1
  • 120
    • 4143105617 scopus 로고    scopus 로고
    • ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
    • Rassenti, L. Z. et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N. Engl. J. Med. 351, 893-901 (2004).
    • (2004) N. Engl. J. Med , vol.351 , pp. 893-901
    • Rassenti, L.Z.1
  • 121
    • 0347318114 scopus 로고    scopus 로고
    • ZAP-70 expression and prognosis in chronic lymphocytic leukaemia
    • Orchard, J. A. et al. ZAP-70 expression and prognosis in chronic lymphocytic leukaemia. Lancet 363, 105-111 (2004).
    • (2004) Lancet , vol.363 , pp. 105-111
    • Orchard, J.A.1
  • 122
    • 84899742457 scopus 로고    scopus 로고
    • CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia
    • Bulian, P. et al. CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia. J. Clin. Oncol. 32, 897-904 (2014).
    • (2014) J. Clin. Oncol , vol.32 , pp. 897-904
    • Bulian, P.1
  • 123
    • 1842328565 scopus 로고    scopus 로고
    • 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis
    • Dohner, H. et al. 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood 89, 2516-2522 (1997).
    • (1997) Blood , vol.89 , pp. 2516-2522
    • Dohner, H.1
  • 124
    • 0029829395 scopus 로고    scopus 로고
    • Serum b2-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma
    • Hallek, M. et al. Serum b2-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma. Leuk. Lymphoma 22, 439-447 (1996).
    • (1996) Leuk. Lymphoma , vol.22 , pp. 439-447
    • Hallek, M.1
  • 125
    • 84992463458 scopus 로고    scopus 로고
    • Major prognostic value of complex karyotype in addition to TP53 and IGHV mutational status in first-line chronic lymphocytic leukemia
    • Le Bris, Y. et al. Major prognostic value of complex karyotype in addition to TP53 and IGHV mutational status in first-line chronic lymphocytic leukemia. Hematol. Oncol. http://dx.doi.org/10.1002/hon.2349 (2016).
    • Hematol. Oncol , vol.2016
    • Le Bris, Y.1
  • 126
    • 84943579968 scopus 로고    scopus 로고
    • Complex karyotype is a stronger predictor than del(17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinib-based regimens
    • Thompson, P. A. et al. Complex karyotype is a stronger predictor than del(17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinib-based regimens. Cancer 121, 3612-3621 (2015).
    • (2015) Cancer , vol.121 , pp. 3612-3621
    • Thompson, P.A.1
  • 127
    • 33644847307 scopus 로고    scopus 로고
    • Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: Justification for risk-Adapted therapy
    • Byrd, J. C. et al. Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: justification for risk-Adapted therapy. J. Clin. Oncol. 24, 437-443 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 437-443
    • Byrd, J.C.1
  • 128
    • 84941640385 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
    • Eichhorst, B. et al. Chronic lymphocytic leukaemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 26 (Suppl. 5), v78-v84 (2015).
    • (2015) Ann. Oncol , vol.26 , pp. v78-v84
    • Eichhorst, B.1
  • 129
    • 85013667861 scopus 로고    scopus 로고
    • Appendix 6: Chronic lymphocytic leukaemia: EUpdate published online September 2016
    • Eichhorst, B. et al. Appendix 6: chronic lymphocytic leukaemia: eUpdate published online September 2016 (http://www.esmo.org/Guidelines/Haematological-Malignancies). Ann. Oncol. 27 (Suppl. 5), v143-v144 (2016).
    • (2016) Ann. Oncol , vol.27 , pp. v143-v144
    • Eichhorst, B.1
  • 130
    • 29244492252 scopus 로고    scopus 로고
    • Therapy of chronic lymphocytic leukaemia with purine nucleoside analogues: Facts and controversies
    • Robak, T. Therapy of chronic lymphocytic leukaemia with purine nucleoside analogues: facts and controversies. Drugs Aging 22, 983-1012 (2005).
    • (2005) Drugs Aging , vol.22 , pp. 983-1012
    • Robak, T.1
  • 131
    • 84863101100 scopus 로고    scopus 로고
    • Bendamustine for treatment of chronic lymphocytic leukemia
    • Chang, J. E. & Kahl, B. S. Bendamustine for treatment of chronic lymphocytic leukemia. Expert Opin. Pharmacother. 13, 1495-1505 (2012).
    • (2012) Expert Opin. Pharmacother , vol.13 , pp. 1495-1505
    • Chang, J.E.1    Kahl, B.S.2
  • 132
    • 84880959171 scopus 로고    scopus 로고
    • Fludarabine: A review of the clear benefits and potential harms
    • Lukenbill, J. & Kalaycio, M. Fludarabine: A review of the clear benefits and potential harms. Leuk. Res. 37, 986-994 (2013).
    • (2013) Leuk. Res , vol.37 , pp. 986-994
    • Lukenbill, J.1    Kalaycio, M.2
  • 133
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek, M. et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial. Lancet 376, 1164-1174 (2010).
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.1
  • 134
    • 84894552888 scopus 로고    scopus 로고
    • Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions
    • Goede, V. et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N. Engl. J. Med. 370, 1101-1110 (2014).
    • (2014) N. Engl. J. Med , vol.370 , pp. 1101-1110
    • Goede, V.1
  • 135
    • 84929505415 scopus 로고    scopus 로고
    • Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): A randomised, multicentre, open-label phase 3 trial
    • Hillmen, P. et al. Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): A randomised, multicentre, open-label phase 3 trial. Lancet 385, 1873-1883 (2015).
    • (2015) Lancet , vol.385 , pp. 1873-1883
    • Hillmen, P.1
  • 136
    • 77950502126 scopus 로고    scopus 로고
    • Ofatumumab as single-Agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia
    • Wierda, W. G. et al. Ofatumumab as single-Agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia. J. Clin. Oncol. 28, 1749-1755 (2010).
    • (2010) J. Clin. Oncol , vol.28 , pp. 1749-1755
    • Wierda, W.G.1
  • 137
    • 84964478073 scopus 로고    scopus 로고
    • Combination of bendamustine and rituximab as front-line therapy for patients with chronic lymphocytic leukaemia: Multicenter, retrospective clinical practice experience with 279 cases outside of controlled clinical trials
    • Gentile, M. et al. Combination of bendamustine and rituximab as front-line therapy for patients with chronic lymphocytic leukaemia: multicenter, retrospective clinical practice experience with 279 cases outside of controlled clinical trials. Eur. J. Cancer 60, 154-165 (2016).
    • (2016) Eur. J. Cancer , vol.60 , pp. 154-165
    • Gentile, M.1
  • 138
    • 84928799883 scopus 로고    scopus 로고
    • Obinutuzumab plus fludarabine/cyclophosphamide or bendamustine in the initial therapy of CLL patients: The phase 1b GALTON trial
    • Brown, J. R. et al. Obinutuzumab plus fludarabine/cyclophosphamide or bendamustine in the initial therapy of CLL patients: The phase 1b GALTON trial. Blood 125, 2779-2785 (2015).
    • (2015) Blood , vol.125 , pp. 2779-2785
    • Brown, J.R.1
  • 139
    • 84969523604 scopus 로고    scopus 로고
    • First-line chemoimmunotherapy with bendamustine and rituximab versus fludarabine, cyclophosphamide, and rituximab in patients with advanced chronic lymphocytic leukaemia (CLL10): An international, open-label, randomised, phase 3, non-inferiority trial
    • Eichhorst, B. et al. First-line chemoimmunotherapy with bendamustine and rituximab versus fludarabine, cyclophosphamide, and rituximab in patients with advanced chronic lymphocytic leukaemia (CLL10): An international, open-label, randomised, phase 3, non-inferiority trial. Lancet Oncol. 17, 928-942 (2016).
    • (2016) Lancet Oncol , vol.17 , pp. 928-942
    • Eichhorst, B.1
  • 140
    • 84955482904 scopus 로고    scopus 로고
    • Long-Term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: Updated results of the CLL8 trial
    • Fischer, K. et al. Long-Term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial. Blood 127, 208-215 (2016).
    • (2016) Blood , vol.127 , pp. 208-215
    • Fischer, K.1
  • 141
    • 84944248903 scopus 로고    scopus 로고
    • Molecular prediction of durable remission after first-line fludarabine-cyclophosphamide-rituximab in chronic lymphocytic leukemia
    • Rossi, D. et al. Molecular prediction of durable remission after first-line fludarabine-cyclophosphamide-rituximab in chronic lymphocytic leukemia. Blood 126, 1921-1924 (2015).
    • (2015) Blood , vol.126 , pp. 1921-1924
    • Rossi, D.1
  • 142
    • 84958181962 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide, and rituximab treatment achieves long-Term disease-free survival in IGHV-mutated chronic lymphocytic leukemia
    • Thompson, P. A. et al. Fludarabine, cyclophosphamide, and rituximab treatment achieves long-Term disease-free survival in IGHV-mutated chronic lymphocytic leukemia. Blood 127, 303-309 (2016).
    • (2016) Blood , vol.127 , pp. 303-309
    • Thompson, P.A.1
  • 143
    • 84863011553 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and
    • Ponader, S. et al. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 119, 1182-1189 (2012).
    • (2012) Vivo. Blood , vol.119 , pp. 1182-1189
    • Ponader, S.1
  • 144
    • 84958012485 scopus 로고    scopus 로고
    • Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib
    • Guo, A. et al. Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib. Oncotarget 7, 4598-4610 (2016).
    • (2016) Oncotarget , vol.7 , pp. 4598-4610
    • Guo, A.1
  • 145
    • 84904252369 scopus 로고    scopus 로고
    • Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
    • Byrd, J. C. et al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N. Engl. J. Med. 371, 213-223 (2014).
    • (2014) N. Engl. J. Med , vol.371 , pp. 213-223
    • Byrd, J.C.1
  • 146
    • 84950133717 scopus 로고    scopus 로고
    • Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia
    • Burger, J. A. et al. Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia. N. Engl. J. Med. 373, 2425-2437 (2015).
    • (2015) N. Engl. J. Med , vol.373 , pp. 2425-2437
    • Burger, J.A.1
  • 147
    • 84902183019 scopus 로고    scopus 로고
    • Resistance mechanisms for the Brutons tyrosine kinase inhibitor ibrutinib
    • Woyach, J. A. et al. Resistance mechanisms for the Brutons tyrosine kinase inhibitor ibrutinib. N. Engl. J. Med. 370, 2286-2294 (2014).
    • (2014) N. Engl. J. Med , vol.370 , pp. 2286-2294
    • Woyach, J.A.1
  • 148
    • 84955481177 scopus 로고    scopus 로고
    • Acalabrutinib (ACP-196) in relapsed chronic lymphocytic leukemia
    • Byrd, J. C. et al. Acalabrutinib (ACP-196) in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 374, 323-332 (2016).
    • (2016) N. Engl. J. Med , vol.374 , pp. 323-332
    • Byrd, J.C.1
  • 149
    • 84958230944 scopus 로고    scopus 로고
    • A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies
    • Walter, H. S. et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood 127, 411-419 (2016).
    • (2016) Blood , vol.127 , pp. 411-419
    • Walter, H.S.1
  • 150
    • 84984920989 scopus 로고    scopus 로고
    • Second-generation inhibitors of Bruton tyrosine kinase
    • Wu, J., Liu, C., Tsui, S. T. & Liu, D. Second-generation inhibitors of Bruton tyrosine kinase. J. Hematol. Oncol. 9, 80 (2016).
    • (2016) J. Hematol. Oncol , vol.9 , pp. 80
    • Wu, J.1    Liu, C.2    Tsui, S.T.3    Liu, D.4
  • 151
    • 84942244150 scopus 로고    scopus 로고
    • Pharmacological targeting of PI3K isoforms as a therapeutic strategy in chronic lymphocytic leukaemia
    • Blunt, M. D. & Steele, A. J. Pharmacological targeting of PI3K isoforms as a therapeutic strategy in chronic lymphocytic leukaemia. Leuk. Res. Rep. 4, 60-63 (2015).
    • (2015) Leuk. Res. Rep , vol.4 , pp. 60-63
    • Blunt, M.D.1    Steele, A.J.2
  • 152
    • 84896692766 scopus 로고    scopus 로고
    • Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
    • Furman, R. R. et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 370, 997-1007 (2014).
    • (2014) N. Engl. J. Med , vol.370 , pp. 997-1007
    • Furman, R.R.1
  • 153
    • 84978389613 scopus 로고    scopus 로고
    • Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity
    • Lampson, B. L. et al. Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity. Blood 128, 195-203 (2016).
    • (2016) Blood , vol.128 , pp. 195-203
    • Lampson, B.L.1
  • 154
    • 84941200862 scopus 로고    scopus 로고
    • Management of adverse events associated with idelalisib treatment: Expert panel opinion
    • Coutre, S. E. et al. Management of adverse events associated with idelalisib treatment: expert panel opinion. Leuk. Lymphoma 56, 2779-2786 (2015).
    • (2015) Leuk. Lymphoma , vol.56 , pp. 2779-2786
    • Coutre, S.E.1
  • 155
    • 84893143226 scopus 로고    scopus 로고
    • Prophylaxis against hepatitis B reactivation among patients with lymphoma receiving rituximab
    • Buensalido, J. A. & Chandrasekar, P. H. Prophylaxis against hepatitis B reactivation among patients with lymphoma receiving rituximab. Expert Rev. Anti Infect. Ther. 12, 151-154 (2014).
    • (2014) Expert Rev. Anti Infect. Ther , vol.12 , pp. 151-154
    • Buensalido, J.A.1    Chandrasekar, P.H.2
  • 156
    • 77951002653 scopus 로고    scopus 로고
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
    • Friedberg, J. W. et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood 115, 2578-2585 (2010).
    • (2010) Blood , vol.115 , pp. 2578-2585
    • Friedberg, J.W.1
  • 157
    • 84873540049 scopus 로고    scopus 로고
    • ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
    • Souers, A. J. et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat. Med. 19, 202-208 (2013).
    • (2013) Nat. Med , vol.19 , pp. 202-208
    • Souers, A.J.1
  • 158
    • 33845994359 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia requires bcl2 to sequester prodeath bim, explaining sensitivity to bcl2 antagonist abt-737
    • Del Gaizo Moore, V. et al. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J. Clin. Invest. 117, 112-121 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 112-121
    • Del Gaizo Moore, V.1
  • 159
    • 84955491187 scopus 로고    scopus 로고
    • Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia
    • Roberts, A. W. et al. Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 374, 311-322 (2016).
    • (2016) N. Engl. J. Med , vol.374 , pp. 311-322
    • Roberts, A.W.1
  • 160
    • 84970032000 scopus 로고    scopus 로고
    • Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: A multicentre, open-label, phase 2 study
    • Stilgenbauer, S. et al. Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: A multicentre, open-label, phase 2 study. Lancet Oncol. 17, 768-778 (2016).
    • (2016) Lancet Oncol , vol.17 , pp. 768-778
    • Stilgenbauer, S.1
  • 161
    • 84942899779 scopus 로고    scopus 로고
    • Pharmacological and protein profiling suggests venetoclax (ABT-199) as optimal partner with ibrutinib in chronic lymphocytic leukemia
    • Cervantes-Gomez, F. et al. Pharmacological and protein profiling suggests venetoclax (ABT-199) as optimal partner with ibrutinib in chronic lymphocytic leukemia. Clin. Cancer Res. 21, 3705-3715 (2015).
    • (2015) Clin. Cancer Res , vol.21 , pp. 3705-3715
    • Cervantes-Gomez, F.1
  • 162
    • 84938596484 scopus 로고    scopus 로고
    • Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors
    • Thijssen, R. et al. Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors. Haematologica 100, e302-e306 (2015).
    • (2015) Haematologica , vol.100 , pp. e302-e306
    • Thijssen, R.1
  • 163
    • 84958177610 scopus 로고    scopus 로고
    • Eliminating minimal residual disease as a therapeutic end point: Working toward cure for patients with CLL
    • Thompson, P. A. & Wierda, W. G. Eliminating minimal residual disease as a therapeutic end point: working toward cure for patients with CLL. Blood 127, 279-286 (2016).
    • (2016) Blood , vol.127 , pp. 279-286
    • Thompson, P.A.1    Wierda, W.G.2
  • 164
    • 56249095457 scopus 로고    scopus 로고
    • Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia
    • Castro, J. E., Sandoval-Sus, J. D., Bole, J., Rassenti, L. & Kipps, T. J. Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia. Leukemia 22, 2048-2053 (2008).
    • (2008) Leukemia , vol.22 , pp. 2048-2053
    • Castro, J.E.1    Sandoval-Sus, J.D.2    Bole, J.3    Rassenti, L.4    Kipps, T.J.5
  • 165
    • 45949100928 scopus 로고    scopus 로고
    • Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
    • Ferrajoli, A. et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 111, 5291-5297 (2008).
    • (2008) Blood , vol.111 , pp. 5291-5297
    • Ferrajoli, A.1
  • 166
    • 84905865264 scopus 로고    scopus 로고
    • Lenalidomide and rituximab for the initial treatment of patients with chronic lymphocytic leukemia: A multicenter clinical-Translational study from the chronic lymphocytic leukemia research consortium
    • James, D. F. et al. Lenalidomide and rituximab for the initial treatment of patients with chronic lymphocytic leukemia: A multicenter clinical-Translational study from the chronic lymphocytic leukemia research consortium. J. Clin. Oncol. 32, 2067-2073 (2014).
    • (2014) J. Clin. Oncol , vol.32 , pp. 2067-2073
    • James, D.F.1
  • 167
    • 85010952208 scopus 로고    scopus 로고
    • Patterns of resistance to B cell-receptor pathway antagonists in chronic lymphocytic leukemia and strategies for management
    • Woyach, J. A. Patterns of resistance to B cell-receptor pathway antagonists in chronic lymphocytic leukemia and strategies for management. Hematol. Am. Soc. Hematol. Educ. Program 2015, 355-360 (2015).
    • (2015) Hematol. Am. Soc. Hematol. Educ. Program , vol.2015 , pp. 355-360
    • Woyach, J.A.1
  • 168
    • 84991702543 scopus 로고    scopus 로고
    • Rituximab maintenance versus observation alone in patients with chronic lymphocytic leukaemia who respond to first-line or second-line rituximab-containing chemoimmunotherapy: Final results of the AGMT CLL-8a Mabtenance randomised trial
    • Greil, R. et al. Rituximab maintenance versus observation alone in patients with chronic lymphocytic leukaemia who respond to first-line or second-line rituximab-containing chemoimmunotherapy: final results of the AGMT CLL-8a Mabtenance randomised trial. Lancet Haematol. 3, e317-e329 (2016).
    • (2016) Lancet Haematol , vol.3 , pp. e317-e329
    • Greil, R.1
  • 169
    • 34848896596 scopus 로고    scopus 로고
    • Quality of life in chronic lymphocytic leukemia: An international survey of 1482 patients
    • Shanafelt, T. D. et al. Quality of life in chronic lymphocytic leukemia: An international survey of 1482 patients. Br. J. Haematol. 139, 255-264 (2007).
    • (2007) Br. J. Haematol , vol.139 , pp. 255-264
    • Shanafelt, T.D.1
  • 170
    • 84940204465 scopus 로고    scopus 로고
    • Perturbation of the normal immune system in patients with CLL
    • Forconi, F. & Moss, P. Perturbation of the normal immune system in patients with CLL. Blood 126, 573-581 (2015).
    • (2015) Blood , vol.126 , pp. 573-581
    • Forconi, F.1    Moss, P.2
  • 171
    • 0023764718 scopus 로고
    • Intravenous immunoglobulin for the prevention of infection in chronic lymphocytic leukemia
    • [No authors listed.] A Randomized, Controlled Clinical Trial Cooperative Group for the study of immunoglobulin in chronic lymphocytic leukemia
    • [No authors listed.] Intravenous immunoglobulin for the prevention of infection in chronic lymphocytic leukemia. A Randomized, Controlled Clinical Trial Cooperative Group for the study of immunoglobulin in chronic lymphocytic leukemia. N. Engl. J. Med. 319, 902-907 (1988).
    • (1988) N. Engl. J. Med , vol.319 , pp. 902-907
  • 172
    • 84963647521 scopus 로고    scopus 로고
    • Intravenous versus subcutaneous immunoglobulin replacement in secondary hypogammaglobulinemia
    • Spadaro, G., Pecoraro, A., De Renzo, A., Della Pepa, R. & Genovese, A. Intravenous versus subcutaneous immunoglobulin replacement in secondary hypogammaglobulinemia. Clin. Immunol. 166-167, 103-104 (2016).
    • (2016) Clin. Immunol , vol.166-167 , pp. 103-104
    • Spadaro, G.1    Pecoraro, A.2    De Renzo, A.3    Della Pepa, R.4    Genovese, A.5
  • 173
    • 84898057363 scopus 로고    scopus 로고
    • Antibody deficiency secondary to chronic lymphocytic leukemia: Should patients be treated with prophylactic replacement immunoglobulin?
    • Dhalla, F. et al. Antibody deficiency secondary to chronic lymphocytic leukemia: should patients be treated with prophylactic replacement immunoglobulin? J. Clin. Immunol. 34, 277-282 (2014).
    • (2014) J. Clin. Immunol , vol.34 , pp. 277-282
    • Dhalla, F.1
  • 174
    • 85006474631 scopus 로고    scopus 로고
    • Autoimmune cytopenias in chronic lymphocytic leukemia
    • Visco, C. et al. Autoimmune cytopenias in chronic lymphocytic leukemia. Am. J. Hematol. 89, 1055-1062 (2014).
    • (2014) Am. J. Hematol , vol.89 , pp. 1055-1062
    • Visco, C.1
  • 175
    • 79958835948 scopus 로고    scopus 로고
    • Autoimmune cytopenia in chronic lymphocytic leukaemia: Diagnosis and treatment
    • Hodgson, K., Ferrer, G., Pereira, A., Moreno, C. & Montserrat, E. Autoimmune cytopenia in chronic lymphocytic leukaemia: diagnosis and treatment. Br. J. Haematol. 154, 14-22 (2011).
    • (2011) Br. J. Haematol , vol.154 , pp. 14-22
    • Hodgson, K.1    Ferrer, G.2    Pereira, A.3    Moreno, C.4    Montserrat, E.5
  • 176
    • 84945495673 scopus 로고    scopus 로고
    • Mycophenolate mofetil therapy for severe immune thrombocytopenia
    • Taylor, A. et al. Mycophenolate mofetil therapy for severe immune thrombocytopenia. Br. J. Haematol. 171, 625-630 (2015).
    • (2015) Br. J. Haematol , vol.171 , pp. 625-630
    • Taylor, A.1
  • 178
    • 77958518731 scopus 로고    scopus 로고
    • Merkel cell carcinoma, chronic lymphocytic leukemia and other lymphoproliferative disorders: An old bond with possible new viral ties
    • Tadmor, T., Aviv, A. & Polliack, A. Merkel cell carcinoma, chronic lymphocytic leukemia and other lymphoproliferative disorders: An old bond with possible new viral ties. Ann. Oncol. 22, 250-256 (2011).
    • (2011) Ann. Oncol , vol.22 , pp. 250-256
    • Tadmor, T.1    Aviv, A.2    Polliack, A.3
  • 179
    • 77950803129 scopus 로고    scopus 로고
    • Second malignancies in B-cell chronic lymphocytic leukaemia: Possible association with human papilloma virus
    • Flynn, J. M., Andritsos, L., Lucas, D. & Byrd, J. C. Second malignancies in B-cell chronic lymphocytic leukaemia: possible association with human papilloma virus. Br. J. Haematol. 149, 388-390 (2010).
    • (2010) Br. J. Haematol , vol.149 , pp. 388-390
    • Flynn, J.M.1    Andritsos, L.2    Lucas, D.3    Byrd, J.C.4
  • 180
    • 84970023379 scopus 로고    scopus 로고
    • Effect of first-line treatment on second primary malignancies and Richters transformation in patients with CLL
    • Maurer, C. et al. Effect of first-line treatment on second primary malignancies and Richters transformation in patients with CLL. Leukemia 30, 2019-2025 (2016).
    • (2016) Leukemia , vol.30 , pp. 2019-2025
    • Maurer, C.1
  • 181
    • 83555178475 scopus 로고    scopus 로고
    • Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukaemia: A retrospective analysis of world literature
    • Bockorny, B., Codreanu, I. & Dasanu, C. A. Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukaemia: A retrospective analysis of world literature. Br. J. Haematol. 156, 50-66 (2012).
    • (2012) Br. J. Haematol , vol.156 , pp. 50-66
    • Bockorny, B.1    Codreanu, I.2    Dasanu, C.A.3
  • 182
    • 84959525298 scopus 로고    scopus 로고
    • Richter syndrome: Pathogenesis and management
    • Rossi, D. & Gaidano, G. Richter syndrome: pathogenesis and management. Semin. Oncol. 43, 311-319 (2016).
    • (2016) Semin. Oncol , vol.43 , pp. 311-319
    • Rossi, D.1    Gaidano, G.2
  • 183
    • 67650393955 scopus 로고    scopus 로고
    • Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome
    • Rossi, D. et al. Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome. Clin. Cancer Res. 15, 4415-4422 (2009).
    • (2009) Clin. Cancer Res , vol.15 , pp. 4415-4422
    • Rossi, D.1
  • 184
    • 84930574902 scopus 로고    scopus 로고
    • Diagnostic and prognostic role of PET/CT in patients with chronic lymphocytic leukemia and progressive disease
    • Mauro, F. R. et al. Diagnostic and prognostic role of PET/CT in patients with chronic lymphocytic leukemia and progressive disease. Leukemia 29, 1360-1365 (2015).
    • (2015) Leukemia , vol.29 , pp. 1360-1365
    • Mauro, F.R.1
  • 185
    • 84959330438 scopus 로고    scopus 로고
    • Outcomes for patients with chronic lymphocytic leukemia and acute leukemia or myelodysplastic syndrome
    • Tambaro, F. P. et al. Outcomes for patients with chronic lymphocytic leukemia and acute leukemia or myelodysplastic syndrome. Leukemia 30, 325-330 (2016).
    • (2016) Leukemia , vol.30 , pp. 325-330
    • Tambaro, F.P.1
  • 186
    • 84973278445 scopus 로고    scopus 로고
    • Results of a phase II study of lenalidomide and rituximab for refractory/relapsed chronic lymphocytic leukemia
    • Chavez, J. C. et al. Results of a phase II study of lenalidomide and rituximab for refractory/relapsed chronic lymphocytic leukemia. Leuk. Res. 47, 78-83 (2016).
    • (2016) Leuk. Res , vol.47 , pp. 78-83
    • Chavez, J.C.1
  • 187
    • 84907047022 scopus 로고    scopus 로고
    • Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21WAF1/Cip1-dependent mechanism independent of functional p53
    • Fecteau, J. F. et al. Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21WAF1/Cip1-dependent mechanism independent of functional p53. Blood 124, 1637-1644 (2014).
    • (2014) Blood , vol.124 , pp. 1637-1644
    • Fecteau, J.F.1
  • 188
    • 46749132717 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
    • Ramsay, A. G. et al. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J. Clin. Invest. 118, 2427-2437 (2008).
    • (2008) J. Clin. Invest , vol.118 , pp. 2427-2437
    • Ramsay, A.G.1
  • 189
    • 80053350801 scopus 로고    scopus 로고
    • Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia
    • Badoux, X. C. et al. Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia. Blood 118, 3489-3498 (2011).
    • (2011) Blood , vol.118 , pp. 3489-3498
    • Badoux, X.C.1
  • 190
    • 81855166080 scopus 로고    scopus 로고
    • Treating chronic lymphocytic leukemia with thalidomide and lenalidomide
    • Giannopoulos, K., Mertens, D. & Stilgenbauer, S. Treating chronic lymphocytic leukemia with thalidomide and lenalidomide. Expert Opin. Pharmacother. 12, 2857-2864 (2011).
    • (2011) Expert Opin. Pharmacother , vol.12 , pp. 2857-2864
    • Giannopoulos, K.1    Mertens, D.2    Stilgenbauer, S.3
  • 191
    • 84867911904 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT00910910 (2015).
    • (2015) ClinicalTrials.gov
  • 192
    • 84875451856 scopus 로고    scopus 로고
    • Phase II study of lenalidomide and rituximab as salvage therapy for patients with relapsed or refractory chronic lymphocytic leukemia
    • Badoux, X. C. et al. Phase II study of lenalidomide and rituximab as salvage therapy for patients with relapsed or refractory chronic lymphocytic leukemia. J. Clin. Oncol. 31, 584-591 (2013).
    • (2013) J. Clin. Oncol , vol.31 , pp. 584-591
    • Badoux, X.C.1
  • 193
    • 84969262601 scopus 로고    scopus 로고
    • Ofatumumab and lenalidomide for patients with relapsed or refractory chronic lymphocytic leukemia: Correlation between responses and immune characteristics
    • Vitale, C. et al. Ofatumumab and lenalidomide for patients with relapsed or refractory chronic lymphocytic leukemia: correlation between responses and immune characteristics. Clin. Cancer Res. 22, 2359-2367 (2016).
    • (2016) Clin. Cancer Res , vol.22 , pp. 2359-2367
    • Vitale, C.1
  • 194
    • 84936930551 scopus 로고    scopus 로고
    • Lenalidomide induces ubiquitination and degradation of CK1a in del(5q) MDS
    • Kronke, J. et al. Lenalidomide induces ubiquitination and degradation of CK1a in del(5q) MDS. Nature 523, 183-188 (2015).
    • (2015) Nature , vol.523 , pp. 183-188
    • Kronke, J.1
  • 195
    • 80053901737 scopus 로고    scopus 로고
    • Nonmyeloablative allogeneic stem cell transplantation in relapsed/refractory chronic lymphocytic leukemia: Long-Term follow-up, prognostic factors, and effect of human leukocyte histocompatibility antigen subtype on outcome
    • Khouri, I. F. et al. Nonmyeloablative allogeneic stem cell transplantation in relapsed/refractory chronic lymphocytic leukemia: long-Term follow-up, prognostic factors, and effect of human leukocyte histocompatibility antigen subtype on outcome. Cancer 117, 4679-4688 (2011).
    • (2011) Cancer , vol.117 , pp. 4679-4688
    • Khouri, I.F.1
  • 196
    • 84879173666 scopus 로고    scopus 로고
    • TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: Six-year follow-up of the GCLLSG CLL3X trial
    • Dreger, P. et al. TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: six-year follow-up of the GCLLSG CLL3X trial. Blood 121, 3284-3288 (2013).
    • (2013) Blood , vol.121 , pp. 3284-3288
    • Dreger, P.1
  • 197
    • 84940881287 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
    • Porter, D. L. et al. Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Sci. Transl Med. 7, 303ra139 (2015).
    • (2015) Sci. Transl Med , vol.7 , pp. 303ra139
    • Porter, D.L.1
  • 198
    • 84960444794 scopus 로고    scopus 로고
    • Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia
    • Fraietta, J. A. et al. Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia. Blood 127, 1117-1127 (2016).
    • (2016) Blood , vol.127 , pp. 1117-1127
    • Fraietta, J.A.1
  • 199
    • 84879480191 scopus 로고    scopus 로고
    • Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells
    • Hudecek, M. et al. Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells. Clin. Cancer Res. 19, 3153-3164 (2013).
    • (2013) Clin. Cancer Res , vol.19 , pp. 3153-3164
    • Hudecek, M.1
  • 200
    • 84933056343 scopus 로고    scopus 로고
    • Sleeping beauty transposition of chimeric antigen receptors targeting receptor tyrosine kinase-like orphan receptor-1 (ROR1) into diverse memory T-cell populations
    • Deniger, D. C. et al. Sleeping beauty transposition of chimeric antigen receptors targeting receptor tyrosine kinase-like orphan receptor-1 (ROR1) into diverse memory T-cell populations. PLoS ONE 10, e0128151 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0128151
    • Deniger, D.C.1
  • 201
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: Toward combination strategies with curative potential
    • Sharma, P. & Allison, J. P. Immune checkpoint targeting in cancer therapy: Toward combination strategies with curative potential. Cell 161, 205-214 (2015).
    • (2015) Cell , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 202
    • 84937780079 scopus 로고    scopus 로고
    • PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia
    • McClanahan, F. et al. PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia. Blood 126, 203-211 (2015).
    • (2015) Blood , vol.126 , pp. 203-211
    • McClanahan, F.1
  • 203
    • 85007579605 scopus 로고    scopus 로고
    • Cirmtuzumab inhibits wnt5a-induced rac1-Activation in chronic lymphocytic leukemia treated with ibrutinib
    • Yu, J. et al. Cirmtuzumab inhibits Wnt5a-induced Rac1-Activation in chronic lymphocytic leukemia treated with ibrutinib. Leukemia http://dx.doi.org/10.1038/leu.2016.368 (2016).
    • Leukemia , vol.2016
    • Yu, J.1
  • 204
    • 84937847194 scopus 로고    scopus 로고
    • Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: Diagnosis, natural history, and risk stratification
    • Strati, P. & Shanafelt, T. D. Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification. Blood 126, 454-462 (2015).
    • (2015) Blood , vol.126 , pp. 454-462
    • Strati, P.1    Shanafelt, T.D.2
  • 205
    • 77949422979 scopus 로고    scopus 로고
    • Monoclonal B-cell lymphocytosis (MBL): Biology, natural history and clinical management
    • Shanafelt, T. D., Ghia, P., Lanasa, M. C., Landgren, O. & Rawstron, A. C. Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management. Leukemia 24, 512-520 (2010).
    • (2010) Leukemia , vol.24 , pp. 512-520
    • Shanafelt, T.D.1    Ghia, P.2    Lanasa, M.C.3    Landgren, O.4    Rawstron, A.C.5
  • 206
    • 49249119141 scopus 로고    scopus 로고
    • Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia
    • Rawstron, A. C. et al. Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N. Engl. J. Med. 359, 575-583 (2008).
    • (2008) N. Engl. J. Med , vol.359 , pp. 575-583
    • Rawstron, A.C.1
  • 207
    • 0027488805 scopus 로고
    • Common clonal origin of chronic lymphocytic leukemia and high-grade lymphoma of Richters syndrome
    • Cherepakhin, V., Baird, S. M., Meisenholder, G. W. & Kipps, T. J. Common clonal origin of chronic lymphocytic leukemia and high-grade lymphoma of Richters syndrome. Blood 82, 3141-3147 (1993).
    • (1993) Blood , vol.82 , pp. 3141-3147
    • Cherepakhin, V.1    Baird, S.M.2    Meisenholder, G.W.3    Kipps, T.J.4
  • 208
    • 85027954380 scopus 로고    scopus 로고
    • Epstein-Barr virus-positive diffuse large B cell lymphoma arising from a chronic lymphocytic leukemia: Overlapping features with classical Hodgkin lymphoma
    • Chen, Y. A., Wang, R. C., Yang, Y. & Chuang, S. S. Epstein-Barr virus-positive diffuse large B cell lymphoma arising from a chronic lymphocytic leukemia: overlapping features with classical Hodgkin lymphoma. Pathol. Int. 66, 393-397 (2016).
    • (2016) Pathol. Int , vol.66 , pp. 393-397
    • Chen, Y.A.1    Wang, R.C.2    Yang, Y.3    Chuang, S.S.4
  • 209
    • 84891038503 scopus 로고    scopus 로고
    • Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome
    • Chigrinova, E. et al. Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome. Blood 122, 2673-2682 (2013).
    • (2013) Blood , vol.122 , pp. 2673-2682
    • Chigrinova, E.1
  • 210
    • 79953117852 scopus 로고    scopus 로고
    • The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation
    • Rossi, D. et al. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood 117, 3391-3401 (2011).
    • (2011) Blood , vol.117 , pp. 3391-3401
    • Rossi, D.1
  • 211
    • 84886851785 scopus 로고    scopus 로고
    • Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome
    • Fabbri, G. et al. Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome. J. Exp. Med. 210, 2273-2288 (2013).
    • (2013) J. Exp. Med , vol.210 , pp. 2273-2288
    • Fabbri, G.1
  • 213
    • 84878007509 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: Molecular heterogeneity revealed by high-Throughput genomics
    • Landau, D. A. & Wu, C. J. Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-Throughput genomics. Genome Med. 5, 47 (2013)
    • (2013) Genome Med , vol.5 , pp. 47
    • Landau, D.A.1    Wu, C.J.2


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