메뉴 건너뛰기




Volumn 43, Issue 2, 2016, Pages 311-319

Richter syndrome: Pathogenesis and management

Author keywords

Chronic lymphocytic leukemia; Diffuse large B cell lymphoma; NOTCH1; Richter syndrome; Subset 8

Indexed keywords

ANTILEUKEMIC AGENT; NEW DRUG; SELINEXOR;

EID: 84959525298     PISSN: 00937754     EISSN: 15328708     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2016.02.012     Document Type: Review
Times cited : (68)

References (66)
  • 2
    • 34748861564 scopus 로고    scopus 로고
    • IgVH mutational status and clonality analysis of Richter's transformation
    • Z. Mao, L. Quintanilla-Martinez, M. Raffeld, and et al. IgVH mutational status and clonality analysis of Richter's transformation Am J Surg Pathol 31 2007 1605 1614
    • (2007) Am J Surg Pathol , vol.31 , pp. 1605-1614
    • Mao, Z.1    Quintanilla-Martinez, L.2    Raffeld, M.3
  • 3
    • 67650393955 scopus 로고    scopus 로고
    • Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome
    • D. Rossi, V. Spina, M. Cerri, and et al. Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome Clin Cancer Res 15 2009 4415 4422
    • (2009) Clin Cancer Res , vol.15 , pp. 4415-4422
    • Rossi, D.1    Spina, V.2    Cerri, M.3
  • 4
    • 79953117852 scopus 로고    scopus 로고
    • The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation
    • D. Rossi, V. Spina, C. Deambrogi, and et al. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation Blood 117 2011 3391 3401
    • (2011) Blood , vol.117 , pp. 3391-3401
    • Rossi, D.1    Spina, V.2    Deambrogi, C.3
  • 5
    • 77956801193 scopus 로고    scopus 로고
    • Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia («accelerated» chronic lymphocytic leukemia) with aggressive clinical behavior
    • E. Giné, A. Martinez, N. Villamor, and et al. Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia («accelerated» chronic lymphocytic leukemia) with aggressive clinical behavior Haematologica 95 2010 1526 1533
    • (2010) Haematologica , vol.95 , pp. 1526-1533
    • Giné, E.1    Martinez, A.2    Villamor, N.3
  • 6
    • 33749030181 scopus 로고    scopus 로고
    • Hodgkin transformation of chronic lymphocytic leukemia: The M. D. Anderson Cancer Center experience
    • A.M. Tsimberidou, S. O'Brien, H.M. Kantarjian, and et al. Hodgkin transformation of chronic lymphocytic leukemia: The M. D. Anderson Cancer Center experience Cancer 107 2006 1294 1302
    • (2006) Cancer , vol.107 , pp. 1294-1302
    • Tsimberidou, A.M.1    O'Brien, S.2    Kantarjian, H.M.3
  • 7
    • 83555178475 scopus 로고    scopus 로고
    • Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukaemia: A retrospective analysis of world literature
    • B. Bockorny, I. Codreanu, and C.A. Dasanu Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukaemia: A retrospective analysis of world literature Br J Haematol 156 2012 50 66
    • (2012) Br J Haematol , vol.156 , pp. 50-66
    • Bockorny, B.1    Codreanu, I.2    Dasanu, C.A.3
  • 8
    • 0032031463 scopus 로고    scopus 로고
    • Origin of the Hodgkin/Reed-Sternberg cells in chronic lymphocytic leukemia with hodgkin's transformation
    • T. Ohno, B.N. Smir, D.D. Weisenburger, R.D. Gascoyne, S.D. Hinrichs, and W.C. Chan Origin of the Hodgkin/Reed-Sternberg cells in chronic lymphocytic leukemia with Hodgkin's transformation Blood 91 1998 1757 1761
    • (1998) Blood , vol.91 , pp. 1757-1761
    • Ohno, T.1    Smir, B.N.2    Weisenburger, D.D.3    Gascoyne, R.D.4    Hinrichs, S.D.5    Chan, W.C.6
  • 9
  • 10
    • 2342581550 scopus 로고    scopus 로고
    • Distinct clonal origin in two cases of Hodgkin's lymphoma variant of Richter's syndrome associated with EBV infection
    • L. de Leval, M. Vivario, B. De Prijck, and et al. Distinct clonal origin in two cases of Hodgkin's lymphoma variant of Richter's syndrome associated With EBV infection Am J Surg Pathol 28 2004 679 686
    • (2004) Am J Surg Pathol , vol.28 , pp. 679-686
    • De Leval, L.1    Vivario, M.2    De Prijck, B.3
  • 11
    • 0032529509 scopus 로고    scopus 로고
    • Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy
    • M.J. Keating, S. O'Brien, S. Lerner, and et al. Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy Blood 92 1998 1165 1171
    • (1998) Blood , vol.92 , pp. 1165-1171
    • Keating, M.J.1    O'Brien, S.2    Lerner, S.3
  • 13
    • 0033566295 scopus 로고    scopus 로고
    • Clinical characteristics and outcome of young chronic lymphocytic leukemia patients: A single institution study of 204 cases
    • F.R. Mauro, R. Foa, D. Giannarelli, and et al. Clinical characteristics and outcome of young chronic lymphocytic leukemia patients: A single institution study of 204 cases Blood 94 1999 448 454
    • (1999) Blood , vol.94 , pp. 448-454
    • Mauro, F.R.1    Foa, R.2    Giannarelli, D.3
  • 14
    • 9144241003 scopus 로고    scopus 로고
    • Second malignancies and Richter's syndrome in patients with chronic lymphocytic leukaemia treated with cladribine
    • T Robak, JZ Blonski, J. Gora-Tybor, and et al. Second malignancies and Richter's syndrome in patients with chronic lymphocytic leukaemia treated with cladribine Eur J Cancer 40 2004 383 389
    • (2004) Eur J Cancer , vol.40 , pp. 383-389
    • Robak, T.1    Blonski, J.Z.2    Gora-Tybor, J.3
  • 15
    • 13844255162 scopus 로고    scopus 로고
    • Richter's transformation of chronic lymphocytic leukemia. The possible role of fludarabine and the Epstein-Barr virus in its pathogenesis
    • P.D. Thornton, C. Bellas, A. Santon, and et al. Richter's transformation of chronic lymphocytic leukemia. The possible role of fludarabine and the Epstein-Barr virus in its pathogenesis Leukemia Res 29 2005 389 395
    • (2005) Leukemia Res , vol.29 , pp. 389-395
    • Thornton, P.D.1    Bellas, C.2    Santon, A.3
  • 16
    • 34848904482 scopus 로고    scopus 로고
    • Risk factors for development of a second malignancy in patients with chronic lymphocytic leukaemia
    • K. Maddocks-Christianson, S.L. Slager, C.S. Zent, and et al. Risk factors for development of a second malignancy in patients with chronic lymphocytic leukaemia Br J Haematol 139 2006 398 404
    • (2006) Br J Haematol , vol.139 , pp. 398-404
    • Maddocks-Christianson, K.1    Slager, S.L.2    Zent, C.S.3
  • 17
    • 33744800308 scopus 로고    scopus 로고
    • Clinical outcomes and prognostic factors in patients with Richter's syndrome treated with chemotherapy or chemoimmunotherapy with or without stem-cell transplantation
    • A.-M. Tsimberidou, S. O'Brien, I. Khouri, and et al. Clinical outcomes and prognostic factors in patients with Richter's syndrome treated with chemotherapy or chemoimmunotherapy with or without stem-cell transplantation J Clin Oncol 24 2006 2343 2351
    • (2006) J Clin Oncol , vol.24 , pp. 2343-2351
    • Tsimberidou, A.-M.1    O'Brien, S.2    Khouri, I.3
  • 18
    • 34447530283 scopus 로고    scopus 로고
    • Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial
    • D. Catovsky, S. Richards, E. Matutes, and et al. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial Lancet 370 2007 230 239
    • (2007) Lancet , vol.370 , pp. 230-239
    • Catovsky, D.1    Richards, S.2    Matutes, E.3
  • 19
    • 84886638464 scopus 로고    scopus 로고
    • Richter transformation of chronic lymphocytic leukemia: Incidence, risk factors and outcome
    • S. Alipour, H. Leiitch, L.M. Vickars, and et al. Richter transformation of chronic lymphocytic leukemia: Incidence, risk factors and outcome Blood (ASH Annual Meeting Abstracts) 112 2008 3179
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , pp. 3179
    • Alipour, S.1    Leiitch, H.2    Vickars, L.M.3
  • 20
    • 47249117983 scopus 로고    scopus 로고
    • Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome
    • D. Rossi, M. Cerri, D. Capello, C. Deambrogi, and et al. Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome Br J Haematol 142 2008 202 215
    • (2008) Br J Haematol , vol.142 , pp. 202-215
    • Rossi, D.1    Cerri, M.2    Capello, D.3    Deambrogi, C.4
  • 21
    • 84878898569 scopus 로고    scopus 로고
    • Extended follow up of the CLL8 protocol, a randomized phase-III trial of the German CLL Study Group (GCLLSG) comparing fludarabine and cyclophosphamide (FC) to FC plus rituximab (FCR) for previously untreated patients with chronic lymphocytic leukemia (CLL): Results on survival, progression-free survival, delayed neutropenias and secondary malignancies confirm superiority of the FCR regimen
    • K. Fischer, J. Bahlo, A.M. Fink, and et al. Extended follow up of the CLL8 protocol, a randomized phase-III trial of the German CLL Study Group (GCLLSG) comparing fludarabine and cyclophosphamide (FC) to FC plus rituximab (FCR) for previously untreated patients with chronic lymphocytic leukemia (CLL): Results on survival, progression-free survival, delayed neutropenias and secondary malignancies confirm superiority of the FCR regimen Blood (ASH Annual Meeting Abstracts) 120 2012 435
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120 , pp. 435
    • Fischer, K.1    Bahlo, J.2    Fink, A.M.3
  • 22
    • 84879748062 scopus 로고    scopus 로고
    • Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
    • J.C. Byrd, R.R. Furman, S.E. Coutre, and et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia N Engl J Med 369 2013 32 42
    • (2013) N Engl J Med , vol.369 , pp. 32-42
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 23
    • 84883305814 scopus 로고    scopus 로고
    • Diffuse large B-cell lymphoma (Richter syndrome) in patients with chronic lymphocytic leukaemia (CLL): A cohort study of newly diagnosed patients
    • S.A. Parikh, K.G. Rabe, T.G. Call, and et al. Diffuse large B-cell lymphoma (Richter syndrome) in patients with chronic lymphocytic leukaemia (CLL): A cohort study of newly diagnosed patients Br J Haematol 162 2013 774 782
    • (2013) Br J Haematol , vol.162 , pp. 774-782
    • Parikh, S.A.1    Rabe, K.G.2    Call, T.G.3
  • 24
    • 84872032663 scopus 로고    scopus 로고
    • The impact of initial fludarabine therapy on transformation to Richter's syndrome or prolymphocytic leukemia in patients with chronic lymphocytic leukemia: Analysis of an intergroup trial (CALGB 9011)
    • M. Solh, K.R. Rai, B.L. Peterson, and et al. The impact of initial fludarabine therapy on transformation to Richter's syndrome or prolymphocytic leukemia in patients with chronic lymphocytic leukemia: Analysis of an intergroup trial (CALGB 9011) Leuk Lymphoma 54 2013 252 254
    • (2013) Leuk Lymphoma , vol.54 , pp. 252-254
    • Solh, M.1    Rai, K.R.2    Peterson, B.L.3
  • 25
    • 84932166175 scopus 로고    scopus 로고
    • Second cancers in patients with chronic lymphocytic leukemia who received frontline fludarabine, cyclophosphamide and rituximab therapy: Distribution and clinical outcomes
    • O. Benjamini, P. Jain, L. Trinh, and et al. Second cancers in patients with chronic lymphocytic leukemia who received frontline fludarabine, cyclophosphamide and rituximab therapy: Distribution and clinical outcomes Leuk Lymphoma 56 2015 1643 1650
    • (2015) Leuk Lymphoma , vol.56 , pp. 1643-1650
    • Benjamini, O.1    Jain, P.2    Trinh, L.3
  • 26
    • 84904252369 scopus 로고    scopus 로고
    • Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
    • J.C. Byrd, J.R. Brown, S. O'Brien, and et al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia N Engl J Med 371 2014 213 223
    • (2014) N Engl J Med , vol.371 , pp. 213-223
    • Byrd, J.C.1    Brown, J.R.2    O'Brien, S.3
  • 27
    • 84891373281 scopus 로고    scopus 로고
    • Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: An open-label, multicentre, phase 1b/2 trial
    • S. O'Brien, R.R. Furman, S.E. Coutre, and et al. Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: An open-label, multicentre, phase 1b/2 trial Lancet Oncol 15 2014 48 58
    • (2014) Lancet Oncol , vol.15 , pp. 48-58
    • O'Brien, S.1    Furman, R.R.2    Coutre, S.E.3
  • 28
    • 84905191712 scopus 로고    scopus 로고
    • Outcomes of first-line treatment for chronic lymphocytic leukemia with 17p deletion
    • P. Strati, M.J. Keating, S.M. O'Brien, and et al. Outcomes of first-line treatment for chronic lymphocytic leukemia with 17p deletion Haematologica 99 2014 1350 1355
    • (2014) Haematologica , vol.99 , pp. 1350-1355
    • Strati, P.1    Keating, M.J.2    O'Brien, S.M.3
  • 29
    • 84921740802 scopus 로고    scopus 로고
    • Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: A phase 2, single-arm trial
    • M.Z. Farooqui, J. Valdez, S. Martyr, and et al. Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: A phase 2, single-arm trial Lancet Oncol 16 2015 169 176
    • (2015) Lancet Oncol , vol.16 , pp. 169-176
    • Farooqui, M.Z.1    Valdez, J.2    Martyr, S.3
  • 30
    • 84926178507 scopus 로고    scopus 로고
    • Outcomes of patients with chronic lymphocytic leukemia (CLL) after discontinuing ibrutinib
    • P. Jain, M. Keating, W. Wierda, and et al. Outcomes of patients with chronic lymphocytic leukemia (CLL) after discontinuing ibrutinib Blood 125 2015 2062 2067
    • (2015) Blood , vol.125 , pp. 2062-2067
    • Jain, P.1    Keating, M.2    Wierda, W.3
  • 31
    • 84925325517 scopus 로고    scopus 로고
    • Hodgkin transformation of chronic lymphocytic leukemia: Incidence, outcomes, and comparison to de novo Hodgkin lymphoma
    • S.A. Parikh, T.M. Habermann, K.G. Chaffee, and et al. Hodgkin transformation of chronic lymphocytic leukemia: Incidence, outcomes, and comparison to de novo Hodgkin lymphoma Am J Hematol 90 2015 334 338
    • (2015) Am J Hematol , vol.90 , pp. 334-338
    • Parikh, S.A.1    Habermann, T.M.2    Chaffee, K.G.3
  • 32
    • 47049131482 scopus 로고    scopus 로고
    • CD38 gene polymorphism and chronic lymphocytic leukemia: A role in transformation to Richter syndrome?
    • S. Aydin, D. Rossi, L. Bergui, and et al. CD38 gene polymorphism and chronic lymphocytic leukemia: A role in transformation to Richter syndrome? Blood 111 2008 5646 5653
    • (2008) Blood , vol.111 , pp. 5646-5653
    • Aydin, S.1    Rossi, D.2    Bergui, L.3
  • 33
    • 78651276641 scopus 로고    scopus 로고
    • A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome
    • S. Rasi, V. Spina, A. Bruscaggin, and et al. A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome Br J Haematol 152 2011 284 294
    • (2011) Br J Haematol , vol.152 , pp. 284-294
    • Rasi, S.1    Spina, V.2    Bruscaggin, A.3
  • 35
    • 84855854025 scopus 로고    scopus 로고
    • Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
    • D. Rossi, S. Rasi, G. Fabbri, and et al. Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia Blood 119 2012 521 529
    • (2012) Blood , vol.119 , pp. 521-529
    • Rossi, D.1    Rasi, S.2    Fabbri, G.3
  • 36
    • 84863833162 scopus 로고    scopus 로고
    • Different impact of NOTCH1and SF3B1 mutations on the risk of chronic lymphocytic leukemia transformation to Richter syndrome
    • D. Rossi, S. Rasi, V. Spina, and et al. Different impact of NOTCH1and SF3B1 mutations on the risk of chronic lymphocytic leukemia transformation to Richter syndrome Br J Haematol 158 2012 426 429
    • (2012) Br J Haematol , vol.158 , pp. 426-429
    • Rossi, D.1    Rasi, S.2    Spina, V.3
  • 37
    • 84877635463 scopus 로고    scopus 로고
    • NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome
    • N. Villamor, L. Conde, A. Martínez-Trillos, and et al. NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome Leukemia 27 2013 1100 1106
    • (2013) Leukemia , vol.27 , pp. 1100-1106
    • Villamor, N.1    Conde, L.2    Martínez-Trillos, A.3
  • 38
    • 0344236261 scopus 로고    scopus 로고
    • Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia
    • S.M. O'Brien, H.M. Kantarjian, D.A. Thomas, and et al. Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia Cancer 98 2003 2657 2663
    • (2003) Cancer , vol.98 , pp. 2657-2663
    • O'Brien, S.M.1    Kantarjian, H.M.2    Thomas, D.A.3
  • 39
    • 33751214547 scopus 로고    scopus 로고
    • Alemtuzumab as first-line therapy for B-cell chronic lymphocytic leukemia: Long-term follow-up of clinical effects, infectious complications and risk of Richter transformation
    • C. Karlsson, S. Norin, E. Kimby, and et al. Alemtuzumab as first-line therapy for B-cell chronic lymphocytic leukemia: Long-term follow-up of clinical effects, infectious complications and risk of Richter transformation Leukemia 20 2006 2204 2207
    • (2006) Leukemia , vol.20 , pp. 2204-2207
    • Karlsson, C.1    Norin, S.2    Kimby, E.3
  • 40
    • 51649107160 scopus 로고    scopus 로고
    • EBV-positive immunodeficiency lymphoma after alemtuzumab-CHOP therapy for peripheral T-cell lymphoma
    • H.C. Kluin-Nelemans, J.L. Coenen, J.E. Boers, G.W. van Imhoff, and S. Rosati EBV-positive immunodeficiency lymphoma after alemtuzumab-CHOP therapy for peripheral T-cell lymphoma Blood 112 2008 1039 1041
    • (2008) Blood , vol.112 , pp. 1039-1041
    • Kluin-Nelemans, H.C.1    Coenen, J.L.2    Boers, J.E.3    Van Imhoff, G.W.4    Rosati, S.5
  • 41
    • 84861795688 scopus 로고    scopus 로고
    • Excess mortality after treatment with fludarabine and cyclophosphamide in combination with alemtuzumab in previously untreated patients with chronic lymphocytic leukemia in a randomized phase 3 trial
    • S. Lepretre, T. Aurran, B. Mahé, and et al. Excess mortality after treatment with fludarabine and cyclophosphamide in combination with alemtuzumab in previously untreated patients with chronic lymphocytic leukemia in a randomized phase 3 trial Blood 119 2012 5104 5110
    • (2012) Blood , vol.119 , pp. 5104-5110
    • Lepretre, S.1    Aurran, T.2    Mahé, B.3
  • 42
    • 84886851785 scopus 로고    scopus 로고
    • Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome
    • G. Fabbri, H. Khiabanian, A.B. Holmes, and et al. Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome J Exp Med 210 2013 2273 2288
    • (2013) J Exp Med , vol.210 , pp. 2273-2288
    • Fabbri, G.1    Khiabanian, H.2    Holmes, A.B.3
  • 43
    • 84859896966 scopus 로고    scopus 로고
    • Molecular history of Richter syndrome: Origin from a cell already present at the time of chronic lymphocytic leukemia diagnosis
    • D. Rossi, V. Spina, F. Forconi, and et al. Molecular history of Richter syndrome: Origin from a cell already present at the time of chronic lymphocytic leukemia diagnosis Int J Cancer 130 2012 3006 3010
    • (2012) Int J Cancer , vol.130 , pp. 3006-3010
    • Rossi, D.1    Spina, V.2    Forconi, F.3
  • 44
    • 84891038503 scopus 로고    scopus 로고
    • Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome
    • E. Chigrinova, A. Rinaldi, I. Kwee, and et al. Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome Blood 122 2013 2673 2682
    • (2013) Blood , vol.122 , pp. 2673-2682
    • Chigrinova, E.1    Rinaldi, A.2    Kwee, I.3
  • 45
    • 33750022561 scopus 로고    scopus 로고
    • Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma
    • D. Rossi, E. Berra, M. Cerri, and et al. Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma Haematologica 91 2006 1405 1409
    • (2006) Haematologica , vol.91 , pp. 1405-1409
    • Rossi, D.1    Berra, E.2    Cerri, M.3
  • 46
    • 84876275925 scopus 로고    scopus 로고
    • MGA, a suppressor of MYC, is recurrently inactivated in high risk chronic lymphocytic leukemia
    • L. de Paoli, M. Cerri, S. Monti, and et al. MGA, a suppressor of MYC, is recurrently inactivated in high risk chronic lymphocytic leukemia Leuk Lymphoma 54 2013 1087 1090
    • (2013) Leuk Lymphoma , vol.54 , pp. 1087-1090
    • De Paoli, L.1    Cerri, M.2    Monti, S.3
  • 47
    • 84863605700 scopus 로고    scopus 로고
    • MAX and MYC: A heritable breakup
    • A. Cascón, and M. Robledo MAX and MYC: A heritable breakup Cancer Res 72 2012 3119 3124
    • (2012) Cancer Res , vol.72 , pp. 3119-3124
    • Cascón, A.1    Robledo, M.2
  • 48
    • 79960353160 scopus 로고    scopus 로고
    • Analysis of the chronic lymphocytic leukemia coding genome: Role of NOTCH1 mutational activation
    • G. Fabbri, S. Rasi, D. Rossi, V. Trifonov, H. Khiabanian, J. Ma, and et al. Analysis of the chronic lymphocytic leukemia coding genome: Role of NOTCH1 mutational activation J Exp Med 208 2011 1389 1401
    • (2011) J Exp Med , vol.208 , pp. 1389-1401
    • Fabbri, G.1    Rasi, S.2    Rossi, D.3    Trifonov, V.4    Khiabanian, H.5    Ma, J.6
  • 49
    • 79960036578 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • X.S. Puente, M. Pinyol, V. Quesada, L. Conde, G.R. Ordóñez, N. Villamor, and et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia Nature 475 2011 101 105
    • (2011) Nature , vol.475 , pp. 101-105
    • Puente, X.S.1    Pinyol, M.2    Quesada, V.3    Conde, L.4    Ordóñez, G.R.5    Villamor, N.6
  • 50
    • 80555129351 scopus 로고    scopus 로고
    • Oncogenic and tumor suppressor functions of Notch in cancer: It's NOTCH what you think
    • C. Lobry, P. Oh, and I. Aifantis Oncogenic and tumor suppressor functions of Notch in cancer: It's NOTCH what you think J Exp Med 208 2011 1931 1935
    • (2011) J Exp Med , vol.208 , pp. 1931-1935
    • Lobry, C.1    Oh, P.2    Aifantis, I.3
  • 51
    • 84899902477 scopus 로고    scopus 로고
    • Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia
    • F. Arruga, B. Gizdic, S. Serra, and et al. Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia Leukemia 28 2014 1060 1070
    • (2014) Leukemia , vol.28 , pp. 1060-1070
    • Arruga, F.1    Gizdic, B.2    Serra, S.3
  • 52
    • 84920695988 scopus 로고    scopus 로고
    • The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells
    • M. López-Guerra, S. Xargay-Torrent, L. Rosich, and et al. The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells Leukemia 29 2015 96 106
    • (2015) Leukemia , vol.29 , pp. 96-106
    • López-Guerra, M.1    Xargay-Torrent, S.2    Rosich, L.3
  • 53
    • 84886638665 scopus 로고    scopus 로고
    • Promiscuous antigen reactivity may underlie clinical aggressiveness and increased risk for Richter's syndrome in chronic lymphocytic leukemia with stereotyped IGHV4-39/IGKV1(D)-39 B cell receptors
    • M. Gounari, S. Ntoufa, C.C. Chu, and et al. Promiscuous antigen reactivity may underlie clinical aggressiveness and increased risk for Richter's syndrome in chronic lymphocytic leukemia with stereotyped IGHV4-39/IGKV1(D)-39 B cell receptors Blood (ASH Annual Meeting Abstracts) 120 2012 561
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120 , pp. 561
    • Gounari, M.1    Ntoufa, S.2    Chu, C.C.3
  • 54
    • 33749054253 scopus 로고    scopus 로고
    • Detection of Richter's transformation of chronic lymphocytic leukemia by PET/CT
    • J.F. Bruzzi, H. Macapinlac, A.M. Tsimberidou, and et al. Detection of Richter's transformation of chronic lymphocytic leukemia by PET/CT J Nucl Med 47 2006 1267 1273
    • (2006) J Nucl Med , vol.47 , pp. 1267-1273
    • Bruzzi, J.F.1    MacApinlac, H.2    Tsimberidou, A.M.3
  • 55
    • 84922392142 scopus 로고    scopus 로고
    • Poor efficacy and tolerability of R-CHOP in relapsed/refractory chronic lymphocytic leukemia and Richter transformation
    • P. Langerbeins, R. Busch, N. Anheier, and et al. Poor efficacy and tolerability of R-CHOP in relapsed/refractory chronic lymphocytic leukemia and Richter transformation Am J Hematol 89 2014 E239 E243
    • (2014) Am J Hematol , vol.89 , pp. E239-E243
    • Langerbeins, P.1    Busch, R.2    Anheier, N.3
  • 56
    • 38349163290 scopus 로고    scopus 로고
    • Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter's syndrome or fludarabine-refractory chronic lymphocytic leukemia
    • A.M. Tsimberidou, W.G. Wierda, W. Plunkett, and et al. Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter's syndrome or fludarabine-refractory chronic lymphocytic leukemia J Clin Oncol 26 2008 196 203
    • (2008) J Clin Oncol , vol.26 , pp. 196-203
    • Tsimberidou, A.M.1    Wierda, W.G.2    Plunkett, W.3
  • 57
    • 84884154021 scopus 로고    scopus 로고
    • Phase I-II clinical trial of oxaliplatin, fludarabine, cytarabine, and rituximab therapy in aggressive relapsed/refractory chronic lymphocytic leukemia or Richter syndrome
    • A.M. Tsimberidou, W.G. Wierda, S. Wen, and et al. Phase I-II clinical trial of oxaliplatin, fludarabine, cytarabine, and rituximab therapy in aggressive relapsed/refractory chronic lymphocytic leukemia or Richter syndrome Clin Lymphoma Myeloma Leuk 13 2013 568 574
    • (2013) Clin Lymphoma Myeloma Leuk , vol.13 , pp. 568-574
    • Tsimberidou, A.M.1    Wierda, W.G.2    Wen, S.3
  • 58
    • 0034904399 scopus 로고    scopus 로고
    • Fractionated cyclophosphamide, vincristine, liposomal daunorubicin (daunoXome), and dexamethasone (hyper-CVXD) regimen in Richter's syndrome
    • B.S. Dabaja, S.M. O'Brien, H.M. Kantarjian, and et al. Fractionated cyclophosphamide, vincristine, liposomal daunorubicin (daunoXome), and dexamethasone (hyper-CVXD) regimen in Richter's syndrome Leuk Lymphoma 42 2001 329 337
    • (2001) Leuk Lymphoma , vol.42 , pp. 329-337
    • Dabaja, B.S.1    O'Brien, S.M.2    Kantarjian, H.M.3
  • 59
    • 0037378469 scopus 로고    scopus 로고
    • Fractionated cyclophosphamide, vincristine, liposomal daunorubicin, and dexamethasone plus rituximab and granulocyte macrophage- colony stimulating factor (GM-CSF) alternating with methotrexate and cytarabine plus rituximab and GMCSF in patients with Richter syndrome or fludarabine refractory chronic lymphocytic leukemia
    • A.M. Tsimberidou, H.M. Kantarjian, J. Cortes, and et al. Fractionated cyclophosphamide, vincristine, liposomal daunorubicin, and dexamethasone plus rituximab and granulocyte macrophage- colony stimulating factor (GM-CSF) alternating with methotrexate and cytarabine plus rituximab and GMCSF in patients with Richter syndrome or fludarabine refractory chronic lymphocytic leukemia Cancer 97 2003 1711 1720
    • (2003) Cancer , vol.97 , pp. 1711-1720
    • Tsimberidou, A.M.1    Kantarjian, H.M.2    Cortes, J.3
  • 60
    • 0036239496 scopus 로고    scopus 로고
    • Phase II study of fludarabine, cytarabine (Ara-C), cyclophosphamide, cisplatin and GM-CSF (FACPGM) in patients with Richter's syndrome or refractory lymphoproliferative disorders
    • A.M. Tsimberidou, S.M. O'Brien, J.E. Cortes, and et al. Phase II study of fludarabine, cytarabine (Ara-C), cyclophosphamide, cisplatin and GM-CSF (FACPGM) in patients with Richter's syndrome or refractory lymphoproliferative disorders Leuk Lymphoma 43 2002 767 772
    • (2002) Leuk Lymphoma , vol.43 , pp. 767-772
    • Tsimberidou, A.M.1    O'Brien, S.M.2    Cortes, J.E.3
  • 61
    • 2342648074 scopus 로고    scopus 로고
    • Yttrium-90 ibritumomab tiuxetan radioimmunotherapy in Richter syndrome
    • A.M. Tsimberidou, J.L. Murray, S. O'Brien, W.G. Wierda, and M.J. Keating Yttrium-90 ibritumomab tiuxetan radioimmunotherapy in Richter syndrome Cancer 100 2004 2195 2200
    • (2004) Cancer , vol.100 , pp. 2195-2200
    • Tsimberidou, A.M.1    Murray, J.L.2    O'Brien, S.3    Wierda, W.G.4    Keating, M.J.5
  • 62
    • 84863995593 scopus 로고    scopus 로고
    • Autologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter's syndrome): A retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma working party of the European Group for Blood and Marrow Transplantation
    • K. Cwynarski, A. van Biezen, L. de Wreede, and et al. Autologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter's syndrome): A retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma working party of the European Group for Blood and Marrow Transplantation J Clin Oncol 30 2012 2211 2217
    • (2012) J Clin Oncol , vol.30 , pp. 2211-2217
    • Cwynarski, K.1    Van Biezen, A.2    De Wreede, L.3
  • 63
    • 84924149342 scopus 로고    scopus 로고
    • Selective inhibitors of nuclear export (SINE) - A novel class of anti-cancer agents
    • K. Parikh, S. Cang, A. Sekhri, and D. Liu Selective inhibitors of nuclear export (SINE) - A novel class of anti-cancer agents J Hematol Oncol 7 2014 78
    • (2014) J Hematol Oncol , vol.7 , pp. 78
    • Parikh, K.1    Cang, S.2    Sekhri, A.3    Liu, D.4
  • 64
    • 84938553527 scopus 로고    scopus 로고
    • The oral selective inhibitor of nuclear export (SINE) selinexor (KPT-330) demonstrates broad and durable clinical activity in relapsed/refractory non Hodgkin's lymphoma (NHL)
    • J. Kuruvilla, J.C. Byrd, J.M. Flynn, and et al. The oral selective inhibitor of nuclear export (SINE) selinexor (KPT-330) demonstrates broad and durable clinical activity in relapsed/refractory non Hodgkin's lymphoma (NHL) Blood (ASH Annual Meeting Abstracts) 124 2014 396
    • (2014) Blood (ASH Annual Meeting Abstracts) , vol.124 , pp. 396
    • Kuruvilla, J.1    Byrd, J.C.2    Flynn, J.M.3
  • 65
    • 85027920668 scopus 로고    scopus 로고
    • Richter's transformation to diffuse large B-cell lymphoma: A retrospective study reporting clinical data, outcome, and the benefit of adding rituximab to chemotherapy, from the Israeli CLL Study Group
    • T. Tadmor, L. Shvidel, O. Bairey, and et al. Richter's transformation to diffuse large B-cell lymphoma: A retrospective study reporting clinical data, outcome, and the benefit of adding rituximab to chemotherapy, from the Israeli CLL Study Group Am J Hematol 89 2014 E218 E222
    • (2014) Am J Hematol , vol.89 , pp. E218-E222
    • Tadmor, T.1    Shvidel, L.2    Bairey, O.3
  • 66
    • 84897064002 scopus 로고    scopus 로고
    • Hodgkin's variant of Richter transformation in chronic lymphocytic leukemia; a retrospective study from the Israeli CLL study group
    • T. Tadmor, L. Shvidel, N. Goldschmidt, and et al. Hodgkin's variant of Richter transformation in chronic lymphocytic leukemia; a retrospective study from the Israeli CLL study group Anticancer Res 34 2014 785 790
    • (2014) Anticancer Res , vol.34 , pp. 785-790
    • Tadmor, T.1    Shvidel, L.2    Goldschmidt, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.