-
1
-
-
79959404661
-
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
-
Herman SE, Gordon AL, Hertlein E, et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood. 2011;117(23):6287-6296.
-
(2011)
Blood
, vol.117
, Issue.23
, pp. 6287-6296
-
-
Herman, S.E.1
Gordon, A.L.2
Hertlein, E.3
-
2
-
-
84863011553
-
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
-
Ponader S, Chen SS, Buggy JJ, et al. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood. 2012;119(5): 1182-1189.
-
(2012)
Blood
, vol.119
, Issue.5
, pp. 1182-1189
-
-
Ponader, S.1
Chen, S.S.2
Buggy, J.J.3
-
3
-
-
84901439281
-
Ibrutinib inhibits BCR and NF-kappaB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL
-
Herman SE, Mustafa RZ, Gyamfi JA, et al. Ibrutinib inhibits BCR and NF-kappaB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL. Blood. 2014;123(21):3286-3295.
-
(2014)
Blood
, vol.123
, Issue.21
, pp. 3286-3295
-
-
Herman, S.E.1
Mustafa, R.Z.2
Gyamfi, J.A.3
-
4
-
-
84927732048
-
Three-year follow-up of treatment-naive and previously treated patients with CLL and SLL receiving single-agent ibrutinib
-
Byrd JC, Furman RR, Coutre SE, et al. Three-year follow-up of treatment-naive and previously treated patients with CLL and SLL receiving single-agent ibrutinib. Blood. 2015;125(16):2497-2506.
-
(2015)
Blood
, vol.125
, Issue.16
, pp. 2497-2506
-
-
Byrd, J.C.1
Furman, R.R.2
Coutre, S.E.3
-
5
-
-
84904252369
-
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
-
Byrd JC, Brown JR, O'Brien S, et al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N Engl J Med. 2014; 371(3):213-223.
-
(2014)
N Engl J Med
, vol.371
, Issue.3
, pp. 213-223
-
-
Byrd, J.C.1
Brown, J.R.2
O'Brien, S.3
-
6
-
-
84921740802
-
Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: A phase 2, single-arm trial
-
Farooqui MZ, Valdez J, Martyr S, et al. Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trial. Lancet Oncol. 2015; 16(2):169-176.
-
(2015)
Lancet Oncol
, vol.16
, Issue.2
, pp. 169-176
-
-
Farooqui, M.Z.1
Valdez, J.2
Martyr, S.3
-
7
-
-
77957201023
-
Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
-
Herman SE, Gordon AL, Wagner AJ, et al. Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116(12):2078-2088.
-
(2010)
Blood
, vol.116
, Issue.12
, pp. 2078-2088
-
-
Herman, S.E.1
Gordon, A.L.2
Wagner, A.J.3
-
8
-
-
84901712964
-
Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110delta, for relapsed/refractory chronic lymphocytic leukemia
-
Brown JR, Byrd JC, Coutre SE, et al. Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110delta, for relapsed/refractory chronic lymphocytic leukemia. Blood. 2014;123(22):3390-3397.
-
(2014)
Blood
, vol.123
, Issue.22
, pp. 3390-3397
-
-
Brown, J.R.1
Byrd, J.C.2
Coutre, S.E.3
-
9
-
-
84924378555
-
Second interim analysis of a phase 3 study of idelalisib (ZYDELIG) plus Rituximab (R) for relapsed chronic lymphocytic leukemia (CLL): Efficacy analysis in patient subpopulations with Del(17p) and other adverse prognostic factors
-
Abstract 330
-
Sharman JP, Coutre SE, Furman RR, et al. Second interim analysis of a phase 3 study of idelalisib (ZYDELIG) plus Rituximab (R) for relapsed chronic lymphocytic leukemia (CLL): efficacy analysis in patient subpopulations with Del(17p) and other adverse prognostic factors. Blood. 2014;Abstract 330.
-
(2014)
Blood
-
-
Sharman, J.P.1
Coutre, S.E.2
Furman, R.R.3
-
10
-
-
84902183019
-
Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib
-
Woyach JA, Furman RR, Liu TM, et al. Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. N Engl J Med. 2014;370(24): 2286-2294.
-
(2014)
N Engl J Med
, vol.370
, Issue.24
, pp. 2286-2294
-
-
Woyach, J.A.1
Furman, R.R.2
Liu, T.M.3
-
11
-
-
84927656208
-
Functional characterization of BTK mutation that confers ibrutinib resistance: Exploration of alternative kinase inhibitors
-
Cheng S, Guo A, Lu P, Ma J, Coleman M, Wang YL. Functional characterization of BTK mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors. Leukemia. 2015;29(4):895-900.
-
(2015)
Leukemia
, vol.29
, Issue.4
, pp. 895-900
-
-
Cheng, S.1
Guo, A.2
Lu, P.3
Ma, J.4
Coleman, M.5
Wang, Y.L.6
-
12
-
-
84867255789
-
A hypermorphic missense mutation in PLCG2, encoding phospholipase Cgamma2, causes a dominantly inherited autoinflammatory disease with immunodeficiency
-
Zhou Q, Lee GS, Brady J, et al. A hypermorphic missense mutation in PLCG2, encoding phospholipase Cgamma2, causes a dominantly inherited autoinflammatory disease with immunodeficiency. Am J Human Genet. 2012;91(4):713-720.
-
(2012)
Am J Human Genet
, vol.91
, Issue.4
, pp. 713-720
-
-
Zhou, Q.1
Lee, G.S.2
Brady, J.3
-
13
-
-
84937841721
-
Hypermorphic mutation of phospholipase C, gamma 2 acquired in ibrutinib resistant CLL confers BTK independency upon BCR activation
-
Liu TM, Woyach JA, Zhong Y, et al. Hypermorphic mutation of phospholipase C, gamma 2 acquired in ibrutinib resistant CLL confers BTK independency upon BCR activation. Blood. 2015;126(1): 61-68.
-
(2015)
Blood
, vol.126
, Issue.1
, pp. 61-68
-
-
Liu, T.M.1
Woyach, J.A.2
Zhong, Y.3
-
14
-
-
84994504370
-
Etiology of ibrutinib therapy discontinuation and outcomes in patients with chronic lymphocytic leukemia
-
Maddocks KJ, Ruppert AS, Lozanski G, et al. Etiology of ibrutinib therapy discontinuation and outcomes in patients with chronic lymphocytic leukemia. JAMA Oncol. 2015;1(1):80-87.
-
(2015)
JAMA Oncol
, vol.1
, Issue.1
, pp. 80-87
-
-
Maddocks, K.J.1
Ruppert, A.S.2
Lozanski, G.3
-
15
-
-
84902163170
-
Clonal evolution in patients with chronic lymphocytic leukemia (CLL) developing resistance to BTK inhibition
-
Abstract 866
-
Burger JA, Landau D, Hoellenriegel J, et al. Clonal evolution in patients with chronic lymphocytic leukemia (CLL) developing resistance to BTK inhibition. Blood. 2013;122(21):Abstract 866.
-
(2013)
Blood
, vol.122
, Issue.21
-
-
Burger, J.A.1
Landau, D.2
Hoellenriegel, J.3
-
16
-
-
84907284539
-
Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL)
-
Komarova NL, Burger JA, Wodarz D. Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL). Proc Natl Acad Sci USA. 2014;111(38):13906-13911.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, Issue.38
, pp. 13906-13911
-
-
Komarova, N.L.1
Burger, J.A.2
Wodarz, D.3
-
17
-
-
84919483332
-
Ibrutinib-naive chronic lymphocytic leukemia lacks Bruton tyrosine kinase mutations associated with treatment resistance
-
Fama R, Bomben R, Rasi S, et al. Ibrutinib-naive chronic lymphocytic leukemia lacks Bruton tyrosine kinase mutations associated with treatment resistance. Blood. 2014;124(25):3831-3833.
-
(2014)
Blood
, vol.124
, Issue.25
, pp. 3831-3833
-
-
Fama, R.1
Bomben, R.2
Rasi, S.3
-
18
-
-
84906903473
-
Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma
-
Chiron D, Di Liberto M, Martin P, et al. Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma. Cancer Discov. 2014;4(9):1022-1035.
-
(2014)
Cancer Discov
, vol.4
, Issue.9
, pp. 1022-1035
-
-
Chiron, D.1
Liberto M, D.I.2
Martin, P.3
-
19
-
-
84920679727
-
The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia
-
Cao Y, Hunter ZR, Liu X, et al. The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia. Leukemia 2015;29(1):169-176.
-
(2015)
Leukemia
, vol.29
, Issue.1
, pp. 169-176
-
-
Cao, Y.1
Hunter, Z.R.2
Liu, X.3
-
20
-
-
84901796219
-
A prospective multicenter study of the Bruton's tyrosine kinase inhibitor ibrutinib in patients with relapsed or refractory Waldenstrom's macroglobulinemia
-
Abstract 251
-
Treon SP, Tripsas CK, Yang G, et al. A prospective multicenter study of the Bruton's tyrosine kinase inhibitor ibrutinib in patients with relapsed or refractory Waldenstrom's macroglobulinemia. Blood. 2013;122(21): Abstract 251.
-
(2013)
Blood
, vol.122
, Issue.21
-
-
Treon, S.P.1
Tripsas, C.K.2
Yang, G.3
-
21
-
-
84862152044
-
Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma
-
Yang Y, Shaffer AL III, Emre NC, et al. Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma. Cancer Cell. 2012;21(6):723-737.
-
(2012)
Cancer Cell
, vol.21
, Issue.6
, pp. 723-737
-
-
Yang, Y.1
Shaffer, A.L.2
Emre, N.C.3
-
22
-
-
73849145729
-
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
-
Davis RE, Ngo VN, Lenz G, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature. 2010;463(7277):88-92.
-
(2010)
Nature
, vol.463
, Issue.7277
, pp. 88-92
-
-
Davis, R.E.1
Ngo, V.N.2
Lenz, G.3
-
23
-
-
79960036578
-
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
-
Puente XS, Pinyol M, Quesada V, et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature. 2011;475(7354):101-105.
-
(2011)
Nature
, vol.475
, Issue.7354
, pp. 101-105
-
-
Puente, X.S.1
Pinyol, M.2
Quesada, V.3
-
24
-
-
84891861044
-
Clonal evolution in hematological malignancies and therapeutic implications
-
Landau DA, Carter SL, Getz G, Wu CJ. Clonal evolution in hematological malignancies and therapeutic implications. Leukemia 2014;28(1):34-43.
-
(2014)
Leukemia
, vol.28
, Issue.1
, pp. 34-43
-
-
Landau, D.A.1
Carter, S.L.2
Getz, G.3
Wu, C.J.4
-
25
-
-
84877930029
-
P110alpha-mediated constitutive PI3K signaling limits the efficacy of p110delta-selective inhibition in mantle cell lymphoma, particularly with multiple relapse
-
Iyengar S, Clear A, Bodor C, et al. P110alpha-mediated constitutive PI3K signaling limits the efficacy of p110delta-selective inhibition in mantle cell lymphoma, particularly with multiple relapse. Blood. 2013;121(12):2274-2284.
-
(2013)
Blood
, vol.121
, Issue.12
, pp. 2274-2284
-
-
Iyengar, S.1
Clear, A.2
Bodor, C.3
-
26
-
-
84903751985
-
Acquired PIK3CA amplification causes resistance to selective phosphoinositide 3-kinase inhibitors in breast cancer
-
Huw LY, O'Brien C, Pandita A, et al. Acquired PIK3CA amplification causes resistance to selective phosphoinositide 3-kinase inhibitors in breast cancer. Oncogenesis. 2013;2:e83.
-
(2013)
Oncogenesis
, vol.2
, pp. e83
-
-
Huw, L.Y.1
O'Brien, C.2
Pandita, A.3
-
27
-
-
80054863376
-
A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer
-
Muellner MK, Uras IZ, Gapp BV, et al. A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer. Nat Chem Biol. 2011;7(11):787-793.
-
(2011)
Nat Chem Biol
, vol.7
, Issue.11
, pp. 787-793
-
-
Muellner, M.K.1
Uras, I.Z.2
Gapp, B.V.3
-
28
-
-
84924378560
-
Complex karyotype, rather than Del(17p), is associated with inferior outcomes in relapsed or refractory CLL patients treated with ibrutinib-based regimens
-
Abstract 22
-
Thompson PA, Wierda WG, Ferrajoli A, et al. Complex karyotype, rather than Del(17p), is associated with inferior outcomes in relapsed or refractory CLL patients treated with ibrutinib-based regimens. Blood. 2014;124(21):Abstract 22.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Thompson, P.A.1
Wierda, W.G.2
Ferrajoli, A.3
-
29
-
-
84907061764
-
ABT-199 (GDC-0199) in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL): High complete-response rate and durable disease control
-
Abstract 7015
-
Seymour JF, Davids MS, Pagel JM, et al. ABT-199 (GDC-0199) in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL): high complete-response rate and durable disease control. J Clin Oncol. 2014;32(5s):Abstract 7015.
-
(2014)
J Clin Oncol
, vol.32
, Issue.5
-
-
Seymour, J.F.1
Davids, M.S.2
Pagel, J.M.3
-
30
-
-
84925484937
-
Determination of recommended phase 2 dose of ABT-199 (GDC-0199) combined with Rituximab (R) in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)
-
Abstract 325
-
Roberts AW, Ma S, Brander DM, et al. Determination of recommended phase 2 dose of ABT-199 (GDC-0199) combined with Rituximab (R) in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) Blood. 2014:Abstract 325.
-
(2014)
Blood
-
-
Roberts, A.W.1
Ma, S.2
Brander, D.M.3
-
31
-
-
84915822064
-
IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells
-
Dong S, Guinn D, Dubovsky JA, et al. IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells. Blood. 2014;124(24):3583-3586.
-
(2014)
Blood
, vol.124
, Issue.24
, pp. 3583-3586
-
-
Dong, S.1
Guinn, D.2
Dubovsky, J.A.3
-
32
-
-
84930330798
-
Clinical activity of duvelisib (IPI-145), a phosphoinositide-3-kinase , inhibitor, in patients previously treated with ibrutinib
-
Abstract 3335
-
Porcu P, Flinn I, Kahl BS, et al. Clinical activity of duvelisib (IPI-145), a phosphoinositide-3-kinase , inhibitor, in patients previously treated with ibrutinib. Blood. 2014;124(21):Abstract 3335.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Porcu, P.1
Flinn, I.2
Kahl, B.S.3
-
33
-
-
85010999076
-
Evaluation of reversible BTK inhibitors in cell lines with clinically relevant Ibrutinib resistance mutations
-
Abstract 136
-
Choy RW, Burton L, Young W, Crawford JJ, Penuel E, Belmont LD. Evaluation of reversible BTK inhibitors in cell lines with clinically relevant Ibrutinib resistance mutations Am Assoc Cancer Res. 2015: Abstract 136.
-
(2015)
Am Assoc Cancer Res
-
-
Choy, R.W.1
Burton, L.2
Young, W.3
Crawford, J.J.4
Penuel, E.5
Belmont, L.D.6
-
34
-
-
84938132878
-
Newer-generation HSP90 inhibitors can overcome ibrutinib resistance and suppress proliferation in human mantle cell lymphoma in vitro and in vivo
-
Abstract 1686
-
Kopp N, Tschuri S, Haebe S, et al. Newer-generation HSP90 inhibitors can overcome ibrutinib resistance and suppress proliferation in human mantle cell lymphoma in vitro and in vivo. Blood. 2014:Abstract 1686.
-
(2014)
Blood
-
-
Kopp, N.1
Tschuri, S.2
Haebe, S.3
-
35
-
-
84964694021
-
Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia
-
Hing ZA, Mantel R, Beckwith KA, et al. Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia. Blood. 2015;125(20):3128-3132.
-
(2015)
Blood
, vol.125
, Issue.20
, pp. 3128-3132
-
-
Hing, Z.A.1
Mantel, R.2
Beckwith, K.A.3
-
36
-
-
84907322714
-
PKC-beta as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL
-
El-Gamal D, Williams K, LaFollette TD, et al. PKC-beta as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL. Blood. 2014;124(9):1481-1491.
-
(2014)
Blood
, vol.124
, Issue.9
, pp. 1481-1491
-
-
El-Gamal, D.1
Williams, K.2
LaFollette, T.D.3
-
37
-
-
84888216911
-
Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
-
Dubovsky JA, Beckwith KA, Natarajan G, et al. Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes. Blood. 2013;122(15):2539-2549.
-
(2013)
Blood
, vol.122
, Issue.15
, pp. 2539-2549
-
-
Dubovsky, J.A.1
Beckwith, K.A.2
Natarajan, G.3
-
38
-
-
80051928145
-
Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia
-
Lee BN, Gao H, Cohen EN, et al. Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia. Cancer. 2011;117(17): 3999-4008.
-
(2011)
Cancer
, vol.117
, Issue.17
, pp. 3999-4008
-
-
Lee, B.N.1
Gao, H.2
Cohen, E.N.3
-
39
-
-
84938132879
-
T-cell dysfunction in CLL is mediated not only by PD-1/PD-L1 but also by PD-1/PD-L2 interactions-partial functionality is maintained in PD-1 defined CD8 subsets and this can be further promoted by ibrutinib treatment
-
Abstract 4120
-
McClanahan F, Miller S, Riches JC, et al. T-cell dysfunction in CLL is mediated not only by PD-1/PD-L1 but also by PD-1/PD-L2 interactions-partial functionality is maintained in PD-1 defined CD8 subsets and this can be further promoted by ibrutinib treatment. Blood. 2013;122(21): Abstract 4120.
-
(2013)
Blood
, vol.122
, Issue.21
-
-
McClanahan, F.1
Miller, S.2
Riches, J.C.3
-
40
-
-
84924033378
-
Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK
-
Sagiv-Barfi I, Kohrt HE, Czerwinski DK, Ng PP, Chang BY, Levy R. Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK. Proc Natl Acad Sci USA. 2015;112(9):E966-E972.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, Issue.9
, pp. E966-E972
-
-
Sagiv-Barfi, I.1
Kohrt, H.E.2
Czerwinski, D.K.3
Ng, P.P.4
Chang, B.Y.5
Levy, R.6
|