메뉴 건너뛰기




Volumn 2015, Issue 1, 2015, Pages 355-360

Patterns of resistance to B cell-receptor pathway antagonists in chronic lymphocytic leukemia and strategies for management

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; B LYMPHOCYTE RECEPTOR INHIBITOR; IBRUTINIB; IDELALISIB; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN KINASE INHIBITOR; PURINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; QUINAZOLINONE DERIVATIVE;

EID: 85010952208     PISSN: 15204391     EISSN: 15204383     Source Type: Journal    
DOI: 10.1182/asheducation-2015.1.355     Document Type: Review
Times cited : (20)

References (40)
  • 1
    • 79959404661 scopus 로고    scopus 로고
    • Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
    • Herman SE, Gordon AL, Hertlein E, et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood. 2011;117(23):6287-6296.
    • (2011) Blood , vol.117 , Issue.23 , pp. 6287-6296
    • Herman, S.E.1    Gordon, A.L.2    Hertlein, E.3
  • 2
    • 84863011553 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
    • Ponader S, Chen SS, Buggy JJ, et al. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood. 2012;119(5): 1182-1189.
    • (2012) Blood , vol.119 , Issue.5 , pp. 1182-1189
    • Ponader, S.1    Chen, S.S.2    Buggy, J.J.3
  • 3
    • 84901439281 scopus 로고    scopus 로고
    • Ibrutinib inhibits BCR and NF-kappaB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL
    • Herman SE, Mustafa RZ, Gyamfi JA, et al. Ibrutinib inhibits BCR and NF-kappaB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL. Blood. 2014;123(21):3286-3295.
    • (2014) Blood , vol.123 , Issue.21 , pp. 3286-3295
    • Herman, S.E.1    Mustafa, R.Z.2    Gyamfi, J.A.3
  • 4
    • 84927732048 scopus 로고    scopus 로고
    • Three-year follow-up of treatment-naive and previously treated patients with CLL and SLL receiving single-agent ibrutinib
    • Byrd JC, Furman RR, Coutre SE, et al. Three-year follow-up of treatment-naive and previously treated patients with CLL and SLL receiving single-agent ibrutinib. Blood. 2015;125(16):2497-2506.
    • (2015) Blood , vol.125 , Issue.16 , pp. 2497-2506
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 5
    • 84904252369 scopus 로고    scopus 로고
    • Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
    • Byrd JC, Brown JR, O'Brien S, et al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N Engl J Med. 2014; 371(3):213-223.
    • (2014) N Engl J Med , vol.371 , Issue.3 , pp. 213-223
    • Byrd, J.C.1    Brown, J.R.2    O'Brien, S.3
  • 6
    • 84921740802 scopus 로고    scopus 로고
    • Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: A phase 2, single-arm trial
    • Farooqui MZ, Valdez J, Martyr S, et al. Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trial. Lancet Oncol. 2015; 16(2):169-176.
    • (2015) Lancet Oncol , vol.16 , Issue.2 , pp. 169-176
    • Farooqui, M.Z.1    Valdez, J.2    Martyr, S.3
  • 7
    • 77957201023 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
    • Herman SE, Gordon AL, Wagner AJ, et al. Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116(12):2078-2088.
    • (2010) Blood , vol.116 , Issue.12 , pp. 2078-2088
    • Herman, S.E.1    Gordon, A.L.2    Wagner, A.J.3
  • 8
    • 84901712964 scopus 로고    scopus 로고
    • Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110delta, for relapsed/refractory chronic lymphocytic leukemia
    • Brown JR, Byrd JC, Coutre SE, et al. Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110delta, for relapsed/refractory chronic lymphocytic leukemia. Blood. 2014;123(22):3390-3397.
    • (2014) Blood , vol.123 , Issue.22 , pp. 3390-3397
    • Brown, J.R.1    Byrd, J.C.2    Coutre, S.E.3
  • 9
    • 84924378555 scopus 로고    scopus 로고
    • Second interim analysis of a phase 3 study of idelalisib (ZYDELIG) plus Rituximab (R) for relapsed chronic lymphocytic leukemia (CLL): Efficacy analysis in patient subpopulations with Del(17p) and other adverse prognostic factors
    • Abstract 330
    • Sharman JP, Coutre SE, Furman RR, et al. Second interim analysis of a phase 3 study of idelalisib (ZYDELIG) plus Rituximab (R) for relapsed chronic lymphocytic leukemia (CLL): efficacy analysis in patient subpopulations with Del(17p) and other adverse prognostic factors. Blood. 2014;Abstract 330.
    • (2014) Blood
    • Sharman, J.P.1    Coutre, S.E.2    Furman, R.R.3
  • 10
    • 84902183019 scopus 로고    scopus 로고
    • Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib
    • Woyach JA, Furman RR, Liu TM, et al. Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. N Engl J Med. 2014;370(24): 2286-2294.
    • (2014) N Engl J Med , vol.370 , Issue.24 , pp. 2286-2294
    • Woyach, J.A.1    Furman, R.R.2    Liu, T.M.3
  • 11
    • 84927656208 scopus 로고    scopus 로고
    • Functional characterization of BTK mutation that confers ibrutinib resistance: Exploration of alternative kinase inhibitors
    • Cheng S, Guo A, Lu P, Ma J, Coleman M, Wang YL. Functional characterization of BTK mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors. Leukemia. 2015;29(4):895-900.
    • (2015) Leukemia , vol.29 , Issue.4 , pp. 895-900
    • Cheng, S.1    Guo, A.2    Lu, P.3    Ma, J.4    Coleman, M.5    Wang, Y.L.6
  • 12
    • 84867255789 scopus 로고    scopus 로고
    • A hypermorphic missense mutation in PLCG2, encoding phospholipase Cgamma2, causes a dominantly inherited autoinflammatory disease with immunodeficiency
    • Zhou Q, Lee GS, Brady J, et al. A hypermorphic missense mutation in PLCG2, encoding phospholipase Cgamma2, causes a dominantly inherited autoinflammatory disease with immunodeficiency. Am J Human Genet. 2012;91(4):713-720.
    • (2012) Am J Human Genet , vol.91 , Issue.4 , pp. 713-720
    • Zhou, Q.1    Lee, G.S.2    Brady, J.3
  • 13
    • 84937841721 scopus 로고    scopus 로고
    • Hypermorphic mutation of phospholipase C, gamma 2 acquired in ibrutinib resistant CLL confers BTK independency upon BCR activation
    • Liu TM, Woyach JA, Zhong Y, et al. Hypermorphic mutation of phospholipase C, gamma 2 acquired in ibrutinib resistant CLL confers BTK independency upon BCR activation. Blood. 2015;126(1): 61-68.
    • (2015) Blood , vol.126 , Issue.1 , pp. 61-68
    • Liu, T.M.1    Woyach, J.A.2    Zhong, Y.3
  • 14
    • 84994504370 scopus 로고    scopus 로고
    • Etiology of ibrutinib therapy discontinuation and outcomes in patients with chronic lymphocytic leukemia
    • Maddocks KJ, Ruppert AS, Lozanski G, et al. Etiology of ibrutinib therapy discontinuation and outcomes in patients with chronic lymphocytic leukemia. JAMA Oncol. 2015;1(1):80-87.
    • (2015) JAMA Oncol , vol.1 , Issue.1 , pp. 80-87
    • Maddocks, K.J.1    Ruppert, A.S.2    Lozanski, G.3
  • 15
    • 84902163170 scopus 로고    scopus 로고
    • Clonal evolution in patients with chronic lymphocytic leukemia (CLL) developing resistance to BTK inhibition
    • Abstract 866
    • Burger JA, Landau D, Hoellenriegel J, et al. Clonal evolution in patients with chronic lymphocytic leukemia (CLL) developing resistance to BTK inhibition. Blood. 2013;122(21):Abstract 866.
    • (2013) Blood , vol.122 , Issue.21
    • Burger, J.A.1    Landau, D.2    Hoellenriegel, J.3
  • 16
    • 84907284539 scopus 로고    scopus 로고
    • Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL)
    • Komarova NL, Burger JA, Wodarz D. Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL). Proc Natl Acad Sci USA. 2014;111(38):13906-13911.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.38 , pp. 13906-13911
    • Komarova, N.L.1    Burger, J.A.2    Wodarz, D.3
  • 17
    • 84919483332 scopus 로고    scopus 로고
    • Ibrutinib-naive chronic lymphocytic leukemia lacks Bruton tyrosine kinase mutations associated with treatment resistance
    • Fama R, Bomben R, Rasi S, et al. Ibrutinib-naive chronic lymphocytic leukemia lacks Bruton tyrosine kinase mutations associated with treatment resistance. Blood. 2014;124(25):3831-3833.
    • (2014) Blood , vol.124 , Issue.25 , pp. 3831-3833
    • Fama, R.1    Bomben, R.2    Rasi, S.3
  • 18
    • 84906903473 scopus 로고    scopus 로고
    • Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma
    • Chiron D, Di Liberto M, Martin P, et al. Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma. Cancer Discov. 2014;4(9):1022-1035.
    • (2014) Cancer Discov , vol.4 , Issue.9 , pp. 1022-1035
    • Chiron, D.1    Liberto M, D.I.2    Martin, P.3
  • 19
    • 84920679727 scopus 로고    scopus 로고
    • The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia
    • Cao Y, Hunter ZR, Liu X, et al. The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia. Leukemia 2015;29(1):169-176.
    • (2015) Leukemia , vol.29 , Issue.1 , pp. 169-176
    • Cao, Y.1    Hunter, Z.R.2    Liu, X.3
  • 20
    • 84901796219 scopus 로고    scopus 로고
    • A prospective multicenter study of the Bruton's tyrosine kinase inhibitor ibrutinib in patients with relapsed or refractory Waldenstrom's macroglobulinemia
    • Abstract 251
    • Treon SP, Tripsas CK, Yang G, et al. A prospective multicenter study of the Bruton's tyrosine kinase inhibitor ibrutinib in patients with relapsed or refractory Waldenstrom's macroglobulinemia. Blood. 2013;122(21): Abstract 251.
    • (2013) Blood , vol.122 , Issue.21
    • Treon, S.P.1    Tripsas, C.K.2    Yang, G.3
  • 21
    • 84862152044 scopus 로고    scopus 로고
    • Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma
    • Yang Y, Shaffer AL III, Emre NC, et al. Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma. Cancer Cell. 2012;21(6):723-737.
    • (2012) Cancer Cell , vol.21 , Issue.6 , pp. 723-737
    • Yang, Y.1    Shaffer, A.L.2    Emre, N.C.3
  • 22
    • 73849145729 scopus 로고    scopus 로고
    • Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
    • Davis RE, Ngo VN, Lenz G, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature. 2010;463(7277):88-92.
    • (2010) Nature , vol.463 , Issue.7277 , pp. 88-92
    • Davis, R.E.1    Ngo, V.N.2    Lenz, G.3
  • 23
    • 79960036578 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • Puente XS, Pinyol M, Quesada V, et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature. 2011;475(7354):101-105.
    • (2011) Nature , vol.475 , Issue.7354 , pp. 101-105
    • Puente, X.S.1    Pinyol, M.2    Quesada, V.3
  • 24
    • 84891861044 scopus 로고    scopus 로고
    • Clonal evolution in hematological malignancies and therapeutic implications
    • Landau DA, Carter SL, Getz G, Wu CJ. Clonal evolution in hematological malignancies and therapeutic implications. Leukemia 2014;28(1):34-43.
    • (2014) Leukemia , vol.28 , Issue.1 , pp. 34-43
    • Landau, D.A.1    Carter, S.L.2    Getz, G.3    Wu, C.J.4
  • 25
    • 84877930029 scopus 로고    scopus 로고
    • P110alpha-mediated constitutive PI3K signaling limits the efficacy of p110delta-selective inhibition in mantle cell lymphoma, particularly with multiple relapse
    • Iyengar S, Clear A, Bodor C, et al. P110alpha-mediated constitutive PI3K signaling limits the efficacy of p110delta-selective inhibition in mantle cell lymphoma, particularly with multiple relapse. Blood. 2013;121(12):2274-2284.
    • (2013) Blood , vol.121 , Issue.12 , pp. 2274-2284
    • Iyengar, S.1    Clear, A.2    Bodor, C.3
  • 26
    • 84903751985 scopus 로고    scopus 로고
    • Acquired PIK3CA amplification causes resistance to selective phosphoinositide 3-kinase inhibitors in breast cancer
    • Huw LY, O'Brien C, Pandita A, et al. Acquired PIK3CA amplification causes resistance to selective phosphoinositide 3-kinase inhibitors in breast cancer. Oncogenesis. 2013;2:e83.
    • (2013) Oncogenesis , vol.2 , pp. e83
    • Huw, L.Y.1    O'Brien, C.2    Pandita, A.3
  • 27
    • 80054863376 scopus 로고    scopus 로고
    • A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer
    • Muellner MK, Uras IZ, Gapp BV, et al. A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer. Nat Chem Biol. 2011;7(11):787-793.
    • (2011) Nat Chem Biol , vol.7 , Issue.11 , pp. 787-793
    • Muellner, M.K.1    Uras, I.Z.2    Gapp, B.V.3
  • 28
    • 84924378560 scopus 로고    scopus 로고
    • Complex karyotype, rather than Del(17p), is associated with inferior outcomes in relapsed or refractory CLL patients treated with ibrutinib-based regimens
    • Abstract 22
    • Thompson PA, Wierda WG, Ferrajoli A, et al. Complex karyotype, rather than Del(17p), is associated with inferior outcomes in relapsed or refractory CLL patients treated with ibrutinib-based regimens. Blood. 2014;124(21):Abstract 22.
    • (2014) Blood , vol.124 , Issue.21
    • Thompson, P.A.1    Wierda, W.G.2    Ferrajoli, A.3
  • 29
    • 84907061764 scopus 로고    scopus 로고
    • ABT-199 (GDC-0199) in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL): High complete-response rate and durable disease control
    • Abstract 7015
    • Seymour JF, Davids MS, Pagel JM, et al. ABT-199 (GDC-0199) in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL): high complete-response rate and durable disease control. J Clin Oncol. 2014;32(5s):Abstract 7015.
    • (2014) J Clin Oncol , vol.32 , Issue.5
    • Seymour, J.F.1    Davids, M.S.2    Pagel, J.M.3
  • 30
    • 84925484937 scopus 로고    scopus 로고
    • Determination of recommended phase 2 dose of ABT-199 (GDC-0199) combined with Rituximab (R) in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)
    • Abstract 325
    • Roberts AW, Ma S, Brander DM, et al. Determination of recommended phase 2 dose of ABT-199 (GDC-0199) combined with Rituximab (R) in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) Blood. 2014:Abstract 325.
    • (2014) Blood
    • Roberts, A.W.1    Ma, S.2    Brander, D.M.3
  • 31
    • 84915822064 scopus 로고    scopus 로고
    • IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells
    • Dong S, Guinn D, Dubovsky JA, et al. IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells. Blood. 2014;124(24):3583-3586.
    • (2014) Blood , vol.124 , Issue.24 , pp. 3583-3586
    • Dong, S.1    Guinn, D.2    Dubovsky, J.A.3
  • 32
    • 84930330798 scopus 로고    scopus 로고
    • Clinical activity of duvelisib (IPI-145), a phosphoinositide-3-kinase , inhibitor, in patients previously treated with ibrutinib
    • Abstract 3335
    • Porcu P, Flinn I, Kahl BS, et al. Clinical activity of duvelisib (IPI-145), a phosphoinositide-3-kinase , inhibitor, in patients previously treated with ibrutinib. Blood. 2014;124(21):Abstract 3335.
    • (2014) Blood , vol.124 , Issue.21
    • Porcu, P.1    Flinn, I.2    Kahl, B.S.3
  • 33
    • 85010999076 scopus 로고    scopus 로고
    • Evaluation of reversible BTK inhibitors in cell lines with clinically relevant Ibrutinib resistance mutations
    • Abstract 136
    • Choy RW, Burton L, Young W, Crawford JJ, Penuel E, Belmont LD. Evaluation of reversible BTK inhibitors in cell lines with clinically relevant Ibrutinib resistance mutations Am Assoc Cancer Res. 2015: Abstract 136.
    • (2015) Am Assoc Cancer Res
    • Choy, R.W.1    Burton, L.2    Young, W.3    Crawford, J.J.4    Penuel, E.5    Belmont, L.D.6
  • 34
    • 84938132878 scopus 로고    scopus 로고
    • Newer-generation HSP90 inhibitors can overcome ibrutinib resistance and suppress proliferation in human mantle cell lymphoma in vitro and in vivo
    • Abstract 1686
    • Kopp N, Tschuri S, Haebe S, et al. Newer-generation HSP90 inhibitors can overcome ibrutinib resistance and suppress proliferation in human mantle cell lymphoma in vitro and in vivo. Blood. 2014:Abstract 1686.
    • (2014) Blood
    • Kopp, N.1    Tschuri, S.2    Haebe, S.3
  • 35
    • 84964694021 scopus 로고    scopus 로고
    • Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia
    • Hing ZA, Mantel R, Beckwith KA, et al. Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia. Blood. 2015;125(20):3128-3132.
    • (2015) Blood , vol.125 , Issue.20 , pp. 3128-3132
    • Hing, Z.A.1    Mantel, R.2    Beckwith, K.A.3
  • 36
    • 84907322714 scopus 로고    scopus 로고
    • PKC-beta as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL
    • El-Gamal D, Williams K, LaFollette TD, et al. PKC-beta as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL. Blood. 2014;124(9):1481-1491.
    • (2014) Blood , vol.124 , Issue.9 , pp. 1481-1491
    • El-Gamal, D.1    Williams, K.2    LaFollette, T.D.3
  • 37
    • 84888216911 scopus 로고    scopus 로고
    • Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
    • Dubovsky JA, Beckwith KA, Natarajan G, et al. Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes. Blood. 2013;122(15):2539-2549.
    • (2013) Blood , vol.122 , Issue.15 , pp. 2539-2549
    • Dubovsky, J.A.1    Beckwith, K.A.2    Natarajan, G.3
  • 38
    • 80051928145 scopus 로고    scopus 로고
    • Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia
    • Lee BN, Gao H, Cohen EN, et al. Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia. Cancer. 2011;117(17): 3999-4008.
    • (2011) Cancer , vol.117 , Issue.17 , pp. 3999-4008
    • Lee, B.N.1    Gao, H.2    Cohen, E.N.3
  • 39
    • 84938132879 scopus 로고    scopus 로고
    • T-cell dysfunction in CLL is mediated not only by PD-1/PD-L1 but also by PD-1/PD-L2 interactions-partial functionality is maintained in PD-1 defined CD8 subsets and this can be further promoted by ibrutinib treatment
    • Abstract 4120
    • McClanahan F, Miller S, Riches JC, et al. T-cell dysfunction in CLL is mediated not only by PD-1/PD-L1 but also by PD-1/PD-L2 interactions-partial functionality is maintained in PD-1 defined CD8 subsets and this can be further promoted by ibrutinib treatment. Blood. 2013;122(21): Abstract 4120.
    • (2013) Blood , vol.122 , Issue.21
    • McClanahan, F.1    Miller, S.2    Riches, J.C.3
  • 40
    • 84924033378 scopus 로고    scopus 로고
    • Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK
    • Sagiv-Barfi I, Kohrt HE, Czerwinski DK, Ng PP, Chang BY, Levy R. Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK. Proc Natl Acad Sci USA. 2015;112(9):E966-E972.
    • (2015) Proc Natl Acad Sci USA , vol.112 , Issue.9 , pp. E966-E972
    • Sagiv-Barfi, I.1    Kohrt, H.E.2    Czerwinski, D.K.3    Ng, P.P.4    Chang, B.Y.5    Levy, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.