메뉴 건너뛰기




Volumn 122, Issue 15, 2013, Pages 2664-2672

Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD19 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; IBRUTINIB; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; CELL SURFACE RECEPTOR; CXCR4 PROTEIN, HUMAN; IMMOBILIZED ANTIBODY; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84891519509     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-02-485425     Document Type: Article
Times cited : (52)

References (41)
  • 4
    • 74949107027 scopus 로고    scopus 로고
    • The normal ighv1-69-derived b-cell repertoire contains stereotypic patterns characteristic of unmutated Cll
    • Forconi F, Potter KN, Wheatley I, et al. The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL. Blood. 2010;115(1):71-77.
    • (2010) Blood , vol.115 , Issue.1 , pp. 71-77
    • Forconi, F.1    Potter, K.N.2    Wheatley, I.3
  • 5
    • 0033567968 scopus 로고    scopus 로고
    • Ig v gene mutation status and cd38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94(6):1840-1847.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 6
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated ig v(h) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94(6): 1848-1854.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 7
    • 34248354409 scopus 로고    scopus 로고
    • Reversible anergy of sigm-mediated signaling in the two subsets of cll defined by vh-gene mutational status
    • Mockridge CI, Potter KN, Wheatley I, Neville LA, Packham G, Stevenson FK. Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status. Blood. 2007;109(10):4424-4431.
    • (2007) Blood , vol.109 , Issue.10 , pp. 4424-4431
    • Mockridge, C.I.1    Potter, K.N.2    Wheatley, I.3    Neville, L.A.4    Packham, G.5    Stevenson, F.K.6
  • 8
    • 80054853285 scopus 로고    scopus 로고
    • B-cell receptor signaling in chronic lymphocytic leukemia
    • Stevenson FK, Krysov S, Davies AJ, Steele AJ, Packham G. B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2011;118(16): 4313-4320.
    • (2011) Blood , vol.118 , Issue.16 , pp. 4313-4320
    • Stevenson, F.K.1    Krysov, S.2    Davies, A.J.3    Steele, A.J.4    Packham, G.5
  • 9
    • 0037306842 scopus 로고    scopus 로고
    • Differential signaling via surface igm is associated with vh gene mutational status and cd38 expression in chronic lymphocytic leukemia
    • Lanham S, Hamblin T, Oscier D, Ibbotson R, Stevenson F, Packham G. Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia. Blood. 2003;101(3): 1087-1093.
    • (2003) Blood , vol.101 , Issue.3 , pp. 1087-1093
    • Lanham, S.1    Hamblin, T.2    Oscier, D.3    Ibbotson, R.4    Stevenson, F.5    Packham, G.6
  • 10
    • 84859256604 scopus 로고    scopus 로고
    • Inhibiting b-cell receptor signaling pathways in chronic lymphocytic leukemia
    • Burger JA. Inhibiting B-cell receptor signaling pathways in chronic lymphocytic leukemia. Curr Hematol Malig Rep. 2012;7(1):26-33.
    • (2012) Curr Hematol Malig Rep , vol.7 , Issue.1 , pp. 26-33
    • Burger, J.A.1
  • 11
    • 38949203770 scopus 로고    scopus 로고
    • Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: Implications for the role of antigen selection in leukemogenesis
    • Murray F, Darzentas N, Hadzidimitriou A, et al. Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood. 2008;111(3): 1524-1533.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1524-1533
    • Murray, F.1    Darzentas, N.2    Hadzidimitriou, A.3
  • 12
    • 33846108722 scopus 로고    scopus 로고
    • Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
    • Stamatopoulos K, Belessi C, Moreno C, et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood. 2007;109(1):259-270.
    • (2007) Blood , vol.109 , Issue.1 , pp. 259-270
    • Stamatopoulos, K.1    Belessi, C.2    Moreno, C.3
  • 13
    • 4944244255 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia b cells of more than 1% of patients express virtually identical immunoglobulins
    • Widhopf GF II, Rassenti LZ, Toy TL, Gribben JG, Wierda WG, Kipps TJ. Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood. 2004;104(8):2499-2504.
    • (2004) Blood , vol.104 , Issue.8 , pp. 2499-2504
    • Widhopf, G.F.1    Rassenti, L.Z.2    Toy, T.L.3    Gribben, J.G.4    Wierda, W.G.5    Kipps, T.J.6
  • 14
    • 0035164178 scopus 로고    scopus 로고
    • Normal b cells express 51p1-encoded ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia b cells
    • Widhopf GF II, Kipps TJ. Normal B cells express 51p1-encoded Ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia B cells. J Immunol. 2001;166(1):95-102.
    • (2001) J Immunol. , vol.166 , Issue.1 , pp. 95-102
    • Widhopf, G.F.1    Kipps, T.J.2
  • 15
    • 78649786581 scopus 로고    scopus 로고
    • Antigens in chronic lymphocytic leukemia: Implications for cell origin and leukemogenesis
    • Rosén A, Murray F, Evaldsson C, Rosenquist R. Antigens in chronic lymphocytic leukemia: implications for cell origin and leukemogenesis. Semin Cancer Biol. 2010;20(6):400-409.
    • (2010) Semin Cancer Biol. , vol.20 , Issue.6 , pp. 400-409
    • Rosén, A.1    Murray, F.2    Evaldsson, C.3    Rosenquist, R.4
  • 16
    • 79951498701 scopus 로고    scopus 로고
    • Cellular origin(s) of chronic lymphocytic leukemia: Cautionary notes and additional considerations and possibilities
    • Chiorazzi N, Ferrarini M. Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood. 2011;117(6):1781-1791.
    • (2011) Blood , vol.117 , Issue.6 , pp. 1781-1791
    • Chiorazzi, N.1    Ferrarini, M.2
  • 17
    • 77649221374 scopus 로고    scopus 로고
    • Impact of the host genetic background on prognosis of chronic lymphocytic leukemia
    • Rasi S, Forconi F, Bruscaggin A, Sozzi E, Gaidano G, Rossi D. Impact of the host genetic background on prognosis of chronic lymphocytic leukemia. Blood. 2010;115(5):1106-1107.
    • (2010) Blood , vol.115 , Issue.5 , pp. 1106-1107
    • Rasi, S.1    Forconi, F.2    Bruscaggin, A.3    Sozzi, E.4    Gaidano, G.5    Rossi, D.6
  • 18
    • 84857711341 scopus 로고    scopus 로고
    • The Ighv1-69/ighj3 recombinations of unmutated cll are distinct from those of normal b cells
    • Forconi F, Potter KN, Sozzi E, et al. The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells. Blood. 2012; 119(9):2106-2109.
    • (2012) Blood , vol.119 , Issue.9 , pp. 2106-2109
    • Forconi, F.1    Potter, K.N.2    Sozzi, E.3
  • 19
    • 78751549662 scopus 로고    scopus 로고
    • The lymph node microenvironment promotes b-cell receptor signaling, nf-kappab activation, and tumor proliferation in chronic lymphocytic leukemia
    • Herishanu Y, Pérez-Galán P, Liu D, et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood. 2011;117(2):563-574.
    • (2011) Blood , vol.117 , Issue.2 , pp. 563-574
    • Herishanu, Y.1    Pérez-Galán, P.2    Liu, D.3
  • 20
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature b-cell malignancies: A target for new treatment strategies
    • Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood. 2009;114(16):3367-3375.
    • (2009) Blood , vol.114 , Issue.16 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3    Caligaris-Cappio, F.4
  • 21
    • 78649786160 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in chronic lymphocytic leukemia (cll): From understanding the basics towards therapeutic targeting
    • Burger JA. Chemokines and chemokine receptors in chronic lymphocytic leukemia (CLL): from understanding the basics towards therapeutic targeting. Semin Cancer Biol. 2010;20(6): 424-430.
    • (2010) Semin Cancer Biol. , vol.20 , Issue.6 , pp. 424-430
    • Burger, J.A.1
  • 22
    • 33344464945 scopus 로고    scopus 로고
    • Cxcr4: A key receptor in the crosstalk between tumor cells and their microenvironment
    • Burger JA, Kipps TJ. CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood. 2006;107(5): 1761-1767.
    • (2006) Blood , vol.107 , Issue.5 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 23
    • 0033519236 scopus 로고    scopus 로고
    • B cell antigen receptor engagement inhibits stromal cell-derived factor (sdf)-1alpha chemotaxis and promotes protein kinase c (pkc)-induced internalization of Cxcr4
    • Guinamard R, Signoret N, Ishiai M, Marsh M, Kurosaki T, Ravetch JV. B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1alpha chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4. J Exp Med. 1999;189(9):1461-1466.
    • (1999) J Exp Med. , vol.189 , Issue.9 , pp. 1461-1466
    • Guinamard, R.1    Signoret, N.2    Ishiai, M.3    Marsh, M.4    Kurosaki, T.5    Ravetch, J.V.6
  • 24
    • 69249120197 scopus 로고    scopus 로고
    • Down-regulation of cxcr4 and cd62l in chronic lymphocytic leukemia cells is triggered by b-cell receptor ligation and associated with progressive disease
    • Vlad A, Deglesne P-A, Letestu R, et al. Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease. Cancer Res. 2009;69(16):6387-6395.
    • (2009) Cancer Res. , vol.69 , Issue.16 , pp. 6387-6395
    • Vlad, A.1    Deglesne, P.-A.2    Letestu, R.3
  • 25
    • 70349237504 scopus 로고    scopus 로고
    • B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, r406
    • Quiroga MP, Balakrishnan K, Kurtova AV, et al. B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood. 2009; 114(5):1029-1037.
    • (2009) Blood , vol.114 , Issue.5 , pp. 1029-1037
    • Quiroga, M.P.1    Balakrishnan, K.2    Kurtova, A.V.3
  • 26
    • 84863393559 scopus 로고    scopus 로고
    • Surface igm stimulation induces Mek1/2-dependent myc expression in chronic lymphocytic leukemia cells
    • Krysov S, Dias S, Paterson A, et al. Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells. Blood. 2012;119(1):170-179.
    • (2012) Blood , vol.119 , Issue.1 , pp. 170-179
    • Krysov, S.1    Dias, S.2    Paterson, A.3
  • 27
    • 8644241022 scopus 로고    scopus 로고
    • Hairy cell leukemia: At the crossroad of somatic mutation and isotype switch
    • Forconi F, Sahota SS, Raspadori D, Ippoliti M, Babbage G, Lauria F, et al. Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch. Blood. 2004;104(10):3312-3317.
    • (2004) Blood , vol.104 , Issue.10 , pp. 3312-3317
    • Forconi, F.1    Sahota, S.S.2    Raspadori, D.3    Ippoliti, M.4    Babbage, G.5    Lauria, F.6
  • 28
    • 66949168111 scopus 로고    scopus 로고
    • The prognosis of clinical monoclonal b cell lymphocytosis differs from prognosis of rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors
    • Rossi D, Sozzi E, Puma A, et al. The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors. Br J Haematol. 2009;146(1):64-75.
    • (2009) Br J Haematol , vol.146 , Issue.1 , pp. 64-75
    • Rossi, D.1    Sozzi, E.2    Puma, A.3
  • 29
    • 20444389401 scopus 로고    scopus 로고
    • Sustained signaling through the b-cell receptor induces mcl-1 and promotes survival of chronic lymphocytic leukemia b cells
    • Petlickovski A, Laurenti L, Li X, et al. Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells. Blood. 2005;105(12): 4820-4827.
    • (2005) Blood , vol.105 , Issue.12 , pp. 4820-4827
    • Petlickovski, A.1    Laurenti, L.2    Li, X.3
  • 30
    • 0018097999 scopus 로고
    • Comparing stimulation of lymphocytes in different samples: Separate effects of numbers of responding cells and their capacity to respond
    • Knight SC, Farrant J. Comparing stimulation of lymphocytes in different samples: separate effects of numbers of responding cells and their capacity to respond. J Immunol Methods. 1978; 22(1-2):63-71.
    • (1978) J Immunol Methods , vol.22 , Issue.1-2 , pp. 63-71
    • Knight, S.C.1    Farrant, J.2
  • 31
    • 79955601718 scopus 로고    scopus 로고
    • Cd49d is an independent prognostic marker that is associated with cxcr4 expression in Cll
    • Majid A, Lin TT, Best G, et al. CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL. Leuk Res. 2011; 35(6):750-756.
    • (2011) Leuk Res , vol.35 , Issue.6 , pp. 750-756
    • Majid, A.1    Lin, T.T.2    Best, G.3
  • 32
    • 77953767084 scopus 로고    scopus 로고
    • Bcr-mediated decrease of cxcr4 and cd62l in Cll
    • author reply 5195
    • Quiroga MP, Burger JA. BCR-mediated decrease of CXCR4 and CD62L in CLL. Cancer Res. 2010; 70(12):5194; author reply 5195.
    • (2010) Cancer Res , vol.70 , Issue.12 , pp. 5194
    • Quiroga, M.P.1    Burger, J.A.2
  • 33
    • 74049148128 scopus 로고    scopus 로고
    • In vivo intraclonal and interclonal kinetic heterogeneity in b-cell chronic lymphocytic leukemia
    • Calissano C, Damle RN, Hayes G, et al. In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia. Blood. 2009; 114(23):4832-4842.
    • (2009) Blood , vol.114 , Issue.23 , pp. 4832-4842
    • Calissano, C.1    Damle, R.N.2    Hayes, G.3
  • 34
    • 82855177892 scopus 로고    scopus 로고
    • Intraclonal complexity in chronic lymphocytic leukemia: Fractions enriched in recently born/divided and older/quiescent cells
    • Calissano C, Damle RN, Marsilio S, et al. Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells. Mol Med. 2011; 17(11-12):1374-1382.
    • (2011) Mol Med , vol.17 , Issue.11-12 , pp. 1374-1382
    • Calissano, C.1    Damle, R.N.2    Marsilio, S.3
  • 35
    • 20044372326 scopus 로고    scopus 로고
    • In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia b cells
    • Messmer BT, Messmer D, Allen SL, et al. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest. 2005;115(3):755-764.
    • (2005) J Clin Invest , vol.115 , Issue.3 , pp. 755-764
    • Messmer, B.T.1    Messmer, D.2    Allen, S.L.3
  • 36
    • 84875678492 scopus 로고    scopus 로고
    • Association between b-cell receptor responsiveness and disease progression in b-cell chronic lymphocytic leukemia: Results from single cell network profiling studies
    • Cesano A, Perbellini O, Evensen E, et al. Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies. Haematologica. 2013;98:626-634.
    • (2013) Haematologica , vol.98 , pp. 626-634
    • Cesano, A.1    Perbellini, O.2    Evensen, E.3
  • 37
    • 77955916272 scopus 로고    scopus 로고
    • Molecular underpinning of b-cell anergy
    • Yarkoni Y, Getahun A, Cambier JC. Molecular underpinning of B-cell anergy. Immunol Rev. 2010;237(1):249-263.
    • (2010) Immunol Rev. , vol.237 , Issue.1 , pp. 249-263
    • Yarkoni, Y.1    Getahun, A.2    Cambier, J.C.3
  • 38
    • 60549091762 scopus 로고    scopus 로고
    • Functional anergy in a subpopulation of naive b cells from healthy humans that express autoreactive immunoglobulin receptors
    • Duty JA, Szodoray P, Zheng NY, et al. Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors. J Exp Med. 2009; 206(1):139-151.
    • (2009) J Exp Med , vol.206 , Issue.1 , pp. 139-151
    • Duty, J.A.1    Szodoray, P.2    Zheng, N.Y.3
  • 39
    • 8644249116 scopus 로고    scopus 로고
    • Intracellular localization and constitutive endocytosis of cxcr4 in human cd341 hematopoietic progenitor cells
    • Zhang Y, Foudi A, Geay JF, et al. Intracellular localization and constitutive endocytosis of CXCR4 in human CD341 hematopoietic progenitor cells. Stem Cells. 2004;22(6): 1015-1029.
    • (2004) Stem Cells , vol.22 , Issue.6 , pp. 1015-1029
    • Zhang, Y.1    Foudi, A.2    Geay, J.F.3
  • 40
    • 0018689243 scopus 로고
    • Cross-linking of lymphocytic surface immunoglobulin inhibits its production via a cyclic nucleotide mechanism
    • Glennie M, Stevenson FK, Stevenson GT, Virji M. Cross-linking of lymphocytic surface immunoglobulin inhibits its production via a cyclic nucleotide mechanism. Nature. 1979;281(5729): 305-307.
    • (1979) Nature , vol.281 , Issue.5729 , pp. 305-307
    • Glennie, M.1    Stevenson, F.K.2    Stevenson, G.T.3    Virji, M.4
  • 41
    • 84874428346 scopus 로고    scopus 로고
    • Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
    • Rossi D, Rasi S, Spina V, et al. Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood. 2013;121(8): 1403-1412.
    • (2013) Blood , vol.121 , Issue.8 , pp. 1403-1412
    • Rossi, D.1    Rasi, S.2    Spina, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.