Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib

Oncotarget

Volumn 7, Issue 4, 2016, Pages 4598-4610

  Guo, Ailin ^a   Lu, Pin ^a   Galanina, Natalie ^a   Nabhan, Chadi ^a   Smith, Sonali M ^a   Coleman, Morton ^b   Wang, Y Lynn ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

BCR pathway; BTK; CLL proliferation; Ibrutinib; IGHV mutational status

Indexed keywords

B LYMPHOCYTE RECEPTOR; BRUTON TYROSINE KINASE; CD40 LIGAND; IBRUTINIB; AGAMMAGLOBULINAEMIA TYROSINE KINASE; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN VARIABLE REGION; PROTEIN TYROSINE KINASE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; TUMOR MARKER;

ARTICLE; CANCER PROGNOSIS; CELL PROLIFERATION; CELL VIABILITY; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CORRELATIONAL STUDY; CPG ISLAND; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; MAJOR CLINICAL STUDY; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CASE CONTROL STUDY; DRUG EFFECTS; DRUG RESISTANCE; ENZYME IMMUNOASSAY; FLOW CYTOMETRY; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; METABOLISM; MUTATION; PATHOLOGY; PHOSPHORYLATION; PROGNOSIS; TUMOR CELL CULTURE; WESTERN BLOTTING;

APOPTOSIS; BIOMARKERS, TUMOR; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MUTATION; PHOSPHORYLATION; PROGNOSIS; PROTEIN-TYROSINE KINASES; PYRAZOLES; PYRIMIDINES; TUMOR CELLS, CULTURED;

EID: 84958012485     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6727     Document Type: Article

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