메뉴 건너뛰기




Volumn 127, Issue 3, 2016, Pages 279-286

Eliminating minimal residual disease as a therapeutic end point: Working toward cure for patients with CLL

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMBUCIL; CYCLOPHOSPHAMIDE; FLUDARABINE; OBINUTUZUMAB; RITUXIMAB; ANTINEOPLASTIC AGENT;

EID: 84958177610     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-08-634816     Document Type: Review
Times cited : (106)

References (72)
  • 1
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • International Group of Investigators; German Chronic Lymphocytic Leukaemia Study Group
    • Hallek M, Fischer K, Fingerle-Rowson G, et al; International Group of Investigators; German Chronic Lymphocytic Leukaemia Study Group. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376(9747):1164-1174
    • (2011) Lancet , vol.376 , Issue.9747 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 2
    • 51649093353 scopus 로고    scopus 로고
    • Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
    • Tam CS, O'Brien S, Wierda W, et al. Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia. Blood. 2008;112(4): 975-980
    • (2008) Blood , vol.112 , Issue.4 , pp. 975-980
    • Tam, C.S.1    O'Brien, S.2    Wierda, W.3
  • 3
    • 40749128044 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide, and mitoxantrone as initial therapy of chronic lymphocytic leukemia: High response rate and disease eradication
    • Bosch F, Ferrer A, Villamor N, et al. Fludarabine, cyclophosphamide, and mitoxantrone as initial therapy of chronic lymphocytic leukemia: high response rate and disease eradication. Clin Cancer Res. 2008; 14(1):155-161
    • (2008) Clin Cancer Res , vol.14 , Issue.1 , pp. 155-161
    • Bosch, F.1    Ferrer, A.2    Villamor, N.3
  • 4
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • Hillmen P, Skotnicki AB, Robak T, et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol. 2007;25(35):5616-5623
    • (2007) J Clin Oncol , vol.25 , Issue.35 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.B.2    Robak, T.3
  • 5
    • 23044501404 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia
    • Wierda W, O'Brien S, Wen S, et al. Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia. J Clin Oncol. 2005;23(18):4070-4078
    • (2005) J Clin Oncol , vol.23 , Issue.18 , pp. 4070-4078
    • Wierda, W.1    O'Brien, S.2    Wen, S.3
  • 6
    • 33846258434 scopus 로고    scopus 로고
    • Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia
    • Kay NE, Geyer SM, Call TG, et al. Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia. Blood. 2007;109(2): 405-411
    • (2007) Blood , vol.109 , Issue.2 , pp. 405-411
    • Kay, N.E.1    Geyer, S.M.2    Call, T.G.3
  • 7
    • 34247594390 scopus 로고    scopus 로고
    • International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia
    • Rawstron AC, Villamor N, Ritgen M, et al. International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia. Leukemia. 2007;21(5): 956-964
    • (2007) Leukemia , vol.21 , Issue.5 , pp. 956-964
    • Rawstron, A.C.1    Villamor, N.2    Ritgen, M.3
  • 8
    • 84873571380 scopus 로고    scopus 로고
    • Improving efficiency and sensitivity: European Research Initiative in CLL (ERIC) update on the international harmonised approach for flow cytometric residual disease monitoring in CLL
    • European Research Initiative in CLL
    • Rawstron AC, Bottcher S, Letestu R, et al; European Research Initiative in CLL. Improving efficiency and sensitivity: European Research Initiative in CLL (ERIC) update on the international harmonised approach for flow cytometric residual disease monitoring in CLL. Leukemia. 2013;27(1): 142-149
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 142-149
    • Rawstron, A.C.1    Bottcher, S.2    Letestu, R.3
  • 9
    • 84875781702 scopus 로고    scopus 로고
    • The role of minimal residual disease measurements in the therapy for CLL: Is it ready for prime time?
    • Bottcher S, Hallek M, Ritgen M, Kneba M. The role of minimal residual disease measurements in the therapy for CLL: is it ready for prime time? Hematol Oncol Clin North Am. 2013;27(2): 267-288
    • (2013) Hematol Oncol Clin North Am , vol.27 , Issue.2 , pp. 267-288
    • Bottcher, S.1    Hallek, M.2    Ritgen, M.3    Kneba, M.4
  • 10
    • 84860630561 scopus 로고    scopus 로고
    • Minimal residual disease quantification is an independent predictor of progression-free and overall survival in chronic lymphocytic leukemia: A multivariate analysis from the randomized GCLLSG CLL8 trial
    • Bottcher S, Ritgen M, Fischer K, et al. Minimal residual disease quantification is an independent predictor of progression-free and overall survival in chronic lymphocytic leukemia: a multivariate analysis from the randomized GCLLSG CLL8 trial. J Clin Oncol. 2012;30(9):980-988
    • (2012) J Clin Oncol , vol.30 , Issue.9 , pp. 980-988
    • Bottcher, S.1    Ritgen, M.2    Fischer, K.3
  • 11
    • 84905191712 scopus 로고    scopus 로고
    • Outcomes of first-line treatment for chronic lymphocytic leukemia with 17p deletion
    • Strati P, Keating MJ, O'Brien SM, et al. Outcomes of first-line treatment for chronic lymphocytic leukemia with 17p deletion. Haematologica. 2014; 99(8):1350-1355
    • (2014) Haematologica , vol.99 , Issue.8 , pp. 1350-1355
    • Strati, P.1    Keating, M.J.2    O'Brien, S.M.3
  • 12
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai KR, Peterson BL, Appelbaum FR, et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 2000;343(24):1750-1757
    • (2000) N Engl J Med , vol.343 , Issue.24 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 13
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progressionfree survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • Byrd JC, Rai K, Peterson BL, et al. Addition of rituximab to fludarabine may prolong progressionfree survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood. 2005;105(1):49-53
    • (2005) Blood , vol.105 , Issue.1 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3
  • 14
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Albitar M, et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol. 2005;23(18):4079-4088
    • (2005) J Clin Oncol , vol.23 , Issue.18 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3
  • 15
    • 84894552888 scopus 로고    scopus 로고
    • Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions
    • Goede V, Fischer K, Busch R, et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med. 2014;370(12):1101-1110
    • (2014) N Engl J Med , vol.370 , Issue.12 , pp. 1101-1110
    • Goede, V.1    Fischer, K.2    Busch, R.3
  • 16
    • 84929505415 scopus 로고    scopus 로고
    • Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): A randomised, multicentre, open-label phase 3 trial
    • COMPLEMENT 1 Study Investigators
    • Hillmen P, Robak T, Janssens A, et al; COMPLEMENT 1 Study Investigators. Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): a randomised, multicentre, open-label phase 3 trial. Lancet. 2015;385(9980): 1873-1883
    • (2015) Lancet , vol.385 , Issue.9980 , pp. 1873-1883
    • Hillmen, P.1    Robak, T.2    Janssens, A.3
  • 17
    • 84904252369 scopus 로고    scopus 로고
    • Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
    • RESONATE Investigators
    • Byrd JC, Brown JR, O'Brien S, et al; RESONATE Investigators. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N Engl J Med. 2014;371(3):213-223
    • (2014) N Engl J Med , vol.371 , Issue.3 , pp. 213-223
    • Byrd, J.C.1    Brown, J.R.2    O'Brien, S.3
  • 18
    • 84879748062 scopus 로고    scopus 로고
    • Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
    • Byrd JC, Furman RR, Coutre SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med. 2013;369(1):32-42
    • (2013) N Engl J Med , vol.369 , Issue.1 , pp. 32-42
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 19
    • 84927732048 scopus 로고    scopus 로고
    • Threeyear follow-up of treatment-naive and previously treated patients with CLL and SLL receiving single-Agent ibrutinib
    • Byrd JC, Furman RR, Coutre SE, et al. Threeyear follow-up of treatment-naive and previously treated patients with CLL and SLL receiving single-Agent ibrutinib. Blood. 2015;125(16): 2497-2506
    • (2015) Blood , vol.125 , Issue.16 , pp. 2497-2506
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 20
    • 84896692766 scopus 로고    scopus 로고
    • Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
    • Furman RR, Sharman JP, Coutre SE, et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med. 2014; 370(11):997-1007
    • (2014) N Engl J Med , vol.370 , Issue.11 , pp. 997-1007
    • Furman, R.R.1    Sharman, J.P.2    Coutre, S.E.3
  • 21
    • 84891373281 scopus 로고    scopus 로고
    • Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: An open-label, multicentre, phase 1b/2 trial
    • O'Brien S, Furman RR, Coutre SE, et al. Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial. Lancet Oncol. 2014;15(1):48-58
    • (2014) Lancet Oncol , vol.15 , Issue.1 , pp. 48-58
    • O'Brien, S.1    Furman, R.R.2    Coutre, S.E.3
  • 22
    • 33745942111 scopus 로고    scopus 로고
    • Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: Report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG CLL2)
    • Polish Leukemia Group (PALG CLL2)
    • Robak T, Blonski JZ, Gora-Tybor J, et al; Polish Leukemia Group (PALG CLL2). Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG CLL2). Blood. 2006;108(2): 473-479
    • (2006) Blood , vol.108 , Issue.2 , pp. 473-479
    • Robak, T.1    Blonski, J.Z.2    Gora-Tybor, J.3
  • 23
    • 0026776598 scopus 로고
    • Response assessment in chronic lymphocytic leukemia after fludarabine plus prednisone: Clinical, pathologic, immunophenotypic, and molecular analysis
    • Robertson LE, Huh YO, Butler JJ, et al. Response assessment in chronic lymphocytic leukemia after fludarabine plus prednisone: clinical, pathologic, immunophenotypic, and molecular analysis. Blood. 1992;80(1):29-36
    • (1992) Blood , vol.80 , Issue.1 , pp. 29-36
    • Robertson, L.E.1    Huh, Y.O.2    Butler, J.J.3
  • 24
    • 0026637511 scopus 로고
    • Evaluation of residual disease in B-cell chronic lymphocytic leukemia patients in clinical and bone-marrow remission using CD5-CD19 markers and PCR study of gene rearrangements
    • Vuillier F, Claisse JF, Vandenvelde C, et al. Evaluation of residual disease in B-cell chronic lymphocytic leukemia patients in clinical and bone-marrow remission using CD5-CD19 markers and PCR study of gene rearrangements. Leuk Lymphoma. 1992;7(3):195-204
    • (1992) Leuk Lymphoma , vol.7 , Issue.3 , pp. 195-204
    • Vuillier, F.1    Claisse, J.F.2    Vandenvelde, C.3
  • 25
    • 0028285289 scopus 로고
    • Residual disease in B-cell chronic lymphocytic leukemia patients and prognostic value
    • Lenormand B, Bizet M, Fruchart C, et al. Residual disease in B-cell chronic lymphocytic leukemia patients and prognostic value. Leukemia. 1994; 8(6):1019-1026
    • (1994) Leukemia , vol.8 , Issue.6 , pp. 1019-1026
    • Lenormand, B.1    Bizet, M.2    Fruchart, C.3
  • 26
    • 0030665507 scopus 로고    scopus 로고
    • Analysis of residual disease in chronic lymphocytic leukemia by flow cytometry
    • Cabezudo E, Matutes E, Ramrattan M, Morilla R, Catovsky D. Analysis of residual disease in chronic lymphocytic leukemia by flow cytometry. Leukemia. 1997;11(11):1909-1914
    • (1997) Leukemia , vol.11 , Issue.11 , pp. 1909-1914
    • Cabezudo, E.1    Matutes, E.2    Ramrattan, M.3    Morilla, R.4    Catovsky, D.5
  • 27
    • 0035412369 scopus 로고    scopus 로고
    • Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy
    • Rawstron AC, Kennedy B, Evans PA, et al. Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy. Blood. 2001;98(1):29-35
    • (2001) Blood , vol.98 , Issue.1 , pp. 29-35
    • Rawstron, A.C.1    Kennedy, B.2    Evans, P.A.3
  • 28
    • 70450233582 scopus 로고    scopus 로고
    • Standardized MRD flow and ASO IGH RQ-PCR for MRD quantification in CLL patients after rituximab-containing immunochemotherapy: A comparative analysis
    • Bottcher S, Stilgenbauer S, Busch R, et al. Standardized MRD flow and ASO IGH RQ-PCR for MRD quantification in CLL patients after rituximab-containing immunochemotherapy: a comparative analysis. Leukemia. 2009;23(11): 2007-2017
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 2007-2017
    • Bottcher, S.1    Stilgenbauer, S.2    Busch, R.3
  • 29
    • 84896114362 scopus 로고    scopus 로고
    • Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice
    • Stehĺikova O, Chovancova J, Tichy B, et al. Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice. Int J Lab Hematol. 2014;36(2):165-171
    • (2014) Int J Lab Hematol , vol.36 , Issue.2 , pp. 165-171
    • Stehĺikova, O.1    Chovancova, J.2    Tichy, B.3
  • 30
    • 84904051707 scopus 로고    scopus 로고
    • Minimal residual disease monitoring in chronic lymphocytic leukaemia patients. A comparative analysis of flow cytometry and ASO IgH RQ-PCR
    • Raponi S, Della Starza I, De Propris MS, et al. Minimal residual disease monitoring in chronic lymphocytic leukaemia patients. A comparative analysis of flow cytometry and ASO IgH RQ-PCR. Br J Haematol. 2014;166(3):360-368
    • (2014) Br J Haematol , vol.166 , Issue.3 , pp. 360-368
    • Raponi, S.1    Della Starza, I.2    De Propris, M.S.3
  • 31
    • 84874286828 scopus 로고    scopus 로고
    • A single tube 10-color flow cytometry assay optimizes detection of minimal residual disease in chronic lymphocytic leukemia
    • Sartor MM, Gottlieb DJ. A single tube 10-color flow cytometry assay optimizes detection of minimal residual disease in chronic lymphocytic leukemia. Cytometry B Clin Cytom. 2013;84(2): 96-103
    • (2013) Cytometry B Clin Cytom , vol.84 , Issue.2 , pp. 96-103
    • Sartor, M.M.1    Gottlieb, D.J.2
  • 32
    • 84927767074 scopus 로고    scopus 로고
    • Minimal residual disease detection with tumor-specific CD160 correlates with event-free survival in chronic lymphocytic leukemia
    • Farren TW, Giustiniani J, Fanous M, et al. Minimal residual disease detection with tumor-specific CD160 correlates with event-free survival in chronic lymphocytic leukemia. Blood Cancer J. 2015;5:e273
    • (2015) Blood Cancer J , vol.5 , pp. e273
    • Farren, T.W.1    Giustiniani, J.2    Fanous, M.3
  • 33
    • 0034034410 scopus 로고    scopus 로고
    • A real-time PCR assay for the quantification of residual malignant cells in B cell chronic lymphatic leukemia
    • Pfitzner T, Engert A, Wittor H, et al. A real-time PCR assay for the quantification of residual malignant cells in B cell chronic lymphatic leukemia. Leukemia. 2000;14(4):754-766
    • (2000) Leukemia , vol.14 , Issue.4 , pp. 754-766
    • Pfitzner, T.1    Engert, A.2    Wittor, H.3
  • 34
    • 0038040665 scopus 로고    scopus 로고
    • Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: Principles, approaches, and laboratory aspects
    • van der Velden VH, Hochhaus A, Cazzaniga G, Szczepanski T, Gabert J, van Dongen JJ. Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects. Leukemia. 2003; 17(6):1013-1034
    • (2003) Leukemia , vol.17 , Issue.6 , pp. 1013-1034
    • Van Der Velden, V.H.1    Hochhaus, A.2    Cazzaniga, G.3    Szczepanski, T.4    Gabert, J.5    Van Dongen, J.J.6
  • 35
    • 33947362505 scopus 로고    scopus 로고
    • Analysis of minimal residual disease by Ig/TCR gene rearrangements: Guidelines for interpretation of real-time quantitative PCR data
    • European Study Group on MRD detection in ALL (ESG-MRD-ALL)
    • van der Velden VH, Cazzaniga G, Schrauder A, et al; European Study Group on MRD detection in ALL (ESG-MRD-ALL). Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data. Leukemia. 2007;21(4): 604-611
    • (2007) Leukemia , vol.21 , Issue.4 , pp. 604-611
    • Van Der Velden, V.H.1    Cazzaniga, G.2    Schrauder, A.3
  • 36
    • 0030698409 scopus 로고    scopus 로고
    • A novel nested-PCR strategy for the detection of rearranged immunoglobulin heavy-chain genes in B cell tumors
    • Voena C, Ladetto M, Astolfi M, et al. A novel nested-PCR strategy for the detection of rearranged immunoglobulin heavy-chain genes in B cell tumors. Leukemia. 1997;11(10):1793-1798
    • (1997) Leukemia , vol.11 , Issue.10 , pp. 1793-1798
    • Voena, C.1    Ladetto, M.2    Astolfi, M.3
  • 37
    • 84881478607 scopus 로고    scopus 로고
    • Minimal residual disease quantification using consensus primers and high-throughput IGH sequencing predicts post-transplant relapse in chronic lymphocytic leukemia
    • Logan AC, Zhang B, Narasimhan B, et al. Minimal residual disease quantification using consensus primers and high-throughput IGH sequencing predicts post-transplant relapse in chronic lymphocytic leukemia. Leukemia. 2013;27(8): 1659-1665
    • (2013) Leukemia , vol.27 , Issue.8 , pp. 1659-1665
    • Logan, A.C.1    Zhang, B.2    Narasimhan, B.3
  • 38
    • 84871525322 scopus 로고    scopus 로고
    • Deepsequencing approach for minimal residual disease detection in acute lymphoblastic leukemia
    • Faham M, Zheng J, Moorhead M, et al. Deepsequencing approach for minimal residual disease detection in acute lymphoblastic leukemia. Blood. 2012;120(26):5173-5180
    • (2012) Blood , vol.120 , Issue.26 , pp. 5173-5180
    • Faham, M.1    Zheng, J.2    Moorhead, M.3
  • 39
    • 84931287940 scopus 로고    scopus 로고
    • Non-invasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing
    • Kurtz DM, Green MR, Bratman SV, et al. Non-invasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing. Blood. 2015;125(24):3679-3687
    • (2015) Blood , vol.125 , Issue.24 , pp. 3679-3687
    • Kurtz, D.M.1    Green, M.R.2    Bratman, S.V.3
  • 40
    • 0028901878 scopus 로고
    • The leukaemic phase of non-Hodgkin's lymphoma
    • Bain BJ, Catovsky D. The leukaemic phase of non-Hodgkin's lymphoma. J Clin Pathol. 1995; 48(3):189-193
    • (1995) J Clin Pathol , vol.48 , Issue.3 , pp. 189-193
    • Bain, B.J.1    Catovsky, D.2
  • 41
    • 84865149544 scopus 로고    scopus 로고
    • Characteristics and outcomes of diffuse large B-cell lymphoma presenting in leukaemic phase
    • Muringampurath-John D, Jaye DL, Flowers CR, et al. Characteristics and outcomes of diffuse large B-cell lymphoma presenting in leukaemic phase. Br J Haematol. 2012;158(5):608-614
    • (2012) Br J Haematol , vol.158 , Issue.5 , pp. 608-614
    • Muringampurath-John, D.1    Jaye, D.L.2    Flowers, C.R.3
  • 42
    • 79957458567 scopus 로고    scopus 로고
    • Cell-free nucleic acids as biomarkers in cancer patients
    • Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer. 2011;11(6):426-437
    • (2011) Nat Rev Cancer , vol.11 , Issue.6 , pp. 426-437
    • Schwarzenbach, H.1    Hoon, D.S.2    Pantel, K.3
  • 43
    • 59149106873 scopus 로고    scopus 로고
    • Sequential therapy with fludarabine, high-dose cyclophosphamide, and rituximab in previously untreated patients with chronic lymphocytic leukemia produces high-quality responses: Molecular remissions predict for durable complete responses
    • Lamanna N, Jurcic JG, Noy A, et al. Sequential therapy with fludarabine, high-dose cyclophosphamide, and rituximab in previously untreated patients with chronic lymphocytic leukemia produces high-quality responses: molecular remissions predict for durable complete responses. J Clin Oncol. 2009;27(4):491-497
    • (2009) J Clin Oncol , vol.27 , Issue.4 , pp. 491-497
    • Lamanna, N.1    Jurcic, J.G.2    Noy, A.3
  • 44
    • 70350342741 scopus 로고    scopus 로고
    • IGHV gene mutational status and LPL/ADAM29 gene expression as clinical outcome predictors in CLL patients in remission following treatment with oral fludarabine plus cyclophosphamide
    • Maloum K, Settegrana C, Chapiro E, et al. IGHV gene mutational status and LPL/ADAM29 gene expression as clinical outcome predictors in CLL patients in remission following treatment with oral fludarabine plus cyclophosphamide. Ann Hematol. 2009;88(12):1215-1221
    • (2009) Ann Hematol , vol.88 , Issue.12 , pp. 1215-1221
    • Maloum, K.1    Settegrana, C.2    Chapiro, E.3
  • 45
    • 84958227353 scopus 로고    scopus 로고
    • Independent prognostic significance of minimal residual disease status in chronic lymphocytic leukaemia
    • special issue
    • Kwok M, Rawstron A, Varghese A, et al. Independent prognostic significance of minimal residual disease status in chronic lymphocytic leukaemia. Lancet. 2014;383(special issue): S66
    • (2014) Lancet , vol.383 , pp. S66
    • Kwok, M.1    Rawstron, A.2    Varghese, A.3
  • 46
    • 84866531516 scopus 로고    scopus 로고
    • Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: A multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group
    • Fischer K, Cramer P, Busch R, et al. Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol. 2012;30(26): 3209-3216
    • (2012) J Clin Oncol , vol.30 , Issue.26 , pp. 3209-3216
    • Fischer, K.1    Cramer, P.2    Busch, R.3
  • 47
    • 84891114095 scopus 로고    scopus 로고
    • Rituximab maintenance after first-line therapy with rituximab, fludarabine, cyclophosphamide, and mitoxantrone (R-FCM) for chronic lymphocytic leukemia
    • Abrisqueta P, Villamor N, Terol MJ, et al. Rituximab maintenance after first-line therapy with rituximab, fludarabine, cyclophosphamide, and mitoxantrone (R-FCM) for chronic lymphocytic leukemia. Blood. 2013;122(24):3951-3959
    • (2013) Blood , vol.122 , Issue.24 , pp. 3951-3959
    • Abrisqueta, P.1    Villamor, N.2    Terol, M.J.3
  • 48
    • 84902590340 scopus 로고    scopus 로고
    • Eradication of bone marrow minimal residual disease may prompt early treatment discontinuation in CLL
    • Strati P, Keating MJ, O'Brien SM, et al. Eradication of bone marrow minimal residual disease may prompt early treatment discontinuation in CLL. Blood. 2014;123(24): 3727-3732
    • (2014) Blood , vol.123 , Issue.24 , pp. 3727-3732
    • Strati, P.1    Keating, M.J.2    O'Brien, S.M.3
  • 49
    • 33744495070 scopus 로고    scopus 로고
    • Clinical significance of minimal residual disease, as assessed by different techniques, after stem cell transplantation for chronic lymphocytic leukemia
    • Moreno C, Villamor N, Colomer D, et al. Clinical significance of minimal residual disease, as assessed by different techniques, after stem cell transplantation for chronic lymphocytic leukemia. Blood. 2006;107(11):4563-4569
    • (2006) Blood , vol.107 , Issue.11 , pp. 4563-4569
    • Moreno, C.1    Villamor, N.2    Colomer, D.3
  • 50
    • 84863769805 scopus 로고    scopus 로고
    • Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: Final results of the national cancer research institute CLL206 trial
    • Pettitt AR, Jackson R, Carruthers S, et al. Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: final results of the national cancer research institute CLL206 trial. J Clin Oncol. 2012;30(14):1647-1655
    • (2012) J Clin Oncol , vol.30 , Issue.14 , pp. 1647-1655
    • Pettitt, A.R.1    Jackson, R.2    Carruthers, S.3
  • 51
    • 21144456107 scopus 로고    scopus 로고
    • Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival
    • Moreton P, Kennedy B, Lucas G, et al. Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival. J Clin Oncol. 2005;23(13):2971-2979
    • (2005) J Clin Oncol , vol.23 , Issue.13 , pp. 2971-2979
    • Moreton, P.1    Kennedy, B.2    Lucas, G.3
  • 52
    • 77957743452 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: Long-term clinical and MRD results of the German CLL Study Group CLL3X trial
    • German CLL Study Group
    • Dreger P, Dohner H, Ritgen M, et al; German CLL Study Group. Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood. 2010;116(14):2438-2447
    • (2011) Blood , vol.116 , Issue.14 , pp. 2438-2447
    • Dreger, P.1    Dohner, H.2    Ritgen, M.3
  • 53
    • 66049119568 scopus 로고    scopus 로고
    • Qualitative and quantitative polymerase chain reaction monitoring of minimal residual disease in relapsed chronic lymphocytic leukemia: Early assessment can predict long-term outcome after reduced intensity allogeneic transplantation
    • Farina L, Carniti C, Dodero A, et al. Qualitative and quantitative polymerase chain reaction monitoring of minimal residual disease in relapsed chronic lymphocytic leukemia: early assessment can predict long-term outcome after reduced intensity allogeneic transplantation. Haematologica. 2009;94(5):654-662
    • (2009) Haematologica , vol.94 , Issue.5 , pp. 654-662
    • Farina, L.1    Carniti, C.2    Dodero, A.3
  • 54
    • 33749019995 scopus 로고    scopus 로고
    • Simplified sensitive method for the detection of B-cell clonality in lymphoid malignancies
    • Jilani I, Keating M, Day A, et al. Simplified sensitive method for the detection of B-cell clonality in lymphoid malignancies. Clin Lab Haematol. 2006;28(5):325-331
    • (2006) Clin Lab Haematol , vol.28 , Issue.5 , pp. 325-331
    • Jilani, I.1    Keating, M.2    Day, A.3
  • 55
    • 84958181962 scopus 로고    scopus 로고
    • Fludarabine cyclophosphamide and rituximab achieves long-term disease-free survival in IGHVmutated chronic lymphocytic leukemia
    • [published online ahead of print October 22
    • Thompson PA, Tam CS, O'Brien SM, et al. Fludarabine, cyclophosphamide and rituximab achieves long-term disease-free survival in IGHVmutated chronic lymphocytic leukemia [published online ahead of print October 22, 2015]. Blood. doi:10.1182/blood-2015-09-667675
    • (2015) Blood
    • Thompson, P.A.1    Tam, C.S.2    O'Brien, S.M.3
  • 56
    • 84863522508 scopus 로고    scopus 로고
    • Immune dysfunction in chronic lymphocytic leukemia: The role for immunotherapy
    • Riches JC, Ramsay AG, Gribben JG. Immune dysfunction in chronic lymphocytic leukemia: the role for immunotherapy. Curr Pharm Des. 2012; 18(23):3389-3398
    • (2012) Curr Pharm des , vol.18 , Issue.23 , pp. 3389-3398
    • Riches, J.C.1    Ramsay, A.G.2    Gribben, J.G.3
  • 57
    • 84976241611 scopus 로고    scopus 로고
    • Other cancers in long-term survivors of chronic lymphocytic leukemia: Incidence and prognostic relevance
    • Falchi L, Keating M, Lerner S, et al. Other cancers in long-term survivors of chronic lymphocytic leukemia: incidence and prognostic relevance. Blood. 2014;124(21):3323
    • (2014) Blood , vol.124 , Issue.21 , pp. 3323
    • Falchi, L.1    Keating, M.2    Lerner, S.3
  • 58
    • 80053350801 scopus 로고    scopus 로고
    • Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia
    • Badoux XC, Keating MJ, Wen S, et al. Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia. Blood. 2011; 118(13):3489-3498
    • (2011) Blood , vol.118 , Issue.13 , pp. 3489-3498
    • Badoux, X.C.1    Keating, M.J.2    Wen, S.3
  • 59
    • 84865165316 scopus 로고    scopus 로고
    • Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: Establishing a reversible immune evasion mechanism in human cancer
    • Ramsay AG, Clear AJ, Fatah R, Gribben JG. Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. Blood. 2012;120(7):1412-1421
    • (2012) Blood , vol.120 , Issue.7 , pp. 1412-1421
    • Ramsay, A.G.1    Clear, A.J.2    Fatah, R.3    Gribben, J.G.4
  • 60
    • 70349153856 scopus 로고    scopus 로고
    • Immune dysfunction in chronic lymphocytic leukemia T cells and lenalidomide as an immunomodulatory drug
    • Ramsay AG, Gribben JG. Immune dysfunction in chronic lymphocytic leukemia T cells and lenalidomide as an immunomodulatory drug. Haematologica. 2009;94(9):1198-1202
    • (2009) Haematologica , vol.94 , Issue.9 , pp. 1198-1202
    • Ramsay, A.G.1    Gribben, J.G.2
  • 61
    • 84907061764 scopus 로고    scopus 로고
    • ABT-199 (GDC-0199) in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL): High completeresponse rate and durable disease control
    • Seymour JF, Davids MS, Pagel JM, et al. ABT-199 (GDC-0199) in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL): high completeresponse rate and durable disease control. J Clin Oncol. 2014;32(15 suppl):7015
    • (2014) J Clin Oncol , vol.32 , Issue.15 , pp. 7015
    • Seymour, J.F.1    Davids, M.S.2    Pagel, J.M.3
  • 62
    • 84959212620 scopus 로고    scopus 로고
    • Venetoclax (ABT-199/GDC-0199) combined with rituximab induces deep responses in patients with relapsed/refractory chronic lymphocytic leukemia [abstract]
    • Abstract S431
    • Roberts AW, Ma S, Brander DM, et al. Venetoclax (ABT-199/GDC-0199) combined with rituximab induces deep responses in patients with relapsed/refractory chronic lymphocytic leukemia [abstract]. Haematologica. 2015;100(Suppl 1):154. Abstract S431
    • (2015) Haematologica , vol.100 , pp. 154
    • Roberts, A.W.1    Ma, S.2    Brander, D.M.3
  • 63
    • 77958595179 scopus 로고    scopus 로고
    • Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: An analysis from the International Randomized Study of Interferon and STI571 (IRIS)
    • IRIS investigators
    • Hughes TP, Hochhaus A, Branford S, et al; IRIS investigators. Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS). Blood. 2010; 116(19):3758-3765
    • (2011) Blood , vol.116 , Issue.19 , pp. 3758-3765
    • Hughes, T.P.1    Hochhaus, A.2    Branford, S.3
  • 64
    • 84942899779 scopus 로고    scopus 로고
    • Pharmacological and protein profiling suggest ABT-199 as optimal partner with ibrutinib in chronic lymphocytic leukemia
    • Cervantes-Gomez F, Lamothe B, Woyach JA, et al. Pharmacological and protein profiling suggest ABT-199 as optimal partner with ibrutinib in chronic lymphocytic leukemia. Clin Cancer Res. 2015;21(16):3705-3715
    • (2015) Clin Cancer Res , vol.21 , Issue.16 , pp. 3705-3715
    • Cervantes-Gomez, F.1    Lamothe, B.2    Woyach, J.A.3
  • 65
    • 84976252624 scopus 로고    scopus 로고
    • Minimal residual disease (MRD) re-growth kinetics are an independent predictor for progression free survival (PFS) in chronic lymphocytic leukemia (CLL) and are related to biologically defined CLL-subgroups: Results from the CLL8 trial of the German CLL Study Group (GCLLSG
    • Boettcher S, Ritgen M, Fischer K, et al. Minimal residual disease (MRD) re-growth kinetics are an independent predictor for progression free survival (PFS) in chronic lymphocytic leukemia (CLL) and are related to biologically defined CLL-subgroups: results from the CLL8 trial of the German CLL Study Group (GCLLSG). Blood. 2011;118(21):1777
    • (2011) Blood , vol.118 , Issue.21 , pp. 1777
    • Boettcher, S.1    Ritgen, M.2    Fischer, K.3
  • 66
    • 85015858206 scopus 로고    scopus 로고
    • Value of minimal residual disease (MRD) negative status at response evaluation in chronic lymphocytic leukemia (CLL): Combined analysis of two phase III studies of the German CLL Study Group (GCLLSG
    • Kovacs G, Boettcher S, Bahlo J, et al. Value of minimal residual disease (MRD) negative status at response evaluation in chronic lymphocytic leukemia (CLL): combined analysis of two phase III studies of the German CLL Study Group (GCLLSG). Blood. 2014;124(21):23
    • (2014) Blood , vol.124 , Issue.21 , pp. 23
    • Kovacs, G.1    Boettcher, S.2    Bahlo, J.3
  • 67
    • 2942694373 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission-experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG)
    • German CLL Study Group (GCLLSG)
    • Wendtner CM, Ritgen M, Schweighofer CD, et al; German CLL Study Group (GCLLSG). Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission-experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG). Leukemia. 2004;18(6):1093-1101
    • (2004) Leukemia , vol.18 , Issue.6 , pp. 1093-1101
    • Wendtner, C.M.1    Ritgen, M.2    Schweighofer, C.D.3
  • 68
    • 57649088296 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab improves progression-free survival in patients with chronic lymphocytic leukaemia (CLL) in first remission: Long-term follow-up of a randomized phase III trial of the German CLL Study Group (GCLLSG
    • Schweighofer CD, Ritgen M, Eichhorst BF, et al. Consolidation with alemtuzumab improves progression-free survival in patients with chronic lymphocytic leukaemia (CLL) in first remission: long-term follow-up of a randomized phase III trial of the German CLL Study Group (GCLLSG). Br J Haematol. 2009;144(1):95-98
    • (2009) Br J Haematol , vol.144 , Issue.1 , pp. 95-98
    • Schweighofer, C.D.1    Ritgen, M.2    Eichhorst, B.F.3
  • 69
    • 65349160420 scopus 로고    scopus 로고
    • Relevance of the immunoglobulin VH somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens
    • Lin KI, Tam CS, Keating MJ, et al. Relevance of the immunoglobulin VH somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens. Blood. 2009;113(14):3168-3171
    • (2009) Blood , vol.113 , Issue.14 , pp. 3168-3171
    • Lin, K.I.1    Tam, C.S.2    Keating, M.J.3
  • 70
    • 84880276168 scopus 로고    scopus 로고
    • Longterm repair of T-cell synapse activity in a phase II trial of chemoimmunotherapy followed by lenalidomide consolidation in previously untreated chronic lymphocytic leukemia (CLL
    • Shanafelt TD, Ramsay AG, Zent CS, et al. Longterm repair of T-cell synapse activity in a phase II trial of chemoimmunotherapy followed by lenalidomide consolidation in previously untreated chronic lymphocytic leukemia (CLL). Blood. 2013; 121(20):4137-4141
    • (2013) Blood , vol.121 , Issue.20 , pp. 4137-4141
    • Shanafelt, T.D.1    Ramsay, A.G.2    Zent, C.S.3
  • 71
    • 84896323847 scopus 로고    scopus 로고
    • Treatment of older patients with chronic lymphocytic leukemia: Key questions and current answers
    • Shanafelt T. Treatment of older patients with chronic lymphocytic leukemia: key questions and current answers. Hematol Am Soc Hematol Educ Progr. 2013;2013:158-167
    • (2013) Hematol Am Soc Hematol Educ Progr , vol.2013 , pp. 158-167
    • Shanafelt, T.1
  • 72
    • 84906855910 scopus 로고    scopus 로고
    • Safety and activity of ibrutinib plus rituximab for patients with high-risk chronic lymphocytic leukaemia: A single-Arm, phase 2 study
    • Burger JA, Keating MJ, Wierda WG, et al. Safety and activity of ibrutinib plus rituximab for patients with high-risk chronic lymphocytic leukaemia: a single-Arm, phase 2 study. Lancet Oncol. 2014; 15(10):1090-1099.
    • (2014) Lancet Oncol , vol.15 , Issue.10 , pp. 1090-1099
    • Burger, J.A.1    Keating, M.J.2    Wierda, W.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.