메뉴 건너뛰기




Volumn 127, Issue 24, 2016, Pages 3015-3025

IL-4 enhances expression and function of surface IgM in CLL cells

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD19 ANTIGEN; CD23 ANTIGEN; CD69 ANTIGEN; CD71 ANTIGEN; CD79B ANTIGEN; CELL SURFACE RECEPTOR; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; HEAT SHOCK COGNATE PROTEIN 70; IBRUTINIB; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 21; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; JANUS KINASE 3; MESSENGER RNA; PHOSPHOTRANSFERASE INHIBITOR; STAT6 PROTEIN; IL4 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; STAT6 PROTEIN, HUMAN;

EID: 84976274450     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-11-682906     Document Type: Article
Times cited : (78)

References (63)
  • 1
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94(6):1848-1854.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 2
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94(6):1840-1847.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 3
    • 80054853285 scopus 로고    scopus 로고
    • B-cell receptor signaling in chronic lymphocytic leukemia
    • Stevenson FK, Krysov S, Davies AJ, Steele AJ, Packham G. B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2011;118(16):4313-4320.
    • (2011) Blood , vol.118 , Issue.16 , pp. 4313-4320
    • Stevenson, F.K.1    Krysov, S.2    Davies, A.J.3    Steele, A.J.4    Packham, G.5
  • 4
    • 84927732048 scopus 로고    scopus 로고
    • Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib
    • Byrd JC, Furman RR, Coutre SE, et al. Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib. Blood. 2015;125(16):2497-2506.
    • (2015) Blood , vol.125 , Issue.16 , pp. 2497-2506
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 5
    • 34248354409 scopus 로고    scopus 로고
    • Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status
    • Mockridge CI, Potter KN, Wheatley I, Neville LA, Packham G, Stevenson FK. Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status. Blood. 2007;109(10):4424-4431.
    • (2007) Blood , vol.109 , Issue.10 , pp. 4424-4431
    • Mockridge, C.I.1    Potter, K.N.2    Wheatley, I.3    Neville, L.A.4    Packham, G.5    Stevenson, F.K.6
  • 6
    • 14944352799 scopus 로고    scopus 로고
    • ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia
    • Chen L, Apgar J, Huynh L, et al. ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood. 2005;105(5):2036-2041.
    • (2005) Blood , vol.105 , Issue.5 , pp. 2036-2041
    • Chen, L.1    Apgar, J.2    Huynh, L.3
  • 7
    • 41949140313 scopus 로고    scopus 로고
    • ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia
    • Chen L, Huynh L, Apgar J, et al. ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. Blood. 2008;111(5):2685-2692.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2685-2692
    • Chen, L.1    Huynh, L.2    Apgar, J.3
  • 8
    • 0037114744 scopus 로고    scopus 로고
    • Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia
    • Chen L, Widhopf G, Huynh L, et al. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2002;100(13):4609-4614.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4609-4614
    • Chen, L.1    Widhopf, G.2    Huynh, L.3
  • 9
    • 84866152172 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
    • Dühren-von Minden M, Übelhart R, Schneider D, et al. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature. 2012;489(7415):309-312.
    • (2012) Nature , vol.489 , Issue.7415 , pp. 309-312
    • Dühren-Von Minden, M.1    Übelhart, R.2    Schneider, D.3
  • 10
    • 84881036532 scopus 로고    scopus 로고
    • Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells
    • Zwick C, Fadle N, Regitz E, et al. Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells. Blood. 2013;121(23):4708-4717.
    • (2013) Blood , vol.121 , Issue.23 , pp. 4708-4717
    • Zwick, C.1    Fadle, N.2    Regitz, E.3
  • 11
    • 84858019141 scopus 로고    scopus 로고
    • Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen
    • Steininger C, Widhopf GF II, Ghia EM, et al. Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen. Blood. 2012;119(10):2293-2301.
    • (2012) Blood , vol.119 , Issue.10 , pp. 2293-2301
    • Steininger, C.1    Widhopf, G.F.2    Ghia, E.M.3
  • 12
    • 84874542878 scopus 로고    scopus 로고
    • A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi
    • Hoogeboom R, van Kessel KP, Hochstenbach F, et al. A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi. J Exp Med. 2013;210(1):59-70.
    • (2013) J Exp Med. , vol.210 , Issue.1 , pp. 59-70
    • Hoogeboom, R.1    Van Kessel, K.P.2    Hochstenbach, F.3
  • 13
    • 0029242481 scopus 로고
    • The tyrosine activation motif as a target of protein tyrosine kinases and SH2 domains
    • Flaswinkel H, Barner M, Reth M. The tyrosine activation motif as a target of protein tyrosine kinases and SH2 domains. Semin Immunol. 1995;7(1):21-27.
    • (1995) Semin Immunol. , vol.7 , Issue.1 , pp. 21-27
    • Flaswinkel, H.1    Barner, M.2    Reth, M.3
  • 14
    • 0032009864 scopus 로고    scopus 로고
    • Structure of and signal transduction through interleukin-4 and interleukin-13 receptors
    • review
    • Murata T, Obiri NI, Puri RK. Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review). Int J Mol Med. 1998;1(3):551-557.
    • (1998) Int J Mol Med. , vol.1 , Issue.3 , pp. 551-557
    • Murata, T.1    Obiri, N.I.2    Puri, R.K.3
  • 15
    • 78649457614 scopus 로고    scopus 로고
    • The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: Potential for reversal of cytoprotection by the microenvironment
    • Steele AJ, Prentice AG, Cwynarski K, et al. The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment. Blood. 2010;116(22):4569-4577.
    • (2010) Blood , vol.116 , Issue.22 , pp. 4569-4577
    • Steele, A.J.1    Prentice, A.G.2    Cwynarski, K.3
  • 16
    • 79955574671 scopus 로고    scopus 로고
    • Transcriptional regulation by STAT6
    • Goenka S, Kaplan MH. Transcriptional regulation by STAT6. Immunol Res. 2011;50(1):87-96.
    • (2011) Immunol Res. , vol.50 , Issue.1 , pp. 87-96
    • Goenka, S.1    Kaplan, M.H.2
  • 17
    • 0027943064 scopus 로고
    • Role of interleukin-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells
    • Punnonen J, Aversa G, Cocks BG, de Vries JE. Role of interleukin-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells. Allergy. 1994;49(8):576-586.
    • (1994) Allergy , vol.49 , Issue.8 , pp. 576-586
    • Punnonen, J.1    Aversa, G.2    Cocks, B.G.3    De Vries, J.E.4
  • 18
    • 65549114338 scopus 로고    scopus 로고
    • IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    • King IL, Mohrs M. IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J Exp Med. 2009;206(5):1001-1007.
    • (2009) J Exp Med. , vol.206 , Issue.5 , pp. 1001-1007
    • King, I.L.1    Mohrs, M.2
  • 19
    • 1642275659 scopus 로고    scopus 로고
    • Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells
    • Cunningham AF, Serre K, Toellner KM, et al. Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells. Eur J Immunol. 2004;34(3):686-694.
    • (2004) Eur J Immunol. , vol.34 , Issue.3 , pp. 686-694
    • Cunningham, A.F.1    Serre, K.2    Toellner, K.M.3
  • 20
    • 0028906467 scopus 로고
    • Impaired mucosal immune responses in interleukin 4-targeted mice
    • Vajdy M, Kosco-Vilbois MH, Kopf M, Köhler G, Lycke N. Impaired mucosal immune responses in interleukin 4-targeted mice. J Exp Med. 1995;181(1):41-53.
    • (1995) J Exp Med. , vol.181 , Issue.1 , pp. 41-53
    • Vajdy, M.1    Kosco-Vilbois, M.H.2    Kopf, M.3    Köhler, G.4    Lycke, N.5
  • 21
    • 0027379859 scopus 로고
    • Interleukin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukaemia cells in vitro
    • Panayiotidis P, Ganeshaguru K, Jabbar SA, Hoffbrand AV. Interleukin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukaemia cells in vitro. Br J Haematol. 1993;85(3):439-445.
    • (1993) Br J Haematol. , vol.85 , Issue.3 , pp. 439-445
    • Panayiotidis, P.1    Ganeshaguru, K.2    Jabbar, S.A.3    Hoffbrand, A.V.4
  • 22
    • 0027499535 scopus 로고
    • Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal
    • Ranheim EA, Kipps TJ. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med. 1993;177(4):925-935.
    • (1993) J Exp Med. , vol.177 , Issue.4 , pp. 925-935
    • Ranheim, E.A.1    Kipps, T.J.2
  • 23
    • 27144549307 scopus 로고    scopus 로고
    • Differential effects on CLL cell survival exerted by different microenvironmental elements
    • Ghia P, Circosta P, Scielzo C, et al. Differential effects on CLL cell survival exerted by different microenvironmental elements. Curr Top Microbiol Immunol. 2005;294:135-145.
    • (2005) Curr Top Microbiol Immunol. , vol.294 , pp. 135-145
    • Ghia, P.1    Circosta, P.2    Scielzo, C.3
  • 24
    • 84890548695 scopus 로고    scopus 로고
    • Distinctive patterns of naïve/memory subset distribution and cytokine expression in CD4 T lymphocytes in ZAP-70 B-chronic lymphocytic patients
    • Monserrat J, Sánchez MA, de Paz R, et al. Distinctive patterns of naïve/memory subset distribution and cytokine expression in CD4 T lymphocytes in ZAP-70 B-chronic lymphocytic patients. Cytometry B Clin Cytom. 2014;86(1):32-43.
    • (2014) Cytometry B Clin Cytom , vol.86 , Issue.1 , pp. 32-43
    • Monserrat, J.1    Sánchez, M.A.2    De Paz, R.3
  • 25
    • 0033025248 scopus 로고    scopus 로고
    • IL4 production and increased CD30 expression by a unique CD8+ T-cell subset in B-cell chronic lymphocytic leukaemia
    • de Totero D, Reato G, Mauro F, et al. IL4 production and increased CD30 expression by a unique CD8+ T-cell subset in B-cell chronic lymphocytic leukaemia. Br J Haematol. 1999;104(3):589-599.
    • (1999) Br J Haematol. , vol.104 , Issue.3 , pp. 589-599
    • De Totero, D.1    Reato, G.2    Mauro, F.3
  • 26
    • 0036348617 scopus 로고    scopus 로고
    • Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B-CLL)
    • Rossmann ED, Lewin N, Jeddi-Tehrani M, Osterborg A, Mellstedt H. Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B-CLL). Eur J Haematol. 2002;68(5):299-306.
    • (2002) Eur J Haematol. , vol.68 , Issue.5 , pp. 299-306
    • Rossmann, E.D.1    Lewin, N.2    Jeddi-Tehrani, M.3    Osterborg, A.4    Mellstedt, H.5
  • 27
    • 0030986972 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-beta
    • Douglas RS, Capocasale RJ, Lamb RJ, Nowell PC, Moore JS. Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-beta. Blood. 1997;89(3):941-947.
    • (1997) Blood , vol.89 , Issue.3 , pp. 941-947
    • Douglas, R.S.1    Capocasale, R.J.2    Lamb, R.J.3    Nowell, P.C.4    Moore, J.S.5
  • 28
    • 0036936831 scopus 로고    scopus 로고
    • Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells
    • Zheng Z, Venkatapathy S, Rao G, Harrington CA. Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells. Leukemia. 2002;16(12):2429-2437.
    • (2002) Leukemia , vol.16 , Issue.12 , pp. 2429-2437
    • Zheng, Z.1    Venkatapathy, S.2    Rao, G.3    Harrington, C.A.4
  • 29
    • 84925285029 scopus 로고    scopus 로고
    • Loss of cooperativity of secreted CD40L and increased dose-response to IL4 on CLL cell viability correlates with enhanced activation of NF-kB and STAT6
    • Bhattacharya N, Reichenzeller M, Caudron-Herger M, et al. Loss of cooperativity of secreted CD40L and increased dose-response to IL4 on CLL cell viability correlates with enhanced activation of NF-kB and STAT6. Int J Cancer. 2015;136(1):65-73.
    • (2015) Int J Cancer , vol.136 , Issue.1 , pp. 65-73
    • Bhattacharya, N.1    Reichenzeller, M.2    Caudron-Herger, M.3
  • 30
    • 79956275845 scopus 로고    scopus 로고
    • A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease
    • Bagnara D, Kaufman MS, Calissano C, et al. A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease. Blood. 2011;117(20):5463-5472.
    • (2011) Blood , vol.117 , Issue.20 , pp. 5463-5472
    • Bagnara, D.1    Kaufman, M.S.2    Calissano, C.3
  • 31
    • 84880100161 scopus 로고    scopus 로고
    • IL-4 upregulates Igα and Igβ protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation
    • Guo B, Rothstein TL. IL-4 upregulates Igα and Igβ protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation. J Immunol. 2013;191(2):670-677.
    • (2013) J Immunol. , vol.191 , Issue.2 , pp. 670-677
    • Guo, B.1    Rothstein, T.L.2
  • 32
    • 17844410418 scopus 로고    scopus 로고
    • B cell receptor (BCR) cross-talk: IL-4 creates an alternate pathway for BCR-induced ERK activation that is phosphatidylinositol 3-kinase independent
    • Guo B, Rothstein TL. B cell receptor (BCR) cross-talk: IL-4 creates an alternate pathway for BCR-induced ERK activation that is phosphatidylinositol 3-kinase independent. J Immunol. 2005;174(9):5375-5381.
    • (2005) J Immunol. , vol.174 , Issue.9 , pp. 5375-5381
    • Guo, B.1    Rothstein, T.L.2
  • 33
    • 0027092054 scopus 로고
    • Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors
    • Fluckiger AC, Rossi JF, Bussel A, Bryon P, Banchereau J, Defrance T. Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors. Blood. 1992;80(12):3173-3181.
    • (1992) Blood , vol.80 , Issue.12 , pp. 3173-3181
    • Fluckiger, A.C.1    Rossi, J.F.2    Bussel, A.3    Bryon, P.4    Banchereau, J.5    Defrance, T.6
  • 34
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • International Workshop on Chronic Lymphocytic Leukemia
    • Hallek M, Cheson BD, Catovsky D, et al; International Workshop on Chronic Lymphocytic Leukemia. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111(12):5446-5456.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 35
    • 55749105875 scopus 로고    scopus 로고
    • p53-mediated apoptosis of CLL cells: Evidence for a transcription-independent mechanism
    • Steele AJ, Prentice AG, Hoffbrand AV, et al. p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism. Blood. 2008;112(9):3827-3834.
    • (2008) Blood , vol.112 , Issue.9 , pp. 3827-3834
    • Steele, A.J.1    Prentice, A.G.2    Hoffbrand, A.V.3
  • 36
    • 84911929992 scopus 로고    scopus 로고
    • Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK
    • Krysov S, Steele AJ, Coelho V, et al. Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK. Blood. 2014;124(20):3101-3109.
    • (2014) Blood , vol.124 , Issue.20 , pp. 3101-3109
    • Krysov, S.1    Steele, A.J.2    Coelho, V.3
  • 37
    • 77953647130 scopus 로고    scopus 로고
    • Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo
    • Krysov S, Potter KN, Mockridge CI, et al. Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo. Blood. 2010;115(21):4198-4205.
    • (2010) Blood , vol.115 , Issue.21 , pp. 4198-4205
    • Krysov, S.1    Potter, K.N.2    Mockridge, C.I.3
  • 38
    • 0032476611 scopus 로고    scopus 로고
    • Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
    • Klein U, Rajewsky K, Küppers R. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med. 1998;188(9):1679-1689.
    • (1998) J Exp Med. , vol.188 , Issue.9 , pp. 1679-1689
    • Klein, U.1    Rajewsky, K.2    Küppers, R.3
  • 39
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102(43):15545-15550.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.43 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3
  • 40
    • 84930679763 scopus 로고    scopus 로고
    • The gene expression response of chronic lymphocytic leukemia cells to IL-4 is specific, depends on ZAP-70 status and is differentially affected by an NFκB inhibitor
    • Ruiz-Lafuente N, Alcaraz-García MJ, Sebastián-Ruiz S, et al. The gene expression response of chronic lymphocytic leukemia cells to IL-4 is specific, depends on ZAP-70 status and is differentially affected by an NFκB inhibitor. PLoS One. 2014;9(10):e109533.
    • (2014) PLoS One , vol.9 , Issue.10
    • Ruiz-Lafuente, N.1    Alcaraz-García, M.J.2    Sebastián-Ruiz, S.3
  • 41
    • 78751549662 scopus 로고    scopus 로고
    • The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
    • Herishanu Y, Pérez-Galán P, Liu D, et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood. 2011;117(2):563-574.
    • (2011) Blood , vol.117 , Issue.2 , pp. 563-574
    • Herishanu, Y.1    Pérez-Galán, P.2    Liu, D.3
  • 42
    • 0032600012 scopus 로고    scopus 로고
    • Sharing of receptor subunits and signal transduction pathway between the IL-4 and IL-13 receptor system
    • Murata T, Taguchi J, Puri RK, Mohri H. Sharing of receptor subunits and signal transduction pathway between the IL-4 and IL-13 receptor system. Int J Hematol. 1999;69(1):13-20.
    • (1999) Int J Hematol. , vol.69 , Issue.1 , pp. 13-20
    • Murata, T.1    Taguchi, J.2    Puri, R.K.3    Mohri, H.4
  • 44
    • 0030890949 scopus 로고    scopus 로고
    • Initiation and processing of signals from the B cell antigen receptor
    • Reth M, Wienands J. Initiation and processing of signals from the B cell antigen receptor. Annu Rev Immunol. 1997;15:453-479.
    • (1997) Annu Rev Immunol. , vol.15 , pp. 453-479
    • Reth, M.1    Wienands, J.2
  • 45
    • 79959404661 scopus 로고    scopus 로고
    • Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
    • Herman SE, Gordon AL, Hertlein E, et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood. 2011;117(23):6287-6296.
    • (2011) Blood , vol.117 , Issue.23 , pp. 6287-6296
    • Herman, S.E.1    Gordon, A.L.2    Hertlein, E.3
  • 46
    • 77957201023 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
    • Herman SE, Gordon AL, Wagner AJ, et al. Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116(12):2078-2088.
    • (2010) Blood , vol.116 , Issue.12 , pp. 2078-2088
    • Herman, S.E.1    Gordon, A.L.2    Wagner, A.J.3
  • 47
    • 78649786160 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in chronic lymphocytic leukemia (CLL): From understanding the basics towards therapeutic targeting
    • Burger JA. Chemokines and chemokine receptors in chronic lymphocytic leukemia (CLL): from understanding the basics towards therapeutic targeting. Semin Cancer Biol. 2010;20(6):424-430.
    • (2010) Semin Cancer Biol. , vol.20 , Issue.6 , pp. 424-430
    • Burger, J.A.1
  • 48
    • 0033485625 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells
    • Burger JA, Burger M, Kipps TJ. Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood. 1999;94(11):3658-3667.
    • (1999) Blood , vol.94 , Issue.11 , pp. 3658-3667
    • Burger, J.A.1    Burger, M.2    Kipps, T.J.3
  • 49
    • 84891519509 scopus 로고    scopus 로고
    • Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function
    • Coelho V, Krysov S, Steele A, et al. Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function. Blood. 2013;122(15):2664-2672.
    • (2013) Blood , vol.122 , Issue.15 , pp. 2664-2672
    • Coelho, V.1    Krysov, S.2    Steele, A.3
  • 50
    • 0036624881 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes
    • Damle RN, Ghiotto F, Valetto A, et al. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood. 2002;99(11):4087-4093.
    • (2002) Blood , vol.99 , Issue.11 , pp. 4087-4093
    • Damle, R.N.1    Ghiotto, F.2    Valetto, A.3
  • 51
    • 84903642390 scopus 로고    scopus 로고
    • The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: Proliferation or anergy
    • Packham G, Krysov S, Allen A, et al. The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy. Haematologica. 2014;99(7):1138-1148.
    • (2014) Haematologica , vol.99 , Issue.7 , pp. 1138-1148
    • Packham, G.1    Krysov, S.2    Allen, A.3
  • 52
    • 84904887947 scopus 로고    scopus 로고
    • MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia
    • Cui B, Chen L, Zhang S, et al. MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. Blood. 2014;124(4):546-554.
    • (2014) Blood , vol.124 , Issue.4 , pp. 546-554
    • Cui, B.1    Chen, L.2    Zhang, S.3
  • 53
    • 46749145421 scopus 로고    scopus 로고
    • CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment
    • Patten PEM, Buggins AGS, Richards J, et al. CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment. Blood. 2008;111(10):5173-5181.
    • (2008) Blood , vol.111 , Issue.10 , pp. 5173-5181
    • Patten, P.E.M.1    Buggins, A.G.S.2    Richards, J.3
  • 54
    • 84880262286 scopus 로고    scopus 로고
    • Enhancement of CD154/IL4 proliferation by the T follicular helper (Tfh) cytokine, IL21 and increased numbers of circulating cells resembling Tfh cells in chronic lymphocytic leukaemia
    • Ahearne MJ, Willimott S, Piñon L, et al. Enhancement of CD154/IL4 proliferation by the T follicular helper (Tfh) cytokine, IL21 and increased numbers of circulating cells resembling Tfh cells in chronic lymphocytic leukaemia. Br J Haematol. 2013;162(3):360-370.
    • (2013) Br J Haematol. , vol.162 , Issue.3 , pp. 360-370
    • Ahearne, M.J.1    Willimott, S.2    Piñon, L.3
  • 55
    • 46749132717 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
    • Ramsay AG, Johnson AJ, Lee AM, et al. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest. 2008;118(7):2427-2437.
    • (2008) J Clin Invest. , vol.118 , Issue.7 , pp. 2427-2437
    • Ramsay, A.G.1    Johnson, A.J.2    Lee, A.M.3
  • 56
    • 84876478036 scopus 로고    scopus 로고
    • T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production
    • Riches JC, Davies JK, McClanahan F, et al. T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production. Blood. 2013;121(9):1612-1621.
    • (2013) Blood , vol.121 , Issue.9 , pp. 1612-1621
    • Riches, J.C.1    Davies, J.K.2    McClanahan, F.3
  • 57
    • 34247138020 scopus 로고    scopus 로고
    • Cutting Edge: B cell receptor (BCR) crosstalk: The IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn
    • Guo B, Blair D, Chiles TC, Lowell CA, Rothstein TL. Cutting Edge: B cell receptor (BCR) crosstalk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn. J Immunol. 2007;178(8):4726-4730.
    • (2007) J Immunol. , vol.178 , Issue.8 , pp. 4726-4730
    • Guo, B.1    Blair, D.2    Chiles, T.C.3    Lowell, C.A.4    Rothstein, T.L.5
  • 58
    • 15944393986 scopus 로고    scopus 로고
    • Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the mu and CD79a chains
    • Vuillier F, Dumas G, Magnac C, et al. Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the mu and CD79a chains. Blood. 2005;105(7):2933-2940.
    • (2005) Blood , vol.105 , Issue.7 , pp. 2933-2940
    • Vuillier, F.1    Dumas, G.2    Magnac, C.3
  • 59
    • 0025916889 scopus 로고
    • The B-cell antigen receptor of the five immunoglobulin classes
    • Venkitaraman AR, Williams GT, Dariavach P, Neuberger MS. The B-cell antigen receptor of the five immunoglobulin classes. Nature. 1991;352(6338):777-781.
    • (1991) Nature , vol.352 , Issue.6338 , pp. 777-781
    • Venkitaraman, A.R.1    Williams, G.T.2    Dariavach, P.3    Neuberger, M.S.4
  • 60
    • 0032067283 scopus 로고    scopus 로고
    • IL-4 induces functional cell-surface expression of CXCR4 on human T cells
    • published correction appears in J Immunol. 1999;162(5)3105
    • Jourdan P, Abbal C, Noraz N, et al. IL-4 induces functional cell-surface expression of CXCR4 on human T cells [published correction appears in J Immunol. 1999;162(5)3105]. J Immunol. 1998;160(9):4153-4157.
    • (1998) J Immunol. , vol.160 , Issue.9 , pp. 4153-4157
    • Jourdan, P.1    Abbal, C.2    Noraz, N.3
  • 61
    • 69249120197 scopus 로고    scopus 로고
    • Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease
    • Vlad A, Deglesne PA, Letestu R, et al. Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease. Cancer Res. 2009;69(16):6387-6395.
    • (2009) Cancer Res. , vol.69 , Issue.16 , pp. 6387-6395
    • Vlad, A.1    Deglesne, P.A.2    Letestu, R.3
  • 62
    • 70349237504 scopus 로고    scopus 로고
    • B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406
    • Quiroga MP, Balakrishnan K, Kurtova AV, et al. B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood. 2009;114(5):1029-1037.
    • (2009) Blood , vol.114 , Issue.5 , pp. 1029-1037
    • Quiroga, M.P.1    Balakrishnan, K.2    Kurtova, A.V.3
  • 63
    • 33645054305 scopus 로고    scopus 로고
    • Epstein-Barr virus infection negatively impacts the CXCR4-dependent migration of tonsillar B cells
    • Ehlin-Henriksson B, Mowafi F, Klein G, Nilsson A. Epstein-Barr virus infection negatively impacts the CXCR4-dependent migration of tonsillar B cells. Immunology. 2006;117(3):379-385.
    • (2006) Immunology , vol.117 , Issue.3 , pp. 379-385
    • Ehlin-Henriksson, B.1    Mowafi, F.2    Klein, G.3    Nilsson, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.